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All Journal MEDIA MEDIKA INDONESIANA Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Andalas Indonesian Journal of Biotechnology INDONESIAN JOURNAL OF PHARMACY Oto Rhino Laryngologica Indonesiana Journal of Community Empowerment for Health Indonesian Journal of Cancer Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Camelia Herdini
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok Bedah Kepala Leher, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pewarnaan Toluidin blue sebagai petanda ketepatan biopsi pasca terapi karsinoma sel skuamosa kepala-leher Bambang Hariwiyanto; Camelia Herdini; Inawati Bobot
Oto Rhino Laryngologica Indonesiana Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.44 KB) | DOI: 10.32637/orli.v42i1.41

Abstract

Background: Squamous cell carcinoma (SCC) is the most frequent malignancy in the head and neck. The treatment modalities of SCC are surgery followed by chemotherapy and/or radiotherapy, could also chemotherapy and/or radiotherapy without surgery. The gold standard of assessing success  in SCC treatment is if there no malignant cells found not only in frozen section tissues, but also in  post chemotherapy and/or radiotherapy tissues. Determining the spot of biopsy tissue for malignancy assessment after treatment is not easy. Toluidin Blue (TB) is a staining material, absorbed by intercellular space in epithelial dysplasia, included SCC.   To determine the validity of Toluidin Blue as sign of accuracy for biopsy site in SCC post treatment malignancy, which not only for surgically treated cases, but also after chemotherapy and/or radiotherapy without surgical treatment. Method: Diagnostic test study to determine sensitivity test, specificity test, positive predictive value and negative predictive value of TB to detect malignant cells in post treatment head and neck SCC patients. Result: There were 30 samples biopsy material from 30 post treatment SCC patients. Sensitivity test was 83,3%, specificity  test: 66,7%, positive predictive value: 79.0%, negative predictive value: 72,7%. Conclusion: TB staining is accurate for determining biopsy spot in post treatment head and neck SCC. Keyword : Validity, toluidin blue, squamous cell carcinoma, post treatment.  Abstrak :  Latar belakang: Karsinoma sel skuamosa (KSS) merupakan jenis keganasan kepala dan leher yang paling sering dijumpai dibanding keganasan yang lain. KSS kepala leher dapat dilakukan terapi pembedahan diikuti kemoterapi dan/atau radioterapi maupun kemoterapi dan/atau radioterapi tanpa pembedahan. Penentuan keberhasilan radikalitas pengobatan ditandai dengan tidak adanya sisa tumor secara mikroskopis yang diambil pada jaringan pasca kemoradiasi tanpa pembedahan, atau pemeriksaan jaringan secara frozen section. Untuk menentukan apakah pada jaringan masih ada sisa tumor atau sudah bebas tumor secara makroskopis terkadang sulit. Toluidin Blue (TB) adalah zat pewarna yang dapat terserap pada ruang interseluler epitel yang mengalami displasia seperti yang terjadi pada KSS. Tujuan: Menilai validitas pewarnaan TB sebagai petanda ketepatan lokasi biopsi KSS pasca terapi, baik pasca pembedahan, maupun yang diterapi dengan kemoterapi dan/atau radioterapi tanpa pembedahan. Metode: Uji diagnostik untuk menentukan sensitifitas dan spesifitas pewarnaan, nilai duga positif dan nilai duga negatif TB sebagai salah satu petanda ketepatan biopsi KSS pasca terapi KSS kepala-leher. Hasil: Didapatkan 30 sampel penelitian yang berasal dari 26 penderita KSS yang telah dilakukan terapi baik bedah maupun kemoradiasi tanpa bedah. Sensitifitas pewarnaan TB terhadap hasil biopsi pasca terapi 83,3%, spesifitas 66,7%, nilai duga positif 79,0% dan nilai duga negatif 72,7%. Kesimpulan: Pewarnaan TB valid untuk menentukan ketepatan biopsi keganasan KSS kepala dan leher pasca terapi. Kata kunci: Validitas, toluidin blue, karsinoma sel skuamosa, pasca terapi
Meningioma ekstrakranial primer pada sinus paranasal Kenny Kenny; Camelia Herdini; Bambang Hariwiyanto
Oto Rhino Laryngologica Indonesiana Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2497.482 KB) | DOI: 10.32637/orli.v46i2.167

