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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Media Farmasi Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Edijanti Goenarwo
Bagian Farmakologi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Ekstrak Daun Sirsak (Annona muricata) Sebagai Penghambat Perkembangan Tumor Payudara Hussaana, Atina; Djam’an, Qathrunnada; Goenarwo, Edijanti; ., Chodidjah
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (834.866 KB) | DOI: 10.33508/jfst.v2i2.723

Abstract

Kanker payudara merupakan penyebab kematian kedua setelah kanker leher rahim pada wanita. Pengobatan kanker sampai sekarang masih belum berhasil dengan baik. Daun sirsak merupakan obat tradisional yang secara empirik dipakai masyarakat Indonesia sebagai obat antiinflamasi dan antikanker. Kandungan aktif acetogenin pada daun sirsak diketahui dapat menginduksi apoptosis dengan meningkatkan aktivitas caspase-3 dan menghambat proliferasi pada kultur sel kanker. Dengan tujuan untuk mengetahui potensi antikanker ekstrak daun sirsak, penelitian ini dilakukan dengan rancangan post test randomized control group design, menggunakan 24 ekor mencit C3H yang telah diinokulasi bubur tumor jenis adenokasrsinoma mamma dan telah tumbuh tumor. Mencit kemudian dikelompokkan secara random menjadi kelompok 1 (kontrol), 2 dan 3, berturut-turut mendapatkan aquades, ekstrak daun sirsak dosis 10 mg/kg dan 20 mg/kg. Perlakuan diberikan peroral selama 30 hari. Selama perlakuan, volume tumor diamati tiap 3 hari untuk mengetahui penghambatan per-kembangan tumor payudara. Pada hari ke-31, jaringan tumor diambil dan dibuat preparat histopatologi untuk pengecatan imunohistokimia terhadap ekspresi protein Ki-67 dan pengecatan Tunnel, berturut-turut untuk mengetahui tingkat proliferasi serta jumlah sel kanker yang mengalami apoptosis. Data di uji dengan uji One Way Anova. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak mampu memperlambat pertumbuhan tumor payudara tetapi tidak mengurangi besar tumor akhir. Disamping itu, ekstrak daun sirsak mampu meng-hambat proliferasi sel melalui hambatan ekspresi Ki-67 dan mampu meningkatkan apoptosis. Kata kunci : daun sirsak, Annona muricata, tumor payudara, Ki-67, apoptosis.
Effect of Ginger Juice Water on Blood Glucose Levels and Histopathology of Pancreatic Beta Cells Experimental Studies on Alloxan Induced Wistar Male Rats Djaman, Qatthrunnada; Goenarwo, Edijanti; Mashoedi, Imam
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.211 KB) | DOI: 10.30659/sainsmed.v4i2.373

Abstract

Background: Hyperglycemia is one of the signs of diabetes mellitus, the disease is still being suffered by the people of Indonesia. Oral antidiabetic drugs mostly give unwanted side effects, then the experts developed a system of traditional medicine for diabetes mellitus. The research aimed to determine the effect of ginger juice on blood glucose levels and histopathological of pancreatic beta cells in male wistar rats induced by alloxan.Design and methods: An experimental study with a post-test only control group design, the study subjects white male wistar rats. Rats were divided into 5 groups, each group consisted of 5 rats, the group I was the control group (no treatment), group II is diabetic group (negative control), group III is Ginger + diabetes group, diabetes group is a group IV + Ginger + glibenclamide at a dose of each half, the group is the group of diabetic + V Glibenklamid.Results: The mean blood glucose levels were highest 172.02 ± 21.40 mg / dl is the K II. Lowest mean glucose levels were 112.72 ± 14.49 mg / dl for KV. Score the highest rates of pancreatic beta cell damage that is at the K II, while the lowest in the K V. Conclusion: Ginger Juice effect on blood glucose levels alloxan-induced rats. Ginger juice histopathologic effect on pancreatic beta cells alloxan-induced rats (Sains Medika, 4(2):165-173).
The Trial on the Effectiveness of Honey on White Rats Using Geliate Acetate Method An Experimental Study in Male Wistar Rat Goenarwo, Edijanti; Chodidjah, Chodidjah; Susanto, Heri
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.687 KB) | DOI: 10.30659/sainsmed.v3i1.408

