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All Journal Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences SPIN: Jurnal Kimia & Pendidikan Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
Yoshihito Shiono
Yamagata University
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Materials Science & Nanotechnology Mathematics Physics

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FLAVONOLS FROM THE LEAVES Lygodium microphyllum (Lygodiaceae) Hadi Kuncoro; Kindi Farabi; Euis Julaeha; Laode Rijai; Yoshihito Shiono; Unang Supratman
Jurnal Kimia (Journal of Chemistry) Vol. 11. No. 1 Januari 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.797 KB) | DOI: 10.24843/JCHEM.2017.v11.i01.p02

Abstract

Flavonol compounds, quercetin (1) and quercetin-3-O-?-D-glucopyranoside (2) have been isolated from the ethyl acetate extract of Lygodium microphyllum leaves. The chemical structures of flavonol compounds were identified based on spectroscopic data and by comparison of spectral data obtained previously. The discovery of flavonol compounds in Lygodium microphyllum was shown in this study for the first time.
Flavonoid Compounds from the Herb of Krokot (Lygodium microphyllum) and their antioxidant activity against DPPH Hadi Kuncoro; Kindi Farabi; Laode Rijai; Euis Julaeha; Unang Supratman; Yoshihito Shiono
Journal of Mathematical and Fundamental Sciences Vol. 50 No. 2 (2018)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2018.50.2.7

Abstract

Six flavonoid compounds, kaempferol (1), quercetin (2), acacetin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), and isorhamnetin-3-O-β-D-glucopyranoside (6), were isolated from the methanol extract of the Lygodium microphyllum herb. The chemical structures of compounds 1-6 were identified on the basis of spectroscopic evidence and comparison with previously reported spectral data. Compounds 1-6 were isolated for first time from this plant. Their antioxidant activity against DPPH (2,2-Diphenyl-1-picrylhydrazyl) was evaluated. Among the compounds, quercetin (2) showed high antioxidant activity with IC50 values of 6.94 ± 0.03 μg/mL.
EKSPLORASI JAMUR ENDOFIT DARI TANAMAN KERINYU (Cromolaena odorata L.) DAMPAK STRES LINGKUNGAN SERTA AKTIVITAS ANTI BAKTERI DAN ANTI JAMURNYA Muhlisun Azim; Yoshihito Shiono; Nanang Rudianto Ariefta
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 3 No. 1 (2021): Januari - Juni 2021
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v3i1.3108

Abstract

Endofit merupakan sumber kimia bahan alam yang potensial sebagai agen senyawa bioaktif. Keberagaman struktur kimia yang dihasilkan dari jamur endofit terbentuk berdasarkan lingkungan, media jamur endofit dan inang jamur endofit tersebut diisolasi. Penelitian ini bertujuan untuk mengetahui potensi ekstrak jamur endofit sebagai agen antibakteri yang berasosiasi dengan tanaman Kerinyu (Cromolaena odorata L.), agar dapat dijadikan sebagai acuan untuk melakukan penelitian lanjutan. Sampel tanaman diambil di sekitar bangker Kaliadem Yogyakarta. Metode penelitian yang digunakan adalah eksplorasi dan eksperimen laboratorium dengan sampling acak terhadap isolat strain jamur murni yang dikultur pada media agar Potato Dextrose Agar (PDA) dan Potato Dextrose Agar Cyclosporin A (PDA-CS). Diperoleh 10 strain jamur endofit murni dengan media isolasi jamur endofit PDA dan PDA-CS. Hasil isolasi jamur endofit selanjutnya difermentasi dengan beras cokelat selama 1 bulan kemudian dimaserasi dengan metanol p.a selama 3 hari dan ekstrak metanol diuji aktivitas anti mikroba dan anti jamurnya dengan metode difusi agar. Dari 10 isolat jamur endofit, terdapat 4 strain jamur yang aktif sebagai anti bakteri dan anti jamur dengan kode NP-MB-COK-10-2, NP-MB-COK-10-1, PDA-MB-COK-6-4 dan NP-MB-COK-2.
A Known Naphthalene, Isoeleutherol, from the Herb of Lygodium microphyllum Kuncoro, Hadi; Farabi, Kindi; Rijai, Laode; Julaeha, Euis; Shiono, Yoshihito; Supratman, Unang
Makara Journal of Science Vol. 22, No. 4
Publisher : UI Scholars Hub

