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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Keperawatan Padjadjaran Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmu Kefarmasian Indonesia JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Sri Purwaningsih
Universitas Airlangga
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PENGARUH CARA PENGOLAHAN BAWANG PUTIH (Allium sativum) TERHADAP EFEK ANTITROMBOTIK PADA MENCIT Prillye Deasy Octaviantie; Sri Purwaningsih; Arifoel Hajat
Jurnal Kedokteran Syiah Kuala Vol 17, No 3 (2017): Volume 17 Nomor 3 Desember 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v17i3.9064

Abstract

ABSTRAK.Bawang putih (Allium sativum) telah terbukti memiliki banyak efek positif untuk kesehatan, antara lain antibakteri, antivirus, antijamur dan juga antioksidan. Selain itu, bawang putih juga memiliki beragam efek positif untuk sistem kardiovaskular, antara lain menyebabkan penurunan tekanan darah, mencegah terjadinya aterosklerosis, dan juga bersifat antitrombotik. Salah satu obat antitrombotik yang umum digunakan oleh masyarakat adalah aspirin. Aspirin bekerja dengan cara menghambat pembentukan tromboksan A2. Komponen antitrombotik yang dimiliki bawang putih adalah allisin, yang bekerja dengan berbagai cara, salah satunya dengan cara menghambat jalur pembentukan tromboksan A2 dan ADP. Penelitian ini bertujuan untuk mengetahui efektivitas bawang putih mentah, rebus, dan goreng bila dibandingkan dengan aspirin. Desain dari peneltian ini adalah eksperimental laboratoris dengan 8 (delapan) kelompok yang terdiri dari kelompok kontrol negative (CMC 1%), kontrol positif (Aspirin), kelompok bawang putih mentah dosis tinggi, bawang putih mentah dosis rendah, bawang putih rebus dosis tinggi, bawang putih rebus dosis rendah, bawang putih goring dosis tinggi, dan bawang putih goreng dosis rendah. Setiap kelompok terdiri dari 5 (lima) mencit yang akan menerima perlakuan dalam 1 (satu) bulan. Pada hari ke 30, waktu perdarahan dari setiap mencit akan diukur dengan cara memotong ekor mencit. Hasil dari penelitian ini menunjukkan bahwa kelompok kontrol positif (aspirin) memiliki waktu perdarahan terpanjang, disusul dengan kelompok bawang putih mentah dosis tinggi. Di peringkat ketiga ada kelompok kontrol negative (CMC 1%) dan kelompok bawang putih mentah dosis rendah yang memiliki waktu perdarahan yang sama. Sementara itu, kelompok bawang putih rebus dan goreng, baik pada dosis tinggi maupun rendah, menunjukkan waktu perdarahan yang lebih panjang dibandingkan dengan kelompok kontrol negative (CMC 1%).Pemanjangan waktu perdarahan ini kemungkinan disebabkan karena allisin pada bawang putih yang bersifat termolabil dan terdegradasi dengan peningkatan suhu.
Effectivity of Cacao Rind Ethanol Extract in Inhibiting Streptococcus Pyogenes Growth In Vitro Cynthia Dwi Ramadhanie; Sri Purwaningsih; Eko Budi Koendhori
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 11 No. 1 (2020): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V11I12020.6-8

Abstract

Introduction: Infectious disease is still a common cause of illness and death in developing countries, such as Indonesia. One of the bacteria that causes infectious disease is Streptococcus pyogenes. Cacao fruit is a large commodity in Indonesia and has benefit for human. Cacao’s rind is known to contain several active compounds such as flavonoid and alkaloid that have antibacterial effect that can inhibit Streptococcus pyogenes growth. This research aims to evaluate the Minimum Bactericidal Concentration (MBC) of cacao rind ethanol extract in inhibiting Streptococcus pyogenes growth in vitro.  Methods: This research was a laboratory experimental study, testing antibacterial activity of cacao’s rind ethanol extract in inhibiting growth of bacteria Streptococcus pyogenes using dilution method in vitro to know the MIC and MBC result. Sample of bacteria Streptococcus pyogenes was obtained from Balai Besar Laboratorium, Surabaya. Sample of cacao’s rind ethanol extract was extracted at Balai Materia Medica, Batu.  Results: At the beginning this experiment was done to find the MIC and MBC of cacao’s rind ethanol extract against the growth of bacteria Streptococcus pyogenes, but the researcher can only find the MBC result, because the extract color is very dark, so the turbidity result of tubes P1 – P7 cannot be compared to control tube. From the results, the researcher draws a table showing how turbid and dark those tubes are. More (+) signs means more turbid or darker the tube is. From dilution test, the MBC of cacao’s rind ethanol extract against the growth of bacteria Streptococcus pyogenes is 12.5%. Conclusion: Cacao’s rind (Theobroma cacao L.) was quite effective in increasing the growth of bacteria Streptococcus pyogenes in vitro, the Minimum Bactericidal Concentration (MBC) is 12.5%
Risk Factor Prevalence of Late Onset Preeclampsia in Dr. Soetomo General Hospital Surabaya Fajrinka Pralampito; Agus Sulistyono; Sri Purwaningsih
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 2 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I22021.54-56

