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All Journal Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Communications in Science and Technology Chemistry Indonesian Journal of Chemical Research
Syaharuddin Kasim
Laboratorium Kimia Farmasi, Fakultas Farmasi, Universitas Hasanuddin, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology

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Hubungan Obesitas dan Hipertrigliseridemia dengan Risiko Perlemakan Hati pada Pasien di Makassar Kasim, Syaharuddin; Arief, Mansur; Sulaeman, Agus; Widodo, Joko
Indonesian Journal of Clinical Pharmacy Vol 1, No 4 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.406 KB)

Abstract

Perlemakan hati terjadi akibat lipolisis berlebihan dari jaringan lemak dan peningkatan suplai asam lemak bebas ke hati. Derajat keparahan perlemakan hati berkorelasi dengan peningkatan berat badan. Penelitian ini bertujuan untuk menemukan hubungan antara obesitas, trigliserida, obesitas dan hipertrigliseridemia terhadap risiko terjadinya perlemakan hati. Penelitian cross sectional menggunakan data retrospektif yang diambil dari pasien check up di Laboratorium Klinik Prodia Makassar selama tahun 2006. Diagnosis perlemakan hati melalui pemeriksaan ultrasonografi, obesitas ditentukan dari indeks massa tubuh, dan trigliserida diukur dengan metode enzimatik kolorimetri. Dari 204 pasien check up, 67 pasien (32,8%) mengalami perlemakan hati. Pada pasien dengan perlemakan hati sebanyak 95,5% mengalami obesitas, 67,2% hipertrigliseridemia, dan 32,8% trigliserida normal. Terdapat hubungan bermakna antara obesitas (risiko relatif (RR)=18,7; 95% C.I 5,6–62,4; p=0,001), obesitas disertai hipertrigliseridemia (RR=5,1; 95% C.I 2,7–9,5; p<0,001) dengan perlemakan hati. Didapatkan hubungan bermakna antara perlemakan hati dengan obesitas. Trigliserida tidak berhubungan langsung tetapi hipertrigliseridemia disertai obesitas berhubungan bermakna dengan kejadian perlemakan.Kata kunci: Obesitas, trigliserida, hipertrigliseridemia, perlemakan hati Relationship between Obesity and Hypertriglyceridemia on Fatty Liver in Patients at MakassarAbstractFatty liver is caused by a failure of normal hepatic fat metabolism due to a dysfunction of either within the hepatocytes. The degree of fatty liver is correlating to the increase of body weight. The aim of this study is to investigate any specific relationship between fatty liver and obesity as well as hypertriglyceridemia.This is a cross sectional study by using the retrospective data which is obtained from medical check up at Prodia clinical laboratory during 2006, fatty liver is diagnosed by using ultrasonography,obesity on body mass index (BMI), and triglyceride level by enzymatic colorimetric method.In 204 subjects of medical check up subjects were analyzed. Fatty liver has been found in 67 subjects (32.8%),95.5% of subjects with obesity, 32.8 subjects with normal triglyceride and 67.2% subjects with hypertriglyceridemia. There are significant relationship of obesity (relative risk(RR)=18.7; 95% C.I 5.6–62.4;p=0.001), obesity and hypertrigliseridemia (RR=5.1; 95% C.I 2.7–9.5; p<0.001) with fatty liver. Thereare a significant relationship of fatty liver and as well as obesity. Triglyceride is not contributing directlyto fatty liver but hypertriglyceridemia with obesity have significant relationship with fatty liver.Key words: Obesity, triglyceride, hypertriglyceridemia, fatty liver
Adsorption of Bismarck Brown R Dyes Using Mesoporous Silica MCM-48 Zakir, Muhammad; Nuraeni, Andi; Taba, Paulina; Wahab, Abdul Wahid; Dali, Seniwati; Kasim, Syaharuddin; Nafie, Nursiah La
Indonesian Journal of Chemical Research Vol 10 No 2 (2022): Edition for September 2022
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2022.10-muh

