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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Biomedika Universa Medicina Jurnal Penelitian Kesehatan Suara Forikes JSFK (Jurnal Sains Farmasi & Klinis) Amerta Nutrition Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Masyarakat Kedokteran Journal of Health and Nutrition Research Indonesian Journal of Medical and Pharmaceutical Science Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Atina Hussaana
Bagian Farmakologi Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension Hussaana, Atina; Sarosa, Hadi; Indrayani, Ulfah Dian; Chodidjah, Chodidjah; Widiyanto, Bagas; Pertiwi, Danis
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.81-88

Abstract

BACKGROUNDHypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients. METHODSThis double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.RESULTSThe results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p <0.05). The decrease in systolic blood pressure between the two groups was identical (p>0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p <0.05). CONCLUSIONFrom this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.
Ekstrak Daun Sirsak (Annona muricata) Sebagai Penghambat Perkembangan Tumor Payudara Hussaana, Atina; Djam’an, Qathrunnada; Goenarwo, Edijanti; ., Chodidjah
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (834.866 KB) | DOI: 10.33508/jfst.v2i2.723

Abstract

Kanker payudara merupakan penyebab kematian kedua setelah kanker leher rahim pada wanita. Pengobatan kanker sampai sekarang masih belum berhasil dengan baik. Daun sirsak merupakan obat tradisional yang secara empirik dipakai masyarakat Indonesia sebagai obat antiinflamasi dan antikanker. Kandungan aktif acetogenin pada daun sirsak diketahui dapat menginduksi apoptosis dengan meningkatkan aktivitas caspase-3 dan menghambat proliferasi pada kultur sel kanker. Dengan tujuan untuk mengetahui potensi antikanker ekstrak daun sirsak, penelitian ini dilakukan dengan rancangan post test randomized control group design, menggunakan 24 ekor mencit C3H yang telah diinokulasi bubur tumor jenis adenokasrsinoma mamma dan telah tumbuh tumor. Mencit kemudian dikelompokkan secara random menjadi kelompok 1 (kontrol), 2 dan 3, berturut-turut mendapatkan aquades, ekstrak daun sirsak dosis 10 mg/kg dan 20 mg/kg. Perlakuan diberikan peroral selama 30 hari. Selama perlakuan, volume tumor diamati tiap 3 hari untuk mengetahui penghambatan per-kembangan tumor payudara. Pada hari ke-31, jaringan tumor diambil dan dibuat preparat histopatologi untuk pengecatan imunohistokimia terhadap ekspresi protein Ki-67 dan pengecatan Tunnel, berturut-turut untuk mengetahui tingkat proliferasi serta jumlah sel kanker yang mengalami apoptosis. Data di uji dengan uji One Way Anova. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak mampu memperlambat pertumbuhan tumor payudara tetapi tidak mengurangi besar tumor akhir. Disamping itu, ekstrak daun sirsak mampu meng-hambat proliferasi sel melalui hambatan ekspresi Ki-67 dan mampu meningkatkan apoptosis. Kata kunci : daun sirsak, Annona muricata, tumor payudara, Ki-67, apoptosis.
Latar Belakang, Pengetahuan dan Sikap Pemberi Layanan Kesehatan Tentang Terapi Stem Cell Setyo Trisnadi; Mohammad Rizal Nur Fauzi; Atina Hussaana
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 12, No 3 (2021): Juli 2021
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v12i3.1196

