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All Journal International Journal of Advances in Applied Sciences Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Jurnal Ilmu Kefarmasian Indonesia SPEKTA (Jurnal Pengabdian Kepada Masyarakat : Teknologi dan Aplikasi) Jurnal Kajian Ilmiah Open Community Service Journal Indonesian Journal of Pharmacy and Natural Product JAMAS: Jurnal Abdi Masyarakat Journal of Food and Pharmaceutical Sciences
Novitasari, Putri Rachma
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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A Simple Liquid-Liquid Fractionation (LLF) Method for Isolating Deoxyandrographolide dan Andrographolide from Herbs of Andrographis paniculata (Burm., F) Ness and Its Cytotoxic Activity on 3T3-L1 Preadipocyte Cells Putri Rachma Novitasari; Novia Tri Astuti; Suwijiyo Pramono; Raymond Tjandrawinata; Agung Endro Nugroho
Journal of Food and Pharmaceutical Sciences Vol 8, No 3 (2020): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.875

Abstract

The main bitter constituents of sambiloto (Androgaphis paniculata (Burm., F) Ness) are diterpene lactones, namely andrographolide and deoxyandrographolide which have been reported to have antidiabetic, cytotoxic, antiatherosclerosis, anti-inflammatory, and antimicrobial activity. There are many studies that performed the isolation of deoxyandrographolide and andrographolide from A. paniculata herbs, but most of them included several steps that make them not efficient. This research was conducted to do an isolation of deoxyandrographolide and andrographolide through liquid-liquid fractionation (LLF) due to its simplicity, low cost, and time efficient. The extraction of deoxyandrographolide and andrographolide from the herbs was carried out using chloroform as the solvent by using Soxhlet apparatus, and LLF was performed to isolate the compounds. The identities of the compounds were confirmed by TLC scanner compared to its standard references. Hence, these present methods were successfully isolated and determined deoxyandrographolide and andrographolide of A. paniculata. The compounds were also showed relatively moderate cytotoxicity on 3T3-L1 cell lines using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay, with LC50 of deoxyandrographolide and andrographolide; 29.3173 µg/mL and 37.7011 µg/mL, respectively.
Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Abstract

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.
Anti‐diabetic effect of andrographolide from Sambiloto herbs (Andrographis paniculata (Burm.f.) Nees) through the expression of PPARγ and GLUT‐4 in adipocytes Novia Tri Astuti; Putri Rachma Novitasari; Raymond Tjandrawinata; Agung Endro Nugroho; Suwijiyo Pramono
Indonesian Journal of Biotechnology Vol 27, No 4 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.68800

Abstract

Andrographolide has been shown to have a pharmacological effect as an antidiabetic. Nevertheless, the comprehensive mechanism of action has yet to be determined. Andrographolide is a primary component of the sambiloto herb (Andrographis paniculata (Burm.f.) Nees), in which a simple isolation process can obtain high yields. This study aimed to explain the anti‐diabetic effect of andrographolide compared to pioglitazone (a positive control) on glucose uptake by measuring the expression levels of peroxisome proliferator‐activated receptor gamma (PPARγ) and glucose transporter type 4 (GLUT‐4) genes in 3T3‐LI mouse adipocytes as an in vitro model. The differentiation of mature adipocytes from 3T3‐L1 fibroblasts was induced with 3‐isobutyl‐1‐methylxanthine, dexamethasone, and insulin. Andrographolide was provided through direct isolation from A. paniculata herbs. The gene expression was detected using the reverse transcription‐polymerase chain reaction (RT‐PCR). Pioglitazone and andrographolide significantly increased glucose uptake capability. Andrographolide was able to increase the mRNA levels of PPARγ and GLUT‐4 compared to pioglitazone with the best concentration at 5.6 µM. In conclusion, andrographolide can improve glucose uptake by increasing mRNA levels of PPARγ and GLUT‐4 that encodes protein, which are key factors for glucose homeostasis. Therefore, this finding further establishes the potency of andrographolide from A. paniculata as an antidiabetic.
Interprofessional education applied in first-year and third-year health students: cross-sectional study Dyah Aryani Perwitasari; Faridah Baroroh; Andriana Sari; Putri Rachma Novitasari; Nurul Kodriati; Ratu Matahari; Barkah Djaka Purwanto
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27253

