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All Journal Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences SPIN: Jurnal Kimia & Pendidikan Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
Yoshihito Shiono
Yamagata University
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Materials Science & Nanotechnology Mathematics Physics

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Journal : Makara Journal of Science

 1 
A Known Naphthalene, Isoeleutherol, from the Herb of Lygodium microphyllum Kuncoro, Hadi; Farabi, Kindi; Rijai, Laode; Julaeha, Euis; Shiono, Yoshihito; Supratman, Unang
Makara Journal of Science Vol. 22, No. 4
Publisher : UI Scholars Hub

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Abstract

A known naphthalene, isoeleutherol (1), was isolated from the herb ofLygodium microphyllum. The chemical structure of 1 was determined on the basis of spectroscopic data mainly UV, IR, HRTOFMS, 1D-and 2D-NMR spectroscopy, aswell as by comparing with compounds previously reported. Isoeleutherol was isolated from this plant for the first timeand showed moderate antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) with IC50 value of 53.96 ± 2.87 μg/mL.
Activity of Cytotoxic Flavanoids against a P-388 Murine Leukemia Cell Line from the Stem Bark of Aglaia elliptica (Meliaceae) Hidayat, Ace Tatang; Farabi, Kindi; Harneti, Desi; Maharani, Rani; Nurlelasari,; Supratman, Unang; Shiono, Yoshihito
Makara Journal of Science Vol. 21, No. 4
Publisher : UI Scholars Hub

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Two mixtures of flavanoid compounds (1 and 2), a mixture of catechin (1a) and epicatechin (1b), and a mixture of gallocatechin (2a) and epigallocatechin (2b), were isolated from the active fraction of the stem bark of Aglaia elliptica methanol extract. The chemical structure of the compounds was identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and additionally compared with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compound 2 showed cytotoxicity against the P-388 murine leukemia cell, with an IC50 value of 7.79 µg/mL, but compound 1 was found not to be active (more than 100 µg/mL).
Co-Authors Ace Tatang Hidayat Ace Tatang Hidayat Akhmad Darmawan Desi Harneti Putri Huspa Dewa Gede Katja Erina Hilmayanti Euis Julaeha Hadi Kuncoro Kindi Farabi Laode Rijai Mohamad Nurul Azmi Muhlisun Azim Nanang Rudianto Ariefta Nurlelasari Nurlelasari Nurlelasari Nurlelasari Rani Maharani Sofa Fajriah Unang Supratman