Abstract

The results of studies abroad show that the knowledge of health care providers about stem cell therapy in the good category is only 56%. This study aimed to analyze the relationship between background (age, gender, education, religion, occupation) and the level of knowledge of health care providers with attitudes towards stem cell therapy at RSI Sultan Agung Semarang, using a cross-sectional study design. Data were collected through filling out a questionnaire and then analyzed using the Chi square test. P value for background = 0.339, gender = 0.859, knowledge = 0.864, education = 0.052, occupation = 0.476. Thus, it was concluded that there was no relationship between background (age, gender, education, religion, occupation) and level of knowledge with the attitude of health service providers regarding stem cell therapy at Sultan Agung Hospital, Semarang. Keywords: stem cell therapy; background; knowledge; attitude ABSTRAK Hasil studi di luar negeri menunjukkan bahwa pengetahuan penyedia layanan kesehatan tentang terapi stem cell dalam kategori baik hanya 56%. Penelitian ini bertujuan untuk menganalisis hubungan antara latar belakang (usia, jenis kelamin, pendidikan, agama, pekerjaan) dan tingkat pengetahuan pemberi layanan kesehatan dengan sikap terhadap terapi stem cell di RSI Sultan Agung Semarang, menggunakan desain penelitian ini adalah cross-sectional. Data dikumpulkan melalui pengisian kuesioner lalu dianalisis menggunakan uji Chi square. Nilai p untuk latar belakang = 0,339, jenis kelamin = 0,859, pengetahuan = 0,864, pendidikan = 0,052, pekerjaan = 0,476. Dengan demikian disimpulkan bahwa tidak ada hubungan antara latar belakang (usia, jenis kelamin, pendidikan, agama, pekerjaan) dan tingkat pengetahuan dengan sikap pemberi layanan kesehatan mengenai terapi stem cell di RSI Sultan Agung Semarang. Kata kunci: terapi stem cell; latar belakang; pengetahuan; sikap
PERBEDAAN EFEK PEMBERIAN SECARA KOMBINASI DAN TUNGGAL EKSTRAK BIJI ANGGUR (Vitis vinifera L.) DAN GLUTATION TERHADAP MOTILITAS, JUMLAH, DAN MORFOLOGI SPERMA TIKUS WISTAR YANG DIBERI PAPARAN ASAP ROKOK Conita Yuniarifa; Atina Hussaana; Mohamad Riza
Biomedika Vol 14, No 1 (2022): Biomedika Februari 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i1.13449

Abstract

ABSTRAKAsap rokok menyebabkan peningkatan stres oksidatif dan menimbulkan infertilitas. Ekstrak biji anggur dan glutation dapat mencegah stres oksidatif. Penelitian ini bertujuan untuk mengetahui efek pemberian secara kombinasi dan tunggal ekstrak biji anggur dan glutation terhadap motilitas, jumlah dan morfologi sperma pada tikus yang dipapar asap rokok. Penelitian ini eksperimental dengan post test only control group design. Subyek berjumlah 30 ekor tikus dibagi acak menjadi 5 kelompok. K(-) tidak diberikan asap rokok dan perlakuan, K(+) hanya diberi paparan asap rokok, PI diberi kombinasi ekstrak biji anggur dan glutation, PII diberi ekstrak biji anggur, PIII diberi glutation. Dosis ekstrak biji anggur 5,4 mg/ekor/hari dan glutation 1,8 mg/hari. Paparan asap rokok diberikan 3 batang/hari dilanjutkan perlakuan dilakukan selama 21 hari. Hari ke-22 dilakukan pengambilan sperma untuk meniliai motilitas, jumlah dan morfologi. Data dianalisis parametik dengan tingkat signifikasi p0,05. Uji One Way Anova menunjukkan ada perbedaan bermakna yaitu pada morfologi sperma (p=0,000). Uji kruskal wallis menunjukkan ada perbedaan bermakna yaitu pada jumlah sperma (p=0,000) dan motilitas sperma (p=0,000). Rerata tertinggi pada morfologi sperma yaitu PI (37,6 ± 1,23%), jumlah sperma yaitu PIII (49,3 ± 1,06 sel/ml) dan motilitas sperma yaitu (64,2 ± 0,52%). Pemberian kombinasi ekstrak biji anggur dan glutation berefek paling baik terhadap motilitas dan morfologi sperma, dan pemberian glutation secara tunggal berefek paling baik terhadap jumlah sperma.Kata Kunci : ekstrak biji anggur, glutation, motilitas, jumlah dan morfologi sperma.ABSTRACTCigarette smoke causes an increase in oxidative stress and causes infertility. Grape seed extract and glutathione can prevent oxidative stress. This study to determined the effect of the combined and single administration of grape seed extract and glutathione on motility, number and morphology of sperm in rats exposed to cigarette smoke. This study was experimental with post test only control group design. Subjects totaling 30 rats were randomly divided into 5 groups. K(-) was not given cigarette smoke and treatment, K(+) was only given exposure to cigarette smoke, PI was given a combination of grape seed extract and glutathione, PII was given grape seed extract alone, and PIII was given glutathione alone. The dose of grape seed extract was 5.4 mg/head/day and glutathione 1.8 mg/day. Exposure to cigarette smoke was given 3 sticks/day followed by treatment for 21 days. On the 22nd day, sperm were collected to assess motility, number and morphology. The data were analyzed parametrically with a significance level of p0.05. One Way Anova test showed that there was a significant difference in sperm morphology (p=0.000). Kruskal Wallis test showed that there was a significant difference in sperm count (p=0.000) and sperm motility (p=0.000). The highest mean in sperm morphology was PI (37.6 ± 1.23%), sperm count was PIII (49.3 ± 1.06 cells/ml) and sperm motility was (64.2 ± 0.52%). The combination of grape seed extract and glutathione had the best effect on sperm motility and morphology, and the glutation administration alone had the best effect on sperm count.Keywords: grape seed extract, glutathione, motility, sperm count and morphology.
Peran Obat Herbal dalam Pandemi Covid-19 Atina Hussaana
Jurnal ABDIMAS-KU: Jurnal Pengabdian Masyarakat Kedokteran Vol 1, No 3 (2022): September
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.075 KB) | DOI: 10.30659/abdimasku.1.3.103-108

