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All Journal Nexus Kedokteran Klinik Folia Medica Indonesiana Jurnal Kesehatan Reproduksi Journal of Maternal and Child Health
Supriyadi Hari Respati
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Korioamnionitis Sebagai Faktor Risiko Terjadinya Persalinan Preterm Elita Rahmi; Supriyadi Hari Respati; Eriana Melinawati
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Premature Rupture of Membranes (PROM) is one causes of fetal mortality and morbidity. Suspected chorioamnionitis is a major cause of preterm labor. Methods: This study was observational analytic cross-sectional approach. Sample of 694 study subjects that satisfy with inclusion and exclusion criteria were taken from the medical records of patients who gave birth in RSUD Dr. Moewardi. The data was analyzed using bivariate analysis and processed with Statistical Product and Service Solutions (SPSS) for Windows 20:00. Results: Chorioamnionitis is a risk factor 1.045 times to preterm delivery occur (OR = 1045; CI = 95%, 0737, 1483, p = 0804). Chorioamnionitis caused death of neonatal mortality 1.554 times compared with norma pregnancy (OR = 1554; CI = 95%, 0790, 3057, p = 0.194). Chorioamnionitis 1.747 times risk factors for occur asphyxia in preterm labor and statistically significant (OR = 1747; CI = 95%, 1114, 2741, p = 0.014). Conclusions: There was no significant relationship between chorioamnionitis with preterm labor and chorioamnionitis with neonatal mortality. There is a significant relationship between chorioamnionitis with asphyxia. Keywords: PROM, Chorioamnionitis, preterm labor
EXPRESSION OF HUMAN LEUKOCYTE ANTIGEN-E AND NATURAL KILLER CELLS IN INTRA UTERINE FETAL DEATH Sri Sulistyowati; Muhammad Anggit Nugroho; Supriyadi Hari Respati; Soetrisno Soetrisno
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.127 KB) | DOI: 10.20473/fmi.v53i4.7156

Abstract

Intra Uterine Fetal Death (IUFD) is one contributor to infant mortality. Human Leukocyte Antigen-E (HLA-E) and Natural Killer Cells (NK cells) are believed to play an important role towards IUFD associated with immune maladaptation. This study aimed to determine the expression of HLA-E and NK cells on trophoblast on IUFD and normal pregnancy. The study used cross sectional approach undertaken at Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, networking hospitals, and Anatomic Pathology Laboratory of Faculty of Medicine, Sebelas Maret University. The number of samples were 32 subjects consisting of 16 subjects with normal pregnancy and 16 subjects with IUFD. The expression of HLA-E and NK cells on trophoblast of subjects who met the inclusion and exclusion criteria were examined using immunohistochemistry method and t-test statistical analysis. The mean value of HLA-E expression in the trophoblast of IUFD group was 17.30±6.69, in normal pregnancy was 57.06±32.04, with p=0.00 (p<0.05). The mean value of NK cell expression in trophoblast in IUFD group was 78.62±36.43, in normal pregnancy was 19.87±6.43, with p=0.00 (p<0.05). This study concluded that the expression of HLA-E was lower and NK cells wass higher in IUFD compared to those in normal pregnancy.
KADAR HUMAN LEUKOCYTE ANTIGEN-G (HLAG) DAN TUMOR NERCROSIS FAKTOR ALPHA (TNF-a) PADA ABORTUS DAN KEHAMILAN NORMAL Kresno Condro Adhi; Sri Sulistywati; Supriyadi Hari Respati
JURNAL KESEHATAN REPRODUKSI Vol 2, No 2 (2015)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.12638