Abstract

Introduction: Preeclampsia is a condition of hypertension that occurs after 20 weeks of gestation, followed by the detection of protein in the urine sample, and is one of the major causes of maternal mortality. It is categorized, based on time of gestation, into 2-stage are early and late-onset. One of the more accessible tools in diagnosing and also preventing preeclampsia is by its risk factors. The aim of this study was to observe the appearance of some of the risk factors in patients with late-onset preeclampsia and to allow a better approach in patients with said comorbidities.Methods: This was a descriptive observational study. The sample used was 35 patients diagnosed with late-onset preeclampsia in Dr. Soetomo General Hospital Surabaya from January to December 2016.Results: Among 35 patients diagnosed with late-onset preeclampsia, obesity (65.71%) appeared the most. Maternal age (37.15%) and primigravida (28.57%) appeared in second and third places. Chronic hypertension appeared only in 6 (17.14%) patients, whereas multiple pregnancies appeared in 3 (8.57%). Both patients with a history of previous preeclampsia and diabetes mellitus only appeared once (2.86%).Conclusion: Obesity has the most appearance in patients with late-onset preeclampsia, followed by maternal age and primigravida. 
Skrining Pendahuluan Toksisitas Beberapa Tumbuhan Benalu terhadap Larva Udang Artemia Salina Leach DANTI NUR INDIASTUTI; SRI PURWANINGSIH; YUANI SETIAWATI; NOOR CHOLIES
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1138.28 KB)

Abstract

The brine shrimp lethality test (BSLT) is considered as a useful tool for preliminary assessment of toxicity. It has also been suggested for screening of pharmacological activities of plant extracts. The bioactivity of eight methanol extracts of four parasite plants and two host plants were evaluated using the brine shrimp lethality assay. The results showed that all methanol extracts of the host plants did not have any indication of toxicity The LC50 of methanol extract of Moringa pterygosperma stem was 1085.44±84.32 µg/ml, and of Ficus refusal stem was 1240.86±50.71 µg/ml. But methanol extracts of whole parts of parasite plants showed toxicity to Artemia Salina Leach. The LC50 of methanol extract of Loranthus peretandrus herb parasite was 175.66±29,24 µg/ml while that of Elytranthe evenia leaf parasite was 327.15±38.66 µg/ml; of Elytranthe evenia stem parasite was 320.39±39.57 µg/ml; of Elytranthe evenia flower parasite was 456.79±15.69 µg/ml; of Scurulla atropurpurea herb parasite was 176.44±28.46 µg/ml; and of Viscum articulatum parasite was 53.79±10.83 µg/ml.
Perbandingan Efektivitas Antara Metformin dan Glimepiride Berdasarkan Kadar Gdp pada Pasien Dm Tipe 2 di Rsud Dr.M.Soewandhie pada Tahun 2019 Muhammad Zaim Abbas Hisyam; Sri Purwaningsih; Hermina Novida
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i8.13466

