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Aried Eriadi
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Uji Aktivitas Laksatif Ekstrak Etanol Daun Gynura procumbens (Lour.) Merr. pada Mencit Putih Jantan yang Diinduksi Loperamid Rahimatul Uthia; Devina Prima Yolanda; Aried Eriadi; Dwi Dinni Aulia Bakhtra
Metamorfosa: Journal of Biological Sciences Vol 6 No 2 (2019)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2019.v06.i02.p01

Abstract

Constipation is a symptom of a problematic, non-smooth and irregular defecation process. While laxative is a substance that stimulates intestinal peristalsis as a reflex of direct stimulation of the intestinal wall that can cause or facilitate defecation. This study aimed to determine the ethanol extract of the leaves of Gynura procumbens (L.) Merr. effect as a laxative in white male mice induced by loperamide. The methods used for laxative testing are defecation patterns and intestinal transit methods. The parameters observed included frequency of defecation, stool consistency, stool weight every 30 minutes for 4 hours, and the length of the activated carbon in the mice's intestine. The extract was administered orally at a dose of 75 mg/kg BW, 150 mg/kg BW and 300 mg/kg BW, as a comparison used negative control (Na CMC). From the results of the study, it was found that the administration of ethanol extracts of Gynura procumbens (Lour.) Merr. leaves at the dose of 150 mg/kg BW gave laxative activity to white male mice (P <0.05).
Pengaruh Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan Aried Eriadi; Helmi Arifin; Zet Rizal; Barmitoni Barmitoni
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.523 KB) | DOI: 10.52689/higea.v7i2.127

Abstract

Wound healing is a normal process as responds by the skin tissue injury. This research is purposed to see the effects of ethanol extract in binahong leaf to  healing the wound of male white rats. There are rats which are divided into five treatment groups, group I (negative control), group II is given providone iodine 10% (positive control), group III, IV and V are given the extract of binahong leaf ointment consist of 5%, 10%, 15% for each. By making a wound on the back of the rats about 20 mm long and 2 mm deep. The ointment is applied based on the treatment for each group twice a day during ten days, the lenght count every day by using caliper. The data is analyzed by using two ways ANOVA and continued by Duncan Test. The result showed that ethanol extract in binahong leaf can heal the wound in scale concentration about 10%-15%, length of wound was decrease on seventh day. The more extract concentration given, the more effect in wound healing
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SEMBUNG (BLUMEA BALSAMIFERA (L.) DC.) TERHADAP KADAR GLUKOSA DARAH DAN HISTOPATOLOGI PANKREAS MENCIT PUTIH JANTAN YANG DIINDUKSI ALOKSAN Aried Eriadi; Rahimatul Uthia; Rika Novita
Jurnal Farmasi Higea Vol 9, No 2 (2017)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.387 KB) | DOI: 10.52689/higea.v9i2.168

Abstract

Penelitian ini bertujuan untuk melihat pengaruh ekstrak etanol daun sembung (Blumea balsamifera (L.) DC.)  terhadap kadar glukosa darah dan gambaran histopatologi pankreas. Hewan dibagi atas 5 kelompok yang terdiri dari kontrol negatif, kontrol positif, kelompok dosis 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB.Hewan diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal.Ekstrak diberikan selama 7 hari secara oral. Hasil penelitian yang dianalisis dengan ANOVA satu arah menunjukkan penurunan pada kadar glukosa darah secara signifikan (P<0,05) dan gambaran histopatologi memperlihatkan adanya perbaikan. Hal ini menunjukkan bahwa pemberian ekstrak etanol daun sembung (Blumea balsamifera (L.) DC.) dengan dosis 200 mg/kg BB dapat menurunkan kadar glukosa darah dan memperbaiki gambaran pankreas yang telah rusak dengan lebih bagus dibandingkan dengan dosis yang lain.
Pengaruh Pemberian Ekstrak Etanol Daun Kejibeling (Strobilanthes Crispa Blume) Terhadap Kadar Kolesterol Total Dan LDL Mencit Putih Kantan Hiperkolesterolemia Sri Oktavia; Aried Eriadi; Stagia Valdis
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (462.501 KB) | DOI: 10.52689/higea.v10i2.185

Abstract

Uji Aktivitas Ekstrak Herba Sambiloto (Andrographis paniculata (Burm.f.) Ness) Terhadap Kadar Nitrogen Monoksida Pada Mencit Putih Jantan Hiperkolesterolemia Aried Eriadi; Suhatri Suhatri; Nindywaii Honolhulu
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.22 KB) | DOI: 10.52689/higea.v9i1.152

Abstract

Effect of extract of bitter herbs (Andrographis paniculata (Burm.f.) Ness) has conducted research on the levels of NO in hypercholesterolemic male white mice. Hypercholesterolemia was induced by high-fat foods and propylthiouracil. Bitter herbs extract was administered orally every day for 60 days with a dose of 25 mg/kg BB, 50 mg/kg BB, and 100 mg/kg BB. The negative control group was only given regular meals and a positive control group was given a high-fat foods and propylthiouracil. Parameters measured were the levels of NO in serum. The results showed that the extract of bitter herbs can increase blood levels of NO white male mice when compared to the positive control (hypercholesterolemia), but still lower than the negative control (normal animals) (P<0.05). While the old factor does not affect the administration of organ weight ratio of the heart, liver and kidneys and significantly (P>0.05).
Uji Toksisitas Akut Ekstrak Etanol Daun Kirinyuh (Chromolaenodorata (L) R.M.King & H. Rob) Pada Mencit Putih Jantan Aried Eriadi; Helmi Arifin; Nirwanto Nirwanto
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (479.41 KB) | DOI: 10.52689/higea.v8i2.144

Abstract

A research on the acute toxicity of ethanol extracts of leaves kirinyuh (Chromolaena odorata (L) R.M.King & H.Rob). Parameters observed toxicity is LD50 and delayed toxic effects for 14 days of observation including changes in weight, the volume of water consumption, and the relative weight of the organs of the heart, liver, kidneys, stomach and lungs. The extract ethanol leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) orally at a dose of 4 g/kgBB, 8 g/kgBB and 16 g/kgBB, showed that the ethanol extract of leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) categorized practically non-toxic (LD50> 15 g/kgBB). Delayed toxic effects are seen from the significant differences in body weight, the volume of water, relative organ weight of lung and stomach (P<0.05). There were no significant differences in the relative organ weight of the heart, liver and kidneys (P<0.05).
Co-Authors Barmitoni Barmitoni Devina Prima Yolanda Dwi Dinni Aulia Bakhtra Helmi Arifin Nindywaii Honolhulu Nirwanto Nirwanto Rahimatul Uthia Rahimatul Uthia Rika Novita Sri Oktavia Stagia Valdis Suhatri Suhatri Zet Rizal