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Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

Peran Kader Posyandu terhadap Tingkat Kunjungan Masyarakat Hartini Haritani; Puspawan Hariadi; Ewisa Oktresia; Fitriwati Sovia; Baiq Maylinda Gemantari
Jurnal Kesmas Asclepius Vol 4 No 2 (2022): Jurnal Kesmas Asclepius
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/jka.v4i2.4456

This study aims to describe the role of posyandu cadres on the level of visits by the users. The method used in this study is descriptive qualitative with a program evaluation approach. The results obtained from this study are that the number of visits by pregnant women, toddlers, and the elderly has increased. However, a strategy is needed to increase the interest of young women to utilize posyandu so that they can increase the number of visits by adolescents. In conclusion, the role of Posyandu cadres dramatically contributes to the health needs of small communities, especially in villages. Keywords: Cadres, Posyandu, Healthy

Aktivitas Antimikroba Ekstrak Etil Asetat Fungi Endofit Eutypa linearis Baiq Maylinda Gemantari; Fitra Romadhonsyah; Arief Nurrochmad; Subagus Wahyuono; Puji Astuti
Majalah Farmaseutik Vol 18, No 3 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i3.64133

Fungi endofit banyak dilaporkan mampu memproduksi senyawa metabolit yang memiliki beragam aktivitas biologis. Diisolasi dari salah satu tanaman berkhasiat Indonesia yang dikenal dengan nama tanaman jinten (Coleus amboinicus Lour.), pada penelitian ini dilakukan observasi aktivitas antimikroba fungi endofit Eutypa linearis. Ekstrak etil asetat dari media fermentasi E.linearis dalam beragam konsentrasi diujikan kepada beberapa mikroba bakteri dan fungi yakni Staphyloccocus aureus, Pseudomonas aeruginosa, Bacillus subtilis, dan Candida albicans. Aktivitas antimikroba dievaluasi menggunakan metode mikrodilusi pada media Mueller Hinton Broth untuk kultur bakteri dan Brain Heart Infussion Broth untuk kultur fungi. Nilai optical density pada panjang gelombang 600 nm yang diperoleh dari penggunaan microplate reader digunakan untuk menghitung nilai IC50 ekstrak. Hasil penelitian menunjukkan nilai IC50 ekstrak etil asetat media fermentasi E.linearis pada S.aureus adalah sebesar 260,69 µg/mL; P.aeruginosa 359,32 µg/mL; B.subtilis 163,74 µg/mL; dan C.albicans 92,75 µg/mL. Berdasarkan metode bioautografi kontak, diketahui senyawa aktif sebagai antimikroba tersebut merupakan kelompok senyawa yang polar.

Potential Activity of Caryophyllene Derivatives as Xanthine Oxidase Inhibitor: An in silico Quantitative Structure-Activity Relationship Analysis Arif Setiawansyah; Baiq Maylinda Gemantari
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5485

As the enzyme responsible for the uric acid formation, Xanthine oxidase was considered to be a therapeutic target for hyperuricemic treatment. This study was carried out to assess the potential of caryophyllene, and its derivates usually present in the natural product to inhibit Xanthine oxidase. The molecular docking using Autodock Tool and Biovia Discovery Studio was conducted to visualize the molecular interaction and to reveal the structure-activity relationship of those compounds. The results showed that the derivates of caryophyllene showed a higher affinity to Xanthine Oxide than Allopurinol. Among those all, caryophyllene oxide has the most stable bonding to xanthine oxide. Structure-activity relationship analysis showed that the chemical properties of the compound affected the affinity and molecular interaction to the enzyme as the target site in this study. The number of double bonds, substituents position, conformational structure related to steric hindrance, and the presence of lactone ring were assumed to influence the xanthine oxide inhibitory activity of caryophyllene derivates.

Antioxidant Activity Screening of Callophyllum inophyllum Linn. Seed Fractions Siti Nurhaliza; Baiq Maylinda Gemantari; Yuyun Febriani
Healthy-Mu Journal Vol. 7 No. 1 (2023)
Publisher : MBUnivPress

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/hmj.v7i1.576

Calophyllum inophyllum Linn. known as nyamplung is one of tropical plants widely grown in Indonesia. This plant reported has various chemical compound responsible to treat various deseases and disorders. Antioxidant activity is one of properties that has not been revelad extensively. This study aimed to evaluate antioxidant activity of Calophyllum inophyllum seed fractions using DPPH radical scavenging. Fractination was done gradually by liquid-liquid partition using N-hexane, ethyl acetate and aquadest as solvent. The phytochemical contents of each fraction were analyzed using AlCl3, FeCl3 and Lieberman-Burchard as dyeing reagents. Antioxidant activity was evaluated qualitative and quantitatively. The obtained results showed that N-hexane, ethyl acetate and aquadest fractions contained flavonoids, phenolics, terpenoid and steroid compound. All fractions also revealed antioxidant properties. Quantitatively, N-hexane fraction has the strongest anioxidant properties. This result might imply due to non-polar compound in the seeds dominantly.

Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Semangka Merah Sebagai Krim Antijerawat Tri Puspita Yuliana; Hasratul Kusuma; Puspawan Hariadi; Baiq Maylinda Gemantari
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19590

Acne is a problem caused by Propionibacterium acnes bacteria. Red watermelon rind contains lycopene compounds, antioxidants, has tannin and flavonoid compounds and is very good for skin care, free from acne, functions as an antibacterial. The purpose of this study was to formulate ethanol extract of red watermelon rind into anti-acne cream preparation and determine the inhibition zone and determine the red watermelon rind cream has the best antibacterial activity against Propionibacterium acnes bacteria. The method used in this study was experimental, extract concentration of 15%, 20%, 25%. The antibacterial activity test was conducted using the pitting method and evaluated the physical properties of the cream preparation including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results showed that the evaluation of the physical properties of the cream preparation had characteristics in accordance with the evaluation of the preparation carried out at each concentration, including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results of the antibacterial activity test of ethanol extract of red watermelon rind F1, F2, F3 are: 6.76 mm, 8.33 mm, 8.73 mm. The results of the antibacterial activity test of the cream preparation of ethanol extract of red watermelon rind F1, F2, F3 are: 4.47 mm, 6.04 mm, 8.17 mm. It can be concluded that the cream preparation of ethanol extract of red watermelon rind meets the characteristics of cream preparation stability, meets the criteria of good physical properties at concentrations of 15%, 20%, 25%, has weak to moderate category antibacterial activity against Propionibacterium acnes bacteria.

Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

Potential Activity of Caryophyllene Derivatives as Xanthine Oxidase Inhibitor: An in silico Quantitative Structure-Activity Relationship Analysis Arif Setiawansyah; Baiq Maylinda Gemantari
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5485

As the enzyme responsible for the uric acid formation, Xanthine oxidase was considered to be a therapeutic target for hyperuricemic treatment. This study was carried out to assess the potential of caryophyllene, and its derivates usually present in the natural product to inhibit Xanthine oxidase. The molecular docking using Autodock Tool and Biovia Discovery Studio was conducted to visualize the molecular interaction and to reveal the structure-activity relationship of those compounds. The results showed that the derivates of caryophyllene showed a higher affinity to Xanthine Oxide than Allopurinol. Among those all, caryophyllene oxide has the most stable bonding to xanthine oxide. Structure-activity relationship analysis showed that the chemical properties of the compound affected the affinity and molecular interaction to the enzyme as the target site in this study. The number of double bonds, substituents position, conformational structure related to steric hindrance, and the presence of lactone ring were assumed to influence the xanthine oxide inhibitory activity of caryophyllene derivates.

ANALYSIS OF NaOCl CONTENT OF HAND & BODY LOTION AND FACE WASH CREAM BY IODOMETRIC TITRATION METHOD Jeli Marlita; Yuyun Febriani; Risma Hayatun Nufus; Muhlisun Azim; Baiq Maylinda Gemantari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1242

Cosmetics are needed by the public, such as hand and body lotions and face brightening creams, and there are many misuses of hazardous chemicals in cosmetics, including lotions and face brightening creams. Sodium hypochlorite, a hazardous chemical, can cause skin damage, such as irritation, rash, hypersensitivity, and burns. The purpose of this study was to determine the presence of sodium hypochlorite compounds and sodium hypochlorite in hand and body lotion cosmetics and face brightening cream. The method used in this research was qualitative analysis with color reaction and quantitative analysis with iodometric titration. The results qualitatively showed that color changes occurred in all samples. NaOCl concentration in hand and body lotion at 0.2% concentration showed an average NaOCl concentration of 3.263 % ± 0.25 and face brightening cream concentration at an average concentration of 10 mg showed NaOCl levels of 88.933 % ± 7.57. Based on this, it was concluded that in the samples of hand and body lotion and face brightening cream, sodium hypochlorite compounds with different levels. Therefore, these samples could have side effects and toxicity in their usefulness as cosmetics. Keywords: Hand & body lotion, face brightening cream, sodium hypochlorite (NaOCl), iodometric titration

Peran apoteker dalam edukasi resistensi antibiotik di Kecamatan Keruak Lombok Timur Oktresia, Erma Ewisa; Gemantari, Baiq Maylinda; Yuliana, Tri Puspita; Ramadhan, Leny; Azim, Muhlisun
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 1 (2024): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v5i1.249

Pharmacists is one among others profession whom responsible to manage and to prevent antimicrobial resistance. To perform those function, giving information and educating public are essential to be done. This community service was aimed to provide and to increase knowledge and awareness of antimicrobial usage in public by educational program. Thus, the incidence of antimicrobial resistance could decline. The program was run by classical method and discussion session. There were 30 participants from various village in Keruak district. As speaker, pharmacists delivered some learning materials to participants followed by discussion. On discussion session participant asked some questions about antimicrobial usage. According to questions asked, it showed that participants taking part in this program have not comprehend about how to get, how to use, how to keep and storage and how to dispose antimicrobial yet in a frame to prevent resistance. It is concluded that by taking this educational community service program given by pharmacists, participants in Keruak district could gain information to improve their knowledge about antimicrobial usage in order to prevent and decline antimicrobial resistance.

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