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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia Majalah Obat Tradisional Dental Journal (Majalah Kedokteran Gigi) Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Gici Jurnal Keuangan dan Bisnis

Dahlia Herawati

Faculty Of Dentistry, Universitas Gadjah Mada, Yogyakarta

Author-ID : 2873207

Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Public Health

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Prevalensi periodontitis pada pasien diabetes mellitus (Studi observasional di poliklinik penyakit dalam RSUP Dr. Sardjito) Rezmelia Sari; Dahlia Herawati; Rizky Nurcahyanti; Pramudita Kusuma Wardani
Majalah Kedokteran Gigi Indonesia Vol 3, No 2 (2017): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Prevalence of periodontal diseases in patients with diabetes mellitus (An observational study at internal medicine polyclinic in Dr. Sardjito General Hospital). Diabetes Mellitus (DM) is a chronic disease with an increasing prevalence and causes complications. The most frequent complication found in the oral cavity of patients with diabetes mellitus is periodontal diseases is characterized by the loss of tissue attachment. There have been numerous studies on the association of DM with periodontal diseases but there has not been any data on the prevalence of periodontal diseases in diabetic group, especially in Yogyakarta and Central Java. Dr. Sardjito General Hospital is a referral hospital in DIY and Central Java, so this study is expected to provide a picture regarding the level of periodontal tissue health among people in Yogyakarta and Central Java. This research was an observational study, involving 36 patients with DM according to criteria of the subjects: suffering from type 2 diabetes, being cooperative and willing to sign an informed consent. The controlled variables: being 40 – 60 years of age, having good oral hygiene (OHI) according to Green and Vermillion, taking neither antibiotics nor anti-inammatory drugs in the last 3 months, not having a history of other systemic diseases. Oral hygiene exams were carried out, followed by examination using probe WHO to determine if there is CAL. The data were presented descriptively. The results showed that the prevalence of periodontal diseases in patients with DM at Internal Medicine Polyclinic in Dr. Sardjito General Hospital is 88.24% with a mean of CAL distance of 4.6 mm. The conclusion of this study is that the prevalence of periodontal diseases in patients with DM is high although the oral hygiene status is good. ABSTRAKDiabetes Mellitus (DM) adalah penyakit kronis menahun dengan prevalensi yang semakin meningkat dan menimbulkan komplikasi. Komplikasi yang paling sering terjadi di rongga mulut pasien DM adalah periodontitis yang ditandai dengan kehilangan perlekatan jaringan. Penelitian tentang hubungan DM dengan periodontitis banyak dilakukan namun belum ditemukan data mengenai prevalensi periodontitis pada kelompok DM khususnya di DIY dan Jawa Tengah. RSUP Dr. Sardjito merupakan rumah sakit rujukan DIY dan Jawa Tengah sehingga penelitian ini diharapkan dapat memberi gambaran mengenai tingkat kesehatan jaringan periodontal di masyarakat DIY dan Jawa Tengah. Jenis penelitian ini adalah observasional dengan melibatkan 36 orang pasien DM sesuai kriteria subjek yaitu menderita DM tipe II, kooperatif dan bersedia menandatangani informed consent. Variabel terkendali yaitu usia 40 – 60 tahun, kebersihan mulut (OHI) menurut Green and Vermillion dalam kriteria baik, tidak menggunakan antibiotik dan antiinamasi dalam 3 bulan terakhir dan tidak memiliki riwayat penyakit sistemik lain. Dilakukan pemeriksaan kebersihan mulut dilanjutkan dengan pemeriksaan menggunakan probe WHO untuk menentukan ada tidaknya CAL. Data disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa prevalensi periodontitis pada pasien DM di Poli Klinik Penyakit Dalam RSUP Dr. Sardjito adalah 88,24% dengan rata-rata jarak CAL adalah 4,6 mm. Kesimpulan penelitian ini adalah prevalensi periodontitis pada pasien DM tinggi walaupun status kebersihan mulut tergolong dalam kriteria baik.

