Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences Jurnal Penelitian Sains PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia
Euis Holisotan Hakim
Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Teknologi Bandung,
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology Mathematics Physics

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 23 Documents
Search

 1   2   3 
Ilmu Kimia Tanaman Lauraceae Indonesia: III*. Isolasi Aktinodafnin dan Boldin dari Litsea glutinosa Sjamsul Arifin Achmad; Euis Holisotan Hakim; Lukman Makmur; Helmi Rizal; Adel Zamri
Journal of Mathematical and Fundamental Sciences Vol. 23 No. 1 (1990)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Aktinodafnin (I) dan boldin (lI), dua senyawa alkaloid dari jenis benzilisokuinolin, telah dipisahkan dari kulit akar tanaman Litsea glutinosa (Lour) C.B. Robinson var. littoralis Bl., suatu varitas yang belum pernah diselidiki peneliti lain. Struktur kedua alkaloid ini telah ditetapkan dengan cara-cara spektroskopi. Penemuan ini melanjutkan penemuan kami sebelumnya tentang suatu alkaloid fenantren baru, yang dinamai itebein, dari spesies tanaman yang sama. Two benzylisoquinoline alkaloids, actinodaphnine (I) and boldine (II), have been isolated from the root bark of Litsea glutinosa (Lour) C.B. Robinson var. littoralis Bl., a variety which has not yet been investigated by other workers. The chemical structures of both alkaloids have been determined by spectroscopic methods. This is to follow-up our previous work on the isolation of a new phenanthrene alkaloid, named itebeine, from the same plant species.
Aktivitas Sitotoksik Alkaloid Dari Cryptocarya archboldiana Allen Suwandri Suwandri; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawaty
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 01 Juli 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Cryptocarya merupakan salah satu genus terbesar dari famili Lauraceae dan sebagian besar spesiesnya tumbuh di hutan hujan tropis Asia-Pasifik antara lain hutan di Indonesia. Secara umum genus Cryptocarya mengandung metabolit sekunder utama golongan alkaloid, 2-piron dan flavonoid serta memiliki berbagai aktivitas biologis. Tiga senyawa alkaloid yang telah dikenal telah diisolasi dari tumbuhan Cryptocarya archboldiana; boldin, laurolitsin, dan retikulin. Struktur molekul ketiga senyawa tersebut telah ditetapkan berdasarkan analisis spektroskopi (UV, 1H dan 13C NMR) serta perbandingan dengan data spektrum senyawa yang telah dilaporkan. Senyawa laurolitsin menunjukkan aktivitas sitoksisitas yang moderat, sedangkan boldin dan retikulin memiliki aktivitas yang lemah terhadap sel murine leukemia P388. Kata kunci: C. archboldiana, alkaloid, sitotoksik, aporfin, benzilisokuinolin. ABSTRACT Cryptocarya is one of the largest genus of Lauraceae and most of the species grow in the tropical rain forests of Asia-Pacific, include in Indonesian forest. Generally Cryptocarya contains alkaloids, 2-piron, and flavonoids as well as has a variety of biological activities. Three alkaloids have been isolated from Cryptocarya archboldiana; boldine, laurolitsine, and reticuline. The molecular structure of all these compounds have been established by spectroscopic analysis (UV, 1H, and 13C NMR) and comparison with the spectral data of compounds that have been reported. The cytotoxic of laurolitsine showed moderate activity, while boldine and reticuline have weak activity against P388 murine leukemia cells. Key words: C. archboldiana, alkaloid, cytotoxic, aporphine, benzylisoquinoline.
Discrimination of Metabolite Profiles of Gayo Roasted Arabica and Robusta Coffees Nizar Happyana; Yana Maolana Syah; Euis Holisotan Hakim
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5603

Abstract

Gayo (Aceh) coffee is one of the best coffees from Indonesia. In this work, metabolites in the Gayo roasted arabica and robusta coffees were identified with 1H NMR spectroscopy analysis. Accumulatively 28 compounds were successfully detected, including the major and minor metabolites of the roasted coffee. Multivariate data analysis was applied to evaluate the dataset extracted from 1H NMR spectra of the coffee samples, result in the disclosure of the differences in the chemical profiles between the Gayo roasted coffees of arabica and robusta. Score plots obtained from the models of principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLSDA), classified the roasted coffee samples based on their species. Loading plot and S-plot revealed the discriminant compounds for each coffee. Gayo roasted arabica coffee was characterized with acetic acid and trigonelline, while the robusta coffee was discriminated with fatty acids. This report revealed the chemical differences of both coffees and confirmed the diversity of Gayo coffees.
Co-Authors Adel Zamri Afrizal Afrizal Allan H. White Asnizar Asnizar Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Effendi Effendi Emilia Evi Marlina Emilia L Ghisalberti Emilio L Ghisalberti Emilio L. Ghisalberti Emilio L. Ghisalberti Emilio L. Ghisalberti Eri Bakhtiar Fera Kurniadewi Ferlinahayati Ferlinahayati Hanapi Usman Haryoto Haryoto Helmi Rizal Hiromitsu Takayama Hiromitsu Takayama I Nyoman Adi Winata Ikram M. Said Iqbal M. Choudhary Iqbal Musthapa Jalifah Latip Koichi Takeya Lia Dewi Juliawati Lia Dewi Juliawaty Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur M I Choudhary Mariko Katajima Mariko Kitajima Mariko Kitajima Muhammad N. Jalaluddin Muhtadi Muhtadi Murniana Murniana Nizar Happyana Nordin Hj Lajis Norio Aimi Norio Aimi Norio Aimi Norio Aimi Noviany Noviany Nunuk H Soekamto Riga Riga Rudiyansyah Rudiyansyah Rusjdi Tamin Rusjdi Tamin Sahidin . Silvester Sigit Udjiana Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad SRI ATUN Suwandri Suwandri Suwandri Suwandri Syamsurizal Syamsurizal Tedi Abdul Ghofar Tjodi Harlim Tukiran Tukiran Valentina Adimurti Yana Maolana Syah Yoharmus Syamsu