Abstract

Health professions work together to provide the best service in health care facilities by collaborating with patients, families, worker and the community. Interprofessional education (IPE) were practice of collaboration between two or more students from different health profession programs. The purpose of study was to compare IPE results from first and third year batches. The two batches included 345 first-year students and 460 third-year students, from three different health disciplines, including medicine, pharmacy, and public health. These students met for four weeks to increase interprofessional collaboration, improve communication skills, foster respect and increase knowledge of the various roles each discipline, especially case management, conflict management and team work. Before IPE program, the students were given pre-questionnaire to assess their prior understanding of IPE. Each group of first-year students presented the outcomes of their discussions in the fourth week, while the third-year students created a poster about the subject and presented it in the second week. The students complete the program and post-questionnaire after their presentation. The International Collaborative Competencies Attainment Survey served the development the IPE questionnaire (ICCAS). The result of pre-IPE domains’ score revealed substantial disparities in the team work domain, with third-year students score was lower than the first students, whereas first-year students had the highest score in the most of IPE categories, unless collaboration and conflict management (p>0.05). The post-IPE domains’ score showed significant differences in all of the domains. Most of the IPE domains had higher score in first year students, excluding communication and team work.
Edukasi anak-anak pekerja migran Indonesia di Malaysia untuk pencegahan kekerasan seksual: Educating The Children Of Indonesian Migrant Workers In Malaysia About Sexual Violence Prevention Kodriati, Nurul; Pranungsari, Dessy; Novitasari, Putri Rachma; Fitriani, Isah; Putri, Nur Syifa; Hanastiti
JAMAS : Jurnal Abdi Masyarakat Vol. 1 No. 3 (2023)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/jms.v1i3.64

Abstract

Angka kekerasan seksual terhadap anak yang ada saat ini belum tentu mencerminkan kenyataan karena adanya kemungkinan beberapa kasus tidak terlaporkan. Anak-anak dengan latar belakang orang tua sebagai buruh migran mengalami kerentanan yang lebih dibandingkan anak-anak lainnya karena beberapa faktor. Tujuan utama pengabdian masyarakat ini adalah untuk memberikan edukasi kesehatan masyarakat dan psikologi kepada anak-anak buruh migran Indonesia di Sanggar bimbingan Kepong, Kuala Lumpur, Malaysia untuk pencegahan kekerasan seksual. Pelatihan dilakukan secar luring bekerja sama dengan Pimpinan Cabang Istimewa Aisyiah Malaysia pada anak-anak berusia kurang dari 18 tahun. Edukasi diberikan dengan bermain menggunakan kartu “Roses Magic” disertai pemahaman gender dan kesehatan reproduksi untuk meningkatkan respons melapor jika terjadi kekerasan seksual pada anak. Evaluasi dilakukan dengan memberikan pre-test dan post test sebelum dan setelah edukasi secara berurutan. Hasil pengabdian menunjukkan bahwa terdapat peningkatan pengetahuan yang signifikan pada anak-anak tersebut. Hal ini menunjukkan bahwa model permainan dalam pengabdian masyarakat ini cukup efektif untuk meningkatkan pengetahuan anak-anak.
Solvent Effects on Phytochemical Screening Test of Red Lemongrass (Cymbopogon nardus (L.) Rendl.) Extract and its Potential as Antidiabetic Agent Novitasari, Putri Rachma; Nuraisyah, Fatma; Prihatmadi, Farhan Adyaqsa; Nugroho, Agung Dwi; Yudhana, Anton; Akbar, Son Ali
Journal of Food and Pharmaceutical Sciences Vol 11, No 1 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.6310

