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All Journal Jurnal Kedokteran Syiah Kuala Majalah Obstetri dan Ginekologi Universa Medicina Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Maternal and Child Health Jurnal Biomedika dan Kesehatan Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Plexus Medical Journal Folia Medica Indonesiana

Eric Edwin Yuliantara

Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta

Author-ID : 424684

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Recombinant vascular endothelial growth factor 121 decreases vascular cell adhesion molecule-1 in murine pre-eclampsia model placenta Sulistyowati, Sri; Sondakh, John Arianto; Yuliantara, Eric Edwin; Respati, Supriyadi Hari; Soetrisno, Soetrisno
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.192-198

BackgroundPreeclampsia is one of the major contributors to maternal and fetal morbidity and mortality. Imbalance of soluble Fms-like tyrosine kinase (sFlt-1) as anti-angiogenic factor and vascular endothelial growth factor (VEGF) as pro-angiogenic factor plays a role in the pathogenesis of preeclampsia. Endothelial dysfunction in preeclampsia causes vascular cell adhesion molecule-1 (VCAM-1) to be expressed on its surface. This study aims to evaluate the effect of recombinant VEGF-121 on VCAM-1 expression in the placenta of a murine preeclampsia model. Methods An experimental analytical study conducted from February until March 2016 in the Biomedical Laboratory, Faculty of Veterinary Medicine, Airlangga University. The study sample consisted of 30 pregnant mice, divided into three groups, i.e. 10 normal pregnant mice, 10 mice with preeclampsia model and 10 mice with preeclampsia model and recombinant VEGF-121 therapy. All animals were subjected to immunohistochemical examination of VCAM-1 expression in their placentas. The results were assessed semiquantitatively according to a modified Remmele method. Data analysis was done using one-way ANOVA and Tukeyâs multiple comparisons method. ResultsMean VCAM-1 expression in normal (0.97 Â± 0.54%) murine placentas, compared with placentas (2.94 Â± 0.96%) of murine preeclampsia models (p=0.000), while mean VCAM-1 expression in placentas of murine preeclampsia models with VEGF intervention was 2.14 Â± 0.68% (p=0.030).Conclusion Recombinant VEGF-121 can reduce VCAM-1 expression in placentas of murine preeclampsia models. The present study has shown the potential benefits of VEGF therapy, justifying serious consideration of this therapeutic approach for use in women with preeclampsia.

The Effectiveness of Letrozole-Electroacupuncture Adjuvant Therapy in Reducing Resistance and Pulsatility Indices in Women with Polycystic Ovarian Syndrome Octavia, Dhamayanti Eka; Budihastuti, Uki Retno; Melinawati, Eriana; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Polycystic Ovarian Syndrome (PC

Massive Adherent Placenta, Placenta Percreta Yuliantara, Eric Edwin; Anggraini, Nutria Widya Purna; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Adherent placentas including placenta accreta, increta and percreta are conditions where there is abnormal implanta

Partial molar pregnancy with live fetus in first trimester: what should we do next Eric Edwin; Uki Retno Budihastuti; Cut Sheira Elnita
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18505

Abstract. The incidence of a normal live fetus with a partial mole is extremely rare, and it varies between 5 per 100000 and 1 per 10000 of the pregnancies. A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies.A 27-year-old Primigravide at 13 weeks of gestation got admitted with spotting per vaginam, excessive nausea and vomiting, and her ultrasound revealed a hydropic placenta with multiple cysts with a live fetus. Regarding these findings, the patient continued her pregnancy under close observation, and advanced sonographic evaluations were done to rule out other differentials. Ultrasonography found mosaicism in the partial mole (mostly diploid, a small part is triploid). In this condition, the prognosis condition for the fetus to be born safely is still probable. Ethics committee meetings are held with the consideration of the fetus's condition, whether monitoring is carried out regularly, and terminating the pregnancy in case of fetal emergency.The optimal management of hydatidiform mole with the coexistent live fetus is currently uncertain. Antenatal consultation should include a detailed discussion of maternal and fetal risks. It is also necessary to have close follow-up and evaluation of the patient's condition during the antenatal and postnatal period. Keywords: first trimester, live fetus , management, partial molar pregnancy

