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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian pendidikan, science, teknologi, dan ekonomi Jurnal Farmasi Indonesia
Armini Hadriyati
Stikes Harapan Ibu Jambi
Education Health Professions Medicine & Pharmacology Public Health

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Polypenol Content Test, Antioxidant Activity Test and Sunblock Protection Test of Pinang Peels Yulianis S.Farm, M.Farm, Apt; Armini Hadriyati; Mukhlis Sanuddin; Nofa Putriani; Indah Sagita Cahyani; Eka Fitriani
Jurnal Ipteks Terapan Vol 14, No 2 (2020): JIT
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jit.2020.v14i2.5010

Abstract

Areca nut skin contains phenolic compounds which have antioxidant and sunscreen activities. This study aims to determine the levels of polyphenols, antioxidant activity and sunscreen contained in the extract and fraction of areca nut (Areca catechu L.) skin. Testing levels of polyphenols using Folin-Ciocalteau reagents, testing of antioxidants using the DPPH method with a comparison of vitamin C, and on sunscreen testing using the UV-Vis spectrophotometry method by calculating the SPF value. The results of this study indicate that the fraction of n-Butanol has higher polyphenol levels compared to extracts and other fractions with polyphenol levels of 13.88974%. In antioxidant testing it was found that the n-hexane fraction had very strong antioxidant activity with an IC50 value of 40.848 mg / ml. In the sunscreen activity test, it was found that the highest SPF value was at a concentration of 300 ppm, in the thick ethanol extract, n-hexane fraction, ethyl acetate fraction, n-Butanol fraction, and residual water fraction. The highest sunscreen activity of SPF value is the ethyl acetate fraction that is 24.79. From the results of the study it can be concluded that the skin of betel nuts has antioxidant activity, sunscreen, and polyphenol levels.
Uji Aktivitas Antibakteri Staphylococcus Aureus Dan Escherichia Coli Terhadap Senyawa Sintesis Difeniltin (IV) Metil Ditiokarbamat Mukhlis Sanuddin; Armini Hadriyati; Indah Permata Sari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 1 (2022): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i1.7030

Abstract

ABSTRAKSenyawa organotimah (IV) ditiokarbamat ini telah banyak digunakan dalam bidang farmasi dan kedokteran dan digunakan sebagai antibakteri, atikanker. dan sebagai antijamur. Senyawa. ini berhasil disintesis. dengan tujuan untuk mencari gambaran struktur. dan aktivitas antibakteri terhadap bakteri Staphylococcus aureus dan  Escherichia coli. Senyawa ini disintesis dengan metode in situ yaitu dengan penambahan metil amina (0.02 mol) + karbon disulfida (0.02 mol) + logam difeniltin (IV) diklorida (0.01 mol), dan menghasilkan serbuk sebanyak 1.9 g dilakukan identifikasi menggunakan FTIR, 1H NMR, dan 13C NMR. Pengujian aktivitas antibakteri dilakukan dengan metode difusi kertas cakram dan menggunakan media NA (Nutrient Agar). Hasil penelitian dari senyawa sintesis menggunakan FTIR diperoleh gugus (C-N), (C-S), (C=N), (C=C), (C-H). Hasil pengukuran dari 1H NMR diperoleh δ 2,34 (CH3) dan δ 7.29 – 8,32 (aromatik). Hasil 13C NMR diperoleh δ 11.17 – 20.32 (CH3), δ 128.12 – 142.71 (C aromatik) dan δ 51.03 – 57.39 (CH2), dan hasil pengujian aktivitas antibakteri dengan konsentrasi 90 ppm dapat dikategorikan sangat kuat dalam aktivitas antibakteri. .Kesimpulan senyawa ini berhasil disintesis dan dikarakterisasi dengan gambaran struktur dan senyawa kompleks ini mempunyai aktivitas sebagai agen antibakteri. dengan kategori sangat kuat. Kata kunci : Antibakteri; FTIR; NMR; Organotimah (IV) ditiokarbamat.ABSTRACTThis organotin (IV) dithiocarbamate compound has been widely used in the pharmaceutical and medical fields and is used as an anticancer, antibacterial and antifungal. This compound was successfully synthesized with the aim of finding an overview of the structure and antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. This compound was synthesized by the in situ method by adding methyl amine (0.02 mol) + carbon disulfide (0.02 mol) + metal diphenyltin (IV) dichloride (0.01 mol), and producing a powder of 1.9 g was identified using FTIR, 1H NMR, and 13C NMR. Antibacterial activity testing was carried out using the paper disc diffusion method and using NA (Nutrient Agar) media. The results of the research of synthetic compounds using FTIR obtained groups (C-N), (C-S), (C=N), (C=C), (C-H). The measurement results of 1H NMR obtained 2.34 (CH3) and 7.29 – 8.32 (aromatic). The results of 13C NMR obtained 11.17 – 20.32 (CH3), 128.12 – 142.71 (C aromatic) and 51.03 – 57.39 (CH2), and the results of antibacterial activity test with a concentration of 90 ppm can be categorized as very strong in antibacterial activity. In conclusion, this compound was succesfully synthesized and caracterized by its structure description and this complex compound has activity as an antibacterial agent with a very strong category.Keywords : Antibacterial; FTIR; NMR; Organotimah (IV) ditiocarbamate.
Potensi Interaksi Obat Antihiperlipidemia Pada Pasien Stroke Iskemik Rawat Inap Di RS X Kabupaten Indragiri Hilir Tahun 2022 Nursyifa; Armini Hadriyati; Yuliandani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.196

Abstract

Abstract: Ischemic stroke is caused by a blockage or blood clot that occurs in the brain. Stroke has various risk factors and complications that cause patients to receive many medications (polypharmacy). Polypharmacy can increase the potential for drug interactions that can harm patients. One of the treatment options for ischemic stroke is antihyperlipidemic therapy. Antihyperlipidemia statin group is the first choice of treatment of hyperlipidemia. The purpose of this study was to determine the types of antihyperlipidemic drugs, types of comorbidities, types of mechanisms and severity in stroke patients receiving antihyperlipidemic therapy at X Hospital, Indragiri Hilir Regency in 2022. Data were collected retrospectively in the form of 57 medical records of ischemic stroke patients with therapy inpatient antihyperlipidemia. Data analysis was carried out descriptively. Based on the results of the study it was concluded that the potential for drug interactions occurred in 87 (26.69%) cases that experienced interactions and 239 cases (73.31%) did not experience drug interactions. Based on the type of interaction, there were 84 pharmacokinetic interactions (96.55%) and pharmacodynamic mechanisms in 3 cases (3.45%). Based on the strength of the interaction, major interactions were found in 15 (17.24%) cases, moderate severity in 71 (81.61%) cases, and minor severity in 1 (1.15%) cases. Based on the interacting drugs, there were 3 most, namely atorvastatin with amlodipine 27 cases (31,03%), atorvastatin with clopidogrel 16 cases (18,40%), and simvastatin with amlodipine 15 cases (17,24%). For the statistical analysis of the chi square test, there was a significant relationship between severity and the number of drugs p=0.004, severity and age p=0.003, and there was no significant relationship between severity and comorbidities p=0.236. Keywords: Antihyperlipidemia, Drug Interactions, Ischemic Stroke
Co-Authors Eka Fitriani Indah Permata Sari Indah Sagita Cahyani Nofa Putriani Nursyifa Sanuddin, Mukhlis Yuliandani Yulianis Yulianis