Abstract

Diabetes Mellitus is a chronic metabolic disease characterized by elevated blood sugar levels and impaired carbohydrate, lipid, and protein metabolism due to betta pancreatic-cell dysfunction or insulin resistance in body cells. The prevalence of diabetes mellitus continues to increase worldwide. Indonesia itself has a prevalence of type 2 diabetes mellitus reaching 90% of all diabetes (WHO, 2016) (Riskesdas, 2018). The management of type 2 diabetes mellitus is very diverse, ranging from non-pharmacological therapy to pharmacological therapy such as insulin injection and oral anti-diabetes. Each anti-diabetic drug has a variety of ways of working, administration, and side effects. This study aims to analyze the comparison of the effectiveness of anti-diabetic medications based on blood sugar levels from the use of metformin and glimepiride (sulfonylureas) or a combination of both in patients with type 2 diabetes mellitus at Dr. Soewandhie Regional Public Hospital. This research is an analytic retrospective observational using secondary data in the form of medical records of patients with type 2 Diabetes Mellitus (outpatient) at Dr. Soewandhie Regional Public Hospital in 2019. The sample of this study consisted of 121 samples that met the inclusion criteria (43 patients on metformin therapy, 40 patients on glimepiride therapy, and 38 patients on combination therapy). The analysis of this study used data on FBG (Fasting Blood Glucose) before and three months after receiving metformin or sulfonylurea (glimepiride) therapy or a combination of both in the medical record. Data analysis of this study was performed using the Friedman test. This study showed that there was no significant difference in glycemic control (∆FBG) of metformin, glimepiride, and combination therapy in patients with type 2 diabetes mellitus (p value=0.575). There was no significant difference in the effectiveness of metformin, glimepiride, and combination therapy in patients with type 2 diabetes mellitus in Dr. Soewandhie Regional Public Hospital in 2019. In a study conducted in Japan showed that there’s efficacy of high-dose metformin use in patients with type 2 diabetes mellitus in Japan. The efficacy and safety of metformin are similar when used either twice daily or thrice daily. Further research needs to be done to assess the glycemic control (∆FBG) rate of metformin, glimepiride, and combination therapy in patients with type 2 diabetes mellitus by taking into account other factors such as medication adherence, diet, and physical activity.
Mental health and decision-making participation of adolescent orphans: A pilot study Annette d'Arqom; Farhan Nurdiansyah; Danti Nur Indiastuti; Mhd Zamal Nasution; Nurmawati Fatimah; Sri Purwaningsih; Yuani Setiawati; Kusuma Eko Purwantari
Jurnal Keperawatan Padjadjaran Vol. 11 No. 3 (2023): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v11i3.2358

Abstract

Background: Mental health has been brought to attention lately, with the increase of mental health problems during adolescence. In Indonesia, it is reported that one-third of adolescents develop mental health disorders. Childhood grief, separation from the family, child labor, or abuse affect the orphans’ mental health, including their decision-making participation. Purpose: As a pilot study, this study would like to investigate the mental health conditions and decision-making participation among orphans in one orphanage in Mojokerto district, East Java, Indonesia.Methods: This cross-sectional study utilizes the Depression Anxiety Scale Youth version (DASS-Y) and Child and Adolescent Participation in Decision Making Questionnaire (CAP-DMQ). Thirty-five adolescent orphans of one orphanage in Mojokerto were recruited using convenience sampling. The frequency of respondents’ mental health and decision-making participation were measured, and the mean differences between each group of sociodemographic factors were measured using the Mann-Whitney U test or the Kruskal Wallis test. Association between mental health and decision-making participation was calculated using Chi-square test.Results: The results show that 40% of respondents were categorized as having mild mental health problems, including depression, anxiety, and stress. Mental health problems are mostly found in males (22.90%) and elementary school (20%). The participation of the orphans in decision-making is considered good, with a median of 25.5. The bivariate analysis concludes the association between anxiety, age, grade, and decision-making participation (p= 0.024, p= 0.029, p=0.029, respectively).Conclusion: Taken together, attention to orphans, especially adolescents, and their problems are necessary to reduce the health discrepancies within these vulnerable groups. Broader respondents are needed to understand the complete picture of mental health conditions among Indonesian adolescent orphans, including late adolescents.
Co-Authors Agus Sulistyono Annette d’Arqom, Annette Arifoel Hajat Cynthia Dwi Ramadhanie Eko Budi Koendhori, Eko Budi Fajrinka Pralampito Farhan Nurdiansyah Fatimah, Nurmawati Hermina Novida, Hermina Indiastuti, Danti Nur Kusuma Eko Purwantari Mhd Zamal Nasution Muhammad Zaim Abbas Hisyam NOOR CHOLIES Prillye Deasy Octaviantie Yuani Setiawati