VEGF 121 Rekombinan Dapat Memperbaiki Endoteliosis Gromerular pada Mencit Bunting Model Preeeklampsia Sri Sulistyowati; Donny Irawan; Eric Edwin; Soetrisno Soetrisno
Majalah Obstetri dan Ginekologi Vol. 24 No. 1 (2016): Januari - April
Publisher : Universitas Airlangga

Preeklampsia masih merupakan penyebab utama morbiditas dan mortalitas maternal maupun perinatal. Pada preeklampsia terjadi gangguan ginjal berupa endoteliosis glomerular. Ketidakseimbangan faktor proangiogenik VEGF dan antiangiogenik sFlt-1 diduga terlibat dalam patogenesis preeklampsia. Pemberian VEGF 121 rekombinan memiliki kemampuan untuk memperbaiki fungsi endotel sehingga dapat memperbaiki endoteliosis glomerular. Penelitian ini bertujuan untuk membuktikan pengaruh VEGF 121 rekombinan terhadap perbaikan endoteliosis glomerular pada mencit model preeklampsia menggunakan metode eksperimental analitik dengan RCT, yang dilakukan pada bulan Januari – Mei 2015 di Kandang Hewan Percobaan dan Laboratorium Biomedik Fakultas Kedokteran Hewan Universitas Airlangga. Sampel dari replikasi Steel dan Torrie adalah 30 mencit bunting yang terbagi dalam 3 kelompok yaitu 10 mencit bunting normal, 10 mencit bunting model preeklampsia dan 10 mencit bunting model preeklampsia dengan terapi VEGF 121 rekombinan. Semua sampel dilakukan pemeriksaan pada endotel ginjalnya dengan metode imunohistokimia. Parameter endoteliosis glomerular menggunakan kriteria Stillman (2007) dan Wide-Swensson (2007). Analisa data menggunakan uji Kruskal Wallis dan Mann Whitney. Rerata endoteliosis gromeruler pada mencit bunting normal 1,60 dan mencit bunting model preeklampsia 1,90 dengan nilai p=0,28 (p>0,05). Rerata endoteliosis gromeruler pada mencit bunting model preeklampsia 1,90 dan mencit bunting model preeklampsia dengan terapi VEGF rekombinan 121 adalah 1,30 dengan nilai p=0,02 (p<0,05). Rerata endoteliosis gromeruler pada mencit bunting normal 1,60 dan mencit bunting model preeklampsia dengan terapi VEGF rekombinan 121 adalah 1,30 dengan nilai p=0,28 (p>0,05). Simpulan, VEGF 121 rekombinan dapat memperbaiki endoteliosis gromerular pada mencit bunting model preeeklampsia.

Kasus yang Langka: Sebuah Persalinan Normal dari Wanita Hamil Prematur dengan Janin Sacrococcygeal Teratoma Cut Sheira Elnita; M. Adrianess Bachnas; Eric Edwin
Indonesian Journal of Obstetrics & Gynecology Science Special Issue: Case Report
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

