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All Journal The Indonesian Biomedical Journal Nusantara Medical Science Journal ELS Journal on Interdisciplinary Studies in Humanities Majalah Kedokteran Neurosains Indian Journal of Forensic Medicine & Toxicology Neurona
Jumraini Tammasse
Department of Neurology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Journal : The Indonesian Biomedical Journal

 1 
Differentiation of Low-Grade and High-Grade Glioma Using the Combination of Conventional Magnetic Resonance Imaging and Apparent Diffusion Coefficient Value Rahmad Mulyadi; Mochammad Hatta; Andi Asadul Islam; Bachtiar Murtala; Jumraini Tammase; Reninda Ananda Aman; Eka Susanto
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.996

Abstract

BACKGROUND: The conventional magnetic resonance imaging (cMRI) and apparent diffusion coefficient (ADC) may have a role in predicting tumor grade for gliomas and may in turn assist in identifying tumor biopsy sites. In this study, we aimed to determine the added value of a joint approach of diffusion-weighted imaging (DWI) and cMRI to determine of low grade and high-grade glioma, compare to cMRI alone.METHODS: Data were collected from 56 glioma patients, who underwent examinations and received treatment at Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia, from the period of 2015–2018. Inclusion criteria was patients who underwent cMRI with a DWIADC sequence and patient that were diagnosed with glioma according to the histopathological results. Pathology reports of the imaging results were reviewed independently. A receiver operator curve (ROC) analysis assessed the predictive potential of cMRI and ADC values for low-grade and high-grade gliomas.RESULTS: Fifty-six subjects met the inclusion criteria. The combination of MRI and ADC values increased sensitivity (to 90%) and negative predictive value (to 92.9%), and also improved the negative likelihood ratio (to 0.14). However, the combination of MRI and ADC values had the highest area under the curve (78.6%) and sensitivity (78.6%), which was similar to the separated examination.CONCLUSION: The combination of ADC value and conventional MRI increases sensitivity in differentiating low-grade and high-grade glioma compared to separated examination.KEYWORDS: glioma, conventional MRI, ADC value
Intratumoral and Peritumoral Apparent Diffusion Coefficient and MGMT mRNA Expression in Different Meningioma Histopathological Grade Rahmad Mulyadi; Mochamma Hatta; Andi Asadul Islam; Bachtiar Murtala; Jumraini Tammase; Muhammad Firdaus; Eka Susanto; Joedo Prihartono
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1338

Abstract

BACKGROUND: Histopathological examination is the gold standard for diagnosing meningioma and determining the treatments. However, it is invasive in nature. This study was conducted to identify intratumoral and peritumoral apparent diffusion coefficient (ADC) value and mRNA O6-methylguanine-DNA methyltransferase (MGMT) expression in meningioma.METHODS: Data were collected from 39 patients who were clinically diagnosed with meningioma. However, only 37 patients met the inclusion criteria. These subjects then underwent examinations and received treatment from October 2017 to September 2018. Magnetic resonance imaging (MRI) data with diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) sequence, histopathological diagnosis of meningioma, and results of MGMT mRNA expression were obtained.RESULTS: The most frequent type of low-grade and overall tumor was meningioma not otherwise specified (56.8%). For high-grade tumor, there were two atypical cases: atypical meningioma (2.7%) and rhabdoid meningioma (2.7%). Meningothelial meningioma had the highest mean value of minimum intratumoral ADC at 864.57±219 x10-3 mm2/s, whereas rhabdoid meningioma had the lowest at 417 x10-3 mm2/s. For minimum peritumoral ADC, rhabdoid meningioma had the highest mean value at 1,651 x10-3 mm2/s, while atypical meningioma has the lowest at 1,281 x10-3 mm2/s. For MGMT mRNA, meningothelial meningioma had the highest mean value at 10±1.2 fold change, whereas rhabdoid meningioma had the lowest mean at 6.18 fold change.CONCLUSION: WHO grade I meningiomas had higher minimum intratumoral ADC values and higher MGMT mRNA expression than the high-grade tumors. Minimum peritumoral ADC values differed across the histopathological grades.KEYWORDS: meningioma, RNA, messenger, MRI, methyltransferases, RT-PCR, ADC, MGMT mRNA
Co-Authors Abdul Muis Andi Alfian Zainuddin Andi Asadul Islam Andi Kurnia Bintang, Andi Kurnia Bachtiar Murtala Bachtiar Murtala David Gunawan Dody Perdana Goenadhi Eka Susanto Eka Susanto Herpan Syafii Harahap Joedo Prihartono Mochamma Hatta Mochammad Hatta Muhammad Akbar Muhammad Akbar Muhammad Firdaus Muhammad Iqbal Basri Novika Azirah Azis Rahmad Mulyadi Rahmad Mulyadi Rahman, Fakhriawan Fathu Reninda Ananda Aman Sri Wahyun Tammasse, Tammasse Utami, Iin Fadhilah