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All Journal Jurnal Farmasi Udayana Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences Jurnal Penelitian Sains PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Molekul: Jurnal Ilmiah Kimia
Euis Holisotan Hakim
Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Teknologi Bandung,
Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Ilmu Kimia Tanaman Lauraceae Indonesia: V. Eritrodiol 3-Asetat dari Litsea elliptica Bl. (Lauraceae) Sjamsul Arifin Achmad; Afrizal Afrizal; Emilio L. Ghisalberti; Euis Holisotan Hakim; Lukman Makmur
Journal of Mathematical and Fundamental Sciences Vol. 24 No. 2/3 (1991)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Suatu triterpen, jenis oleanan, yang diperoleh dari kulit akar tanaman Litsea elliptica Bl. (Lauraceae) telah diidentifikasi sebagai olean-12-en-3,28-diol-3-asetat atau eritrodiol 3-asetat (I). Telah ditemukan pula suatu ftalat dan telah diidentifikasi sebagai bis(2-etilheksil) ftalat (III). Struktur kedua senyawa ini telah ditetapkan dengan menggunakan cara spektroskopi. Isolat lain, suatu triterpen yang diberi nama litselligenin, masih terus diteliti. Baik eritrodiol 3-asetat (I) maupun bis(2-etilheksil)ftalat (III) tidak pernah ditemukan sebelumnya pada tanaman Lauraceae, sedangkan senyawa terakhir merupakan senyawa ftalat kedua yang ditemukan pada Luaraceae. An oleanane-type triterpene isolated from the root bark of Litsea elliptica Bl. (Lauraceae) has been identified as olean-12-en-3,28-diol-3-acetate or erythrodiol 3-acetate (I). A phthalate has also been isolated and identified as bis(2-ethylhexyl)phthalate (III). The structure of both compounds have been elucidated based on spectroscopic methods. Work on another isolate, a triterpenoid named litselligenin, is in progress. Neither erythrodiol 3-acetate (l) nor bis(2-ethylhexyl)phthalate (III) have been isolated previously from the Lauraceae, and the latter compound represents a second phthalate to be isolated from Lauraceae.
Ilmu Kimia Tanaman Lauraceae Indonesia: III*. Isolasi Aktinodafnin dan Boldin dari Litsea glutinosa Sjamsul Arifin Achmad; Euis Holisotan Hakim; Lukman Makmur; Helmi Rizal; Adel Zamri
Journal of Mathematical and Fundamental Sciences Vol. 23 No. 1 (1990)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Aktinodafnin (I) dan boldin (lI), dua senyawa alkaloid dari jenis benzilisokuinolin, telah dipisahkan dari kulit akar tanaman Litsea glutinosa (Lour) C.B. Robinson var. littoralis Bl., suatu varitas yang belum pernah diselidiki peneliti lain. Struktur kedua alkaloid ini telah ditetapkan dengan cara-cara spektroskopi. Penemuan ini melanjutkan penemuan kami sebelumnya tentang suatu alkaloid fenantren baru, yang dinamai itebein, dari spesies tanaman yang sama. Two benzylisoquinoline alkaloids, actinodaphnine (I) and boldine (II), have been isolated from the root bark of Litsea glutinosa (Lour) C.B. Robinson var. littoralis Bl., a variety which has not yet been investigated by other workers. The chemical structures of both alkaloids have been determined by spectroscopic methods. This is to follow-up our previous work on the isolation of a new phenanthrene alkaloid, named itebeine, from the same plant species.
Aktivitas Sitotoksik Alkaloid Dari Cryptocarya archboldiana Allen Suwandri Suwandri; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawaty
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 01 Juli 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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ABSTRAK Cryptocarya merupakan salah satu genus terbesar dari famili Lauraceae dan sebagian besar spesiesnya tumbuh di hutan hujan tropis Asia-Pasifik antara lain hutan di Indonesia. Secara umum genus Cryptocarya mengandung metabolit sekunder utama golongan alkaloid, 2-piron dan flavonoid serta memiliki berbagai aktivitas biologis. Tiga senyawa alkaloid yang telah dikenal telah diisolasi dari tumbuhan Cryptocarya archboldiana; boldin, laurolitsin, dan retikulin. Struktur molekul ketiga senyawa tersebut telah ditetapkan berdasarkan analisis spektroskopi (UV, 1H dan 13C NMR) serta perbandingan dengan data spektrum senyawa yang telah dilaporkan. Senyawa laurolitsin menunjukkan aktivitas sitoksisitas yang moderat, sedangkan boldin dan retikulin memiliki aktivitas yang lemah terhadap sel murine leukemia P388. Kata kunci: C. archboldiana, alkaloid, sitotoksik, aporfin, benzilisokuinolin. ABSTRACT Cryptocarya is one of the largest genus of Lauraceae and most of the species grow in the tropical rain forests of Asia-Pacific, include in Indonesian forest. Generally Cryptocarya contains alkaloids, 2-piron, and flavonoids as well as has a variety of biological activities. Three alkaloids have been isolated from Cryptocarya archboldiana; boldine, laurolitsine, and reticuline. The molecular structure of all these compounds have been established by spectroscopic analysis (UV, 1H, and 13C NMR) and comparison with the spectral data of compounds that have been reported. The cytotoxic of laurolitsine showed moderate activity, while boldine and reticuline have weak activity against P388 murine leukemia cells. Key words: C. archboldiana, alkaloid, cytotoxic, aporphine, benzylisoquinoline.
Discrimination of Metabolite Profiles of Gayo Roasted Arabica and Robusta Coffees Nizar Happyana; Yana Maolana Syah; Euis Holisotan Hakim
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5603