Abstract

Phytochemical screening is a preliminary stage in phytochemical research which aims to provide an overview of class compounds contained in the plants. The solvents used in this study consisted of distillated water, methanol, and n-hexane solvent. The purpose of this study was to determine the secondary metabolites in Red Lemongrass (Cymbopogon nardus (L.) Rendl.) extract using different three solvents. Red Lemongrass extract was prepared by maceration method using distillated water, methanol, and n-hexane (10 gram: 100 mL) as solvents. Results of the extract were subjected to a phytochemical screening test consisting of flavonoids, alkaloids, saponins, tannins, and triterpenoids. The results of phytochemical screening showed that alkaloids, flavonoids, triterpenoids, and saponins were drawn attracted to the distillated water solvent. Meanwhile flavonoids and triterpenoids were drawn to methanol solvents. In addition, triterpenoids were drawn to n-hexane solvents. The best solvent on maceration results will be used as a reference for testing the ability of the extract as an antidiabetic agent.
Formulation and Evaluation of Wound Healer Waterproof Spray containing Cymbopogon nardus L. and Musa paradisiaca L. Leaves Wax Novitasari, Putri Rachma; Dwi Nugroho, Agung; Adyaqsa Prihatmadi, Farhan; Kesya Riza Purnama, Sarasevita
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10160

Abstract

Red lemongrass (Cymbopogon nardus L.) is an Indonesian plant which has potential as a wound healer. Red lemongrass contain essential oil which has the potential effect to treat wounds, such as citral. The citral content in every 1 mL of this essential oil is 32.28%. A wound is an injury-induced disturbance of the tissues' normal anatomical relationships. Wound is basically prone to infection, and it can infect bacteria, such as Staphylococcus aureus bacteria. Water splashes exposed the Staphylococcus aureus bacteria, which then caused an infection. Water is a medium for bacterial growth. In this research, kepok banana leaves wax (Musa paradisiaca L.) is added as a waterproof base to prevent wounds from being splashed by water, because wounds on skin tissue are protected by a layer of wax originating from kepok banana leaves (Musa paradisiaca L.). The aim of this research was to make a waterproof gel spray from red lemongrass essential oil using wax of banana leaves as a waterproof base. The result showed waterproof gel spray preparation has yellowish white colour; a distinctive aromatic odor, pH 6,28; viscosity 135 cps, and dry time 7.5 minutes and it has waterproof properties.
Identification and antioxidant activity test of β-tocopherol from Dompu corn oil as anti-aging Permadi, Adi; Budiastuti, Pramudita; Setyanto, Barry Nur; Wulandana, Rachmadian; Nuraisyah, Fatma; Novitasari, Putri Rachma; Syamsuddin, Arief; Ramadhan, Muhammad Kaisar Sutomo; Rosandy, Andi Rifki
International Journal of Advances in Applied Sciences Vol 14, No 1: March 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i1.pp175-184

Abstract

Corn is a well-cultivated food crop that is grown extensively worldwide. The used portion of corn is its seeds, which are rich in oil. The objective of this study is to separate and characterize tocopherol from corn oil in Dompu, Sumbawa by employing spectroscopic techniques such as ultraviolet (UV) spectrophotometry, ultra-performance liquid chromatography (UPLC), nuclear magnetic resonance (NMR), and liquid chromatography-mass spectrometry (LC-MS). Subsequently, the in-vitro antioxidant activity of the tocopherol was assessed. 1 kilogram of dry maize kernels subjected to 70% ethanol extraction yielded 30 grams (35 ml) of corn oil. The purified isolate obtained from the fractionated extract, using radial chromatography, demonstrated the presence of tocopherol. The isolated sample exhibited the presence of beta-tocopherol. Beta-tocopherol's anti-aging properties were assessed by conducting an in-vitro antioxidant activity test utilizing the tyrosinase enzyme. The IC50 value obtained was 83.954±2.849 ppm. The IC50 value indicates that beta-tocopherol possesses significant antioxidant activity, making it suitable for usage as a primary ingredient in cosmetics and pharmaceutical products.
Community Service Based on A Training Method for Making Liquid Hand Sanitizers to Prevent The Spread of COVID-19 in Tegalsari Kulon Progo Astuti, Erna; Sugihartini, Nining; Zainab, Zainab; Novitasari, Putri Rachma
SPEKTA (Jurnal Pengabdian Kepada Masyarakat : Teknologi dan Aplikasi) Vol. 4 No. 1 (2023)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/spekta.v4i1.7821