Abstract

Pencegahan dan penurunan kasus baru dari Covid-19 tidak terlepas dari melakukan dan menerapkan pola hidup sehat serta meminum obat herbal. Obat herbal sangat beragam ditemui di Indonesia, hal ini dapat membantu dalam mencegah penularan covid-19 dan dapat meningkatkan hidup sehat. Metode penelitian yang digunakan adalah metode kualitatif berdasarkan dari data sekunder yang diperoleh dari referensi kepustakaan data yang terkait dengan penelitian. Teknik pengumpulan data menggunakan teknik dokumentasi yakni mengumpulkan data dari berbagai referensi. Jenis data berupa data sekunder yang berupa data kuantitatif dari e-book, junal publikasi dan berita online serta video youtube yang terkait dengan peran obat herbal pada pandemi covid-19.  pada penelitian ini diperoleh informasi bahwa enam obat herbal seperti kunyit (Curcuma longa L.), temulawak (Curcuma xanthorriza Roxb), meniran (Phyllantus niruri L.), jambu biji (Psidium guajava), Jahe dan Sambilito.ditemukannya senyawa atau zat antiviral yang dapat mencegah penyebaran Covid-19 hal ini juga sudah dilakukan uji klinis sehingga dapat dikonsumsi dengan dosis yang pas untuk menghindari adanya efek samping.Prevention and decrease in new cases of Covid-19 is inseparable from doing and implementing a healthy lifestyle and taking herbal medicines. Herbal medicine is very diverse found in Indonesia, this can help in preventing the transmission of covid-19 and can promote a healthy life. The research method used is a qualitative method based on secondary data obtained from data literature references related to research. Data collection techniques use documentation techniques, namely collecting data from various references. The type of data is in the form of secondary data in the form of quantitative data from e-books, publications and online news as well as Youtube videos related to the role of herbal medicine in the pandemic-19.  In this study, information was obtained that six herbal remedies such as turmeric (Curcuma longa L.), temulawak (Curcuma xanthorriza Roxb), meniran (Phyllantus niruri L.), guava (Psidium guajava), Ginger and Sambilito.the discovery of antiviral compounds or substances that can prevent the spread of Covid-19 has also been carried out clinical trials so that it can be consumed at the right dosage to avoid side effects.
Soursop (Annona Muricata, Linn) Leaf Ethanol Extract Cream Application Affected the Expression of TNF-α and VEGF on Balb/C Mice Skin Exposed to Acute UVB Susanto, Agus; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): December 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (724.225 KB) | DOI: 10.30659/sainsmed.v9i2.3030

