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All Journal Jurnal Farmasi Higea Biodiversitas Journal of Biological Diversity

Aried Eriadi

Biologi Farmasi, Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang

Author-ID : 2925913

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Pengaruh Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan Aried Eriadi; Helmi Arifin; Zet Rizal; Barmitoni Barmitoni
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Wound healing is a normal process as responds by the skin tissue injury. This research is purposed to see the effects of ethanol extract in binahong leaf to healing the wound of male white rats. There are rats which are divided into five treatment groups, group I (negative control), group II is given providone iodine 10% (positive control), group III, IV and V are given the extract of binahong leaf ointment consist of 5%, 10%, 15% for each. By making a wound on the back of the rats about 20 mm long and 2 mm deep. The ointment is applied based on the treatment for each group twice a day during ten days, the lenght count every day by using caliper. The data is analyzed by using two ways ANOVA and continued by Duncan Test. The result showed that ethanol extract in binahong leaf can heal the wound in scale concentration about 10%-15%, length of wound was decrease on seventh day. The more extract concentration given, the more effect in wound healing

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SEMBUNG (BLUMEA BALSAMIFERA (L.) DC.) TERHADAP KADAR GLUKOSA DARAH DAN HISTOPATOLOGI PANKREAS MENCIT PUTIH JANTAN YANG DIINDUKSI ALOKSAN Aried Eriadi; Rahimatul Uthia; Rika Novita
Jurnal Farmasi Higea Vol 9, No 2 (2017)
Publisher : STIFARM Padang

Penelitian ini bertujuan untuk melihat pengaruh ekstrak etanol daun sembung (Blumea balsamifera (L.) DC.) terhadap kadar glukosa darah dan gambaran histopatologi pankreas. Hewan dibagi atas 5 kelompok yang terdiri dari kontrol negatif, kontrol positif, kelompok dosis 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB.Hewan diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal.Ekstrak diberikan selama 7 hari secara oral. Hasil penelitian yang dianalisis dengan ANOVA satu arah menunjukkan penurunan pada kadar glukosa darah secara signifikan (P<0,05) dan gambaran histopatologi memperlihatkan adanya perbaikan. Hal ini menunjukkan bahwa pemberian ekstrak etanol daun sembung (Blumea balsamifera (L.) DC.) dengan dosis 200 mg/kg BB dapat menurunkan kadar glukosa darah dan memperbaiki gambaran pankreas yang telah rusak dengan lebih bagus dibandingkan dengan dosis yang lain.

Pengaruh Pemberian Ekstrak Etanol Daun Kejibeling (Strobilanthes Crispa Blume) Terhadap Kadar Kolesterol Total Dan LDL Mencit Putih Kantan Hiperkolesterolemia Sri Oktavia; Aried Eriadi; Stagia Valdis
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Uji Aktivitas Ekstrak Herba Sambiloto (Andrographis paniculata (Burm.f.) Ness) Terhadap Kadar Nitrogen Monoksida Pada Mencit Putih Jantan Hiperkolesterolemia Aried Eriadi; Suhatri Suhatri; Nindywaii Honolhulu
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

Effect of extract of bitter herbs (Andrographis paniculata (Burm.f.) Ness) has conducted research on the levels of NO in hypercholesterolemic male white mice. Hypercholesterolemia was induced by high-fat foods and propylthiouracil. Bitter herbs extract was administered orally every day for 60 days with a dose of 25 mg/kg BB, 50 mg/kg BB, and 100 mg/kg BB. The negative control group was only given regular meals and a positive control group was given a high-fat foods and propylthiouracil. Parameters measured were the levels of NO in serum. The results showed that the extract of bitter herbs can increase blood levels of NO white male mice when compared to the positive control (hypercholesterolemia), but still lower than the negative control (normal animals) (P<0.05). While the old factor does not affect the administration of organ weight ratio of the heart, liver and kidneys and significantly (P>0.05).