Terapi Kombinasi Root Debridement dan Antibiotik terhadap Periodontitis Agresif Dahlia Herawati
Majalah Kedokteran Gigi Indonesia Vol 18, No 2 (2011): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Latar Belakang. Kerusakan periodontal yang signifikan secara klinis selama dewasa atau awal masa dewasa dikenal sebagai periodontitis agresif. Perawatan standar scaling dan root planing sering kurang memuaskan hasilnya sehingga perlu mempelajari periodontitis agresif secara tuntas dan terapi yang harus diberikan sehingga perawatan bisa memberikan hasil yang optimal. Tujuan. Untuk mengupas tentang periodontitis agresif agar bisa menegakkan diagnosis, serta mendapatkan hasil yang optimal dalam perawatannya. Ringkasan Pembahasan. Gigi goyah disebabkan oleh sedikit atau rapuhnya tulang alveoler pendukung gigi sehingga gigi tidak bisa menjalankan fungsinya. Periodontitis agresif menyerang seseorang, diketahui oleh dokter gigi sering tidak dari awal, akan tetapi setelah penyakit tersebut berlanjut. Skrening melalui foto Rontgen pada penderita periodontitis usia awal dewasa berguna untuk mengetahui secara dini periodontitis agresif. Pada perawatan regeneratif dengan mengganti tulang alveoler yang hilang, terlebih dahulu menghentikan aktivitas periodontitis agresif, yaitu dengan memberikan antibiotik dikombinasi dengan root debridement baik secara bedah maupun non bedah. Kesimpulan. 1. Mengenali dan merawat periodontitis agresif secara dini dapat mencegah kerusakan jaringan periodontal yang berat. 2. Perawatan periodontitis agresif terutama mengeliminir bakteri dengan kombinasi tindakan mekanis root debridement dan pemberian antibiotik yang tepat dalam jagka waktu yang cukup secara konsisten. 3. Pemberian antibiotik sebaiknya berdasarkan tes laboratorium bakteri resiten. Background. Periodontal destruction is clinically significant during adulthood or early adulthood is known as aggressive periodontitis. Nursing standard scaling and root planing is often less satisfactory result, so need to study of periodontits aggressive thoroughly and therapy should be given so that treatments can provide result that optimal. The Purpose. To investigated the aggresive periodontitis in order to establish the diagnosis, and obtain optimal results in treatment. Summary of Discussion. Wobbly tooth caused by a slightly or bone fragility alveoler supporting the teeth so the teeth can not perform its function. Aggressive periodontitis someone attack, is is known by dentist often not from the beginning, but after the disease continues. Screening through X-ray in periodontitis someone attack, it is known by dentists often not from the beginning, but after the disease continues. Screening through X-ray in periodontitis patients with adult early age is useful to know early aggresive periodontitis. In the regenerative treatment by replacing the lost bone alveoler, first stop the activities of aggresive periodontitis, namely by giving antibiotics combination with root debridement either surgery or non surgical. Conclusion. 1. Recognizing and treating aggressive periodontitis early can prevent severe damage to periodontal tissues. 2. Treatment of aggressive periodontitis, especially action to eliminate the bacteria with a combination of mechanical root debridement and giving appropriate antibiotics within a sufficient period of time is concictently. 3. The given antibiotics should be based on laboratory tests of resistant bacteria.

Hubungan Dokter Pasien sesuai Harapan Konsil Kedokteran Indonesia Tinjauan pada Profesi Dokter Andy Yok Siswosaputro; Dahlia Herawati
Majalah Kedokteran Gigi Indonesia Vol 19, No 2 (2012): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Latar Belakang. Pelayanan medis oleh dokter mupun dokter gigiberpedoman pada Undang-Undang dan etika yang pada hakekatnya untuk melindungi masyarakat. Konsil Kedokteran Indonesia (KKI) bertugas menjaga kualitas pelayanan medis sebagai upaya perlindungan kepada masyarakat penggunya, dalam pelaksanaan Undang-Undang no 29 tahun 2004 tentang Praktek Kedokteran. Fungsi pengawasan KKI meliputi pembinaan terhadap penyelenggaraan praktek kedokteran, terutama dalam rangka mempertahankan profesionalisme dan peningkatan mutu pelayanan medis. Selain itu KKI juga mensosialisasikan hal-hal yang berhubungan dengan dokter dan pelayanan kesehatan pada masyarakat luas. Tujuan penulisan ini adalah agar dokter-dokter gigi dapat memahami dan melaksanakan tindakan kedokteran sesuai harapan KKI dalam rangka membina hubungan dokter dengan pasie. Tinjauan Pustaka. Hubungan yang baik antara dokter dan pasien akan berjalan baik jika dokter memahami pada 1. Esensi hubungan dokter-pasien; 2. Aspek hukum hubungan dokter-pasien; 3. Kesetaraan dalam hubungan dokter-pasien; 4. Persetujuan tindakan kedokteran. Kesimpulan. Dokter dituntut bersikap bijaksana, memperlakukan pasien penuh tanggung jawab secara etika maupun keilmuan. Background. Medical services by a physician or dentist referring to the Law and ethics in truth to protect society. Konsil Kedokteran Indonesia (KKI) working preserve the quality of medical services in an attempt to cover user communities, in the implementation of Law No 29 of 2004 on the Practice of Medicine. KKI oversight functions include the construction of maintenance medical practice, especially in order to maintain proessionalism and improving the quality of medical services. Additionally KKI also socialize matters relating to doctors and health services in the community. The purpose of this paper is that doctors/dentists can understand and implement the medical actions appropiate expectations KKI in order to foster the relationship between doctor and patient. Review of Literature. Good relationship between doctor and patient will work well if the doctor understands the 1. Essence of the doctor-patient relationship; 2. Legal aspects of the doctor-patient relationship; 3. Equality in the doctor-patient relationship; 4. Medical consent. Conclusion. Physicians are required to be wise, treat patients with ethically responsible and science.

