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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya CRJIM (Clinical and Research Journal in Internal Medicine) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Nelda Aprilia Salim
Divisi Penyakit Tropik Infeksi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Sriwijaya Palembang
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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A CASE REPORT OF MODERATE COVID-19 AND MALARIA FALCIPARUM CO-INFECTION WITH THROMBOCYTOPENIA Nelda Aprilia Salim; Harun Hudari; Mega Permata; Yenny Dian Andayani; Zen Ahmad; Verdiansah Verdiansah
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V8I3.13814

Abstract

The COVID-19 pandemic that attacks the world has made the attention of all medical personnel focused on this disease. The clinical picture is similar to other infectious diseases such as malaria, dengue, influenza, etc., which often leads to misdiagnosis. We report the case of a man, 31 years old, with a history of travel and complaints of high fever persisting for more than 7 days. On physical examination, the temperature was 39-40 C, others were within normal limits. Initial platelet count was 69 x 103/µL, leukocytes was 15.52 x 109/L, CRP was 96 mg/L. The blood smear found Plasmodium falciparum, and PCR SARS-CoV-2 was positive. Chest X-ray showed pneumonia. Dihydroartemisinin-piperaquine and primaquine therapies were administered for malaria, as well as favipiravir, azithromycin, and other symptomatic therapy for COVID-19. Platelets decreased to 38 x 103/µL while D-dimer level increased (> 20 mg/L). Anticoagulant was delayed. On monitoring after therapy, the platelets returned to normal, the D-dimer level decreased, and there was no bleeding. The co-infectious conditions of malaria and COVID-19 should be suspected in patients with suggestive symptoms and travel history from endemic areas, therefore both examinations should be performed. This co-infection has the potential to cause hyper inflammation and hypercoagulation and this is associated with a poor prognosis. Appropriate treatment is needed.
Risk Factors Associated with Long COVID Among Hospitalized Adults in Several Hospitals in Palembang City, Indonesia Hutapea, Hotma Martogi Lorensi; Sudaryo, Mondastri Korib; Parikesit, Arli Aditya; Miko Wahyono, Tri Yunis; Salim, Nelda Aprilia
Kesmas Vol. 20, No. 2
Publisher : UI Scholars Hub

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Abstract

Long COVID is characterized by one or more symptoms experienced by individuals prior to a COVID-19 infection that last for ≥2 months, and its risk factors remain unclear. This study aimed to identify risk factors associated with long COVID among patients admitted between June 1, 2020, and October 31, 2023, at three referral COVID-19 hospitals in Palembang City, Indonesia. This cohort study included adults who were admitted for ≥5 days. The participant’s medical records were reviewed for admission and discharge dates, sociodemographic and clinical characteristics, and vaccination and therapy status. A standardized and validated instrument was used to assess fatigue during admission, and a structured questionnaire was used to evaluate long COVID. Cox regression was employed to determine factors associated with long COVID. Among 256 patients, long COVID was identified in 39.1%. Fatigue during admission, chronic kidney disease, thrombocytosis, and positive RT-PCR test at hospital discharge increased the risk of long COVID, whereas being fully vaccinated decreased its risk. This study identifies five risk factors for long COVID and determines that fatigue during admission is the strongest.
Correlation Between Serum Testosterone Levels and CD4 T Lymphocyte Counts in Naive HIV-Infected Men at dr. Mohammad Hoesin General Hospital Palembang Fahrenheit, Fahrenheit; Kusnadi, Yulianto; Hudari, Harun; Bahar, Erial; Shahab, Alwi; Anggraini, Ratna Maila Dewi; Permata, Mega; Salim, Nelda Aprilia; Yuniza; Bakrie, Muhammad
Clinical and Research Journal in Internal Medicine Vol. 6 No. 2 (2025): Volume 6 No 2, November 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2025.006.02.07

Abstract

Background: HIV infection often leads to endocrine complications, including hypogonadism which characterized by low serum testosterone, potentially affects quality of life and contributes to metabolic issues, such as muscle weakness, depression, osteoporosis, and cardiovascular disease. Some studies have indicated a connection between testosterone levels and CD4 T lymphocyte counts.   Aim: To evaluate the correlation between total serum testosterone levels and CD4 T lymphocyte counts in naive HIV-infected men. Methods: A cross-sectional analitycal study was conducted at Dr. Mohammad Hoesin General Hospital, Palembang, from April to October 2024. Involving 64 naive HIV-infected men. Total serum testosterone and CD4 T cell counts were measured and analyzed. Results: Participants mean age is 36.52 ± 11.03 years with BMI of 19.52 ± 3.71 kg/m². Most subject (62.5%) are reported men who had sex with other men. Poor sleep quality was found in 81%, mild depressive symptoms in 38.1%, and mild erectile dysfunction in 28.6%. Hypogonadism occurred in 32.8% of subjects (28.1% secondary and 4.7% primary). Mean number of testosterone level was 446.75 ± 260.95 ng/dL, with a median CD4 count of 23.5 cells/µL. A significant positive correlation was observed between testosterone levels and CD4 counts (r = 0.313; p = 0.012) although testosterone levels did not significantly differ across HIV clinical stages (p = 0.464). Conclusion: There is a significant positive correlation between serum testosterone levels and CD4 T lymphocyte counts in naive HIV-infected men. Hormonal disturbances may arise in early infection. Hence, testosterone assessment is recommended during the initial evaluation on HIV patients.
Co-Authors Anggraini, Ratna Maila Dewi Arli Aditya Parikesit Bakrie, Muhammad Erial Bahar, Erial Fahrenheit, Fahrenheit Harun Hudari Hudari, Harun Hutapea, Hotma Martogi Lorensi Mega Permata Miko Wahyono, Tri Yunis Nur Riviati, Nur Permata, Mega Rizky Perdana Shahab, Alwi Sudaryo, Mondastri Korib Syarif Husin Verdiansah Verdiansah Widya Mandala Sari Gultom Yenny Dian Andayani Yulianto kusnadi Yuniza Zen Ahmad