Risti Saptarini
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HUBUNGAN POLIMORFISME GEN RESEPTOR ESTROGEN ALFA DENGAN JUMLAH SEL T CD4+ PADA ANAK TERINFEKSI HIV Irna Sufiawati; Risti Saptarini; Eriska Riyanti
ODONTO : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.4.2.94-100

Abstract

Background: Estrogen plays a key role in human physiological processes. Polymorphisms of estrogen receptors have been implicated in the development of numerous diseases. The aim of this study was to evaluate the frequency of ERα gene Pvull and Xbal polymorphisms and assessing their association with CD4+ T-cell counts in HIV-infected children on highly active antiretroviral therapy.Methods: CD4+ T cell counts were determined using the FACS count system. ERα PvuII and XbaI polymorphisms were analyzed by PCR-RFLP.Results: This study enrolled 34 HIV-infected children on HAART. The frequencies of the PvuII and XbaI gene polymorphisms were PP 41,2%, Pp 26,5%, pp 32,4% and XX 35,3%, Xx 17,6%, xx 47,1% respectively. CD4+ T-cell counts were significantly associated with XbaI polymorphisms (p<0.05), but not PvuII polymorphisms (p>0.01).Discussion: Host genetic factor polymorphism is an important determinant of HIV  disease progression and treatment response. The ERα Pvull and Xbal polymorphisms can increase risk for the development of HIV-related complication,including oral diseases.Conclusion: The ERα gene XbaI polymorphism was significantly associated with CD4+ T-cell counts. It may explain the role of estrogen in the regulation of HIV replication. Studying human genetic variation in HIV-infected individuals is important to guide a new therapeutic approach.
GEOGRAPHIC TONGUE PREVALENCE AND NUTRITIONAL STATUS AMONG FIRST GRADE SCHOOL CHILDREN AT TANJUNGSARI SUBDISTRICT OF SUMEDANG Nita Septiani; Indah Suasani Wahyuni; Risti Saptarini; Nanan Nur’aeny
Dentino : Jurnal Kedokteran Gigi Vol 4, No 2 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i2.7053

Abstract

Background: Geographic tongue (GT) is a state of the tongue surface which is characterized by an atrophic filiform papillary, a rising in surrounding borderline with yellowish white appearance, and presentations in varying locations and shapes. One of the predicting factors of GT is nutritional deficiency. Objective: to determine the prevalence of GT and nutritional status among first grade school children at Tanjungsari Subdistrict of Sumedang. Methods: It was a descriptive research with the implementation of survey method. The sampling was obtained according to inclusion criteria. The research locations comprised of three elementary school representatives in Tanjungsari sub-district, Sumedang. Nutritional status was assessed using Food Frequency Questionaire (FFQ) Results: There were 200 children with a prevalence of geographic tongue in a total of 4.5%. Nutritional status obtained a result of 11.11% student included in the above-normal criteria, 22.22% students included in normal criteria, 11.11% student included in low deficiency criteria, 33.33% students included in moderate deficiency criteria, and 22.22% students included in  high deficiency criteria. Conclusion: The prevalence of geographic tongue among first grade school children at Tanjungsari District of Sumedang is 4.5% with the highest nutritional status in moderate deficiency category.Background: Geographic tongue (GT) is a state of the tongue surface which is characterized by an atrophic filiform papillary, a rising in surrounding borderline with yellowish white appearance, and presentations in varying locations and shapes. One of the predicting factors ofGT is nutritional deficiency. Objective: to determine the prevalence of GT and nutritional status among first grade school childrenat Tanjungsari Subdistrict of Sumedang.Methods:It was a descriptive research with the implementation of survey method. The sampling was obtained according to inclusion criteria.The research locations comprised of three elementary school representatives in Tanjungsari sub-district, Sumedang. Nutritional status was assessedusing Food Frequency Questionaire (FFQ)Results: There were 200 children with a prevalence of geographic tongue in a total of 4.5%. Nutritional status obtained a result of 11.11% student included in the above-normal criteria, 22.22% studentsincluded in normal criteria, 11.11% student included in low deficiency criteria, 33.33% students includedin moderate deficiency criteria, and 22.22% students included in  high deficiency criteria. Conclusion: The prevalence of geographic tongue among first grade school children at Tanjungsari District of Sumedang is 4.5% with the highest nutritional status in moderate deficiency category. Keyword:Children, elementary school, first grade, geographic tongue; nutritional status
HUBUNGAN POLIMORFISME GEN RESEPTOR ESTROGEN ALFA DENGAN JUMLAH SEL T CD4+ PADA ANAK TERINFEKSI HIV Irna Sufiawati; Risti Saptarini; Eriska Riyanti
Odonto : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.934 KB) | DOI: 10.30659/odj.4.2.94-100

Abstract

Background: Estrogen plays a key role in human physiological processes. Polymorphisms of estrogen receptors have been implicated in the development of numerous diseases. The aim of this study was to evaluate the frequency of ERα gene Pvull and Xbal polymorphisms and assessing their association with CD4+ T-cell counts in HIV-infected children on highly active antiretroviral therapy.Methods: CD4+ T cell counts were determined using the FACS count system. ERα PvuII and XbaI polymorphisms were analyzed by PCR-RFLP.Results: This study enrolled 34 HIV-infected children on HAART. The frequencies of the PvuII and XbaI gene polymorphisms were PP 41,2%, Pp 26,5%, pp 32,4% and XX 35,3%, Xx 17,6%, xx 47,1% respectively. CD4+ T-cell counts were significantly associated with XbaI polymorphisms (p<0.05), but not PvuII polymorphisms (p>0.01).Discussion: Host genetic factor polymorphism is an important determinant of HIV  disease progression and treatment response. The ERα Pvull and Xbal polymorphisms can increase risk for the development of HIV-related complication,including oral diseases.Conclusion: The ERα gene XbaI polymorphism was significantly associated with CD4+ T-cell counts. It may explain the role of estrogen in the regulation of HIV replication. Studying human genetic variation in HIV-infected individuals is important to guide a new therapeutic approach.