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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research
Oea Khairsyaf
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Relationship Between D-Dimer, Albumin Levels, and Outcome of COVID-19 Patients at Dr. M. Djamil General Hospital, Padang Wahyudin, Hendris Utama Citra; Khairsyaf, Oea; Russilawati, Russilawati
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.128

Abstract

Background: Several studies have found an increase in D-dimer levels in patients who died from a severe clinical condition. COVID-19 exhibits multi-organ dysfunction through several markers, including decreased albumin levels. There were some studies that were interested in understanding how D-dimer and albumin levels relate to the outcomes of COVID-19 patients. The aim of this study was to investigate the relationship between D-dimer, albumin levels, and patient outcomes. Method: This was a cross-sectional study of all COVID-19 patients treated at Dr. M. Djamil General Hospital, Padang, from January 1st, 2021 to December 31st, 2021. Results: The majority of patients (40.71%) were in the group of 18 and 49 years old; more than half of the subjects (56.16%) were female; and obesity was the most common comorbidity (40.9%). The majority of the subjects (42.79%) had moderate clinical COVID-19. Higher D-dimer levels had a statistically significant independent relationship with unfavorable outcomes (P=0.0001). Lower albumin levels had a statistically significant independent relationship with unfavorable outcomes (P=0.0001). Higher D-dimer and lower albumin each contributed 12.6% to patient outcome. Increasing D-dimer levels per 1 ng/mL would increase the probability of an unfavorable outcome by 0.120 times, and on the other hand, increasing albumin levels per 1 g/dL would increase the probability of survival by 2.143 times. Conclusion: Higher D-dimer levels independently had a relationship with an unfavorable outcome. Higher albumin levels were independently related to a favorable outcome.
Association Between Ferritin Levels and Sepsis in Patients with COVID-19 at Dr. M. Djamil Hospital Asrini, Diana Nur; Khairsyaf, Oea; Afriani, Afriani
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.545

Abstract

Background: Ferritin is an important mediator of immunomodulatory dysregulation and pro-inflammatory effects, which contribute to cytokine storms that could lead to sepsis in a critically ill patients with COVID-19. The role of ferritin as a biomarker of sepsis in those patients is yet fully understood. The aim of this study is to investigate an association between ferritin levels and sepsis in patients with COVID-19.Method: This study was a retrospective, cross-sectional study of 474 COVID-19 hospitalized patients at Dr. M. Djamil Hospital, Padang.Result: Most of the COVID-19 patients in this study were between the ages of 18 and 49 (38,61%), female (55.91%), with moderate clinical illness (40.50%), and had one comorbidity (41,14%) with obesity as the most common comorbidity (37.97%). More than half of patients (54,22%) had ferritin levels of ≥500 ng/mL (median 1,201 ng/mL with a range of 503–12,010 ng/mL). The incidence of sepsis was significantly higher in the group whose ferritin level was ≥ 500 ng/ml compared to those with less ferritin level (P<0.001; OR=3.33; 5.99% vs 17.91%; CI 95%=1.74-6.36).Conclusion: There is a statistically significant association between the ferritin level and sepsis in patiens with COVID-19 at DR M Djamil Hospital.
Management of Extensive Subcutaneous Emphysema with Blow Hole Infraclavicular Incision and Continuous Suction Installation Junaidi, Katerine; Oea Khairsyaf; Russilawati Russilawati; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.914

Abstract

Background: Subcutaneous emphysema often occurs in cases of implanted pneumothorax chest tubes and must always be evaluated. Subcutaneous emphysema is a condition where air or gas is found in the tissue under the skin. Case presentation: A 49-year-old man was treated for sudden shortness of breath that occurred after a violent cough accompanied by pain and heaviness in the chest area 1 day before admission to the hospital. The patient had previously received anti-tuberculosis drug treatment for 6 months based on chest X-ray results in 2022, and the patient had undergone a rapid molecular test (TCM) examination, mycobacterium tuberculosis (Mtb), and obtained Mtb results not detected. Lung auscultation obtains sound intensity breath weakness until it disappears in both lung fields. Palpation of the skin revealed widespread crepitus on the face, neck, upper extremities, back, chest, and abdomen. The range of motion areas of the neck, shoulders, and hands are limited due to pain with movement. Evaluation of the chest tube obtained: the chest tube was installed in the anterior axillary line on the right at the level of the 5th intercostal space with number 10 attached to the chest wall and the chest tube well fixed to the chest wall. The end chest tube has been connected to the WSD bottle, and evaluation of the WSD shows that there are undulations and bubbles. Conclusion: The patient was admitted with spontaneous pneumothorax secondary to tuberculosis and was implanted with a chest tube.
One-Way Valve as Management of Chest Tube Ambulation in Pneumothorax Cases Junaidi, Katerine; Oea Khairsyaf; Fenty Anggrainy; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.915