Abstract

Background: Wound healing problems are often associated with TNF-α and VEGF expressions. However, the benefits and effects of ethanol extract cream from soursop leaves towards TNF-α and VEGF expression for burns healing process are yet to be known. Objective: To evaluate the benefits and influence of ethanol extract cream from soursop leaves in decreasing TNF-α expression and stimulate VEGF expression in BALB/c mice exposed to acute UVB radiation. Method: This study is a laboratory-based experimental study with post test only control group design. The subjects were 48 BALB/c female mice, divided into 24 subjects for TNF-α and 24 for the VEGF group, and were randomly distributed into 4 groups in each study, with each group containing 6 BALB/c mice. Group K was smeared with a base cream of 0.3 grams three times daily, while P1, P2 and P3 groups were each applied 0.3 grams of ethanol extract with consecutive consentrations of 2.5%, 5%, and 10% three times daily. On the sixth day, termination was performed on 24 mice to assess Tnf-α expression and on the eighth day also termination on 24 mice to assess VEGF expression. Preparation of substances was done using IHC method, analyzed using Kruskal Wallis test followed by Mann Whitney test.Results: The results of TNF-a and VEGF expression analysis based on Kruskal Wallis test obtained a p value of 0.0001 (p<0.05) showing that the mean expression of TNF-a and VEGF among the four groups ware significantly different. Mann Whitney test results revealed that the differences in expression of TNF-a and VEGF between the two groups were all significant differences (p<0.05). The mean TNF-a expression in the three treatment groups (PI, PII, PIII) ware significantly lower than the control group. The mean TNF-a expression in the PII and PIII treatment groups ware significantly lower than in the PI group, and the mean TNF-a expression in the PIII treatment group was significantly lower than the PII group. The mean VEGF expression in the three treatment groups (PI, PII, PIII) ware significantly higher than the control group. The mean VEGF expression in the PII and PIII treatment groups ware significantly higher than the PI group, and the mean VEGF expression in the PIII treatment group was significantly higher than in the PII group.Conclusion: Ethanol creams made of soursop leaves extract is proven to be useful and decreasing TNF-α expression and increase VEGF expression in BALB/c mice exposed to acute UVB rays.Keywords: Ethanol cream of soursop leaves extract, TNF-α expression, VEGF expression
Administration of Mung Bean Extract (Phaseolus radiatus) in Increasing Hb and Ferritin Level and Decreasing Malondyaldehide (MDA) Level in Anaemic Rats Wijayanti, Heni; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.284 KB) | DOI: 10.30659/sainsmed.v8i2.1981

Abstract

BACKGROUND: Mung bean, not only contains protein, carbohydrates, and fats, but also contains iron and vitamin C which are proven to overcome anemia in pregnant woman. High iron levels are potential to increase ROS production through fenton reaction.OBJECTIVE: to prove the administration of mungbean can increase Hb and ferritin levels and decreasing malondihaldehyde (MDA) in anaemic rats.METHODS: This research uses Post Test Only Control Group Design. A total of 25 anaemic rats were divided into 5 groups: normal group (Nor-G);negative control group (Neg-G), were given low Fe diet; and treatment group with low Fe and mung bean extract at dose of 0,18g/200g/days (GP-0,18), 0,36g/200g/days (GP-0.36), dan 0,72g/200g/days (GP-0.72). Low Fe diet and mung bean extract were administered for 14 days. Hb levels were measured using Sahli method, ferritine level using Immulite Ferritine Kit, and MDA were measured using TBA.RESULTS: Compare to Nor-G and Neg-G, levels of ferritin and Hb on groups with mung bean extract 0,18g (75.56), 0,36g (90.98) and 0,72g (95.87) were significantly higher (p < 0.05). While MDA levels on groups with mung bean 0,18g (4.646), 0,36g (3.396) and 0,72g (1.92) were significantly lower than on Nor-G and Neg-G groups (p < 0.05).CONCLUSION: The administration of mung bean extract can increase Hb and ferritin, also lower MDA level on anaemic rats.
The Potency of Bixa orellana Seedcouts Extract’s as Antiimflamation Drug Hussaana, Atina; Suparmi, Suparmi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.994 KB) | DOI: 10.30659/sainsmed.v4i2.369

