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Nanotechnology in Metformin Delivery: Fasting Blood Glucose and Neutrophil-Lymphocyte Ratio of Diabetic Rat Model David Pakaya; Laurents Christovel Iban Demen; Haerani Harun; Sarifuddin Anwar; Gabriella Bamba Ratih Lintin
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.13358

Abstract

Diabetes Mellitus (DM) is a chronic inflammatory disease characterized by hyperglycemia and increasing the neutrophil-lymphocyte ratio (NLR). Metformin has been widely used to treat hyperglycemia. Metformin nanoparticles can improve bioavailability and may reduce inflammation. This study aims to analyze the effectiveness of metformin nanoparticles delivery through fasting blood glucose (FGB) level and NLR in the diabetic rat model. This study used 16 white male Wistar rats, 8 weeks of age, and body weight (BW) 250-350 grams. The streptozotocin (STZ) 40 mg/kg BW were injected i.p. Rats were divided into 4 groups; K1: normal control; K2: negative control (diabetes model); K3: diabetes model treated with metformin 100mg/Kg BW; K4: diabetes model treated with nanoparticle metformin 100mg/kg BW. Blood analysis tests were conducted using the Pentra hematology analyzer. Data were analyzed using the Graphpad Prism program with the nonparametric Kruskal Wallis test. The K3 group showed a periodical decrease in FBG level from day 7 to day 28 by 122 ± 11.31 mg/dL, and the mean NLR value was 0.48 ± 0.3 x 103/uL. Group of K4 periodically decreased in FBG level, indicating that it was closer to normal than K3. The result showed that at day 28.79 ± 15.39 mg/dL, the mean NLR value slightly increased compared to the K3 group by 0.54 ± 0.3 x103/uL. The statistical tests showed a significant difference between the level of FBG (p 0.0089) but no significant difference in NLR (p 0.347). Metformin nanoparticles could decrease FBG levels and effectively reduce the NLR in the diabetic rat model.
Analisis Faktor Risiko Tingginya kasus Tuberkulosis Paru di Indonesia : Literatur Revieu M. Sabir; Sarifuddin
Jurnal Kolaboratif Sains Vol. 6 No. 6: JUNI 2023
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v6i6.3662

Abstract

Pendahuluan : Penyakit Tuberkulosis Paru disebabkan oleh Mycobacterium tuberculosis masih menjadi masalah Kesehatan dan diduga banyak faktor yang menjadi pencetus sehingga kasus tersebut masih sangat tinggi di Indonesia. Tujuan : Tujuan kajian literatur ini adalah untuk menganalisis faktor risiko yang mempengaruhi tingginya kasus tuberkulosis Paru. Hasil : Hasil pencarian dengan menggunakan database yang berkaitan dengan kata kunci, selanjutnya di lakukan proses skrining, analisis jurnal, dan eliminasi. Diperoleh 15 jurnal yang dikategori layak digunakan sebagai sampel dalam penelitian ini. Kesimpulan : Faktor risiko penyebab terbanyak tingginya kasus TB paru yakni riwayat merokok aktif dan pasif, riwayat kontak dengan pasien TB, riwayat pengobatan pasien TB, Status gizi (kurang), Pengetahuan tentang TB, dan pendapatan rendah.
Understanding Rural Perspectives and Practices of Health in Banggai Laut, Indonesia M. Sabir; Muh. Ardi Munir; Tri Setyawati; Muhammad Nasir; Ary Anggara; Ressy Dwiyanti; Rosa Dwi Wahyuni; Rahma; Vera Diana Towidjojo; Sarifuddin; Aristo; Mochammad Hatta
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 5 No. 3: July 2023
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v5i3.3734

Abstract

Health is always an important value for human beings and the most fundamental condition of life. Health is perceived differently influenced by many factors including education, experience, knowledge, culture, and environment. The study aimed to explore community perception of health, including causes of diseases, and choices of help for health problems in rural setting in Central Sulawesi, Indonesia. The study is a qualitative ethnography with several data collection methods including semi structured in-depth interviews, small group discussion, informal conversations, photography, and direct observation. Study location was in Bangkurung sub-district. The study found that health is perceived as a power, energy, normal physiology of human body, and ability to work normally. Participants understood and believed that health is influenced by many factors including environment, food, lifestyle, social interaction and the rise of megycism, traditionally prohibited behaviors, religious belief, mind, and workload. Community members commonly used both medical treatment and traditional healing methods.