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All Journal Jurnal Periodic Jurusan Kimia UNP Jurnal Riset Kimia Indonesian Journal of Chemical Analysis (IJCA) Pelita Eksakta Acta Chimica Asiana SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Pijar MIPA Jurnal Pengabdian Pada Masyarakat
Trisna Kumala Sari
Universitas Negeri Padang
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The Extracted Pectin from Ambarella Fruit Peel (Spondias dulcis) as Biosorbent in Adsorption of Cu(II) Metal Ions Trisna Kumala Sari; Elinda Fithriana; Indang Dewata; Desy Kurniawati; Romy Dwipa Yamesa Away
Jurnal Riset Kimia Vol. 14 No. 2 (2023): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v14i2.608

Abstract

Heavy metals are known to seriously injure land plants and animals, including humans, as well as marine species when present in contaminated water. For the batch adsorption technique used in this study, Cu(II) ions were removed from an aqueous solution using an inexpensive  environmentally friendly adsorbent prepared from the extracted pectin of ambarella fruit peel. The functional groups of the extracted pectin were studied using Fourier Transform Infrared Spectroscopy (FT-IR). Operational conditions like pH, contact time, and initial adsorbate concentration were investigated. FTIR characterization showed that pectin was successfully extracted from ambarella fruit peel with the appearance of the peaks at 3331.36 cm-1, 2924.02 cm-1, 1727.38 cm-1, 1626.20 cm-1, 1329.31cm−1, 1232.43cm−1, 994.18 cm−1 and these peaks have similar characteristic with a commercial pectin. The maximum uptake of Cu(II) ions was obtained at a pH of 4, a contact time of 90 min, an initial metal concentration of 150 ppm. The extracted pectin has an adsorption capacity of 6.5860 mg/g for the removal of Cu(II) ions from aqueous solution under the optimum adsorption conditions. In addition, the data obtained from contacting the extracted pectin of ambarella fruit peel in Batang Arau River water showed an adsorption capacity of 0.0376 mg/g. Therefore, the pectin that was extracted from the peel of the ambarella fruit could be used to filter out Cu(II) ions from aqueous solutions.
Development of Non-Enzymatic Glucose Sensor Using Ag-Au Bimetallic Modified Pencil Lead Electrode with Voltammetry Method Marlini, Rahmida; Kumala Sari, Trisna; Alizar, Alizar; Dwipa Yamesa Away, Romy
Indonesian Journal of Chemical Analysis (IJCA) Vol. 8 No. 1 (2025): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol8.iss1.art9

Abstract

Glucose is an essential monosaccharide that serves as the main source of energy in the human body. An imbalance in glucose levels in the body can lead to serious metabolic disorders, such as diabetes mellitus. Therefore, effective methods of analyzing and monitoring glucose levels are needed for early detection and more optimal disease management. In this study, a non-enzymatic glucose sensor based on Pencil Lead Electrode (PLE) modified with silver-gold (Ag-Au) bimetallic was developed through electrodeposition method using cyclic voltammetry. This modification aims to improve sensitivity and cost efficiency in glucose detection compared to enzymatic sensors, that are susceptible to denaturation and higher production costs. Electrodeposition is performed in a potential range of 1.6 V to -0.4 V to obtain an optimal bimetallic coating on the PLE surface. The Ag-Au/PLE electrode provided the best electrochemical response in detecting glucose, with oxidation and re-oxidation peaks at +0.01 V in 0.1 M KOH as a supporting electrolyte. The optimal condition was obtained in five electrodeposition cycles, with a correlation coefficient value of 0.9984 and a detection limit of 0.206 mM, indicating high sensitivity and accuracy. These results indicate that Ag-Au/PLE electrodes have great potential as reliable, sensitive and economical non-enzymatic glucose sensors.
Development of a Cr(VI) metal ion detection sensor using a modified pencil lead electrode (PLE) with a silver thin layer using the voltammetry method Nella Aulia Putri; Trisna Kumala Sari; Budhi Oktavia; Sherly Kasuma Warda Ningsih
Acta Chimica Asiana Vol. 9 No. 1 (2026)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v9i1.251

