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All Journal Jurnal Kesehatan Masyarakat Indonesia Indonesian Journal of Tropical and Infectious Disease Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Nasution, Silvia Fitrina
Faculty Of Medicine, UIN Syarif Hidayatullah
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Parasitic Infections among The Refugee of The UNHCR in Ciputat, and Related Risk Factors to The Diseases Silvia Fitrina Nasution; Ela Laelasari
Jurnal Kesehatan Masyarakat Indonesia Volume 16. No. 2. Tahun 2021
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.319 KB) | DOI: 10.26714/jkmi.16.2.2021.91-97

Abstract

Parasitic infections are reported in the most recent years as the disease infected among the refugees from countries with war conflict in Asia and Africa. Several factors have reported as causative agents and routes of transmission of the disease. The objective of the study was to provide epidemiological data of parasitic infections among the UNHCR refugees with some aspects of socio-behavioral and medical history as risk factor to the disease. The design of the study was cross-sectional with a total sampling of the refugees visiting the Puskesmas Pisangan, Ciputat, South Tangerang. We conducted blood diff-count, microscopic examination, and rapid diagnostic tests for the blood; feces by microscopic;while for urine was assayed by dipstick and bacterial culture. The study revealed that there were evidences of parasitic infections in : one patient with positive malaria vivax, one positive patient with non-specific bacteria in urine and with an increased number of leucocyte in the blood (Leucocytosis), also two subjects with higher titer of thrombocyte in their blood (thrombocytosis). Meanwhile, the medical history and transmission profile of the diseases, cultural, social behavior, and other related risk factors to the diseases have shown no strong evidence as a potential disease’s transmission of the parasite from the refugees to their indigenous community.The study has concluded that the evidence of parasitic infections might be at risk of disease’s transmission and should be prevented by a proper response of health services.
PRELIMINARY STUDY OF WUCHERERIA BANCROFTI L3 LARVAE DETECTION IN CULEX QUINQUEFASCIATUS AS VECTOR POTENTIAL OF FILARIASIS IN ENDEMIC AREA OF SOUTH TANGERANG, BY UTILIZING PCR ASSAY FOR L3-ACTIVATED CUTICLIN TRANSCRIPT mRNA GENE AND TPH-1 GENE Nasution, Silvia Fitrina; Adhiyanto, Chris; Indahwati, Evi
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 3 (2018)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.888 KB) | DOI: 10.20473/ijtid.v7i3.7352

Abstract

South Tangerang district is an endemic area for Wuchereria bancrofti filariasis with a prevalence rate of microfilaria (mf) at a range of 1 - 2.4% in 2008-2009. Culex quinquefasciatus plays an important role as the major vector of transmission for the parasite. It remains a problem on how to determine that the mosquitoe roles as a vector or disease transmitter when there is no evidence of filarial parasite larvae 3 (L3) by the microscopic examination. In assessing the transmission risk of the filarial parasite, a DNA-based detection method was carried out to specifically detect the presence of W. bancrofti infective L3 larvae in the mosquitoe. The Polymerase Chain Reaction (PCR) was performed to detect a specific DNA obtained from W. bancrofti L3 larvae in a very low number or low antigen titer. The assay was purposed as preliminary study to detect the presence of L3 filarial of W.bancrofti in Cx. quinquefasciatus by utilizing the expression of L3-activated cuticlin transcript mRNA gene and tph-1 gene. The result of PCR based analysis of mosquitoes collected from the suggested area showed that there is a low but detectable number of L3 infected mosquito with W. bancrofti. Among the 18 isolated DNA samples of mosquitoes, we found 7 positive samples (38.89%) with the presence of filarial larvae DNA expressing L3-activated cuticlin transcript mRNA and tph-1 genes, which determined as 123 bp for Wb-cut-1.2 and 153bp for tph-1. In contrast by microscopic result, we found no evidence of L3 larvae of the parasite in the mosquitoe's dissecting samples. The PCR assay in our study was proven sensitive to detect the presence of Wb-L3 filarial larvae in Cx. quinquefasciatus
Early Detection of Infectious Diseases among the Refugees of UNHCR in South Tangerang, Banten; the Problems and Strategies to Prevent the Disease's Transmission Nasution, Silvia Fitrina; Nisa, Hoirun
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.51708