Abstract

Background: Bixin is an orange-yellow carotenoid derived from the outer seed coats of annatto (Bixa orellana L.), which antioxidant activity. However, the use of this colorant in drug potency as antiimflamatory have been explored yet. The effect of crude extract from the outer seed coats of annatto on the inflammatory was investigated to determine its antiimflamation potency.Design and Method: This study was post test only control group design. Twenty four mice is selected randomly then divided into four groups, KI (extract 0.09 mg), K.II (extract 0.18 mg dose), K.III (aspirin 90 mg), and K.IV (CMCNa 0.125%). Oedema volume was measured before injection karagenin 1%, two, 2.5, three and four hours after injection karagenin. The mean reduction in inflammation were tested by one way anova and pos hoc LSD. Result: Greatest reduction in inflammation indicated by K.III (0.100 ml), then in K.II (0.067 ml), KI (0.072 ml), and lowest in K.IV (-0.017 ml). Differences in the reduction of inflammation significantly different between KI and K.II K.IV; and K.III whereas no significant difference was found between KI and K.III K.II.Conclusion: The extract of the outer seed coats of annatto (Bixa orellana L.) have antiimflamantory activity in mice that was induced by karagenin 1% (Sains Medika, 4(2):134-141).
Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer Widyaningrum, Naniek; Hussaana, Atina; Puspitasari, Nesya Ayu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1446.256 KB) | DOI: 10.30659/sainsmed.v11i1.7030

Abstract

INTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity.OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells.METHODS: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values.RESULTS:The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 μg/mL, 679,593 μg/mL, 1562,356 μg/mL, 746,923μg/mL, 563,626 μg/mL and 13,707 μg/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively.CONCLUSION:The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells.
Propolis Extracted Using CMCE Decreases TNF–α and C-Reactive Protein level of CCl4- Induced Liver Damage in Rats Saputro, Arief Adi; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): June 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (888.767 KB) | DOI: 10.30659/sainsmed.v12i1.5467

Abstract

Introduction: Carbon tetrachloride (CCl4) is a hepatotoxic substance inducing inflammation in liver cells. Inflammation is marked by increase in proinflammatory cytokines level such as tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP) produced by hepatocytes. Propolis extracted using continuous multi-stage countercurrent Extraction (CMCE propolis extract) contains active balsamic, caffeic acid phenetyl ester (CAPE), and flavonoids capable of affecting pro-inflammatory cytokines. Objective: to investigate the effect of CMCE propolis extract on TNF-α and CRP levels in CCl4-induced liver damage.Methods: In this study using a post test only control group design, 28 male Wistar rats were divided into four groups. The control group (C-G) was given CCl4 0.4 ml/200 g on day 14. The P3-G, P7-G, P14-G groups were treated with 3.6 mg/200 g, 7.2 mg/200 g, 14.4 mg/200 g CMCE propolis extract for 14 days and given CCl4 0.4 ml/g on day 14. The TNF-α and CRP levels were assessed using the ELISA kit one-way ANOVA and Post Hoc test (LSD) were applied for the statistical analysis. Results: TNF-α level in P14-G group (3.26 ± 0.93), P7-G (6.17+0.78), and P3-G (10.4±1.34) were significantly lower than that of C-G (17.29+1.56) (p<0.05). CRP levels in P14-G group (0.61±0.09), P7-G (1.38+0.48), and P3-G (12.01±0.65) were significantly lower than those of C-G (2.95+0.668) (p<0.05). The greatest reduction in TNF-α & CRP level was found in the group given propolis at a dose of 14.4 mg/200 g.Conclusion: The administration of CMCE propolis extract reduces TNF-α & CRP levels in CCl4-induced liver damage.
Co-Authors ., Chodidjah Arief Adi Saputro Azida, Nining Farrikh Bagas Widiyanto, Bagas Budiarto, Agnes Chodidjah Chodidjah Conita Yuniarifa Danis Pertiwi Dewi, Dwi Arditi Djajadihardja, Andreas Yudi Prasetyo Djam’an, Qathrunnada Edijanti Goenarwo Hadi Sarosa Heni Wijayanti, Heni Ken Wirastuti Marisa, Ana Maryam Mulyaningsih, Ruri Eka Masfiyah Masfiyah, Masfiyah Mediana, Mecha Amalia Mohamad Riza Mohammad Rizal Nur Fauzi Mushidah Mushidah, Mushidah Naila Shulya Ellyana Naniek Widyaningrum Puspitasari, Nesya Ayu Qathrunnada Djam’an Riza, Mohamad Sari, Amalia Nirma Setyaningrum, Widya Ayu Setyo Trisnadi Setyo Trisnadi SHOLIKHAH, ANISATUS Suparmi Suparmi Susilorini Susilorini, Susilorini Taufiqurrachman Nasihun Taufiqurrahman Nasihun, Taufiqurrahman Tsuraya, Ghefira Ulfah Dian Indrayani Wani, Elsayanti Wiwik Handayani Yuniarifa, Conita