Abstract

Latar belakang: Meningioma ekstrakranial primer merupakan tumor jinak yang berasal dari lapisan otak, tetapi tidak berhubungan dengan aksis sistem saraf pusat, serta tumor ini jarang sekali ditemukan di ekstrakranial, terutama di rongga hidung dan sinus paranasal. Ekstirpasi bedah secara lengkap merupakan pengobatan utama untuk tumor jinak. Tujuan: Memberikan informasi mengenai diagnosis dan tatalaksana meningioma ekstrakranial primer pada regio sinonasal. Kasus: Kasus langka ini ditemukan pada anak laki-laki usia 11 tahun dengan massa tumor pada hidung dan sinus paranasal. Penatalaksanaannya berupa ekstirpasi massa secara lengkap melalui pendekatan rinotomi lateral sinistra, kemudian dilakukan maksilektomi medial dan etmoidektomi eksternal. Pada pemeriksaan histopatologi didapatkan gambaran meningioma tipe transisional (WHO derajat 1). Pewarnaan imunohistokimia vimentin memberikan hasil positif. Setelah dilakukan operasi tampak deformitas minimal pada hidung luar dan proptosis mata kiri dengan visus dalam batas normal. Metode: Penelusuran bukti kepustakaan menghasilkan 81 jurnal, dan hanya 3 jurnal yang relevan dengan pertanyaan klinis kami. Hasil: Ketiga jurnal tersebut merupakan laporan kasus meningioma ekstrakranial sinonasal anak yang ditatalaksana dengan ekstirpasi total, dan tidak didapati kekambuhan pada pemantauan jangka panjang. Kesimpulan: Meningioma ekstrakranial primer mempunyai prognosis yang baik, dengan tingkat kekambuhan yang rendah bila tumor dapat diekstirpasi secara lengkap. Pada kasus ini telah dilaksanakan ekstirpasi total massa tumor.Kata kunci: Meningioma ekstrakranial primer, rinotomi lateral, maksilektomi medialABSTRACT Background: The primary extracranial meningiomas are benign tumors that originate from the meningens of the brain, but not related with the central nervous system axis. This kind of tumor is rarely found extracranially, especially in nasal cavity and paranasal sinuses. A complete surgical extirpation is the primary treatment of this benign tumor. Objective: To provide information about the diagnosis and management of primary extracranial meningioma in sinonasal region. Case: This rare case was found in 11-year-old boy with tumor mass in the nose and paranasal sinuses. The patient underwent complete mass extirpation with left lateral rhinotomy approach, followed by medial maxillectomy and external ethmoidectomy. Transitional type meningioma (WHO grade 1) was obtained on histopathological examination. Vimentin immunohistochemical staining gave a positive result. In post-surgery evaluation, there was a minimal nasal deformity and protusion of the left eye with vision within normal limits. Methods: Searching for evidence produced 81 journals, and only three were relevant to our clinical question. Result: These three journals were case reports of pediatric extracranial sinonasal meningioma extirpated by surgery and without recurrence at long term follow up. Conclusion: The primary extracranial meningiomas prognosis were good and the recurrence rate were low if a complete extirpation of the tumor could be performed. In this case, total extirpation of the tumor mass had been conducted.Keywords: Primary extracranial meningioma, external approach extirpation, medial maxillectomy
Prevalence of Sinonasal Cancer in Dr. Sardjito General Hospital Yogyakarta in The Period between January 2017 and December 2022 Indrasari, Sagung Rai; Herdini, Camelia; Yudistira, Danu; Mary, Cynthia
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1087