Abstract

Gayo (Aceh) coffee is one of the best coffees from Indonesia. In this work, metabolites in the Gayo roasted arabica and robusta coffees were identified with 1H NMR spectroscopy analysis. Accumulatively 28 compounds were successfully detected, including the major and minor metabolites of the roasted coffee. Multivariate data analysis was applied to evaluate the dataset extracted from 1H NMR spectra of the coffee samples, result in the disclosure of the differences in the chemical profiles between the Gayo roasted coffees of arabica and robusta. Score plots obtained from the models of principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLSDA), classified the roasted coffee samples based on their species. Loading plot and S-plot revealed the discriminant compounds for each coffee. Gayo roasted arabica coffee was characterized with acetic acid and trigonelline, while the robusta coffee was discriminated with fatty acids. This report revealed the chemical differences of both coffees and confirmed the diversity of Gayo coffees.
ISOLASI DAN KARAKTERISASI SENYAWA ALIFATIK TAK JENUH DARI KULTUR AKAR MORUS CATHAYANA YUNIANTARI, NI; Holisotan Hakim, Euis
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 7 No. 1 (2025): Publikasi Penelitian Kimia dan Terapannya 2025
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v7i1.4852

Abstract

Moraceae is a plant that is widely distributed in Asia and the Indopacific Islands. One of the genera of Moraceae that has been widely researched and whose bioactive compounds is the Morus, namely M. cathayana. the aim of this research is determining the diversity of secondary metabolite of root cultures of Morus cathayana. Isolation of secondary metabolites from Morus cathayana root cultures was using several chromatographic techniques and eluents combination is n-hexane, acetone, chloroform, ethyl acetate and methanol. In this research, the compound KMAC-4 was isolated. Characterization of the KMAC-4 compound using the FTIR ONE Perkin-Elmer spectrophotometer. showed that the KMAC-4 compound had an absorption at wave number (cm-1): 3654.97; 3650.45; 2936.87; 1718.71; 1465.76; 1381.56; 1049.50. Based on IR spectrum data that has been interpreted, analyzed and studied according to the phytochemical of the Morus, it can be concluded that the KMAC-4 is an unsaturated aliphatic compound which belongs to the steroid or terpenoid group.
Co-Authors Adel Zamri Afrizal Afrizal Allan H. White Asnizar Asnizar Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Effendi Effendi Emilia Evi Marlina Emilia L Ghisalberti Emilio L Ghisalberti Emilio L. Ghisalberti Emilio L. Ghisalberti Emilio L. Ghisalberti Eri Bakhtiar Fera Kurniadewi Ferlinahayati Ferlinahayati Hanapi Usman Haryoto Haryoto Helmi Rizal Hiromitsu Takayama Hiromitsu Takayama I Nyoman Adi Winata Ikram M. Said Iqbal M. Choudhary Iqbal Musthapa Jalifah Latip Koichi Takeya Lia Dewi Juliawati Lia Dewi Juliawaty Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur M I Choudhary Mariko Katajima Mariko Kitajima Mariko Kitajima Muhammad N. Jalaluddin Muhtadi Muhtadi Murniana Murniana Nizar Happyana Nordin Hj Lajis Norio Aimi Norio Aimi Norio Aimi Norio Aimi Noviany Noviany Nunuk H Soekamto Riga Riga Rudiyansyah Rudiyansyah Rusjdi Tamin Rusjdi Tamin Sahidin . Silvester Sigit Udjiana Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sri Atun Suwandri Suwandri Suwandri Suwandri Syamsurizal Syamsurizal Tedi Abdul Ghofar Tjodi Harlim Tukiran Tukiran Valentina Adimurti Yana Maolana Syah Yoharmus Syamsu YUNIANTARI, NI