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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Jurnal Kesehatan Andalas Global Medical and Health Communication The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan Media Dermato-Venereologica Indonesiana
Ilhami Romus
Department Of Pathology Anatomy, Faculty Of Medicine, Universitas Riau, Pekanbaru
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of Immobilization Stress on Gastric Mucosal Histopathology in White Mice (Mus musculus) Male Swiss Webster Strain Rizki Bunaya; Ilhami Romus; Fajri Marindra Siregar; Desby Juananda
Molecular and Cellular Biomedical Sciences Vol 4, No 1 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3816.965 KB) | DOI: 10.21705/mcbs.v4i1.77

Abstract

Background: Immobilization stress is one method of stress induction on experimental animals. It affects the psychology and physical of experimental animals and is the recommended method for assessing changes in histological structure damage. The purpose of research was to analyze the effect of immobilization stress on gastric mucosal in mice.Materials and Methods: This research was experimental with post-test-only control group design. Twenty white mice (Mus musculus) male Swiss Webster strains were used in this study and divided into 4 groups: control, immobilization stress 14 days, immobilization stress 21 days, immobilization stress 28 days. Mice were given immobilization stress using 50 cc syringes for 2 hours every day for 14 days, 21 days and 28 days. Gastric mucosal damage in mice was analyzed under a microscope with of 10 fields of view in each sample. Data were analyzed using the Kruskal Wallis test and Mann Whitney test.Results: Gastric mucosal damage score were 0 in control, 1.42±0.265 in 14 days, 1.82±0.265 in 21 days, and 2.54±0.05 in 28 days. There was significant difference between each group (p<0.05), while the greatest damage was found in the 28 days group.Conclusion: These result indicated that immobilization stress caused gastric mucosal damage and the degree of damage is in accordance with duration of stress.Keywords: gastric mucosal, immobilization, stress
Efek asam alfa lipoat terhadap insulitis pada tikus diabetes melitus tipe 2 Ismawati Ismawati; Mukhyarjon Mukhyarjon; Ilhami Romus; Sonia Dinda Paramitha
Jurnal Gizi Klinik Indonesia Vol 16, No 2 (2019): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.465 KB) | DOI: 10.22146/ijcn.31701

Abstract

Effect of alpha lipoic acid on insulitis in type 2 diabetic ratBackground: The damaging of β cell causes hyperglycemia. Β cell damaged as insulitis happens because of the increase of free radical and the decrease of endogen antioxidant that caused oxidative stress.Objective: The goal of this research was to find out the effect of alpha lipoic acid (ALA) on pancreas Langerhans island’s histopathology in type 2 diabetic rats.Methods: This was an experimental laboratory study with post test only design. Fifteen adult male rats of  Wistar strain were segregated into three groups (n=5) labeled as control, type 2 diabetes (DM), and DM+ALA. The experiment was designed for 3 weeks. The measured parameter was insulitis level on pancreas Langerhans island of groups labeled.Results: The statistical test result showed there was the significant difference between control and type 2 diabetes group (p=0,005), but there was no significant difference between DM and DM+ ALA group (p=0,549).Conclusions: Although not statistically significant, giving ALA 60 mg/kg body weight for 3 weeks decreased the degree of insulitis in diabetic rats.
Efek Inhibitor Proteasom terhadap Histopatologi Arteri Koronaria pada Tikus Model Aterosklerosis Ismawati ismawati; Ilhami Romus; Elfima Aditya Utami
Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2020): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.16.2.135-142