Abstract

Background: Sinonasal cancer is considered a rare disease and data concerning the disease in Indonesia still requires extensive research. This study aimed to describe the factors that contribute to the incidence and outcome of sinonasal cancer. Methods: This was a descriptive study conducted at the Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Sardjito General Hospital Yogyakarta between January 2017 and December 2022. Data regarding histopathological type, sex, age, location of tumor, presence of metabolic syndrome, staging, treatment, overall survival, and cancer recurrence were extracted from the patient’s medical records. All patients diagnosed with sinonasal cancer within the period were included in the study. Results: A total of 117 patients were included in this study ranging from 11 to 85 years of age and averaging 54,5 years. Most patients were diagnosed within the age range of 51 – 60 years. SCC was found to be the most common and it was more prevalent in males than in females. More patients were found to have suprastructure tumors. Most patients were not recorded to have metabolic syndrome. The majority of patients were diagnosed in the late stage of sinonasal cancer and overall survival for most cases was death. More patients received 2 or less therapy, followed by patients who received all 3 types of treatment. Recurrency was found in only 1,7% of all cases. Conclusion: Several conditions can affect the incidence and outcome of sinonasal cancer which include sex, age of diagnosis, presence of risk factors (e.g. metabolic syndrome), location of tumor, staging, treatment, recurrence, and the histopathological type.
Sinonasal Schwannoma and Progressive Nasal Obstruction Fakhriani, Rizka; Herdini, Camelia; Yudistira, Danu
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1092

Abstract

Introduction: Schwannomas, are non-malignant tumors with well-defined encapsulation and gradual growth patterns. These tumors consist of Schwann cells, which originate from the neural crest. The prevalence of schwannoma cases in the head and neck region ranges from approximately 25% to 45%. However, in the sinus cavity, the occurrence is only 4%. Case Presentation: In this study, we provide a clinical case with a 25-year-old female patient with rhinorrhoea symptoms, recurrent epistaxis, and a decreased sense of smell. The patient had a progressive obstruction in the right nasal cavity over one year. A biopsy and computed tomography (CT) scan identified a schwannoma and soft tissue density lesions in the right maxillary ethmoid sinuses and left septal deviation. The confirmation of schwannoma diagnosis is also achieved through histopathological examination. The tumor was surgically excised from the patient's body utilizing lateral rhinotomy and an extirpation technique under general anesthesia. The patient had positive outcomes during the follow-up; the patient revealed the absence of symptoms and no evidence of disease recurrence. Conclusions: Lateral rhinotomy with extirpation methods represents an effective option for managing sinonasal schwannoma due to its ability to access challenging anatomical regions and facilitate the sensitive excision of tumors. 
Efektivitas Seminar Untuk Meningkatkan Pengetahuan Tentang Kewaspadaan Kanker Nasofaring Bagi Tenaga Kesehatan Di Kabupaten Gunungkidul Rosmawati, Ima Dewi; Indrasari, SR; Herdini, Camelia; Fles, Renske; Tan, I. Bing; Fidianingsih, Ika
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 1 No. 2 (2023)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: Di Indonesia, kanker nasofaring (NPC) menempati urutan 4 tumor ganas di seluruh tubuh. Pada daerah kepala dan leher, NPC menempati urutan pertama kanker di daerah kepala dan leher. Kurangnya pengetahuan tenaga kesehatan yang ada di puskesmas dan juga masyarakat tentang NPC menjadi salah satu faktor yang menyebabkan diagnosa dini penyakit ini menjadi terlambat. Perlu adanya upaya untuk meningkatkan kewaspadaan terhadap NPC oleh tenaga kesehatan dalam rangka penegakan diagnosis NPC secara dini. Tujuan: Untuk menjelaskan efektivitas seminar untuk meningkatkan pengetahuan tentang kewaspadaan kanker nasofaring pada tenaga kesehatan di Kabupaten Gunungkidul Metode: Jenis penelitian adalah quasi experimental dengan rancangan pre dan post test only group design. Penelitian ini dilakukan pada 109 tenaga kesehatan yang diambil secara klaster dari seluruh instansi kesehatan di wilayah kabupaten Gunungkidul. Perlakuan yang diberikan pada responden meliputi seminar tentang kewaspadaan NPC. Kuesioner Awareness Program Questionnaire (APQ) digunakan sebagai alat ukur penelitian ini. Data pre dan post-test dari responden dianalisis dengan menggunakan uji paired sample t-test. Data dinyatakan bermakna jika p>0.05 dengan koefisien internal (CI) sebesar 95%  Hasil: Tingkat pengetahuan responden tentang kewaspadaan NPC setelah mengikuti seminar meningkat sebesar 32,3%. Pemahaman tenaga kesehatan sebelum seminar adalah 6,60 ± 2,07 naik menjadi 9,51±2,243 setelah seminar (p<0,01). Simpulan: Metode seminar efektif meningkatkan pengetahuan tentang kewaspadaan NPC pada tenaga kesehatan di Kabupaten Gunung kidul.
Awareness education on the prevention and control of upper respiratory tract infections in medical students of Universitas Muhammadiyah Yogyakarta Widuri, Asti; Daniswara, Deoni; Herdini, Camelia
Journal of Community Empowerment for Health Vol 7, No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.95359