Abstract

KADAR HUMAN LEUKOCYTE ANTIGEN-G (HLAG) DAN TUMOR NERCROSIS FAKTOR ALPHA (TNF-a) PADA ABORTUS DAN KEHAMILAN NORMALKresno Condro Adhi1, Sri Sulistyowati2, Supriyadi Hari Respati3ABSTRACTBackground: Abortion is one of the causes of maternal morbidity and mortality. Rejection of the fetusdue to recognition of paternal antigens by the maternal immune system, is suspected to be a cause ofunexplained pregnancy loss. Human Leukocyte Antigen G (HLA-G) expressed by thropoblast and TumorNecrosis Factor α (TNF-α) suspected as one of important inflammatory mediators associated with abortion.Objective : To analyze levels of the HLA-G and TNF-α in the serum of abortion and normal pregnancy.Method: Observational analytic with Cross sectional approach at the Obstetric and Gynecology DepartmentDr. Moewardi hospital Surakarta and Prodia laboratory since August - November 2014. Number of samplestudied was 40 sample divided into 2 groups, 20 sample abortion and 20 sample normal pregnancy. Allthe sample were examined the HLA-G and TNF-α serum level by ELISA method and analyze by t test withCI 95%.Result and Discussion: Average value of HLA-G in abortion group was 55,0246±26,01 ng/ml and normalpregnancy group with an average 76,7200±32,18 ng/ml with p=0,024 (p≤0,05). Average value of TNF-α inabortion group was 3,83±1,52 ng/ml and normal pregnancy group with an average 2,76±1,49 ng/ml withp=0,032 (p≤0,05).Conclusion: In the abortion serum level of HLA-G is lower and TNF-α is higher than normal pregnancy.Keywords: Abortion, HLA-G, TNF-α.ABSTRAKLatar Belakang : Abortus merupakan salah satu penyebab morbiditas dan mortalitas maternal. Adanyapenolakan janin karena adanya antigen paternal oleh sistim imun ibu, diduga menjadi salah satu penyebabterjadinya abortus. Human Leukocyte Antigen G (HLA-G) yang dihasilkan oleh trofoblas dan Tumor NecrosisFactor Alpha (TNF-α) diduga sebagai salah satu mediator yang berhubungan dengan terjadinya abortus.Tujuan : Mengetahui kadar HLA-G dan TNF-α serum pada abortus dan kehamilan normalMetode: Penelitian ini merupakan penelitian observasional analitik menggunakan pendekatan CrossSectional yang dilakukan di RSUD Dr. Moewardi Surakarta pada bulan Agustus - November 2014. Totalsampel 40 dibagi menjadi 2 kelompok, 20 sampel kelompok abortus dan 20 sampel kelompok kehamilannormal. Semua sampel dilakukan pemeriksaan serum kadar HLA-G dan TNF-α dengan menggunakanmetode ELISA. Analisis menggunakan uji t dengan nilai kepercayaan 95%.Hasil dan Pembahasan: Rerata kadar serum HLA-G pada kelompok abortus adalah 55,0246±26,01 ng/ml dan kelompok kehamilan normal 76,7200±32,18 ng/ml, dengan nilai p=0,024 (p≤0,05). Rerata kadarserum TNF-α pada kelompok abortus 3,83±1,52 ng/ml dan kelompok kehamilan normal 2,76±1,49 ng/mldengan nilai p=0,032 (p≤0,05).Kesimpulan: Pada abortus kadar serum HLA-G lebih rendah dan TNF-α lebih tinggi bila dibandingkandengan kehamilan normal.Kata kunci : Abortus, HLA-G, TNF-α.1,2,3 Bagian Obstetri dan Ginekologi FK UNS/RSUD Dr. Moewardi Surakarta
The Effectiveness of Online Learning to Improve Knowledge About Metabolic Syndrome in Pregnancy Sri Sulistyowati; Muhammad Adrianes Bachnas; Eric Edwin Yuliantara; Anggraini, Nutria Widya Purna; Wisnu Prabowo; Supriyadi Hari Respati; Hafi Nurinasari; Robert Ridwan; Lini Astetri; Arib Farras Wahdan; Yonathan Siswo Pratomo; Vidya Ismiaulia
Journal of Maternal and Child Health Vol. 9 No. 2 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2024.09.02.04

Abstract

Background: Metabolic syndrome is a persistent global health problem and a risk factor for diabetes and heart disease. A metabolic syndrome that occurs during pregnancy will pose a threat to maternal and fetal health. The incidence of metabolic syndrome during pregnancy, especially in developing countries, will become a serious public health problem in the future. This study aims to assess the effectiveness of online learning in improving the knowledge of online learning participants on metabolic syndrome cases in pregnancy. Subjects and Method: This was a cross-sectional study conducted in July through Zoom online learning on Metabolic Syndrome in Pregnancy attended by 125 participants. The dependent variable was knowledge about metabolic syndrome in pregnancy. The independent variable was online learning. The data obtained from this study were in the form of pretest and post-test scores. The data were analyzed by t-test. Results: The mean score of knowledge about metabolic syndrome in pregnancy after online learning was higher (Mean= 90.8; SD= 14.05) than before (Mean= 60.08; SD= 6.94), and this was statistically significant (p= <0.001). Conclusion: Online learning is effective to improve knowledge about metabolic syndrome in pregnancy among Indonesian Obstetrics and Gynecology Association (POGI) members and young POGI members.
Co-Authors Anak Agung Istri Sri Wiadnyani Arib Farras Wahdan Elita Rahmi Eric Edwin Yuliantara Hafi Nurinasari Kresno Condro Adhi Lini Astetri Muhammad Adrianes Bachnas Muhammad Anggit Nugroho Nutria Widya Purna Anggraini Robert Ridwan Soetrisno Soetrisno Sri Sulistyowati Sri Sulistywati Vidya Ismiaulia Wisnu Prabowo Yonathan Siswo Pratomo