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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) The Indonesian Biomedical Journal JBN (Jurnal Bedah Nasional) Jurnal Abdidas
Andi Asadul Islam
Departemen Bedah Saraf, Fakultas Kedokteran, Universitas Hasanuddin, Makassar, 90245, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Treatment of functioning pituitary macroadenoma with endoscopic transsphenoidal surgery: a case report Agusni Agusni; Willy Adhimarta; Andi Asadul Islam; Djoko Widodo; Nasrullah Nasrullah; Andi Ihwan; Prihantono Prihantono; Muhammad Faruk
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202109

Abstract

Pituitary macroadenomas are benign tumors in the pituitary gland measuring more than 1 cm in diameter. Pituitary adenomas account for 8 to 10% of all intracranial tumors and occur primarily in the anterior pituitary lobe and rarely in the posterior lobe. Most pituitary macroadenomas are non-functioning tumors, which show clinical symptoms due to tumor pressure and do not increase hormonal activity. In this case, a 40 y.o. woman was diagnosed with a pituitary macroadenoma after showing clinical symptoms of a functioning tumor, namely acromegaly, prognathism, and large, beefy hands and feet, for the past 4 years. Complaints were accompanied by amenorrhea, intermittent cephalgia, and hemianopsia in the right eye. Blood laboratory tests revealed increased levels of prolactin and growth hormone, while the results of computed tomography (CT) scans and magnetic resonance imaging (MRI) of the head indicate the presence of a pituitary macroadenoma. Endoscopic transsphenoidal surgery, a minimally invasive procedure, was performed with minimal complications.
Differentiation of Low-Grade and High-Grade Glioma Using the Combination of Conventional Magnetic Resonance Imaging and Apparent Diffusion Coefficient Value Rahmad Mulyadi; Mochammad Hatta; Andi Asadul Islam; Bachtiar Murtala; Jumraini Tammase; Reninda Ananda Aman; Eka Susanto
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.996

Abstract

BACKGROUND: The conventional magnetic resonance imaging (cMRI) and apparent diffusion coefficient (ADC) may have a role in predicting tumor grade for gliomas and may in turn assist in identifying tumor biopsy sites. In this study, we aimed to determine the added value of a joint approach of diffusion-weighted imaging (DWI) and cMRI to determine of low grade and high-grade glioma, compare to cMRI alone.METHODS: Data were collected from 56 glioma patients, who underwent examinations and received treatment at Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia, from the period of 2015–2018. Inclusion criteria was patients who underwent cMRI with a DWIADC sequence and patient that were diagnosed with glioma according to the histopathological results. Pathology reports of the imaging results were reviewed independently. A receiver operator curve (ROC) analysis assessed the predictive potential of cMRI and ADC values for low-grade and high-grade gliomas.RESULTS: Fifty-six subjects met the inclusion criteria. The combination of MRI and ADC values increased sensitivity (to 90%) and negative predictive value (to 92.9%), and also improved the negative likelihood ratio (to 0.14). However, the combination of MRI and ADC values had the highest area under the curve (78.6%) and sensitivity (78.6%), which was similar to the separated examination.CONCLUSION: The combination of ADC value and conventional MRI increases sensitivity in differentiating low-grade and high-grade glioma compared to separated examination.KEYWORDS: glioma, conventional MRI, ADC value
Risk Assessment in Hereditary Colorectal Cancer Family by Using APC and MSH2 mRNA Gene Expression and Bayesian Analysis Tjahjadi Robert Tedjasaputra; Mochammad Hatta; Muhammad Nasrum Massi; Rosdiana Natzir; Ilhamjaya Patellongi; Marcellus Simadibrata; Ibrahim Labeda; Rina Masadah; Muhammad Luthfi Parewangi; Prihantono Prihantono; Andi Asadul Islam; Agussalim Bukhari; Budu Budu; Rinda Nariswati
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1329

