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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Majalah Obat Tradisional Dental Journal (Majalah Kedokteran Gigi) Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Gici Jurnal Keuangan dan Bisnis Odonto dental journal
Dahlia Herawati
Faculty Of Dentistry, Universitas Gadjah Mada, Yogyakarta
Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Public Health

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Journal : ODONTO Dental Journal

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Osteocalcin levels in gingival crevicular fluid periodontitis patient with and without type 2 Diabetes Mellitus Wildan, Muhammad Nabeel; Syaify, Ahmad; Herawati, Dahlia
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.214-221

Abstract

Background: Diabetes Mellitus (DM) is a systemic disease with a high prevalence in Indonesia. Periodontitis is a complication of DM with frequent occurrences. Periodontitis with DM causes greater bone damage than non-DM periodontitis because its conditions can affect osteoblast and osteoclast activity. Osteocalcin (OC), mostly synthesized by osteoblasts, regulates the activity of bone formation and turnover so that it can be a marker of bone formation and turnover to see the severity of the disease. OC can be found in gingival crevicular fluid (GCF). This study aimed to determine osteocalcin levels in gingival crevicular fluid periodontitis patients with uncontrolled type 2 Diabetes Mellitus and non-Diabetes Mellitus.Method: Samples used in this study were gingival crevicular fluid taken from 20 samples of periodontitis patients with DM type 2 (DMT2P) and 20 samples of periodontitis non-DM patients. The OC levels were analyzed using ELISA Kit Osteocalcin then statistical tests were carried out.Result: The results showed that the OC level of the DMT2P group was 0.369 ± 0.140 while the periodontitis non-DM group was 0.664 ± 0.141.Conclusion: The OC levels of periodontitis patients with DM are lower than periodontitis patients non-DM.
Co-Authors Ahmad Syaify Ahmad Syaify, Ahmad Andy Yok Siswosaputro Ariska Ratih Damayanti Christopher Imantaka Suwondo Deassy Anggraeni Dedi Sumantri Etty Cahya Pertiwi Fitri Yuniawati Kwartarini Murdiastuti Nungky Devitaningtyas Nungky Devitaningtyas Nunuk Purwanti Nur Rahman Ahmad Seno Aji Nur RAS. Aji Oktarina, Dyah Ayu Mira Pramudita Kusuma Wardani Rezmelia Sari Rizka Dindarini Rizky Nurcahyanti Shinta Ferronika Siti Sunarintyas Sri Kadarsih Sri Kadarsih Soejono Sri Pramestri Lastianny, Sri Pramestri Sudibyo Sudibyo Suryono Suryono Tissa Rahadianti Tissa Rahadianti Wayan T Artama Wayan T Artama Wildan, Muhammad Nabeel