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All Journal Oto Rhino Laryngologica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia MASALIQ: Jurnal Pendidikan dan Sains
Nina Irawati
Poltekkes Bandung
Religion Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Perubahan kualitas hidup, eosinofil mukosa hidung, dan interleukin-5 serum pasien rinitis alergi pasca terapi Pitarini, Arinda Putri; Irawati, Nina; Poerbonegoro, Niken Lestari; Wulandari, Dewi; Badarsono, Saptawati
Oto Rhino Laryngologica Indonesiana Vol. 45 No. 2 (2015): Volume 45, No. 2 July - December 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v45i2.116

Abstract

 Latar belakang: Rinitis alergi adalah suatu penyakit inflamasi pada hidung yang dimediasi oleh imunoglobulin-E, yang terjadi setelah mukosa hidung terpajan alergen. Sel dan mediator inflamasi yang berperan penting adalah eosinofil, histamin, dan sitokin produk Th2. Penyakit ini ditandai dengan gejala rinorea, bersin berulang, hidung tersumbat dan/atau hidung gatal. Selain dari gejala yang mengganggu, rinitis alergi berdampak buruk terhadap kualitas hidup penderita. Tatalaksana komprehensif, meliputi penghindaran alergen, farmakoterapi, imunoterapi dan edukasi, ditujukan untuk menghilangkan gejala dan memperbaiki kualitas hidup pasien. Tujuan: Mengetahui perubahan kualitas hidup, jumlah eosinofil mukosa hidung, dan kadar IL-5 serum pada pasien rinitis alergi setelah mendapat terapi farmaka sesuai panduan. Metode: Penelitian ini merupakan studi pre-eksperimental analitik dengan pengambilan data sebelum dan sesudah pemberian farmakoterapi. Hasil: Sebanyak 31 dari 33 subjek mengalami perubahan kualitas hidup yang bermakna (MID>0,7). Seluruh pasien, 33 subjek memperlihatkan perubahan yang responsif dari jumlah eosinofil mukosa hidung. Sebanyak 30 subjek dinyatakan responsif dan terdapat penurunan kadar IL-5. Tidak ada hubungan yang bermakna antara perubahan kualitas hidup dan kadar IL-5. Kesimpulan: Perubahan kualitas hidup, jumlah eosinofil mukosa hidung, dan kadar IL-5 serum dapat digunakan sebagai penanda objektif keberhasilan terapi rinitis alergi yang dapat dipakai dalam praktik klinis sehari-hari maupun kepentingan riset. Kata kunci: rinitis alergi, kualitas hidup, eosinofil, interleukin-5ABSTRACT Background: Allergic rhinitis defined as an inflammatory disease of the nose mediated by immunoglobulin-E, induced after nasal mucosa exposure to allergen. Important inflammatory cells and mediators are eosinophils, histamine, and Th2-related cytokines. Symptoms include rhinorrhea, repeated sneezing, nasal congestion and/or nasal itching. Aside from its bothersome symptoms, allergic rhinitis decreases patient’s quality of life (QOL). Comprehensive management consist of allergen avoidance, medication, immunotherapy, and education, aimed to diminish symptoms and improve the patient’s quality of life. Purpose: To evaluate changes in quality of life, nasal mucosal eosinophil count, and level of interleukin-5 in allergic rhinitis after medicamentous treatment. Methods: This was an analytic pre-experimental study with data taken before and after medicamentous treatment. Results: Thirty-one of 33 subjects showed significant changes of QOL (MID>0,7). All samples, 33 subjects, experienced responsive changes in nasal mucosal eosinophil count. Thirty subjects were responsive, which showed decrease of IL-5 level. There was no significant relation between changes of QOL and changes of IL-5 level. Conclusion: Changes in quality of life, nasal mucosal eosinophil count, and IL-5 level are objective markers of treatment efficacy in Allergic Rhinitis, which can be used in clinical practices and researches. Keywords: allergic rhinitis, quality of life, eosinophil, interleukin-5, intranasal steroid, antihistamine
Comprehensive therapy in united airway disease: Evidence Based Case Report Irawati, Nina; Vania, Elizabeth; Poerbonegoro, Niken Lestari; Anatriera, Raden Ayu
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.548