Abstract

Chromium(VI) metal ions have harmful effects on the environment and organisms. Chromium(VI) particles can cause chromosomal abnormalities, cross-linking, disruption of the cell cycle, and DNA damage within cells. Therefore, due to its high toxicity, it is crucial to monitor the concentration of chromium(VI) metal ions in the environment. This study aims to detect Cr(VI) metal ions in a simple, rapid, and effective manner. Electrochemical methods are employed to investigate the performance of PLE and Ag/PLE electrodes and to determine the optimal conditions for electrodeposition cycles and supporting electrolyte concentrations in detecting Cr(VI) metal ions. The electrochemical method is based on the specific reaction of the analyte, which generates an electrical signal. The PLE surface is modified with a silver thin layer through electrodeposition using cyclic voltammetry. The silver thin layer used for electrode modification offers several advantages, including improved electron transport and enhanced electrocatalytic response. The results indicate that the performance of Ag/PLE is superior to that of PLE in detecting Cr(VI) metal ions under optimal supporting electrolyte conditions, specifically 0.1 M HNO₃ with one electrodeposition cycle. Calibration curve analysis for Cr(VI) ions yielded the regression equation y = 0.6688x + 0.0085, with a correlation coefficient (R²) of 0.9958 and a limit of detection (LOD) of 0.18 mM.
POTENTIAL OF BAMBOO POWDER AS AN ADSORBENT TO REGENERATE USED COOKING OIL Putri Wulandari; Lulu Luthfiyah; Mizatul Jannah; Wahyu Hidayati; Romy Dwipa Yamesa Away; Trisna Kumala Sari
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 7 No. 1 (2025): January - June 2025
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v7i1.13442

Abstract

Penelitian ini mengevaluasi efektivitas bubuk bambu yang diolah menjadi karbon aktif untuk meregenerasi minyak jelantah menggunakan tiga metode: tanpa perlakuan panas tinggi, aktivasi konvensional, dan aktivasi furnace. Aktivasi dengan KOH meningkatkan porositas dan luas permukaan. Parameter utama yang dianalisis meliputi kadar air, asam lemak bebas (FFA), dan bilangan peroksida (PV). Hasil penelitian menunjukkan bahwa arang aktif metode furnace memiliki kinerja terbaik, menghasilkan kadar air 0,05%, memenuhi SNI 7709:2019 (< 0,1 %). Sebaliknya metode konvensional dan serbuk bambu menghasilkan kadar air masing-masing sebesar 0,12% dan 0,66%. Kandungan FFA terendah sebesar 0,23 % juga terdapat pada arang aktif tungku memenuhi SNI 01-3741 2002 (<0,3%). Selain itu, bilangan peroksida yang dihasilkan arang aktif dengan metode furnace adalah 6,3 mek O2/kg, lebih baik dibandingkan metode konvensional (9,7 mek O2/kg) dan bubuk bambu (13,3 mek O2/kg), keduanya memenuhi SNI No. 01-3741-2013 (< mek 10 O2/kg). Kinerja arang aktif dengan metode furnace unggul disebabkan oleh porositasnya yang optimal, peningkatan kandungan karbon aktif, sifat hidrofobik, dan kemampuan interaksi dengan pengotor. Oleh karena itu, arang bambu yang diaktifkan dengan metode furnace menunjukkan potensi sebagai adsorben yang efektif untuk meregenerasi minyak jelantah.   This research evaluates the effectiveness of bamboo powder processed into activated carbon for regenerating used cooking oil using three methods: no high heat treatment, conventional activation, and furnace activation. The activation with KOH enhances porosity and surface area. Key parameters analyzed included water content, free fatty acids (FFA), and peroxide value (PV). The results indicated that furnace-activated charcoal performed best, yielding an oil content of 0.05%, which is compliant with SNI 7709:2019 (<0.1%). In contrast, conventional and bamboo powder methods produced water contents of 0.12% and 0.66%, respectively. The lowest FFA content of 0.23% was found in the furnace-activated charcoal, which meets the SNI 01-3741-2002 standard (<0.3%). Additionally, the peroxide value was 6.3 meq O2/kg, which is lower than the conventional method (9.7 meq O2/kg) and bamboo powder (13.3 meq O2/kg), both of which meet SNI No. 01-3741-2013 (<10 meq O2/kg). The furnace-activated charcoal's superior performance is attributed to its optimal porosity, increased active carbon content, hydrophobic properties, and interaction capabilities with impurities. Thus, furnace-activated bamboo charcoal shows promise as an effective adsorbent for regenerating used cooking oil.
In Silico Study of Bioactive Compounds from Koro Benguk (Mucuna pruriens (L.) DC.) as Potential Modulators of CYP7A1 for Hypercholesterolemia Therapy Cleofany Aurhelya Paradhise; Trisna Kumala Sari
Jurnal Pijar MIPA Vol. 21 No. 2 (2026)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11676

