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All Journal Oto Rhino Laryngologica Indonesiana MASALIQ: Jurnal Pendidikan dan Sains
Nina Irawati
Poltekkes Bandung
Religion Education Health Professions Medicine & Pharmacology Social Sciences

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Perubahan kualitas hidup, eosinofil mukosa hidung, dan interleukin-5 serum pasien rinitis alergi pasca terapi Pitarini, Arinda Putri; Irawati, Nina; Poerbonegoro, Niken Lestari; Wulandari, Dewi; Badarsono, Saptawati
Oto Rhino Laryngologica Indonesiana Vol. 45 No. 2 (2015): Volume 45, No. 2 July - December 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v45i2.116

Abstract

 Latar belakang: Rinitis alergi adalah suatu penyakit inflamasi pada hidung yang dimediasi oleh imunoglobulin-E, yang terjadi setelah mukosa hidung terpajan alergen. Sel dan mediator inflamasi yang berperan penting adalah eosinofil, histamin, dan sitokin produk Th2. Penyakit ini ditandai dengan gejala rinorea, bersin berulang, hidung tersumbat dan/atau hidung gatal. Selain dari gejala yang mengganggu, rinitis alergi berdampak buruk terhadap kualitas hidup penderita. Tatalaksana komprehensif, meliputi penghindaran alergen, farmakoterapi, imunoterapi dan edukasi, ditujukan untuk menghilangkan gejala dan memperbaiki kualitas hidup pasien. Tujuan: Mengetahui perubahan kualitas hidup, jumlah eosinofil mukosa hidung, dan kadar IL-5 serum pada pasien rinitis alergi setelah mendapat terapi farmaka sesuai panduan. Metode: Penelitian ini merupakan studi pre-eksperimental analitik dengan pengambilan data sebelum dan sesudah pemberian farmakoterapi. Hasil: Sebanyak 31 dari 33 subjek mengalami perubahan kualitas hidup yang bermakna (MID>0,7). Seluruh pasien, 33 subjek memperlihatkan perubahan yang responsif dari jumlah eosinofil mukosa hidung. Sebanyak 30 subjek dinyatakan responsif dan terdapat penurunan kadar IL-5. Tidak ada hubungan yang bermakna antara perubahan kualitas hidup dan kadar IL-5. Kesimpulan: Perubahan kualitas hidup, jumlah eosinofil mukosa hidung, dan kadar IL-5 serum dapat digunakan sebagai penanda objektif keberhasilan terapi rinitis alergi yang dapat dipakai dalam praktik klinis sehari-hari maupun kepentingan riset. Kata kunci: rinitis alergi, kualitas hidup, eosinofil, interleukin-5ABSTRACT Background: Allergic rhinitis defined as an inflammatory disease of the nose mediated by immunoglobulin-E, induced after nasal mucosa exposure to allergen. Important inflammatory cells and mediators are eosinophils, histamine, and Th2-related cytokines. Symptoms include rhinorrhea, repeated sneezing, nasal congestion and/or nasal itching. Aside from its bothersome symptoms, allergic rhinitis decreases patient’s quality of life (QOL). Comprehensive management consist of allergen avoidance, medication, immunotherapy, and education, aimed to diminish symptoms and improve the patient’s quality of life. Purpose: To evaluate changes in quality of life, nasal mucosal eosinophil count, and level of interleukin-5 in allergic rhinitis after medicamentous treatment. Methods: This was an analytic pre-experimental study with data taken before and after medicamentous treatment. Results: Thirty-one of 33 subjects showed significant changes of QOL (MID>0,7). All samples, 33 subjects, experienced responsive changes in nasal mucosal eosinophil count. Thirty subjects were responsive, which showed decrease of IL-5 level. There was no significant relation between changes of QOL and changes of IL-5 level. Conclusion: Changes in quality of life, nasal mucosal eosinophil count, and IL-5 level are objective markers of treatment efficacy in Allergic Rhinitis, which can be used in clinical practices and researches. Keywords: allergic rhinitis, quality of life, eosinophil, interleukin-5, intranasal steroid, antihistamine
Comprehensive therapy in united airway disease: Evidence Based Case Report Irawati, Nina; Vania, Elizabeth; Poerbonegoro, Niken Lestari; Anatriera, Raden Ayu
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.548