Ekspresi Gen CYP19 Aromatase, Estrogen, Androgen pada penderita Periodontitis Agresif Dahlia Herawati; Sri Kadarsih; Wayan T Artama; S. Suryono
Majalah Kedokteran Gigi Indonesia Vol 17, No 1 (2010): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar, dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang. Tujuan penelitian ini adalah menunjukkan ekspresi gen CYP19 aromatase, estrogen, androgen pada penderita periodontitis agresif agar dapat untuk menjadi pertimbangan pada saat melakukan perawatan periodontal. Metode penelitian, pemeriksaan ekspresi gen aromatse CYP19 berasal dari spesimen tulang alveolar menggunakan imunohistokimia, pengukuran hormon estrogen dan androgen dari serum menggunakan Vidas: Elfa. Hasil penelitian ekspresi gene CYP19 aromatase pada periodontitis agresif menunjukkan gambaran lebih rendah densitasnya dibandingkan pada nonperiodontitis. Estrogen dan androgen pad aperiodontitis agresif ada kecenderungan lebih rendah dibandingkan pada nonperiodontitis. Kesimpulan regenerasi tulang alveoler pad a periodontitis agresif terhambat karena sedikitnya gen CYP19 aromatase dan hormon estrogen dan androgen yang berperan pada pembentukan tulang alveoler kurang memadai.

Ekspresi Gen CYP19 dalam Kultur Sel Osteoblas dari Periodontitis Tulang Alveolar Agresif Distimulasi dengan Vitamin D dan atau Deksametason Dahlia Herawati; Sri Kadarsih Soejono; Wayan T Artama; S. Suryono
Majalah Kedokteran Gigi Indonesia Vol 18, No 1 (2011): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Latar Belakang. Estrogen mengatur homeostasis tulang dan disekresikan oleh gonad dan ekstragonad. Selain itu,androgen diubah menjadiestrogen oleh enzim aromatase P450 yang dihasilkan oleh sitokrom P450 aromatase. Ini diproduksi oleh gen sitokrom CYP19. Vitamin D berperan dalam mengatur homeostasis kalsium dan ekspresi gen aromatase langsung. Deksametason bertindak sebagai anti inflamasi, menghentikan peradangan dan meningkatkan kecepatan penyem6uhan. Kerusakan parah tulang alveolar di periodontitis agresif dapat terjadi di usia muda. Tujuan dari penelitian ini adalah untuk menguji ekspresi gen CYP19daiam kultur sel osteoblas periodontitis agresif tulang alveolar pasien dengan stimulasi vitamin D dan atau deksametason. Metode. Fragmen tulang alveolar dari pasien periodontitis agresif dikultur dalam dimodifikasi F-12 medium dilengkapi dengan serum janin sapi (FBS) 20%, antibiotik (penisilin streptomisin) 5%, dan fungizone 2%. Sel-sel osteoblas yang tumbuh dalam kultur dibagi menjadi 4 kelompok. Kelompok 1: kultur diperlakukan non, kelompok 2: diperlakukan dengan vitamin D 10-6 moVL,kelompok 3: diperlakukan dengan deksametason 10.7mol/L, dan kelompok 4: diperlakukan dengan kombinasi vitamin D den deksametason pada dosis yang sarna. Setelah 24 jam perlakuan dihentikan, semua kelompok kultur yang diamati dengan teknik imunositokimia dan menghitung persentase CYP19 ekspresi gen dan sel oeteoblas dalam kultur. Hasilnya menunjukkan bahwa persentase rata-rata CYP19 ekspresi gen untuk kelompok 1, 2, 3, dan 4 adalah 44.18, 38.66,35.26 dan 31.13%, masing-masing, dan perbedaan yang signifikan antara perlakuan dengan p<0.05. Disimpulkan bahwa perlakuan terbaik untuk meningkatkan jumlah sel osteoblas, adalh kombinasi vitamin D dan deksametason, walaupun persentase ekspresi gen CYP19 adalah nilai terendah di antara kelompok.

Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment Christopher Imantaka Suwondo; Dahlia Herawati; Sudibyo Sudibyo
Majalah Kedokteran Gigi Indonesia Vol 4, No 3 (2018): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

One of the regenerative periodontal treatments for infrabony pocket is open flap debridement (OFD) with the addition of growth factor derived from platelet concentrate. Advanced platelet-rich fibrin (A-PRF) is a further development of plateletrich fibrin (PRF) with a lower centrifugation speed (1,500 rpm, 14 minutes). The purpose of this study was to examine the differences in periodontal tissue regeneration after the application of A-PRF and PRF in the treatment of infrabony pockets evaluated from probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The samples were taken from 20 infrabony pockets divided into 2 groups: 10 subjects were treated with OFD+A-PRF and OFD+PRF on the remaining subjects. Probing depth (PD) and relative attachment loss (RAL) measurement were performed on days 0, 30, and 90. Bone height measurements were performed using CBCT X-rays on days 0 and 90. The results showed that PD and RAL reduction in the group of OFD+A-PRF was significantly greater than that in the OFD+PRF group. Bone height reduction in both groups showed no difference. The conclusion obtained from this study is A-PRF application enhances periodontal tissue regeneration by generating greater probing depth and relative attachment loss reduction compared toPRF, as well as an increase in bone height similar to in the treatment of infrabony pockets.

Effect of freeze-drying process of collagen-activated platelet-rich plasma on transforming growth factor-β1 level Kwartarini Murdiastuti; Fitri Yuniawati; Dahlia Herawati; Nunuk Purwanti; Dyah Ayu Mira Oktarina
Majalah Kedokteran Gigi Indonesia Vol 5, No 2 (2019): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.40197

Periodontal tissue damage requires regenerative material to repair the damage. Platelet-rich plasma (PRP) is known as a regenerative material from blood which contains high level of growth factor that plays a role in wound healing and tissue remodeling. However PRP has a weakness, i.e. it is too watery so it is easily dissolved in the oral cavity, and should be used immediately after preparation. Therefore PRP storage method is needed to increase the benefits of PRP. The addition of collagen to PRP serves as a scaffold as well as an activator that stimulates the release of growth factors. One method of storing PRP is by freeze-drying process. The purpose of this study was to analyze the effect of freeze-drying process of collagen-activated PRP (PRP+C) on transforming growth factor-β1 (TGF-β1) levels. Transforming growth factor-β1 is a cytokine content in PRP, that plays a role in bone remodeling and is an important stimulator for osteoblast formation, causing chemotaxis, osteoblast proliferation and differentiation. In this study, PRP was produced from peripheral blood probandus. Platelet-rich plasma was then activated with collagen (PRP+C), and divided into two groups: freeze-dried PRP collagen (FD PRP+C); and non freeze-dried PRP+collagen (PRP+C). Transforming growth factor-β1 levels were measured using the ELISA method, followed by independent t-test. The TGF-B1 level of FD PRP+C group was significantly higher than PRP+C group (p<0.05). From this study it can be concluded that freeze-dried collagen-activated PRP has an effect to increase TGF-β1 level.

Evaluation of Antibacterial Potential of Carbonated Hydroxyapatite Combined with Propolis on Porphyromonas gingivalis Nungky Devitaningtyas; Ahmad Syaify; Dahlia Herawati; Suryono Suryono
Majalah Obat Tradisional Vol 25, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.55173

Carbonated hydroxyapatite is ideal as a bone graft material because it has similar organic matters to the bone, excellent osteoconductive properties, and good biodegradation in the body. Hydroxyapatite contains the risk of being contaminated by bacteria called Porphyromonas gingivalis (P. gingivalis) in the oral cavity because it has no vascularization, therefore, facilitating adhesion of bacteria, and when applied in the oral cavity, it may cause an infection that then inhibits healing. Thus, it is necessary to use a material that has an antibacterial effect with low potential of causing resistance to treat the postsurgical infection properly. Propolis has antibacterial, antiviral, antifungal, antitumor, and immunomodulatory activities. Propolis contains a large number of flavonoids and phenols. The phenol compound in propolis is usually called caffeic acid phenethyl ester (CAPE), and it has a good antibacterial property. The study aims to evaluate the antibacterial effect of carbonated hydroxyapatite when immersed with different propolis concentrations of 2.5%, 5%, 7.5%, and 10% for 24 h and to measure the zone of inhibition against P. gingivalis. The Kruskal–Wallis test resulted in p = 0.00 (p < 0.05), indicating that there were significant differences among the test groups. The data processing was followed by Mann–Whitney U-test, and the results showed a significant difference in the group of carbonated hydroxyapatite-10 % propolis compared with the other groups. Inhibition zone of carbonated hydroxyapatite that immersed with propolis 10% showed the largest mean of diameters zone of inhibition.