Abstract

Introduction: Respiratory tract infections are a subject of public health concern due to their widespread occurrence and significant rates of disease and mortality reported worldwide. Viruses trigger most of these respiratory infections, but bacteria also trigger some. Current measures in prevention efforts are to limit the spread of cases. Health education is crucial in preventing and managing infectious diseases. Given the provided background information, the Faculty of Medicine and Health Sciences service team Universitas Muhammadiyah Yogyakarta, conducted awareness education on preventing and controlling upper respiratory tract infections in medical students of Universitas Muhammadiyah Yogyakarta.Methods: The participants of this community service consisted of 49 students. This community service program was carried out in March 2024. The techniques used in implementing this program in detail are preparation before the implementation of community service, pretest, providing educational material on preventing and controlling upper respiratory tract infections and ending with posttest activities. The delivery of educational material was carried out with a PowerPoint presentation for 90 minutes. Results: This community service activity was attended by 49 participants, with the majority of respondents aged 21 years (51%) and females (61.2%). The analysis found a statistically significant increase in knowledge (p=0.000) between before and after education.Conclusion: In this study, education on preventing and managing upper respiratory tract infections proved significant in enhancing knowledge.
Fibrovascular Polyps of the Hypopharynx: A Case Report Herdini, Camelia; Wirata, I Komang Praba Edi; Indrasari, Sagung Rai; Yudistira, Danu; Alamanda, Monik
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1352

Abstract

Introduction: Fibrovascular polyps are very rare, non-cancerous growths in the hypopharynx, though they can occur anywhere in the pharynx. Surgical excision is the definitive treatment to alleviate the patient's symptoms with an excellent outcome. This case report aims to share knowledge about the clinical presentation and treatment of this rare condition. Case Presentation: A 45-year-old man complained primarily of recurrent sore throat and frequent choking episodes, particularly during sleep. He also felt a mass in his deep throat, which he felt in his mouth just before swallowing, particularly when he vomited. A pedunculated mass originating from the lateral hypopharyngeal wall is detected during physical examination. After the mass was completely resected, he received proton pump inhibitors (PPI) and postoperative antibiotics.Conclusion: For fibrovascular polyps, definitive surgical excision is the preferred treatment. It is recognized that with total resection, malignant transformation and disease recurrence are relatively rare.
Co-Authors Akira Hosoyama Akira Hosoyama Alamanda, Monik Anak Agung Istri Sri Wiadnyani Anton Sony Wibowo Asti Widuri, Asti Atsushi Yamazoe Atsushi Yamazoe Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Udji Djoko Rianto Bustanul Ardianto Daniswara, Deoni Danu Yudistira Didik Setyo Heriyanto Ery Kus Dwianingsih Fles, Renske Harijadi Harijadi Heriwiyanto, Bambang Hideaki Nojiri Hideaki Nojiri Ika Fidianingsih Inawati Bobot Indrasari, SR Irianiwati Widodo Jaap Middeldorp Jajah Fachiro JAKA WIDADA Kenny Kenny Mary, Cynthia Nastiti Wijayanti Nastiti Wijayanti Rizka Fakhriani Rosmawati, Ima Dewi Sagung Rai Indrasari Sagung Rai Indrasari Sagung Rai Indrasari Sagung Rai Indrasari Shinta Hartanto Sofia Mubarika Haryana Susanna Hutajulu Tan IB Tan, I. Bing Taufiqurrahman Taufiqurrahman Taufiqurrahman Taufiqurrahman Wahyu Tri Widayati Wirata, I Komang Praba Edi Yendri, Veby Novri