Abstract

Background: During this Covid-19 pandemic, the use of hand sanitizer needs to be encouraged to maintain hand hygiene. During endemic and new normal times, the use of hand sanitizer is highly recommended. The hand sanitizers circulating in the market are still predominantly made from alcohol. Hand sanitizer in liquid or spray form is more effective than gel hand sanitizer. Contribution: The purpose of this community service is to improve knowledge in making liquid hand sanitizers for the people of Tegalsari Hamlet. With this training, the community can provide hand sanitizer independently. Method: The steps of training were to share videos of making hand sanitizers, organize discussion sessions via Google Meeting, send materials for making hand sanitizers to participants, and did training. The method of making hand sanitizer follows WHO standards. The training participants were 28 teenagers from Tegalsari. Results: From the evaluation, it is known that there is an increase in the ability to make hand sanitizer by 50.74% and an increase in community skills. Conclusion: The training participants succeeded in making hand sanitizer.  This activity got a very good response from training participants. Participants are very enthusiastic and stated that this activity is very useful for them. It was proven that the participants were capable to produce hand sanitizers independently
Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Abstract

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.
Co-Authors Adi Permadi, Adi Adyaqsa Prihatmadi, Farhan Agung Dwi Nugroho, Agung Dwi Agung Endro Nugroho Agung Endro Nugroho Andi Rifki Rosandy Andriana Sari Andriana Sari Anton Yudhana Astri Desmayanti Baiq Maylinda Gemantari Barkah Djaka Purwanto Baroroh, Faridah Budiastuti, Pramudita Desmayanti, Astri Dessy Pranungsari Dwi Nugroho, Agung Dyah Aryani Perwitasari Erna Astuti Faridah Baroroh Fatma Nuraisyah, Fatma Febri Utami Firdausi, Azzahro Aulia Fitri Indah Setiyawati Fitriani, Isah Hanastiti Hani Badriyah Hidayati Hardi Astuti Witasari Hardi Astuti Witasari Imaniar Ranti Juwitaningtyas, Titisari Kesya Riza Purnama, Sarasevita Kintoko Kintoko Kintoko Kintoko Kodriati, Nurul Lina Widiyastuti Mufidah, Syarifatul Nilmawati Nilmawati Nina Salamah Nining Sugihartini Novia Tri Astuti Nuari, Yudha Rizky Nurul Kodriati Prihatmadi, Farhan Adyaqsa Prita Anggraini Kartika Sari Purwanto, Barkah Djaka Putri, Nur Syifa Rachmawati Widyaningrum Ramadhan, Muhammad Kaisar Sutomo Ranti, Imaniar Ratu Matahari Ratu Matahari Raymond R. Tjandrawinata Rifki Febriansah Rifki Febriansah Rusdi, Niswa Fadilah Saputri, Ginanjar Zukhruf Setiyawati, Fitri Indah Setyanto, Barry Nur Son Ali Akbar Suwijiyo Pramono Suwijiyo Pramono Syamsuddin, Arief Utami, Febri Widyaningrum, Rachmawati Wulandana, Rachmadian Yulianto Yulianto Yulianto Yulianto Zainab Zainab