Abstract

An adequate chest drainage system is the main goal of fluid and air evacuation and restoring negative pressure intrapleural so it can help lung development. The intrapleural is a closed, airtight space filled with a small amount of fluid as a lubricant for lung movement during the breathing process. Accumulation of intrapleural air is known as pneumothorax, and one of the initial management options is the implantation chest tube. Chest tubes, which are connected to a water seal, conventionally show varying results and have shortcomings because they require monitoring and limit patient mobility, so the safety of their use in outpatient settings is questionable. Lungs that are not inflated or have an inflated water seal still show air bubbles even though it has been installed. A chest tube adequate for 48 hours is a condition known as persistent air leak, thus requiring extended usage time from chest tube to the drainage management complex. Use of ambulation management through the use of various tools and equipment devices which can be connected with a chest tube can be an option with the aim of reducing treatment time, lowering funding, increasing comfort and hopefully providing better external results.
Bullous Lung Disease (BLD): A Narrative Literature Review Gibran, Muhamad Aqil; Oea Khairsyaf; Afriani Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.946

Abstract

Bullous lung disease (BLD) is often associated with spontaneous pneumothorax, but its role as a predisposing factor for recurrent pneumothorax is still not clearly revealed. Many factors are associated with lung BLD, but because BLD cases are still quite rare, efforts need to be made research further to find out more about the relationship between predisposing factors and BLD. Diagnosis of BLD by paying attention to the history, physical examination and appropriate radiological examination is necessary to determine whether surgery is necessary or not. Management of BLD has now developed with many different therapy options. The choice of invasive or non-invasive procedures is adjusted to clinical needs, equipment availability and medical personnel. Good treatment will of course provide satisfactory results, especially in terms of improving the patient's quality of life.
Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Empyema Thoracis: A Meta-Analysis of Clinical Outcomes Aldo Yulian; Oea Khairsyaf; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1166

Abstract

Background: Empyema thoracis is a severe pulmonary condition characterized by pus accumulation in the pleural space. Intrapleural fibrinolytic therapy is used adjunctively to break down loculations and facilitate lung re-expansion. This meta-analysis evaluated the efficacy and safety of this treatment in adults with empyema thoracis. Methods: A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials was conducted (January 2013 - December 2023) for randomized controlled trials (RCTs) comparing intrapleural fibrinolytics with placebo or no fibrinolytic therapy in adults with empyema. Primary outcomes were treatment success (radiographic improvement and/or clinical resolution), duration of hospital stay, and mortality. Secondary outcomes included major bleeding and bronchopleural fistula. Data were pooled using a random-effects model, and risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CI) were calculated. Results: Six RCTs (n=623 patients) met the inclusion criteria. Intrapleural fibrinolytic therapy showed a significantly higher treatment success rate than the control (RR 1.42, 95% CI 1.18-1.72, p=0.001) and significantly reduced hospital stay (MD -2.84 days, 95% CI -3.36 to -2.33, p<0.001). No significant difference in mortality was found (RR 0.95, 95% CI 0.46-1.93, p=0.93). The incidence of major bleeding and bronchopleural fistula was similar between the groups. Conclusion: Intrapleural fibrinolytic therapy significantly improves treatment success and reduces hospital stays without increasing mortality or major complications. These findings support its use as an adjunctive therapy for drainage in managing empyema thoracis in adults.
Co-Authors Adrifen Berti Akbar Afriani Afriani Afriani Afriani Aldo Yulian Anggraini, Fenty Arni Amir asrini, diana nur Dessy Mizarti Dian Pertiwi Dimas Bayu Firdaus Doppy Andika Eka Irawan Elly Usman Eva Chundrayetti Fenty Anggrainy Gibran, Muhamad Aqil Hadya Gorga Herman, Deddy Irvan Medison Isnaniyah Usman Julizar Julizar Junaidi, Katerine Khairudin Hamdani Masrul Basyar Muhammad Gamal Eddin R.A Ananda Nuriman Raisya Farah Monica Ricky Awal Russilawati, Russilawati Sari, Elsa Purnama Syandrez Prima Putra Vinda Dwi Apriora Wahyudin, Hendris Utama Citra Yessy Susanti Sabti