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Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

Structure-Activity Relationship Study on the Ethyl p-Methoxycinnamate as an Anti-Inflammatory Agent Ismiarni Komala; Supandi Supandi; Nurhasni Nurhasni; Ofa Suzanti Betha; Eka Putri; Syarifatul Mufidah; Muhammad Fikry Awaludin; Mida Fahmi; Muhammad Reza; Nurkhayati Putri Indriyani
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

Ethyl p-methoxycinnamate (EPMC) (1) has been isolated as a major compound from the rhizome of Kaempferia galanga together with the other compound ethyl cinnamate (2). As reported in the literature, EPMC (1) exhibited a significant in vitro and in vivo anti-inflammatory activity. In this research, we investigated the anti-inflammatory activity of compounds 1 and 2 by using anti-denaturation of heat bovine serum albumin (BSA) method. In order to analyze active sites that are responsible for the anti-inflammatory activity, therefore, it is necessary to conduct structural modification of EPMC (1). The structural modification was performed through re-esterification reaction by using conventional and assistance of the unmodified microwave oven. Evaluation of the results of the bioassay indicated that the ester and methoxy functional groups of EPMC (1) play an important role for the anti-inflammatory activity.

Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Putri Rachma Novitasari; Baiq Maylinda Gemantari; Syarifatul Mufidah; Prita Anggraini Kartika Sari
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.1938

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

Sekolah Lansia “SEGAR” Berbasis Pemanfaatan Toga dalam Pencegahan Penyakit Degeneratif Supadmi, Woro; Dania, Haafizah; Akrom, Akrom; Saputri, Ginanjar Zukhruf; Mufidah, Syarifatul; Sari, Prita Anggraini Kartika
Jurnal Peduli Masyarakat Vol 7 No 3 (2025): Jurnal Peduli Masyarakat: Mei 2025
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v7i3.6595

Lansia merupakan kelompok usia yang rentan terhadap penyakit degeneratif, seperti hipertensi, diabetes melitus, dan hiperkolesterolemia, yang memerlukan pengelolaan jangka panjang. Di Kelurahan Wirobrajan, Yogyakarta, prevalensi penyakit ini cukup tinggi, sementara pemahaman dan keterampilan lansia dalam pengelolaan kesehatan secara mandiri masih rendah. Program pengabdian ini bertujuan meningkatkan pengetahuan dan keterampilan lansia dalam pemanfaatan Tanaman Obat Keluarga (TOGA) secara tepat guna sebagai langkah preventif dan pengendalian penyakit degeneratif. Kegiatan dilaksanakan melalui program Sekolah Lansia Segar (Sehat dan Bugar) dalam tiga sesi edukatif yang bersifat partisipatif, diikuti oleh 63 lansia anggota Majelis Tabligh Aisyiyah Ketanggungan. Hasil evaluasi menunjukkan pengetahuan peserta mengenai penyakit degeneratif, penggunaan obat dan pemanfaatan TOGA. Seluruh peserta memahami bahwa TOGA memiliki khasiat sebagai obat, namun konsistensi dalam penggunaannya masih perlu ditingkatkan. Kegiatan ini terbukti efektif dalam memberdayakan lansia untuk mengelola kesehatannya secara mandiri.

In Silico Evaluation of Black Cumin Oil Constituents for Selective Anti-Inflammatory Inhibitor of COX-2 And 5-LOX Mufidah, Syarifatul; Putri Rachma Novitasari; Prita Anggraini Kartika Sari; Hani Badriyah Hidayati
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 02 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i02.4420

Black cumin oil (Nigella sativa) is widely known for its anti-inflammatory properties, attributed to various bioactive compounds. This study aimed to evaluate the binding affinity and selectivity of five major compounds from black cumin oil: dithymoquinone, thymoquinone, thymohydroquinone, p-cymene, and thymol, against key inflammatory enzymes: COX-1, COX-2, and 5-LOX, using an in silico approach. All compounds were assessed for drug-likeness using Lipinski’s Rule of Five before molecular docking with AutoDock Vina. Celecoxib, a selective COX-2 inhibitor, was used as a reference compound. Dithymoquinone demonstrated strong binding affinity to COX-2 (-9.3 kcal/mol) and 5-LOX (-8.4 kcal/mol), comparable to celecoxib (-9.9 and -8.3 kcal/mol, respectively), while showing lower affinity for COX-1 (-7.5 kcal/mol). The interaction analysis revealed hydrogen bonds and van der Waals forces with several active site residues, suggesting a stable and selective interaction. Other compounds showed moderate to high affinity but lacked the same degree of selectivity due to their interaction with COX-1. These findings indicate that dithymoquinone has the potential to act as a selective anti-inflammatory agent with a reduced risk of gastrointestinal side effects commonly associated with non-selective NSAIDs. The results support further investigation of dithymoquinone in preclinical and clinical settings to validate its efficacy and safety.

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