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Latar belakang: Insiden kehamilan dengan janin Sacrococcygeal Teratoma (SCT) yaitu1 dari 35.000 kelahiran hidup. SCT dideteksi dengan skrining ultrasonografi (USG) prenatal trimester kedua.Tujuan; Mendemonstrasikan peran USG janin dalam diagnosis SCT.Laporan kasus: Wanita 20 tahun G2P1A0 kehamilan 28 minggu keluhan kontraksi, pecah selaput ketuban. Teraba janin tunggal, fundus teraba massa padat. Pemeriksaan genital pembukaan serviks 7 cm, USG intrauterin tunggal perkiraan usia kehamilan 28 minggu, tampak massa echogenic campuran dari daerah sacrococcygeal, terdapat daerah padat kistik di dalam massa ukuran 11,4 x 12,3 cm. Kemungkinan invasi ke panggul janin disimpulkan SCT tipe II. Persalinan pervaginam, berat janin 1600 gram , apgar score 2-3-4, dengan massa padat kistik pada sacrum ukuran 13x13cm. Tampak perdarahan dari massa teratoma.Hasil: SCT adalah neoplasma lesi kistik jinak. Komplikasi berupa perdarahan intramural masif dan distosia. Klasifikasi Altman: massa terdapat di eksterior atau intrapelvik, tipe I(47%): terletak di luar janin. tipe II(35%): massa terdapat di eksternal memiliki ekstensi intrapelvic. tipe III(8%): eksternal terletak di dalam panggul dan perut. tipe IV(10%): presakral tanpa presentasi eksternal. Pada USG, SCT muncul sebagai massa echogenisitas campuran yang memanjang dari sacrum. USG pada SCT padat (20%), kistik(30%) dan campuran(50%). Kesimpulan: Ultrasonografi mempengaruhi keputusan dan manajemen klinis sehingga prognosis baik.Kata kunci: Sacrococcygeal Teratoma, Kehamilan PrematurAbstractBackground: The incidence of pregnancy with fetal Sacrococcygeal Teratoma (SCT) occurs in 1 out of every 35.000 live births. SCT detected by second trimester prenatal ultrasonography (USG) screening.Objective: Demonstrating the role of fetal ultrasound in the diagnosis of SCT.Case report: a 20 year old G2P1A0 with 28 weeks pregnancy came with contractions and membranes ruptured. Examination found were single fetus, fundus palpable a mass. The cervical dilatation 7 cm, intrauterine ultrasound a 28 weeks of age fetus, appears an echogenic mass in the sacrococcygeal region containing a dense area 11.4x12.3 cm. We concluded an invasive to the fetal pelvis was type II SCT. Vaginal delivery performed, baby weight 1600 grams, apgar score 2-3-4, solid mass in sacrum 13x13cm. Bleeding from teratoma mass emerged.Result: SCT is a rare tumour. Complications consist of massive bleeding and dystocia. SCT classified according to Altman. Type I(47%): located outside fetus, type II(35%): mass available on external with intrapelvic extension, type III(8%): externally located inside pelvis and abdomen, type IV(10%): presacral without external presentation. On ultrasound, SCT appears as a mixed echogenicity mass extending sacrum. Ultrasound: solid SCT(20%), cystic(30%) and mixed(50%).Conclusion: Ultrasonography affects decisions and clinical management that make a good prognosis.Key words: Sacrococcygeal Teratoma, Premature Pregnancy

THE EFFECT OF ABO BLOOD GROUP ON COVID-19 IN PREGNANCY Sri Sulistyowati; Nutria Widya Purna Anggraini; Soetrisno Soetrisno; Eric Edwin Yuliantara; Supriyadi Hari Respati; Muhammad Adrianes Bachnas; Wisnu Prabowo; Hafi Nurinasari; Dympna Pramelita; Dewi Setiyawati; Metharisa Sujana; Aldi Firmansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art6

Background: The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19, and one of them is pregnant women. Pregnancy increases risks of the COVID-19, especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. Objective:This study aims to investigate relationships between the ABO blood group, the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital, Surakarta.Methods: This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital, Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx, and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions, blood parameters and complications (respiratory, thrombotic, other infections, and death) were calculated by Chi square test and then by One-Way ANOVA. Next, correlation tests for the complications of the blood group and the ages applied a multinomial regression.Results: There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022).Conclusion: The ABO blood group could affect the complication levels in the pregnant women infected with the COVID 19.