Effect of Ozonated Olive Oil in Topical Application towards Osteoblast Number and Angiogenesis of Alveolar Bone in Periodontitis Healing Process (in vivo study in Sprague dawley Rats) Dahlia Herawati; Deassy Anggraeni; Ariska Ratih Damayanti
Majalah Obat Tradisional Vol 25, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.55176

Ozonated olive oil has been widely used as a local infection therapy to overcome bacterial resistance from antibiotics with systemic administration. However, the disadvantage of systemic antibiotics is it cannot be used in large doses for local infection therapy. Periodontitis is an infectious disease that causes alveolar bone damage. In the periodontitis healing process, osteoblasts and angiogenesis play essential roles in bone regeneration. The study aims to determine the effect of topical application ozonated olive oil to osteoblasts number and angiogenesis of alveolar bone in periodontitis healing process using in vivo study. 32 Sprague Dawley rats were divided into two groups: the treatment and placebo groups, 16 rats in each group. The induction of periodontitis was performed by ligating lower incisor with silk ligature for seven days. The treatment group received ozonated olive oil, and the placebo group received 1 % of CMC-Na twice a day. Four rats from each group were necropsied on day 3, 5, 7, and 14 and then processed into histological sample preparations by hematoxylin-eosin staining and counted the number of osteoblast and blood vessels. All collected data were analyzed using two-way ANOVA and posthoc LSD test. The average number of osteoblasts, blood vessels in the treatment group were significantly higher than the placebo group (p <0.05) either on day 3, 5, 7, and 14. Results showed the ozonated olive oil increase the regeneration of alveolar bone in the periodontitis healing process in Sprague Dawley. Therefore ozonated olive oil has the effect of periodontal tissue regeneration.

Application of Ozonated Olive Oil as Adjunctive Therapy after Periodontal Pocket Curettage towards Collagen Density of Alveolar Bone in Periodontitis Healing Process (In Vivo Study with Sprague dawley) Dahlia Herawati; Etty Cahya Pertiwi
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.65984

Periodontitis is an inflammatory disease of the supporting tissue of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with periodontal pocket formation. Application of ozonated olive oil in dentistry is based on the actions such as antimicrobial and therapeutic agent, needed as adjunctive therapy after periodontal pocket curretage. Collagen is the main constituent of alveolar bone extracellular matrix and needed as a scaffold in the formation of mineralized matrix. The aim of this study was to determine the density of collagen in alveolar bone on periodontitis healing process after adjunctive topical application of ozonated olive oil in periodontal pocket curretage. In this study, 32 Sprague dawley rats were randomly divided into two groups: curetted-topical application of ozonated olive oil as treatment groups and curetted-topical application of 1% CMC-Na as placebo group. Periodontitis induced by placing silk-ligature around submandibular incisors for 7 days. Subsequently, the rats were sacrificed on days 3, 5, 7, and 14 after curetted and topical application, and each group was represented by four rats. The staining was done using Mallory staining method. All the results were statistically analyzed using Kruskal-Wallis and Mann-Whitney tests. The results showed that there were significant differences (p<0,05) in the density of collagen between two groups. The study concluded that adjunctive topical application of ozonated olive oil after periodontal pocket curretage significantly increase the density of collagen in alveolar bone on periodontitis healing process in Spraque dawley.

Co-Authors Ahmad Syaify Ahmad Syaify, Ahmad Andy Yok Siswosaputro Ariska Ratih Damayanti Christopher Imantaka Suwondo Deassy Anggraeni Dedi Sumantri Etty Cahya Pertiwi Fitri Yuniawati Kwartarini Murdiastuti Nungky Devitaningtyas Nungky Devitaningtyas Nunuk Purwanti Nur Rahman Ahmad Seno Aji Nur RAS. Aji Oktarina, Dyah Ayu Mira Pramudita Kusuma Wardani Rezmelia Sari Rizka Dindarini Rizky Nurcahyanti Shinta Ferronika Siti Sunarintyas Sri Kadarsih Sri Kadarsih Soejono Sri Pramestri Lastianny, Sri Pramestri Sudibyo Sudibyo Suryono Suryono Tissa Rahadianti Tissa Rahadianti Wayan T Artama Wayan T Artama Wildan, Muhammad Nabeel

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