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Abstract

A known naphthalene, isoeleutherol (1), was isolated from the herb ofLygodium microphyllum. The chemical structure of 1 was determined on the basis of spectroscopic data mainly UV, IR, HRTOFMS, 1D-and 2D-NMR spectroscopy, aswell as by comparing with compounds previously reported. Isoeleutherol was isolated from this plant for the first timeand showed moderate antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) with IC50 value of 53.96 ± 2.87 μg/mL.
Activity of Cytotoxic Flavanoids against a P-388 Murine Leukemia Cell Line from the Stem Bark of Aglaia elliptica (Meliaceae) Hidayat, Ace Tatang; Farabi, Kindi; Harneti, Desi; Maharani, Rani; Nurlelasari,; Supratman, Unang; Shiono, Yoshihito
Makara Journal of Science Vol. 21, No. 4
Publisher : UI Scholars Hub

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Abstract

Two mixtures of flavanoid compounds (1 and 2), a mixture of catechin (1a) and epicatechin (1b), and a mixture of gallocatechin (2a) and epigallocatechin (2b), were isolated from the active fraction of the stem bark of Aglaia elliptica methanol extract. The chemical structure of the compounds was identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and additionally compared with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compound 2 showed cytotoxicity against the P-388 murine leukemia cell, with an IC50 value of 7.79 µg/mL, but compound 1 was found not to be active (more than 100 µg/mL).
Azadirone-Type Limonoids from the Fruit of Chisocheton lasiocarpus and Their Cytotoxic Activity Against MCF-7 Breast Cancer Lines Erina Hilmayanti; Nurlelasari Nurlelasari; Dewa Gede Katja; Ace Tatang Hidayat; Sofa Fajriah; Akhmad Darmawan; Unang Supratman; Mohamad Nurul Azmi; Yoshihito Shiono
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5593

Abstract

Limonoid is derivatives of triterpenoid compound that have a wide variety of structures due to various ring-opening, rearrangements, and high-degree of oxidation. Limonoid is known as compounds that have wide-range of biological activities, including anticancer activity. This research was aimed to determine the chemical structure and cytotoxic activity of limonoid in the n-hexane extract of Chisocheton lasiocarpus fruit. Dried powder of C. lasiocarpus fruit was extracted using methanol followed by fractionated using n-hexane, ethyl acetate, and n-butanol. Five azadirone-type limonoids, 6α-(acetoxy)-14β,15β-epoxyazadirone (1), dysobinin (2), 7α-acetylneotricilenone (3), 6α-O-acetyl-7-deacetylnimocinol (4), and 7α-hyroxyneotricilenone (5), were isolated from the n-hexane extract of Chisocheton lasiocarpus fruit. The chemical structure of all compounds was identified by spectroscopic analysis, including 1D, 2D-NMR, IR, UV and HR-TOF MS as well as by comparison with previous reported spectra data. Compounds 1-5 were investigated from this plant for first time. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined and the results showed that 7α-hyroxyneotricilenone (5) showed the moderate activity with IC50 values of 53 μM
Co-Authors Ace Tatang Hidayat Ace Tatang Hidayat Akhmad Darmawan Desi Harneti Putri Huspa Dewa Gede Katja Erina Hilmayanti Euis Julaeha Hadi Kuncoro Kindi Farabi Laode Rijai Mohamad Nurul Azmi Muhlisun Azim Nanang Rudianto Ariefta Nurlelasari Nurlelasari Nurlelasari Nurlelasari Rani Maharani Sofa Fajriah Unang Supratman