Effect of hypnotherapy on prolactin level in women after cesarean section Supriyadi Hari Respati; Risang Bhaskoro; Eric Edwin Yuliantara; Uki Retno Budihastuti; Debree Septiawan
Universa Medicina Vol. 42 No. 1 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.6-11

BackgroundPostpartum depression occurs in women after cesarean section, due to increased cortisol and decreased prolactin levels, leading to delayed breast milk production. Hypnotherapy is one of the most effective and efficient complementary therapy options for reducing postpartum depression. Hypnotherapy increases oxytocin secretion from the paraventricular nucleus of the anterior pituitary gland, decreases cortisol levels, and increases prolactin, thereby increasing breast milk production. This study evaluates hypnotherapy’s effect on prolactin levels after a cesarean section. MethodsThis study was an experimental non-blinded randomized controlled trial with a post-test-only control group design conducted at Dr. Moewardi General Hospital and UNS hospital. A total of 20 post-cesarean -section women were included in the study. They were randomized into two groups, a group I: given hypnotherapy, and group 2: the control group (without hypnotherapy). Both groups were tested for prolactin levels. Group I received hypnotherapy 6 to 12 hours post-cesarean section, and study participants were confirmed to be unaffected by the anesthetic. Data analysis used the independent t-test and p<0.05. ResultsAt baseline, there was no significant difference in age, parity, and indication for cesarean section between the hypnotherapy and the control groups (p>0.05). After intervention, the mean prolactin level was higher in the hypnotherapy group (247.6 ± 81.1 ng/mL) compared to the control group (120.1 ± 55.4 ng/mL) (p<0.001). ConclusionHypnotherapy increases post-cesarean prolactin levels compared to the controls. Our findings open up a wide range of potential hypnotic applications among women with postpartum depression.

Prenatal Diagnosis and Management of Advanced Abdominal Pregnancy in Dr. Moewardi Hospital Surakarta: A Case Series Akbar, Uchti; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Bachnas, Muhammad Adrianes; Ridwan, Robert; Sulistyowati, Sri
Journal of Maternal and Child Health Vol. 6 No. 5 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: The abdominal pregnancy is a pregnancy anywhere in the abdominal cavity other than the tube, ovary, and broad ligament. Abdominal pregnancy has 7.7 times greater risk than tubal pregnancy and 90 times greater than intrauterine pregnancy. This study aims to reveal the diagnosis and treatment of abdominal pregnancy in Dr. Moewardi Hospital Surakarta. Subjects and Method: This was a case series study conducted at Dr. Moewardi Hospital Surakarta. This study report three cases of advanced abdominal pregnancy at Dr Moewardi Hospital (2019 – 2020), that consisted of two cases of advanced abdominal pregnancy to term, and one advanced abdominal pregnancy with acute abdomen. Case presentation: Case 1 (it was found abdominal pregnancy at 30 weeks), the condition of the mother and the fetus was good, the pregnancy was continued until the gestational age was term. The patient was given corticosteroids for lung maturation and magnesium sulfate for neuroprotection. Case 2 (an abdominal pregnancy was found at term), it was decided to immediately terminate it with good preoperative preparation. Both patients in case 1 and case 2 had good result in both the mother and the fetus. The placenta was left in situ in both cases to prevent massive bleeding and injury to the gastrointestinal organs. Case 3 (advanced abdominal pregnancy with acute abdominal symptoms) decided to undergo an emergency laparotomy and removal of the placenta. Conclusion: Abdominal pregnancy must be diagnosed and managed properly to reduce maternal mortality and morbidity. In advanced abdominal pregnancy, it could be considered to continue the pregnancy until the term. The placenta management of in situ without methotrexate might be considered in cases of abdominal pregnancy.