Abstract

ABSTRACTBackground: The concept of the united airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experience more asthma-related primary and secondary care visits. Purpose: To determine the best treatment option in the case of patients with asthma related allergic rhinitis, both in the control of nasal and pulmonary symptoms. Case report: A case case of 45 years old woman with asthma related to allergic rhinitis treated with combination of intranasal steroid and asthma therapy. Clinical question: In adult patient with allergic rhinitis related to asthma, does the combination of intranasal and inhaled steroids give better clinical improvement subjectively and objectively compared to monotherapy? Method: Literature search through two different databases (PubMed and Cochrane Library) and by searching the bibliography of articles to evaluate the outcome of combination therapy and monotherapy for the disease. Result: Two articles were found relevant with the topic fulfilled the requirements and relevant with the formulation or clinical question. Conclusion: Treating the inflammation associated with allergic rhinitis may have a true impact on the control of asthma, while the failure to treat rhinitis may impair asthma control.ABSTRAKLatar belakang: Konsep United Airway Disease (UAD) mengenali adanya hubungan antara inflamasi alergi pada saluran napas atas dan bawah. Pasien asma yang bersamaan dengan rinitis alergi melakukan lebih banyak kunjungan ke perawatan primer dan sekunder terkait asma. Tujuan: Menentukan pilihan pengobatan terbaik pada pasien dengan rinitis alergi terkait asma, baik dalam pengendalian keluhan hidung maupun paru. Laporan kasus: Satu kasus seorang wanita berusia 45 tahun dengan asma yang berhubungan dengan rinitis alergi. Metode: Mengumpulkan jurnal terkait dari dua database yang berbeda (PubMed dan Cochrane Library). Pencarian artikel juga dilakukan dengan mencari pada daftar pustaka artikel untuk mengevaluasi luaran dari terapi kombinasi dan terapi tunggal untuk penyakit ini. Pertanyaan klinis: Apakah terapi kombinasi dengan steroid intranasal dan steroid hirup dapat memberikan perbaikan lebih signifikan secara subjektif maupun objektif dibandingkan dengan terapi tunggal pada pasien dewasa dengan rinitis alergi dan asma? Hasil: Didapatkan dua artikel yang relevan dengan topik, sesuai dengan pertanyaan klinis serta memiliki penilaian kritis yang baik. Kesimpulan: Mengobati peradangan yang terkait dengan rinitis alergi dapat berdampak nyata pada pengendalian asma, sedangkan kegagalan untuk mengobati rinitis dapat mengganggu pengendalian asma.
Efektivitas Video Berbasis Literasi Sains terhadap Hasil Belajar Mahasiswa Agustina, Degi Alrinda; Bua, Agustinus Toding; Noviantari, Ika; Irawati, Nina
MASALIQ Vol 5 No 1 (2025): JANUARI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i1.4678

Abstract

This research aims to determine the effectiveness of scientific literacy-based videos on student learning outcomes. The scientific literacy-based videos have been validated by material experts, media experts, and language experts. The application of scientific literacy-based learning videos is carried out using blended learning, which integrates learning that combines various physical and virtual sources. The research used a pre-experimental, one-group pre-test-post-test design, namely by giving pre-tests and post-tests to students. Data analysis was carried out by determining N-Gain. The research was carried out using the Google Classroom platform. The results of the research show that the N-gain score is 81.6400, so the use of scientific literacy-based learning videos is effective on student learning outcomes. t-tests to students. Data analysis was carried out by determining N-Gain. The results showed that the N-Gain score was 0.8343 on high criteria and 83.43% on effective criteria., so the use of scientific literacy-based learning videos is effective on student learning outcomes.
Autonomic dysfunction in allergic rhinitis assessed by heart rate variability Irawati, Nina; Poerbonegoro, Niken Lestari; Azzahroh, Faiza; Hanrahan, Joanna Erin
Oto Rhino Laryngologica Indonesiana Vol. 55 No. 2 (2025): VOLUME 55, NO. 2 JULY - DECEMBER 2025
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v55i2.745

Abstract

Background: Allergic rhinitis is a chronic inflammatory condition of the nose mediated by IgE, characterized by symptoms such as nasal congestion, rhinorrhea, repeated sneezing, and nasal itching. Autonomic nervous system dysfunction is a significant factor in the pathophysiology of allergic rhinitis. Purpose: To evaluate autonomic nervous system dysfunction in allergic rhinitis patients using heart rate variability. Case report: A 28-year-old woman with allergic rhinitis who underwent heart rate variability testing, revealed increased parasympathetic nervous system activity. Method: The study involved a literature search through PubMed, EBSCO, Scopus, and ScienceDirect, with screening based on inclusion and exclusion criteria. The selected literatures were critically reviewed using the Oxford Centre for Evidence-based Medicine’s criteria for Etiology Studies. Result: Two cross-sectional studies were identified that matched the case report’s PICO and eligibility criteria. Those studies showed patterns of autonomic nervous system dysfunction, marked by increased parasympathetic and decreased sympathetic activity in allergic rhinitis patients. Conclusion: The findings suggested that autonomic nervous system dysfunction played a role in the pathophysiology of allergic rhinitis, as evidenced by changes in heart rate variability.
Co-Authors Anatriera, Raden Ayu Arini Setiawati Azzahroh, Faiza Badarsono, Saptawati Bua, Agustinus Toding Degi Alrinda Agustina Dewi Wulandari Elise Kasakeyan Hanrahan, Joanna Erin Iwan Darmansjah Iwin Sumarman Mulyarjo Mulyarjo Noviantari, Ika Nur A. Aroeman Pitarini, Arinda Putri Poerbonegoro, Niken Lestari Roestiniadi D. Soemantri Solly Aryza Tety H. Rahim Vania, Elizabeth