Abstract

Hypercholesterolemia is a major risk factor for cardiovascular diseases and remains a significant global health concern. Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the classical bile acid synthesis pathway, plays a crucial role in hepatic cholesterol catabolism and represents a promising therapeutic target for cholesterol regulation. Natural product-derived compounds have attracted increasing attention as potential antihypercholesterolemic agents due to their structural diversity and biological activities. However, studies evaluating phytochemicals from Mucuna pruriens as CYP7A1 modulators remain limited, particularly those integrating molecular docking with pharmacokinetic prediction. Therefore, this study aimed to evaluate the potential of bioactive compounds from Mucuna pruriens as modulators of CYP7A1 using an in silico approach. Twenty-eight phytochemical compounds identified through GC-MS profiling were screened using Lipinski’s Rule of Five. Selected compounds were further analyzed by molecular docking against the CYP7A1 protein (PDB ID: 3DAX), followed by ADMET prediction. Docking protocol validation through redocking of the native ligand showed good conformational agreement at the active site (RMSD < 2 Å), confirming the reliability of the docking parameters. Binding affinity and RMSD were used to evaluate ligand–protein interaction stability. Sterculic acid exhibited the strongest binding affinity with a docking score of −6.6.1 kcal/mol and RMSD of 1.51 Å, slightly stronger than the reference ligand 7-ketocholesterol (−7.335 kcal/mol). Interaction analysis revealed hydrogen bonding with key residues, including Asn126 and Lys98, as well as hydrophobic interactions within the active pocket. Other fatty acid derivatives, including octadecanoic acid and heptadecanoic acid, also showed competitive binding energies. ADMET prediction indicated high intestinal absorption (HIA > 90%), no CYP3A4 inhibition, and low predicted toxicity. These results highlight sterculic acid as a promising CYP7A1 modulator and support the potential of Mucuna pruriens phytochemicals for further molecular dynamics studies and experimental validation in the development of hypercholesterolemia therapy.
Co-Authors Alizar, Alizar Bali Yana Fitri Budhi Oktavia Cleofany Aurhelya Paradhise Desy Kurniawati Desy Kurniawati DESY KURNIAWATI Dina Agustina Edi Nasra Edwina Zainal Elinda Fithriana Elinda Fithriana Fauzana Gazali Ferdi Henfi Pratama Indang Dewata Indang Dewata Isra Yeni Lulu Luthfiyah Marlini, Rahmida Mizatul Jannah Muhammad Habibul Ikhsan Mulia, Melindra Nella Aulia Putri Niza Lian Pernadi Putri Wulandari Rahadian Zainul Riga Riga Romy Dwipa Yamesa Away Roza Herlina Sherly Kasuma Warda Ningsih Sri Benti Etika Suryelita . Syamsi Aini Syamsi Aini Umar Kalmar Nizar Umar Kalmar Nizar Wahyu Hidayati Wandi Oktria Yeni, Isra