Abstract

Background: Pain is the most common complaint of a disease that can be reduced using the analgesic drugs. Besides the pharmacological medication, the traditional medications are available including honey containing flavanoid. The compound can protect the lipid membrane from the damage and inhibit cyclooxygenase, the main path of the synthesis mediator for pain like prostaglandin. This study aims at finding out the efficacy of analgesic of honey using geliate asetate method.Design and methods: In an experimental study using post test only control group design, 25 Wistar rat (80-90 days, BW 180-220 gr) were randomly divided into 3 groups of 5 mice each. Gp1: =aquadest (negative control), Gp2: 0.675 g/BW honey, Gp3: 1.35g honey Gr 4: 2.7 g/kgBW honey and Gr 5 (possitive control): 4.5 mg/ BW of paracetamol. 5 minutes after the treatment, an intraperitoneal injection of acetic acid was given for all groups. Anova followed by post Hoc test was used for data analysis.Result: The honey concentration of 50% (1.35) g was found to have increasing effect of analgesic while the concentration of 25% and 100 % showed a reducing analgesic effect.Conclusion: Honey has been shown to have an analgesic effect in mice with the effective concentration of 50% (1.35 g/kgBW) (Sains Medika, 3(1):48-53).
PENGARUH BASIS SALEP TERHADAP SIFAT FISIK SEDIAAN SALEP EKSTRAK KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) Wijayanti, Rina; Syarifah, Muslihatus; Goenarwo, Edijanti
Media Farmasi Indonesia Vol. 9 No. 2 (2014): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.861 KB)

Abstract

ABSTRACT Roselle calyx contains active compounds such flavonoids, tannins, and saponin which can inhibit the growth of S. Aureus bacteria which cause skin infections. Semi-solid preparations suitable for the treatment of skin infections are ointments. The purpose of this study to determine the physical properties of an ointment base ointment preparations Roselle calyx extract (Hibiscus sabdariffa). Experimental research use the ointment samples with 4 kinds of bases (hydrocarbons, absorption, water washed, and dissolved water), with effective substance Roselle calyx extract 1%. Ointment that is produced by physically tested covers : organoleptis, homogeneity, adhesive power, dispersive power, and pH at day 1, 7, 14, 21, and 28. The results showed that in the organoleptic evaluation, and homogeneity, there are no changes in the results during conservation. Ointment base affect adhesion Roselle calyx extract on day 1, 7, 14, and 28; the dispersive power at day 1, 7, 14, 28, but not on day 2; the pH at day 1, 7, and 14, but not on day 21, and 28. The conclusion showed ointment base effect on the physical properties of extract ointment preparations Roselle calyx : adhesion, dispersive power, and pH. But it does not affect the organoleptic and homogeneity. Effective ointment base hydrocarbon base and absorption.
Ekstrak Daun Sirsak (Annona muricata) Sebagai Penghambat Perkembangan Tumor Payudara Hussaana, Atina; Djam’an, Qathrunnada; Goenarwo, Edijanti; ., Chodidjah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 2 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i2.723

Abstract

Kanker payudara merupakan penyebab kematian kedua setelah kanker leher rahim pada wanita. Pengobatan kanker sampai sekarang masih belum berhasil dengan baik. Daun sirsak merupakan obat tradisional yang secara empirik dipakai masyarakat Indonesia sebagai obat antiinflamasi dan antikanker. Kandungan aktif acetogenin pada daun sirsak diketahui dapat menginduksi apoptosis dengan meningkatkan aktivitas caspase-3 dan menghambat proliferasi pada kultur sel kanker. Dengan tujuan untuk mengetahui potensi antikanker ekstrak daun sirsak, penelitian ini dilakukan dengan rancangan post test randomized control group design, menggunakan 24 ekor mencit C3H yang telah diinokulasi bubur tumor jenis adenokasrsinoma mamma dan telah tumbuh tumor. Mencit kemudian dikelompokkan secara random menjadi kelompok 1 (kontrol), 2 dan 3, berturut-turut mendapatkan aquades, ekstrak daun sirsak dosis 10 mg/kg dan 20 mg/kg. Perlakuan diberikan peroral selama 30 hari. Selama perlakuan, volume tumor diamati tiap 3 hari untuk mengetahui penghambatan per-kembangan tumor payudara. Pada hari ke-31, jaringan tumor diambil dan dibuat preparat histopatologi untuk pengecatan imunohistokimia terhadap ekspresi protein Ki-67 dan pengecatan Tunnel, berturut-turut untuk mengetahui tingkat proliferasi serta jumlah sel kanker yang mengalami apoptosis. Data di uji dengan uji One Way Anova. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak mampu memperlambat pertumbuhan tumor payudara tetapi tidak mengurangi besar tumor akhir. Disamping itu, ekstrak daun sirsak mampu meng-hambat proliferasi sel melalui hambatan ekspresi Ki-67 dan mampu meningkatkan apoptosis. Kata kunci : daun sirsak, Annona muricata, tumor payudara, Ki-67, apoptosis.
Co-Authors ., Chodidjah Atina Hussaana Chodidjah Chodidjah Djaman, Qatthrunnada Djam’an, Qathrunnada Heri Susanto Imam Mashoedi Qathrunnada Djam’an Rina Wijayanti Syarifah, Muslihatus