Abstract

BACKGROUND: Some of colorectal cancers (CRCs) are familial, however, heterozygote relatives have approximately 80% lifetime risk of cancer. Risk assessment of CRC’s family could be calculated by direct measurement of mRNA gene expression and Bayesian theorem which is modifying initial background of pedigree risk with additional conditional information. This application has not been reported.METHODS: The cross-sectional translational sequential studies were performed: (1) adenomatous polyposis coli (APC) and MutS homolog (MSH)2 mRNA quantitative RT PCR gene expressions in tissue and whole blood CRC patients; (2) gene expression was determined in matched controls; and (3) pedigree and Bayesian analysis was calculated in the patient’s family of Proband.RESULTS: Fourty CRC and 31 control subjects were enrolled. The mean blood APC level control’s group was 13,261±670 fold-change (fc) and blood MSH2 level was 12,219±756 fc. The cut-off points for hereditary APC was 12,195 fc and MSH2 was 11,059 fc. The mean APC blood level in CRC subject was 11,578±2,638 fc and MSH2 blood level was 11,411±2,912 fc. There were significant differences APC and MSH level between tissue and blood level in CRC. Eight of 40 CRC subjects had a history of familial CRC. Four patients and 10 Probands were available for recurrence risk evaluation of pedigree analysis, RNA PCR quantitative and Bayesian calculation.CONCLUSION: There was determined a cut-off point of hereditary mRNA quantitative expression. The APC and MSH2 levels in CRC subjects were significantly lower than controls. Bayesian analysis allowed for the calculation of relative risk in CRC family members and considered in clinical practice.KEYWORDS: hereditary CRC, APC gene, MSH gene, Bayesian analysis
Intratumoral and Peritumoral Apparent Diffusion Coefficient and MGMT mRNA Expression in Different Meningioma Histopathological Grade Rahmad Mulyadi; Mochamma Hatta; Andi Asadul Islam; Bachtiar Murtala; Jumraini Tammase; Muhammad Firdaus; Eka Susanto; Joedo Prihartono
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1338

Abstract

BACKGROUND: Histopathological examination is the gold standard for diagnosing meningioma and determining the treatments. However, it is invasive in nature. This study was conducted to identify intratumoral and peritumoral apparent diffusion coefficient (ADC) value and mRNA O6-methylguanine-DNA methyltransferase (MGMT) expression in meningioma.METHODS: Data were collected from 39 patients who were clinically diagnosed with meningioma. However, only 37 patients met the inclusion criteria. These subjects then underwent examinations and received treatment from October 2017 to September 2018. Magnetic resonance imaging (MRI) data with diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) sequence, histopathological diagnosis of meningioma, and results of MGMT mRNA expression were obtained.RESULTS: The most frequent type of low-grade and overall tumor was meningioma not otherwise specified (56.8%). For high-grade tumor, there were two atypical cases: atypical meningioma (2.7%) and rhabdoid meningioma (2.7%). Meningothelial meningioma had the highest mean value of minimum intratumoral ADC at 864.57±219 x10-3 mm2/s, whereas rhabdoid meningioma had the lowest at 417 x10-3 mm2/s. For minimum peritumoral ADC, rhabdoid meningioma had the highest mean value at 1,651 x10-3 mm2/s, while atypical meningioma has the lowest at 1,281 x10-3 mm2/s. For MGMT mRNA, meningothelial meningioma had the highest mean value at 10±1.2 fold change, whereas rhabdoid meningioma had the lowest mean at 6.18 fold change.CONCLUSION: WHO grade I meningiomas had higher minimum intratumoral ADC values and higher MGMT mRNA expression than the high-grade tumors. Minimum peritumoral ADC values differed across the histopathological grades.KEYWORDS: meningioma, RNA, messenger, MRI, methyltransferases, RT-PCR, ADC, MGMT mRNA
Upaya Menurunkan Angka Kematian Ibu Melalui Peningkatan Kesehatan Ibu Hamil dan Kesehatan Reproduksi Mardiana Ahmad; Patmahwati Patmahwati; Sharvianty Arifuddin; Andi Asadul Islam
Jurnal Abdidas Vol. 2 No. 1 (2021): February, Pages 1-160
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v2i1.195