Abstract

The previous study at Puskesmas Pisangan, Ciputat had reported that among 23.8 % patient of the UNHCR was infected by malaria Plasmodium vivax, and one patient with bacterial urinary infection. However, the result can not represent the actual case of the disease, because of the lack number of participant to visit the Puskesmas  since the Covid-19 pandemic which had been contributing to decrease number of the patients. The study purposed to improve data and information about parasitic infection, and to design strategy in early detection and prevention to the disease. Design of the study was approached in cross-sectional with a total sampling method of the UNHCR out patients visiting the Puskesmas Pisangan and Cirendeu.We collected specimen of feces, urine, and blood, and performed blood diff-count, rapid diagnostic, microscopic, dipstick, and bacterial culture. The study revealed some parasitic and bacterial infections as defined: five cases (17.24%) of malaria, which is suspected as imported cases; Enterobacteriacea family as non-specific bacteria of negative gram in urine; also Entamoeba coli in stool. This finding was confirmed 17.24% of leucocytosis in blood diffcount and 24.14 % in urinalysis.  By nationality, Sudanese was detected the most prevalent 10.34% of parasitic infections, followed by Somalia (6.9%), Yaman (3.45%), and Afghanistan (3.45%) respectively. While mosquitoes and poor living conditions were also contributed as the major potential risk of transmission to the diseases. In conclusion, early detection, health screening, vaccination, access to primary, and upgraded levels of healthcare are important for diseases control and management to prevent transmission. 
RESISTENSI INSEKTISIDA PADA AEDES AEGYPTI: MEKANISME BIOLOGIS DAN IMPLIKASINYA TERHADAP PENGENDALIAN DENGUE Irawati, Nur Bebi Ulfah; Hermawati, Luluk; Awalina Zulfa, Hilizza; Fitrina Nasution, Silvia
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 10 No. 2 (2025): Oktober
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v10i2.1977

Abstract

Demam Berdarah Dengue (DBD) masih menjadi masalah kesehatan global dengan Aedes aegypti sebagai vektor utama penularan. Penggunaan insektisida kimia masih menjadi strategi utama dalam pengendalian vektor, namun efektivitasnya semakin menurun akibat berkembangnya resistensi terhadap insektisida. Artikel ini merupakan tinjauan literatur terhadap 36 studi yang dipublikasikan pada 2015–2025 untuk mengeksplorasi mekanisme resistensi Ae. aegypti dan implikasinya terhadap pengendalian dengue. Hasil analisis menunjukkan bahwa resistensi berkembang melalui mekanisme metabolik, target-site (mutasi pada gen VGSC dan ace-1) yang dapat menimbulkan fenomena knockdown resistance (kdr), sementara peningkatan aktivitas enzim metabolik seperti esterases, glutation-S-transferase, dan sitokrom P450 berperan dalam detoksifikasi insektisida, penetrasi kutikula, serta resistensi perilaku nyamuk. Paparan jangka panjang terhadap insektisida juga dapat memicu ekspresi gen baru terkait struktur kutikula, metabolisme energi, dan protease, yang turut memperkuat resistensi. Faktor manusia, lingkungan, dan biologi nyamuk turut mempercepat proses seleksi resistensi. Resistensi yang meluas terbukti menurunkan efektivitas fogging, larvasida, dan insektisida rumah tangga, sehingga meningkatkan risiko penularan dengue. Sebagai respon, pendekatan alternatif seperti rotasi insektisida, penggunaan bioinsektisida, teknologi genetik, serta surveilans resistensi adaptif dinilai penting untuk memperkuat Integrated Vector Management (IVM). Temuan ini menegaskan bahwa resistensi insektisida bukan sekadar isu biologis, melainkan tantangan multidimensional yang menuntut strategi pengendalian terpadu dan berkelanjutan guna menekan insidensi dengue.
Co-Authors Awalina Zulfa, Hilizza CHRIS ADHIYANTO Ela Laelasari Indahwati, Evi Irawati, Nur Bebi Ulfah Luluk Hermawati Nisa, Hoirun