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All Journal Jurnal Farmasi Udayana Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Jacub Tarigan
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Aktivitas Anti Luka Bakar dari Gel Minyak Kemiri (Aleurites moluccana L.) terhadap Tikus Putih (Rattus novergicus) Leny Leny; Evi Ekayanti Ginting; Warnus Laia; Ihsanul Hafiz; Jacub Tarigan
Jurnal Farmasi Udayana Vol. 10, No 2, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i02.p01

Abstract

Candlenut oil is often used as a traditional medicine that is used topically, generally used to treat hair and treat burns. The purpose of this study was to test the anti-burn activity of candlenut oil which has been formulated in the form of a gel. The method used was a laboratory experimental where candlenut oil was formulated in gel containing various concentrations of active substances 15, 20 and 25%, then tested for burn wound healing activity in mice induced by hot plates. Observation of wound healing time was carried out for 21 days. The results showed that 25% candlenut oil gel were similar to the positive control Burnazin® in healing burn wound. All of the candlenut oil gel formulas were completely fulfilled the requirement for gel preparation and have activity to heal burn wound. Keywords: Aleurites moluccana, burn wound healing activity, gel
EFEKTIVITAS ANTI JERAWAT SEDIAAN KRIM EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP Propionibacterium acnes Hafizhatul Abadi; Vivi Eulis Diana; Jacub Tarigan; Tetty Noverita Khairani; Tri Sundari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.419

Abstract

Jackfruit (Artocarpus heterophyllus Lam.) leaves have medicine potential, such as an antibacterial in anti-acne treatment contain flavonoids, tannins and saponins. The study aims to determine whether the ethanol extract of jackfruit leaves 96% can be formulated and determined the effectiveness of concentration preparation in inhibiting the Propionibacterium acnes bacteria. The preparation of cream preparations used a concentration of 20%, 30% and 40% jackfruit leaf ethanol extract. Then carried out the evaluation test of the preparation including the organoleptic test, homogeneity test, spreadability test, and pH test. Furthermore, the antibacterial effectiveness test was carried out by using the diffusion method. The results of evaluation test for cream preparations which included organoleptic tests with the results of three concentrations meeting the requirements, the homogeneity test and the dispersion test of the preparations, the results meet the specified conditions and the results of the pH test with the three concentrations of preparations that met the specified pH requirements. And it can inhibit the growth of Propionibacterium acnes bacteria with an inhibition zone of 7.5 mm at a concentration of 20%, 11 mm at a concentration of 30%, and 11.7 mm at a concentration of 40%. Antibacterial effectiveness test using positive control had an inhibition zone of 25.9 mm. The conclusion of this study is that the ethanol extract of jackfruit leaves can be formulated into anti-acne cream preparations.
Co-Authors Abadi, Hafizhatul Evi Ekayanti Ginting Ihsanul Hafiz Leny Leny Tetty Noverita Khairani Tri Sundari Vivi Eulis Diana Warnus Laia