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All Journal BALI MEDICAL JOURNAL (BMJ) Majalah Kedokteran Nusantara The Journal Of Medical School Narra J Excellent Midwifery Journal Jurnal Neuroanestesi Indonesia The Journal of Society Medicine (JSOCMED)
Suzy Indharty
Departement Of Neurosurgery, Faculty Of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Levetiracetam as an Alternative to Phenytoin for Prophylactic Use in Post-Traumatic Seizures: a Literature Review Nagatri, Gabriela; Situmorang, Dicky Arjuna; Ramoti, Natanael; Siahaan, Andre Marolop Pangihutan; Indharty, Rr. Suzy; Tandean, Steven
Jurnal Neuroanestesi Indonesia Vol 13, No 3 (2024)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i3.622

Abstract

Traumatic brain injury (TBI) is a common concern for the causes of disability and mortality and it can cause post-traumatic seizure (PTS). Currently, Brain Trauma Foundation (BTF) recommends phenytoin (PHY) as early PTS prophylaxis for patients with severe TBI. The two most common drugs prescribed for PTS are levetiracetam (LEV) and PHY. However, PHY displays a wide array of disadvantages. LEV appears as a better alternative to PHY because of its easier administration, the absence of need for drug level monitoring, lower drug-drug interaction, and better side-effects profile. It is due to the linear elimination kinetics LEV had in comparison to PHY that have zero order pharmacokinetics. Theoretically, LEV is better than PHY. But according to prior studies, LEV and PHY have comparable efficacy at preventing PTS in the early stages. Furthermore, the current evidence is insufficient to definitely recommend LEV over PHY in terms of effectiveness and adverse effects. This study aimed to analyze levetiracetam as an alternative to phenytoin for prophylactic use in post-traumatic seizure.
Tanda Bahaya (Red Flag) Nyeri Kepala Pada Ibu Hamil Ossiseanna, Femmy Ruth; Indharty, Rr Suzy; Kartika, Fazarima; Adriani, Yolanda; Pasaribu, Egidia Jemima
Excellent Midwifery Journal Vol. 8 No. 2 (2025): Volume 8 No. 2, Oktober Tahun 2025
Publisher : STIKes Mitra Husada Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55541/emj.v8i2.361

Abstract

Latar Belakang: Data WHO pada tahun 2021 nyeri kepala memengaruhi sekitar 40% populasi global dan menduduki posisi ketiga sebagai penyebab tertinggi disabilitas neurologis (6). Nyeri kepala merupakan salah satu gejala neurologis yang paling umum dijumpai. Nyeri kepala dapat memburuk selama kehamilan akibat perubahan hormonal, hemodinamik, serta beban fisiologis dan nyeri biasa berhubungan dengan gangguan primer seperti migrain atau Tension-Type Headache (TTH), namun beberapa kondisi dapat menandakan gangguan serius yang mengancam jiwa. Tujuan: Pengenalan terhadap red flag dan green flag pada nyeri kepala, khususnya dalam populasi ibu hamil dengan menggunakan instrumen SNNOOP10 sebagai pendekatan evaluatif yang tepat. Metode: Penelitian ini menggunakan metode narrative review yang bertujuan untuk merangkum dan mengkaji secara komprehensif melalui database ilmiah dengan rentang tahun publikasi antara 2013 hingga 2024 kemudian dibuat kesimpulan mengenai topik permasalahan yang dibahas. Hasil: Nyeri kepala pada ibu hamil harus segera diidentifikasi tanda bahaya untuk memutuskan apakah akan segera dirujuk untuk perawatan sekunder. Dalam beberapa kasus, migrain dan tension-type headache dapat ditangani di layanan primer dengan pengetahuan tentang medikamentosa yang dianggap aman.
Co-Authors A. Gofar Sastrodiningrat Abdurrahman Mouza Adella, Cut A. Adriani, Yolanda Daulay, Elvita Rahmi Indra Saputra Irina, Rr Sinta Iskandar Japardi Iskandar Japardi Kartika, Fazarima Muhammad Fadhli Nagatri, Gabriela Ossiseanna, Femmy Ruth Pasaribu, Egidia Jemima Ramoti, Natanael Siahaan, Andre Marolop Pangihutan Siahaan, Andre MP. Situmorang, Dicky Arjuna Sufida dr Tandean, Steven Zamzami, Muhammad Avicienna