Abstract

The adsorption of Bismarck Brown R (BBR) dye has been conducted using mesoporous silica (MCM-48). We synthesized the adsorbent using Ludox HS-40 as a silica source and surfactants of Cetyl Trimethylammonium Bromide (CTAB) and Triton X-100. The characterization of MCM-48 was performed using Fourier transform infrared (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Various contact times were used to study the adsorption kinetics, and concentrations were used to study the adsorption isotherm. The optimum contact time of Bismarck Brown R dye was 120 minutes, and the adsorption followed a pseudo-second-order model. Based on the equation Langmuir and Freundlich adsorption isotherms, the adsorption capacity values of each are obtained 158.7301 mg g-1 and 4.3601 mg g-1. Our results showed that the material can be used as a new dye adsorbent.
Green synthesis of copper oxide (CuO) nanoparticles using Anredera cordifolia leaf extract and their antioxidant activity Munandar, Nurharis; Kasim, Syaharuddin; Arfah, Rugaiyah; Basir, Djabal Nur; Hala, Yusafir; Zakir, Muhammad; Natsir, Hasnah
Communications in Science and Technology Vol 7 No 2 (2022)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.7.2.2022.1004

Abstract

Our present study describes the green synthesis of copper oxide nanoparticles (CuONPs) using a leaf extract from Anredera cordifolia (AC). The presence of flavonoids, saponins, and alkaloids in the plant extract was confirmed by phytochemical analysis, and these chemicals can be used as reducing, stabilizing, and capping agents. UV-Vis Spectrophotometry, XRD, FT-IR, and SEM-EDS were used to characterize the CuONPs. The UV-Vis spectroscopy of the biosynthesized CuONPs revealed an absorption peak at 325 nm. The XRD graph also revealed that the Debye-Scherrer formula observed an average crystalline size of around 43.47 nm. EDS analysis confirmed the composition and purity of CuONPs. The presence of functional groups -OH, C=O, and C-O triggers the synthesis of CuONPs, according to FT-IR analysis. Furthermore, the CuONPs antioxidant property inhibited free radicals as antioxidants with an IC50 value of 34.20 g/mL.
Analisis Zerumbone Dalam Zingiber zerumbet Dan Aktivitas Penghambatannya Terhadap Bakteri Mycobacterium tuberculosis: Analysis of zerumbone in Zingiber zerumbet and inhibitory activity against Mycobacterium tuberculosis Lallo, Subehan; Kasim, Syaharuddin; Tayeb, Rosany; Hasan, Asril Damiyanto; Sere, Hartina; Ismail, Ismail; Arifin, Tamsil
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.802 KB) | DOI: 10.22487/j24428744.2018.v4.i2.11138

Abstract

Zerumbone has been reported for their several biological activities. In our interest to this compound, we have identified and analyzed its content in Zingiber zerumbet, a medicinal plant from Indonesian traditional medicine and investigated its inhibitory activity against Mycobacterium tuberculosis, a known infection bacteria of tuberculosis. Analysis of zerumbone was performed with densitometry to leave, rhizome, flower, and stem of Z. zerumbet which was extracted with various solvent system and extraction methods to determine the best method to isolate zerumbone from Z. zerumbet. Result showed that the highest zerumbone was in rhizome while was not observed in other part. Analysis with various solvent and extraction methods showed the highest yield of zerumbone can be extracted by n-hexane (maceration) and reflux extraction method (methanol). Furthermore, inhibitory activity of zerumbone against M. tuberculosis was tested using Lowenstein Jensen medium by counting the number of M. tuberculosis colony growth in medium. Resulted inhibitory activity of zerumbone at all test concentration (0.5, 0.1, 0.05, 0.01, 0.005%) with the growth of 10, 12, 14, 15, and 50 colonies of M. tuberculosis was observed, respectively. This is indicate that zerumbone can be used as an alternative choice for treatment tuberculosis in the future.
Co-Authors Abdul Wahid Wahab Agus Sulaeman Arfah, Rugaiyah Arief, Mansur Arifin, Tamsil Djabal Nur Basir Djoko Widodo Hasan, Asril Damiyanto Hasnah Natsir Ismail Ismail Lallo, Subehan Muhammad Zakir Munandar, Nurharis NURAENI, ANDI Nursiah La Nafie Paulina Taba Rosany Tayeb Seniwati Dali Sere, Hartina Yusafir Hala