Enhancing Nutrients Knowledge during Pregnancy through Webinars to Prevent Stunting Bachnas, Muhammad Adrianes; Sulistyowati, Sri; Yuliantara, Eric Edwin; Anggraini, Nutria Widya Purna; Prabowo, Wisnu; Respati, Supriyadi Hari; Nurinasari, Hafi; Ridwan, Robert; Astetri, Lini; Yuliani, Saffana Oka; Carissa, Dinda; Alamsyah, Meuthia
Journal of Maternal and Child Health Vol. 7 No. 5 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: Indonesia still has a high stunting rate, 1.2 million out of 5 million births each year result in stunted baby growth. linear growth in utero, the process can be caused by maternal malnutrition, which can result in intrauterine growth inhibition and low birth weight, and result in stunting. This study aims to analyze the effectiveness of the webinar in improving nutrition knowledge during pregnancy to prevent stunting growth. Subjects and Method: This is a cross sectional study conducted in July, 15th 2022 using the Zoom Meeting webinar platform. Target population are all young POGI and POGI Members who took part in webinars and online conversations using the Zoom Meeting program. This study used random sampling, and sample size are 161. The independent variables of this study was learning via webinars while the dependent variable was nutrient knowledge. Data were analyzed by paired t-test statistical test. Results: There was a significant difference score of knowledge in pregnant women after (Mean= 8.60) compared to before webinars (Mean= 6.52). Conclusion: The result of this study indicates that learning method via webinars increased maternal understanding about optimal nutrient during pregnancy. Keywords: stunting, nutrients, webinar, pregnant women Correspondence: Nutria Widya Purna Anggraini. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia. Jl. Kolonel Sutarto No. 132 Jebres, Surakarta. Email: nutria_dr@staff.uns.ac.id. Mobile: 08122651819.

Co-Authors Abkar Raden Adhi Pribadi Akbar, Uchti Alamsyah, Meuthia Aldi Firmansyah Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alim, Fadel Muhammad S. Aloysius Suryawan Anak Agung Ngurah Jaya Kusuma Andanaputra, Waskita Ekamaheswara Kasumba Andonotopo, Wiku Anita Deborah Anwar Annisa Rizki Savitri Arib Farras Wahdan Asih Anggraeni Astetri, Lini Bachnas, Muhammad Adrianes Bambang Sukilarso Bambang Sukilarso Carissa, Dinda Chasanah, Meriska Dewi Cut Meurah Yeni Cut Sheira Elnita Cut Sheira Elnita Darmawan, Ernawati Debree Septiawan Dewi Setiyawati Dharma, Wibisana Andika Krista Dhyani Rahma Sari Dhyani Rahma Sari Djanas, Dovy Donny Irawan Donny Irawan, Donny Dwi Tiara Septiani Dympna Pramelita Efendi Lukas Eriana Melinawati Evert Solomon Pangkahila Firmansyah, Aldi Garwita Anindya Restisa Hadi, Cahyono Hafi Nurinasari Hafi Nurinasari Harry Kurniawan Gondo Hermawan Udiyanto I Nyoman Hariyasa Sanjaya Ida Nurwati John Arianto Sondakh, John Arianto Julian Dewantiningrum Khanisyah Erza Gumilar Khoeronisa, Siti Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Lilik Wijayanti Lilik Wijayanti Lini Astetri Merina, Hikmah F. Metharisa Sujana Muhammad Adrianes Bachnas Muhammad Adrianes Bachnas Muhammad Iqbal Sugiantoro Mutiara Rizky Ananda Nugraha, Gagah B Adi Nugraha, Gagah Baskara Adi Nugraha, Laksmana Adi Krista Nurinasari, Hafi Nuswil Bernolian Nutria Widya Purna Anggraini Nuur, Aliffudin Octavia, Dhamayanti Eka Pradana, Muhammad Denny Gagah Prameilita, Dympna Pramono, Mochammad Besari Adi Prisasanti, Dympna Prameilita Putra, Ridwan Abdullah Rahmawati, Oktantia Dyah Ridwan, Robert Risang Bhaskoro Robert Ridwan Ryan Saktika Mulyana Soetrisno Soetrisno Soetrisno Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Stanojevic, Milan Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Teguh Prakosa, Teguh Tejowati, Ardika Desi Regita Totok Siswanto Trsitiarti, Alfi Marita Uki Retno Budihastuti Vidya Ismiaulia Wiradnyana, Anak Agung Gede Putra Wisnu Prabowo Wisnu Prabowo WISNU PRABOWO Yonathan Siswo Pratomo Yuliani, Saffana Oka

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