Abstract

Penelitian sebelumnya menunjukkan peranan proteasom pada setiap tahap aterosklerosis yaitu tahap inisiasi, progresi dan komplikasi. Hal ini mendorong penelitian inhibitor proteasom sebagai terapi aterosklerosis dan bortezomib merupakan inhibitor proteasom yang pertama kali dikembangkan. Pada penelitian ini akan dianalisis efek pemberian inhibitor proteasom (bortezomib) terhadap pembentukan lesi aterosklerosis pada arteri koronaria tikus model aterosklerosis tahap progresi. Penelitian ini menggunakan 15 ekor tikus (Rattus novergicus) strain Wistar jantan yang dibagi menjadi 3 kelompok yaitu kelompok kontrol (I), kelompok aterosklerosis (II), dan kelompok aterosklerosis dengan pemberian bortezomib (III). Induksi aterosklerosis dilakukan dengan pemberian vitamin D3 (700.000 IU/kg) secara oral, dan dilanjutkan dengan diet aterogenik (kolesterol 2%, lemak kambing 5%, asam kolat 0,2 % dan diet standar 100%) selama 4 hari. Pemberian bortezomib dosis rendah (50 μg/kgBB) pada hari ke-1 dan ke-3 secara intraperitoneal. Penilaian lesi aterosklerosis dilakukan dengan sistem skoring. Hasil penelitian didapatkan skor lesi tertinggi pada kelompok model aterosklerosis dan adanya penurunan rerata skor lesi aterosklerosis pada kelompok aterosklerosis yang diberi bortezomib (0,70 vs 0,44, p<0,05). Disimpulkan bahwa pemberian bortezomib dapat menghambat pembentukkan lesi aterosklerosis pada tahap progresi.
Effects of Proteasome Inhibitor on Catalase Expression and Intima-media Thickness in the Aorta of Atherosclerotic Rats Ismawati Ismawati; Enikarmila Asni; Ilhami Romus; Mukhyarjon Mukhyarjon; Winarto Winarto; Muhammad Fadhillah Arif; M Derillovyandra Dwi Anugrah
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.9508

Abstract

Various studies have been carried out to obtain proper management for atherosclerosis. Proteasome, a subcellular enzyme complex, is a potential therapeutic target for atherosclerosis. However, the effect of proteasome inhibitors on atherosclerosis still needs to be explored. It was an experimental study with a post-test-only control group design conducted at the Faculty of Medicine, Universitas Riau in Juni–November 2021. This study aimed to analyze the effects of proteasome inhibitors on catalase expression and intima-media thickness (IMT) in the thoracic aorta of atherosclerotic rats. Fifteen male Wistar rats were randomly divided into three groups (five rats per group), namely rats given standard feed (control, group I), rats induced atherosclerosis (group II), and rats induced atherosclerosis and given proteasome inhibitor (group III). The proteasome inhibitor, bortezomib, 50 µg/kgBW/day was given intraperitoneally on days one and three. After 4 days, rats were terminated, and the thoracic aorta was taken for the IMT analysis and catalase expression assessment using immunohistochemistry. Catalase expression was carried out quantitatively using Adobe Photoshop software. Analysis of variance test was used to compare the expression of catalase and IMT. A p value<0.05 was considered statistically significant. The results showed a significant decrease in IMT in group III compared to group II and an increase in catalase expression in group III compared to group II but not statistically significant. This study concludes that administration of bortezomib 50 µg/kgBW in atherosclerotic rats could inhibit thickening tunica intima-media in the thoracic aorta, although not significantly increasing the catalase expression.
PIODERMA GANGRENOSUM MULTIPEL DAN BERULANG Alida Widiawaty; Farah Asyuri Yasmin; Ilhami Romus
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.337

Abstract

Pyoderma gangrenosum is a rare, non-infectious inflammatory skin disease. Diagnosis and treatment are challenging since there are no specific diagnostic criteria or gold standard therapy. The case of a 73 years old man, consulted by surgery department with painful and rapidly progressive necrotic ulcer on his left lower limb and right arm. The initial diagnosis was bacterial ulcer, he underwent debridement and received antibiotics. In the few days, his wound had worsened with enhanced in size and extremely painful. Histological examination showed a dense dermal infiltrate of neutrophil (predominant), lymphocyte, and plasma cell; conformable to pyoderma gangrenosum. Injection of methylprednisolone 31.25 mg / day and mometasone furoate cream 0.1% was given. Clinical improvement was noted in 2 weeks after therapy. Two years later, he developed typical necrotic ulcer on right limb. Pyoderma gangrenosum must be considered in any patient with painful and rapidly progressive ulcer that do not respond to broad-spectrum antibiotics. The histological findings can rule out the other causes of cutaneous ulcer. Suppression of inflammatory process is the main goal in therapy. The delay in identify, inappropriate treatment, and recurrence of the disease remain an issue.
Co-Authors Alida Widiawaty Dini Fatimah Elfima Aditya Utami Enikarmila Asni Enny Lestari Farah Asyuri Yasmin Huda Nuri Suraya Imelda E.B Hutagaol Ina Farida Rangkuti Ismawati ismawati Istiana Fiatiningsih Jimy Fran Juananda, Desby Khairun Nisa&#039; M Derillovyandra Dwi Anugrah Melfi Riqqah Muhammad Fadhillah Arif Mukhyarjon Rijalun Arridho Rizki Bunaya Shabrina Sari Medina Siregar, Fajri Marindra Sonia Dinda Paramitha Suyanto " Vini Jum’atur Rahmah Winarto Winarto