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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
ELI HALIMAH
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Efek Antikalkuli Ekstrak Etanol Herba Seledri (Apium graveolens L.) terhadap Tikus yang Diinduksi Hidroksiprolin Taofik Rusdiana; Lutfi Sulaiman; Eli Halimah; Ami Tjitraresmi; Sri Adi Sumiwi; Yanni D. Mardhiani; Anas Subarnas
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.2052

Abstract

The investigation efforts of an alternative treatment of the kidney stone disease by utilizing Indonesian native plants have still continued both for treatment and prevention. This study aims to strengthen the scientific evidence of the activity of celery as an anticalculi by in vivo assessment using hydroxyprolineinduced rat method. The white male wistar rats used in this study were intraperitoneally induced by hydroxyproline in order to form kidney stones, the celery extract preparations were then given at a dose of 50, 100, and 200 mg/kg of body weight orally for 5 days and observed following parameters: concentration of filtrate urinary calcium, concentration of urinary sediment calcium, as well as kidney to body weight ratio. The results showed that the concentration of filtrate urinary calcium in the test group at a dose of 200 mg/ kg body weight was significantly higher than those of negative control group, whereas the other test groups were not significantly different with the negative control group. The similar result was also shown on the parameter of calcium concentration in the urine sediment, while the ratio of kidney to body weight showed significant differences between all test groups and the negative control group. It can be concluded that the ethanol extract of the herb celery has an anticalculi activity in rats at a dose of 200 mg/kg of body weight.
Botanical and Chemical Overview, Traditional Uses and Potential of Anticancer Activity from Several Costus Plants: A Narrative Review Lina Nafisah; Eli Halimah; Yoppi Iskandar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.561

Abstract

Plants in the Costus genus are known to have various activities, starting from an antibacterial agent, anti-inflammatory, antioxidant, anticancer, antidiabetic, and so on. From some previous studies that have been conducted, it is stated that some Costus plants have a high potential to be a prospective anticancer candidate in the future. This review will discuss botanical and chemical overview, traditional uses, and potential anticancer activity of several Costus plants, namely C.speciosus, C.igneus, C.spiralis, and C.pictus. In conclusion, anticancer activity assay was carried out by several methods using various cell cultures resulting in an IC50 value ranging from strong and very strong, with the strongest potency belonging to C.speciosus with an IC50 value of 13.87 µg/ml. In addition, the active phytoconstituent, mainly diosgenin, contributes to the anticancer activity, which also strengthens the potential of Costus plants.
Botanical and Chemical Overview, Traditional Uses and Potential of Anticancer Activity from Several Costus Plants: A Narrative Review Lina Nafisah; Eli Halimah; Yoppi Iskandar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.561

Abstract

Plants in the Costus genus are known to have various activities, starting from an antibacterial agent, anti-inflammatory, antioxidant, anticancer, antidiabetic, and so on. From some previous studies that have been conducted, it is stated that some Costus plants have a high potential to be a prospective anticancer candidate in the future. This review will discuss botanical and chemical overview, traditional uses, and potential anticancer activity of several Costus plants, namely C.speciosus, C.igneus, C.spiralis, and C.pictus. In conclusion, anticancer activity assay was carried out by several methods using various cell cultures resulting in an IC50 value ranging from strong and very strong, with the strongest potency belonging to C.speciosus with an IC50 value of 13.87 µg/ml. In addition, the active phytoconstituent, mainly diosgenin, contributes to the anticancer activity, which also strengthens the potential of Costus plants.
Co-Authors Aep W Irwan Ahmad Muhtadi Ami Tjitraresmi Anas Subarnas DONI DERMAWAN Dwi Prasetyo Erwin Sasmita Evy Liswati Irma Pratiwi Ivan S. Pradipta Jajan Solahudin Lina Nafisah Lutfi Sulaiman Mardhiani, Yanni Dhiani Marline Abdassah MEGANTARA, SANDRA Melisa I. Barliana Muchtaridi Muchtaridi Nasrul Wathoni Nurul Annisa Rano K. Sinuraya Rena Choerunisa RISDA RAHMI ISLAMIATY Salma H. California Sarini Pani Sri A Sumiwi Sri Adi Sumiwi Sriwidodo Sriwidodo Suhendi, Cece Suseno Amin Taofik Rusdiana Vesara A. Gatera Wiwik Rositawati Yoppi Iskandar