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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Natural
Hilda Maysarah
Pharmacy Department, Faculty Of Mathematics And Natural Sciences, Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health

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¬Potensi Biduri [Calotropis gigantea (L.) W.T. Aiton] sebagai Tanaman Obat Meutia Faradilla; Hilda Maysarah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.716 KB)

Abstract

Calotropis gigantea (L.) W.T. Aiton or known as Biduri in Indonesia has been used in traditional medicine as an anti-inflammatory, antitoxin and antipyretic. This plant is often found in hot and arid climates. Research on the potential of this plant has not been done much in Indonesia. This article aims to examine the potential of Biduri as a source of medicinal plants. The study was carried out by reviewing research literatures of the botanical plants both sourced from international and national journals. The results of the study indicate that various types of extracts from the biduri plant have therapeutic activities for further development. The phytochemical testing and isolation has also been carried out to look for active substances that play a role in the pharmacological activity being tested. Based on the studies that have been carried out, biduri plants have great potential to be researched and further developed to become one of the sources of medicinal plants in Indonesia.
FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS Hilda Maysarah; Meutia Faradilla; Tedy Kurniawan Bakri; Misrahanum Misrahanum
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.739 KB) | DOI: 10.24815/jn.v19i2.12151

Abstract

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of  25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli. 
FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS Hilda Maysarah; Meutia Faradilla; Tedy Kurniawan Bakri; Misrahanum Misrahanum
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i2.12151

Abstract

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of  25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli. 
Co-Authors Fauzul Husna Firdausa, Sarah Hijra Novia Suardi Hira Helwati Iflan Nauval Meutia Faradilla Meutia Faradilla Misrahanum Misrahanum Nani Safuni S Suryawati Sadli Sadli Syarifah Dhea Almunawwarah Tedy Kurniawan Bakri Vera Nova