Abstract

ABSTRACTBackground: The concept of the united airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experience more asthma-related primary and secondary care visits. Purpose: To determine the best treatment option in the case of patients with asthma related allergic rhinitis, both in the control of nasal and pulmonary symptoms. Case report: A case case of 45 years old woman with asthma related to allergic rhinitis treated with combination of intranasal steroid and asthma therapy. Clinical question: In adult patient with allergic rhinitis related to asthma, does the combination of intranasal and inhaled steroids give better clinical improvement subjectively and objectively compared to monotherapy? Method: Literature search through two different databases (PubMed and Cochrane Library) and by searching the bibliography of articles to evaluate the outcome of combination therapy and monotherapy for the disease. Result: Two articles were found relevant with the topic fulfilled the requirements and relevant with the formulation or clinical question. Conclusion: Treating the inflammation associated with allergic rhinitis may have a true impact on the control of asthma, while the failure to treat rhinitis may impair asthma control.ABSTRAKLatar belakang: Konsep United Airway Disease (UAD) mengenali adanya hubungan antara inflamasi alergi pada saluran napas atas dan bawah. Pasien asma yang bersamaan dengan rinitis alergi melakukan lebih banyak kunjungan ke perawatan primer dan sekunder terkait asma. Tujuan: Menentukan pilihan pengobatan terbaik pada pasien dengan rinitis alergi terkait asma, baik dalam pengendalian keluhan hidung maupun paru. Laporan kasus: Satu kasus seorang wanita berusia 45 tahun dengan asma yang berhubungan dengan rinitis alergi. Metode: Mengumpulkan jurnal terkait dari dua database yang berbeda (PubMed dan Cochrane Library). Pencarian artikel juga dilakukan dengan mencari pada daftar pustaka artikel untuk mengevaluasi luaran dari terapi kombinasi dan terapi tunggal untuk penyakit ini. Pertanyaan klinis: Apakah terapi kombinasi dengan steroid intranasal dan steroid hirup dapat memberikan perbaikan lebih signifikan secara subjektif maupun objektif dibandingkan dengan terapi tunggal pada pasien dewasa dengan rinitis alergi dan asma? Hasil: Didapatkan dua artikel yang relevan dengan topik, sesuai dengan pertanyaan klinis serta memiliki penilaian kritis yang baik. Kesimpulan: Mengobati peradangan yang terkait dengan rinitis alergi dapat berdampak nyata pada pengendalian asma, sedangkan kegagalan untuk mengobati rinitis dapat mengganggu pengendalian asma.
Efektivitas Video Berbasis Literasi Sains terhadap Hasil Belajar Mahasiswa Agustina, Degi Alrinda; Bua, Agustinus Toding; Noviantari, Ika; Irawati, Nina
MASALIQ Vol 5 No 1 (2025): JANUARI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i1.4678

Abstract

This research aims to determine the effectiveness of scientific literacy-based videos on student learning outcomes. The scientific literacy-based videos have been validated by material experts, media experts, and language experts. The application of scientific literacy-based learning videos is carried out using blended learning, which integrates learning that combines various physical and virtual sources. The research used a pre-experimental, one-group pre-test-post-test design, namely by giving pre-tests and post-tests to students. Data analysis was carried out by determining N-Gain. The research was carried out using the Google Classroom platform. The results of the research show that the N-gain score is 81.6400, so the use of scientific literacy-based learning videos is effective on student learning outcomes. t-tests to students. Data analysis was carried out by determining N-Gain. The results showed that the N-Gain score was 0.8343 on high criteria and 83.43% on effective criteria., so the use of scientific literacy-based learning videos is effective on student learning outcomes.
Efektivitas Terapi Penghambat Pompa Proton pada Anak dengan Otitis Media Kronik: Sebuah Laporan Kasus Berbasis Bukti Hanrahan, Joanna Erin; Calista, Nabilla; Ardiantara, Sabda; Restuti, Ratna Dwi; Irawati, Nina; Rachmawati, Elvie Zulka Kautzia
Majalah Kedokteran Indonesia Vol 73 No 6 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.6-2024-870

Abstract

Introduction: In Indonesia, 82% of children with otitis media have experienced chronic otitis media (COM). COM has a high recurrency rate and is multifactorial, one of which is caused by acid reflux. Proton pump inhibitor (PPI) therapy has been used to treat acid reflux and gives excellent result. Purpose: Reporting one case of a child with COM and laryngopharyngeal reflux (LPR) who received PPI therapy. An evidence-based literature review was done to evaluate the effectiveness of PPI therapy in patient with COM and LPR.Methods: Literature searching was done through 3 databases. Critical appraisal based on the Oxford Center for Evidence Based Medicine Checklists 2011.Results: After we sorted out duplications and screened articles according to our inclusion and exclusion criteria, we retrieved one article. This article is valid and applicable, yet PPI therapy did not give significant clinical improvement because of some reasons.Conclusion: From the literature review, PPI therapy on patient with COM did not give significant clinical improvement such as to stop middle ear discharge, yet in our case, PPI therapy could produce a clinical improvement and in line with previous experimental studies. Therefore, PPI therapy could still be considered given in children with COM.
Pendekatan "Step Up" pada Manajemen Rinitis Alergi pada Anak Irawati, Nina; Awal, Muhammad Irfan Ata Ul
Majalah Kedokteran Indonesia Vol 74 No 2 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.2-2024-1434

Abstract

Allergic rhinitis (AR) is clinically characterized by two or more symptoms including itching, sneezing, nasal obstruction and rhinorrhoea. It is known to be caused by IgE-mediated hypersensitivity reaction in response to inhaled allergens. It has been shown to have high burden of disease, as patients with AR show significant reductions in the number of healthy days, interruption of daily activities due to symptoms, and overall reduction in quality of life. The International Study of Asthma and Allergies in Childhood (ISAAC) estimates the prevalence of AR across children and adults to be about 10-30% in the United States (US) and other developed countries. Allergic rhinitis negatively impacts quality of life directly through, or from the consequences of, its symptoms such as sleep disturbances, fatigue, impaired learning and cognitive functions, leading to reduction in productivity, worsened school performances and may also lead to embarrassment.
Co-Authors Anatriera, Raden Ayu Ardiantara, Sabda Arini Setiawati Awal, Muhammad Irfan Ata Ul Badarsono, Saptawati Bua, Agustinus Toding Calista, Nabilla Degi Alrinda Agustina Dewi Wulandari Elise Kasakeyan Hanrahan, Joanna Erin Iwan Darmansjah Iwin Sumarman Mulyarjo Mulyarjo Noviantari, Ika Nur A. Aroeman Pitarini, Arinda Putri Rachmawati, Elvie Zulka Kautzia Restuti, Ratna Dwi Roestiniadi D. Soemantri Solly Aryza Tety H. Rahim Vania, Elizabeth