Uji Toksisitas Akut Ekstrak Etanol Daun Kirinyuh (Chromolaenodorata (L) R.M.King & H. Rob) Pada Mencit Putih Jantan Aried Eriadi; Helmi Arifin; Nirwanto Nirwanto
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

A research on the acute toxicity of ethanol extracts of leaves kirinyuh (Chromolaena odorata (L) R.M.King & H.Rob). Parameters observed toxicity is LD50 and delayed toxic effects for 14 days of observation including changes in weight, the volume of water consumption, and the relative weight of the organs of the heart, liver, kidneys, stomach and lungs. The extract ethanol leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) orally at a dose of 4 g/kgBB, 8 g/kgBB and 16 g/kgBB, showed that the ethanol extract of leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) categorized practically non-toxic (LD50> 15 g/kgBB). Delayed toxic effects are seen from the significant differences in body weight, the volume of water, relative organ weight of lung and stomach (P<0.05). There were no significant differences in the relative organ weight of the heart, liver and kidneys (P<0.05).

Isolation and evaluation of the antimicrobial activity of endophytic fungi from Orthosiphon aristatus HERLAND SATRIAWAN; NIKY AFRILIA ZAIMI; ARIED ERIADI; MAI EFDI; TRINA EKAWATI TALLEI; REGINA ANDAYANI; DIAN HANDAYANI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 2 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260245

Abstract. Satriawan H, Zaimi NA, Eriadi A, Efdi M, Tallei TE, Andayani R, Handayani D. 2025. Isolation and evaluation of the antimicrobial activity of endophytic fungi from Orthosiphon aristatus. Biodiversitas 26: 963-970. Orthosiphon aristatus, known as cat's whiskers or Javanese tea in Indonesia, has been used in traditional medicine to enhance urination, treat kidney inflammation, mitigate kidney stones, regulate diabetes, address albuminuria and syphilis, alleviate rheumatism, reduce blood glucose levels, and function as an antibacterial agent. The purpose of this study was to investigate the endophytic fungal resources of Orthosiphon aristatus and evaluate its potential as a source of bioactive compounds, particularly against antibiotic-resistant pathogens like Methicillin-resistant Staphylococcus aureus (MRSA). Eleven fungal isolates were obtained from the plant’s leaves, stems, and roots. The ethyl acetate extract of isolates was subjected to comprehensive antimicrobial screening at a concentration of 5%. Three isolates-OAA1, OAA3, and OAD1-exhibited considerable antibacterial activity, with OAD1 displaying the most significant efficacy, as evidenced by a 12.57 ± 1.09 mm inhibition zone against MRSA. Nevertheless, none of the extracts could suppress the proliferation of Candida albicans. Subsequent molecular identification verified that OAD1 was Aspergillus niger. The phytochemical analysis revealed that the triterpenoid and flavonoid groups exhibited a positive reaction, whereas the alkaloid and phenol compound groups exhibited a negative response. The findings highlight the potential of endophytic fungi from O. aristatus as promising sources of novel bioactive compounds, especially for addressing antibiotic-resistant pathogens like MRSA. The identification of A. niger as a powerful antibacterial-producing organism presents promising prospects for the creation of novel pharmaceuticals, particularly regarding multidrug-resistant infections. This study emphasizes the pressing necessity for additional research to identify and characterize the specific compounds that confer antibacterial activity and to investigate their extensive therapeutic applications.

Co-Authors Barmitoni Barmitoni Devina Prima Yolanda Dian Handayani Dwi Dinni Aulia Bakhtra Helmi Arifin HERLAND SATRIAWAN Mai Efdi NIKY AFRILIA ZAIMI Nindywaii Honolhulu Nirwanto Nirwanto Rahimatul Uthia Rahimatul Uthia REGINA ANDAYANI Rika Novita Sri Oktavia Stagia Valdis Suhatri Suhatri TRINA EKAWATI TALLEI Zet Rizal

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