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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Indonesian Andrology and Biomedical Journal
Ilhamjaya Patellongi
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Biochemistry, Genetics & Molecular Biology Dentistry Engineering Health Professions Medicine & Pharmacology Neuroscience Public Health Other

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HbA1C levels in adolescent obesity, overweight and normoweight catholic high school eagles in Makassar Rajawali . Hasanuddin; Ilhamjaya Patellongi; Irfan Idris; . Rosdiana
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.37 KB)

Abstract

HbA1c Levels In Adolescent Obesity, Overweight and Normoweight Catholic High School Eagles in Makassar. Also known as glycohemoglobin or HbA1c abbreviated as A1c, is one of the important blood tests to evaluate blood sugar control. Obesity is the accumulation of adipose (adipocytes: specific fatty tissue that kept the body) to excess which is the major risk factor for diabetes. This study aims to determine differences in HbA1c levels in adolescent obesity, overweight and normoweight. The research was conducted at Catholic High School Eagles Makassar. The research was conducted with a quantitative approach and the type of study is a cross sectional study. Sampling Purposive sampling as many as 40 people and the data were analyzed with non parametric statistical test of Kruskal-Wallis and Mann-Whitney test. Research results show that there are differences in HbA1c levels in adolescent obesity, overweight and normoweight with p value of 0.007 at significance level p = 0.05. While based on Abdominal Circumference (LP) to the category of central obesity and non-obese as well there is a difference with a p value of 0.041 at significance level p = 0.05.
STUDI IN SILICO POTENSI ANTI KANKER SENYAWA TURUNAN KUMARIN TERHADAP PROTEIN BCL-2 Desi Dwirosalia Suparman; Ika Yustisia; Aryadi Arsyad; Muhammad husni Cangara; Ilhamjaya Patellongi; Rosdiana Natsir
Majalah Farmasi dan Farmakologi Vol. 25 No. 2 (2021): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v25i2.13648

Abstract

Mutasi pada protein anti-apoptosis BCL-2 merupakan salah satu penyebab terjadinya kanker payudara. Beberapa studi in vitro telah menunjukkan bahwa Eupatorium triplinerve Vahl, yang mengandung flavonoid, timohidrokuinon, terpenoid, karoten, vitamin C, stigmasterol, dan kumarin memiliki efek sitotoksik terhadap sel kanker payudara. Kumarin telah dilaporkan oleh berbagai penelitian berperan dalam berbagai jalur penghambatan terjadinya kanker. Tujuan penelitian ini adalah untuk melakukan dan menilai docking dari turunan senyawa kumarin yang terdapat pada tanaman Eupatorium triplinerve Vahl, yakni ayapanin dan ayapin, terhadap protein BCL-2. Docking dilakukan dengan menggunakan program command Autodock Vina pada personal computer (PC) dengan sistem operasi Windows 10 64-bit. Struktur protein BCL-2 dengan kode PDB 6QGG diunduh dari RCSB Protein Data Bank dan struktur 3D dari ayapanin dan ayapin diambil dari situs PubChem. Proses moleculer docking dilakukan secara bertahap dari penyiapan ligan dan protein, validasi metode docking, proses docking, hingga analisis data. Energi ikatan yang diperoleh dari docking antara senyawa ayapanin dan ayapin terhadap protein BCL-2 adalah -6.3 kcal/mol dan -6.9 kcal/mol dibandingkan dengan energi ikatan ligan bawaan, yakni -10.3 pada kantung aktif yang sama. Dengan demikian, ayapanin dan ayapanin memiliki potensi sebagai senyawa inhibitor protein anti-apoptosis BCL-2.
HUBUNGAN KADAR ADAMTS 13 DENGAN LUARAN PENDERITA STROK ISKEMIK AKUT Suriyanti; Mansyur Arif; Ruland Pakasi; Darmawaty; Ilhamjaya Patellongi; Abd Muis
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 1 (2024): April
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i1.183