Abstract

Program KB, penyuluhan dan penelitian dalam kelas antenatal merupakan salah satu program upaya pencegahan 3 terlalu dan 4 terlambat dan upaya menurunkan angka kematian ibu. Adapun tujuan dari pemberian konseling dan pelayanan KB yang bertujuan meningkatkan pengetahuan dan mampu menyikapi permasalahan yang berhubungan dengan kehamilan dan persalinan yang bertujuan untuk menurunkan angka kematian ibu. Sasaran dalam kegiatan ini adalah ibu hamil, pasangan usia subur di Desa Leang-Leang Kabupaten Maros dengan peserta pemasangan IUD sebanyak 12 orang dan peserta penyuluhan 57 orang. Metode yamg digunakan adalah penyuluhan melalui ceramah dengan menggunakan media reaflek, demonsterasi dan laptop. Kegiatan ini dilakukan untuk meningkatkan kualitas kesehatan ibu hamil dan pasangan usia subur khususnya dalam bidang keluarga berencana dan pendidikan di wilayahnya secara mandiri.
Peran Poly-(ADP ribose) polymerase (PARP) dan Phosphatidylinositol 3-kinase (PI3K) Terhadap Terjadinya Kejadian Metastasis pada Kanker Payudara I Wayan Gede Suarsana; Andi Asadul Islam; Prihantono Prihantono; Berti Julian Nelwan
JBN (Jurnal Bedah Nasional) Vol 6 No 1 (2022): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBN.2022.v06.i01.p05

Abstract

Kanker payudara merupakan penyebab kematian akibat kanker terbanyak pada wanita di seluruh dunia dengan angka kematian sebesar 458.400 wanita setiap tahunnya. Poly-(ADP ribose) polymerase (PARP) dan phosphatidylinositol 3-kinase (PI3K) adalah dua molekul yang memainkan peran penting pada patofisiologi kanker payudara. Metastasis kanker payudara merupakan sebuah proses berkesinambungan yang melibatkan beberapa tahapan penting seperti invasi, angiogenesis, hingga replikasi sel. Sel yang mengalami mutasi pada kanker payudara akan menyebabkan ekspresi yang berlebihan dari PI3K sehingga terjadi replikasi sel yang tidak terkontrol disertai dengan peningkatan matrix metallopeptidase 9 (MMP-9). MMP-9 memiliki peran dalam degradasi matriks ekstraseluler yang penting untuk proses invasi tumor. Di sisi lain, PARP membantu reparasi sel yang mengalami kerusakan sehingga proses replikasi sel kanker dapat terus berlangsung. Terlebih lagi, PARP diketahui memiliki andil besar dalam proses angiogenesis sel kanker. Gabungan dari kedua fenomena tersebut menghasilkan sel kanker dengan kemampuan replikasi dan metastasis yang tinggi.
Co-Authors Agusni Agusni Andi Ihwan Bachtiar Murtala Bachtiar Murtala Berti Julian Nelwan Budu - Bukhari, Agussalim Djoko Widodo Eka Susanto Eka Susanto I Wayan Gede Suarsana Ibrahim Labeda Ilhamjaya Patellongi Joedo Prihartono Jumraini Tammasse Luthfi, Muhammad Marcellus Simadibrata Mardiana Ahmad Mochamma Hatta Mochammad Hatta Mochammad Hatta Muh. Nasrum Massi Muhammad Faruk Muhammad Firdaus Nasrullah Nasrullah Patmahwati Patmahwati Prihantono Prihantono Rahmad Mulyadi Rahmad Mulyadi Reninda Ananda Aman Rina Masadah Rinda Nariswati Rosdiana Natzir Sharvianty Arifuddin Tjahjadi Robert Tedjasaputra Willy Adhimarta