Garuda - Garba Rujukan Digital

Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

Effect of consumption of vegetables and fruit on nitric oxide levels and T-glutathione levels in type 2 diabetes mellitus patients Prita Anggraini Kartika Sari; Endang Darmawan; Akrom Akrom
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Glutathione is an antioxidant that plays a role in preventing free radicals and reducing oxidative stress, including in patients with type 2 diabetes mellitus (DMT2). One of the factors that affect glutathione status is the individual's ability to produce glutathione and in diabetic patients, T-glutathione levels have decreased. This study aims to determine the effect of fruit and vegetable consumption habits on plasma levels of T-Glutathione. This research method is analytic observational with cross sectional findings, the sample used is 85 subjects in the form of archives of biological materials. Data on habits of consuming vegetables and fruits were collected through interviews, plasma T-GSH levels were determined biochemically using the Elabscience GSH Assay Kit and then analyzed using the Mann Whitney test. The results showed that the average plasma T-GSH levels in patients with the habit of consuming vegetables and fruit and those who did not, were 13.54 Â± 3.34 mol/L and 12.73 Â± 1.44 mol/L, respectively, but not found a significant difference relationship (p = 0.222). This study provides information that the habit of consuming vegetables and fruit does not provide a significant difference to plasma T-GSH levels in T2DM patients. But these habits still need to be done for health maintenance. Further research is needed that is more specific to the amount and type of certain vegetables and fruits consumed and how to cook them.

Peningkatan Kesehatan Keluarga Melalui Pemanfaatan dan Penanaman Tanaman Obat Keluarga (TOGA) di Gampeng, Pajangan, Bantul Vella Lailli Damarwati; Muhammad Fariez Kurniawan; Radhwa Fauztina; Zhafira As Syafa; Putri Arditya; Rahmat A. Hi Wahid; Prita Anggraini
Prosiding Seminar Nasional Program Pengabdian Masyarakat 2022: 3. Kesehatan Keluarga dan Masyarakat
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Tanaman obat keluarga (TOGA) adalah jenis tanaman obat pilihan yang dapat ditanam di pekarangan rumah untuk meningkatkan kesehatan keluarga. TOGA dapat dijadikan sebagai alternatif obat tradisional yang mudah dicari, relatif murah, dan memiliki efek samping yang lebih rendah daripada obat-obatan kimia. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan penyuluhan terkait pemanfaatan TOGA untuk pengobatan tradisional dan pelatihan bagaimana mengelola lahan atau pekarangan kosong dengan menanan tanaman TOGA. Metode yang digunakan adalah ceramah untuk penyuluhan kepada masyarakat terkait TOGA serta pelatihan bagaimana teknik penanaman TOGA yang baik dan benar. Guna menilai pemahaman peserta maka peserta diberikan pretest sdan post-test sebelum dan sesudah dilakukan edukasi. Berdasarkan nilai pretest dan post-test diperoleh rata-rata masing-masing adalah 7,4 dan 8,5. Hal ini menunjukkan adanya peningkatan pemahaman peserta sebelum dan sesudah dilakukan edukasi

Kepatuhan Penggunaan Obat Antidiabetes Oral Di Puskesmas Kotagede Ii Yogyakarta Menggunakan Kuesioner Mars-10 Nurul Zahroh Oktafiani; Hamnah Al Atsariyah; Prita Anggraini Kartika Sari; Merry Ramdhani
SNHRP Vol. 5 (2023): Seminar Nasional Hasil Riset dan Pengabdian (SNHRP) Ke 5 Tahun 2023
Publisher : LPPM Universitas PGRI Adi Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Kepatuhan pengobatan, khususnya pada pasien dengan diabetes mellitus (DM) akan mempengaruhi hasil terapi. Ketidakpatuhan dapat menyebabkan kadar glukosa tidak terkontrol dan meningkatkan risiko komplikasi diabetes. Penelitian ini bertujuan untuk mengidentifikasi kepatuhan penggunaan obat pada pasien DM. Metode penelitian ini yaitu observasional deskriptif dengan pengamatan secara prospektif menggunakan teknik purposive sampling sesuai inklusi. Penelitian dilakukan pada bulan Mei 2023 di Puskesmas Kotagede II Yogyakarta menggunakan instrumen MARS-10. Data dianalisis menggunakan Microsoft Excel 2017. Hasil penelitian yang dilakukan pada 11 responden didapatkan bahwa sebagian besar responden berjenis kelamin perempuan (81,82 persen), berusia ≥ 60 tahun (63,67 persen), bekerja sebagai ibu rumah tangga (54,54 persen), terdiagnosis diabetes selama <6 tahun (63,67 persen), serta mengkonsumsi 1 obat antidiabetes oral (54,54 persen). Analisis hasil menunjukkan bahwa tidak ada satupun pasien yang mendapatkan skor 0-3 (tidak patuh), sedangkan 2 pasien mendapatkan skor 4-6 (cukup patuh), dan 9 pasien mendapatkan skor 7-10 (patuh). Kesimpulan penelitian ini yaitu responden yang patuh (81,82 persen) lebih besar daripada responden yang cukup patuh (18,18 persen).

Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

In Silico Evaluation of Black Cumin Oil Constituents for Selective Anti-Inflammatory Inhibitor of COX-2 And 5-LOX Syarifatul Mufidah; Putri Rachma Novitasari; Prita Anggraini Kartika Sari; Hani Badriyah Hidayati
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 02 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i02.4420

Black cumin oil (Nigella sativa) is widely known for its anti-inflammatory properties, attributed to various bioactive compounds. This study aimed to evaluate the binding affinity and selectivity of five major compounds from black cumin oil: dithymoquinone, thymoquinone, thymohydroquinone, p-cymene, and thymol, against key inflammatory enzymes: COX-1, COX-2, and 5-LOX, using an in silico approach. All compounds were assessed for drug-likeness using Lipinski’s Rule of Five before molecular docking with AutoDock Vina. Celecoxib, a selective COX-2 inhibitor, was used as a reference compound. Dithymoquinone demonstrated strong binding affinity to COX-2 (-9.3 kcal/mol) and 5-LOX (-8.4 kcal/mol), comparable to celecoxib (-9.9 and -8.3 kcal/mol, respectively), while showing lower affinity for COX-1 (-7.5 kcal/mol). The interaction analysis revealed hydrogen bonds and van der Waals forces with several active site residues, suggesting a stable and selective interaction. Other compounds showed moderate to high affinity but lacked the same degree of selectivity due to their interaction with COX-1. These findings indicate that dithymoquinone has the potential to act as a selective anti-inflammatory agent with a reduced risk of gastrointestinal side effects commonly associated with non-selective NSAIDs. The results support further investigation of dithymoquinone in preclinical and clinical settings to validate its efficacy and safety.

Interprofessional collaboration competency: perspectives of doctors and other healthcare professionals Wiwik Kusumawati; Elsye Maria Rosa; Ekorini Listiowati; Prita Anggraini Kartika Sari; Arif Riyanto; Rozzali Taufiqurrahman; Muhammad Roihan Naufal; Suryani Suryani
Jurnal Kebidanan dan Keperawatan Aisyiyah Vol. 22 No. 1 (2026): Juni
Publisher : Universitas Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jkk.4232

Healthcare professionals are responsible for providing quality services, but their role is still not optimal, which can lead to medical errors. Therefore, collaborative practice is important for being able to provide effective and efficient services. This study aims to assess and compare interprofessional collaboration competencies among different healthcare professionals at PKU Muhammadiyah Gamping Hospital. This is quantitative research used an analytical observational design with a cross-sectional approach. The Instrument Interprofessional Collaborative Competency Attainment Survey (ICCAS) was distributed to 113 respondents consisting of 26 doctors, 79 nurses, and 8 pharmacists who were selected randomly using cluster sampling. Data were analyzed using multiple linear regression tests and chi-square tests. The results of the research show that the average percentage of interprofessional collaboration competency for healthcare professionals at PKU Muhammadiyah Gamping Hospital is 81.5%, with details of doctors at 77.5%, nurses at 83.0%, and pharmacists at 81.0%. The interprofessional collaboration competency domain with the highest percentage is collaboration, with 83.0%, and the lowest is roles and responsibilities, with 80.0%. Then the results of the Chi-Square statistical test obtained a significance value of 0.002 (p < 0.05). This shows that there are factors that challenge the realization of interprofessional collaboration, namely the perception of an imbalance in hierarchy and power between professions, as well as a lack of understanding of each other's skills and knowledge. Hospitals should implement in-house training and standard operating procedures for interprofessional collaboration, while educational institutions must evaluate and strengthen interprofessional education programs to improve patient safety and care quality.

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search