Abstract

Penelitian ini bertujuan mengetahui hubungan kadar ADAMTS 13 dengan luaran penderita strok iskemik akut.Penelitian ini dilakukan di RSUP dr. Wahidin Sudirohusodo Makassar. Metode penelitian bersifat kohord prospektif dilakukan selama bulan September sampai Desember 2014. Pemeriksaan laboratorium dilakukan di Unit Penelitian Fakultas Kedokteran Unhas. Total sampel 50 orang, berumur antara 36-81 tahun dan memenuhi kriteria inklusi dan ekslusi. Kadar ADAMTS 13 diukur dengan metode Enzyme Linked Immunosorbent Assay. Hasil penelitian menunjukkan perbedaan kadar ADAMTS 13 terhadap luaran membaik adalah 520.84 ng/mL dan luaran tidak membaik adalah 438.50 ng/mL. Uji t tidak berpasangan memperlihatkan perbedaan bermakna antara luaran penderita SIA dengan nilai p=0.009 (p<0.01). Berdasarkan analisis kadar ADAMTS 13 pada luaran membaik sebanyak 30% dan luaran tidak membaik sebanyak 70%. Analisis korelasi Spearman menunjukkan kadar ADAMTS 13 berkorelasi negatif dengan luaran strok iskemik akut (r=-0,482 dan p=0.000).Kadar ADAMTS 13 dapat digunakan sebagai penanda untuk memprediksi luaran pada penderita strok iskemik akut.
Effect of Intermittent Fasting on Decreased Interleukin-6 Genes mRNA Expression in Mice (Mus Musculus) Herman, Sriyana; Muhammad Basir; Mochammad Hatta; Suryani As’ad; Ilhamjaya Patellongi; Ahmad Hadi Modi
Indonesian Andrology and Biomedical Journal Vol. 5 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i2.65697

Abstract

Nowadays, the development of various degenerative diseases is very rapid. The rapid development of the disease has encouraged the wider community to understand the impact. Intermittent fasting can help prevent the emergence of cancer (one of the degenerative diseases) because during fasting the body's cells are in protective mode so as to protect the body from disease. Intermittent fasting reduces the body's inflammatory status by inhibiting the expression of proinflammatory cytokines, especially interleukin-6 (IL-6). This study aims to examine the effect of intermittent fasting on IL-6 gene mRNA expression. This study is an experiment with Pretest-Posttest with Control Group design to examine the effect of intermittent fasting on the of IL-6 genes mRNA expression. The subjects of this study were 10 mice divided into 2 groups: the intermittent fasting group and the control group. The research was carried out at the Laboratory of Molecular Biology and Immunology Department, Faculty of Medicine, Universitas Hasanuddin, Makassar, as a place for the maintenance and care of experimental animals as well as examination of IL-6 genes mRNA expression. The study was conducted for 30 days. The results showed a decrease in the average value of IL-6 mRNA expression of subjects before and after intermittent fasting with the value of ρ = 0.003 (ρ <0.05) showed that there is a significant effect between intermittent fasting on the decrease in IL-6 genes mRNA expression. In conclusion, there is a decline in the IL-6 genes mRNA expression after intermittent fasting.
Health Promotion Strategies for Managing Exercise Intensity and Duration Among Athletes: A Scoping Review Kahanjak, Donna Novina; Ilhamjaya Patellongi; Mushawwir Taiyeb; Nukhrawi Nawir; Ira Jayanti; Gampa, Evan Kristanto
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12: DESEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i1.9113

Abstract

Introduction: Regular physical exercise offers substantial benefits to cardiovascular health by improving aerobic capacity, cardiac efficiency, and reducing the risk of cardiovascular disease. However, excessive or unregulated training may lead to maladaptive cardiac remodeling and increase the risk of arrhythmias or sudden cardiac death. Understanding the physiological boundaries of exercise-induced cardiac adaptation is therefore crucial for promoting safe and effective athletic performance. Methods: This scoping review followed a systematic protocol based on the PEOS framework (Population, Exposure, Outcome, Study Design). Literature searches were conducted in PubMed, ScienceDirect, EBSCO, and Google Scholar for studies published between 2000 and 2024 using relevant keywords on cardiac responses to exercise. Inclusion criteria covered original research and reviews focusing on cardiac adaptation, remodeling, and training intensity among athletes. From an initial 512 records, 20 eligible studies were critically appraised and synthesized using a narrative approach. Results: Endurance training predominantly induced eccentric hypertrophy and increased left and right ventricular volumes without systolic dysfunction, while resistance training produced concentric hypertrophy due to higher pressure load. These structural adaptations were physiological, reversible, and not associated with fibrosis. Conversely, extreme endurance activities were linked to transient cardiac fatigue and elevated cardiac biomarkers. Detraining studies confirmed regression of cardiac mass, highlighting the reversible nature of physiological remodeling. Conclusion: Cardiac responses to exercise depend on training intensity, duration, and type. Physiological remodeling enhances cardiovascular function, whereas excessive training or genetic predispositions may lead to pathological consequences. Balancing load and recovery, alongside periodic medical evaluation, is essential to optimize performance and prevent cardiovascular complications.
Co-Authors . Hasanuddin . Rosdiana Abd Muis Ahmad Hadi Modi Arsyad, Muhammad Aryadi Cangara, Husni Darmawaty Desi Dwirosalia Suparman Gampa, Evan Kristanto Herman, Sriyana Ika Yustisia Ira Jayanti Irfan Idris Kahanjak, Donna Novina Mansyur Arif Mochammad Hatta Muhammad Basir Mushawwir Taiyeb Nukhrawi Nawir Rosdiana Natsir Ruland Pakasi Suriyanti Suryani As’ad