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All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Gizi Klinik Indonesia

Johan Kurnianda

Division Of Hematology And Medical Oncology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Gadjah Mada / Dr. Sardjito Hospital Yogyakarta

Author-ID : 301448

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Risk Factors of anemia in head and neck cancer patients undergoing chemotherapy with high-dose cisplatin Kurnianda, Johan; Wiyadi, Nugroho; Wulaningsih, Wahyu
Medical Journal of Indonesia Vol 17, No 4 (2008): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Cisplatin is well-known for its effectiveness against cancer, as well as its toxicity to human tissues. Of several documented side effects, anemia was reported to have significant association with decreased quality of life. This study was conducted to investigate development of cisplatin-induced anemia, and to identify independent factors contributing to anemia. Clinical data from head and neck cancer patients treated with high-dose cisplatin between December 2002 and December 2005 were obtained in this study. Incidence and risk factors of anemia were assessed in a model including age, sex, baseline hemoglobin level, baseline creatinine clearance, and occurrence of distant metastases. Multivariate logistic regression was used to define independent predictors of anemia. Among 86 eligible patients, 26 (30.2%) developed anemia, defined as Hb level lower than 11 g/dL. Age > 55 years old (RR = 2.2, 95% CI, 1.2-4.0), female sex (RR = 2.0, 95% CI, 1.2-3.8), baseline Hb â¤ 13 g/dL (RR = 4.2, 95% CI, 1.9-9.4) and baseline CrCl < 50 mL/min (RR = 2.9, 95% CI, 1.7-5.1) were significantly correlated with incidence of anemia (P < 0.05). In multivariate analysis, baseline Hb and baseline CrCl were identified as independent risk factors for anemia. However, considerable confounding was observed in baseline CrCl after stratified by age (aRR = 2.2, 95% CI, 1.1-4.7). Thus, baseline Hb level was the strongest predictor of anemia. The findings suggested that baseline Hb and CrCl were useful to recognize cisplatin-treated patients at risk for anemia who might benefits from preventive measures. (Med J Indones 2008; 17: 248-54)Keywords: anemia, cisplatin, chemotherapy, hemoglobin, creatinine clearance

Morphological characteristics of leukemia cells in acute myeloblastic leukemia with t(8;21)(q22;q22): possible predictability of t(8;21) Purwanto, Ibnu; Tatsumi, Eiji; Syampurnawati, Meilani; Furuta, Kaho; Hayashi, Yoshitaka; Saigo, Katsuyasu; Masuda, Kayoko; Sakoda, Hiroyuki; Kawano, Seiji; Kumagai, Shunichi; Nagai, Ken-Ichi; Takahashi, Takayuki; Isono, Setsuki; Kondo, Shin-Ichi; Kurnianda, Johan; Haryana, Sofia M.
Medical Journal of Indonesia Vol 16, No 2 (2007): April-June
Publisher : Faculty of Medicine Universitas Indonesia

The laboratory systems for chromosomal analysis or the detection of fusion genes are generally not available in Indonesia. Therefore, bone marrow (BM) morphological analysis should be developed and applied to get an accurate diagnosis. In this study the BM smears of eight (8) cases of acute myeloblastic leukemia (AML) which had already been known to have t(8;21)(q22;q22), were morphologically evaluated in order to find out the characteristics, which might be used to predict t(8;21)(q22;q22) or the presence of AML1-ETO(MTG8) fusion gene. All of the cases belonged to AML-M2. The morphological characteristics, indicative of t(8;21) were pink colored cytoplasm in mature neutrophil (75%), neutrophilic myelocytes or metamyelocytes without granules or with scarce granules (2.3%), eosinophilia (eosinophilic myelocytes and metamyelocytes) (above 5%), myelocytes with abundant granules 8.5%, and low percentage of type I blasts (below 10%). These characteristics were not observed in AML-M2 cases without t(8;21) or AML1-ETO(MTG8). The myelocytes with abundant granules have not been described so far, while other characteristics were in line with the findings of Nakamura et al (Leukemia 1997;11:651-55). (Med J Indones 2007; 16:84-8)Keywords: PML-RARA fusion gene, AML1-ETO (MTG8), myelocytes, abundant granul

Non secretory multiple myeloma â a case report Taroeno-Hariadi, Kartika W.; Purwanto, Ibnu; Kurnianda, Johan; Mangunsudirjo, Sagiri; Harijadi, A.; Puntodewo, Puntodewo
Medical Journal of Indonesia Vol 16, No 4 (2007): October-December
Publisher : Faculty of Medicine Universitas Indonesia

A rare variant of multiple mieloma, non-secretory multiple myeloma (NSM), is reported. Diagnosis of NSM is made by presentations of lytic bone lesions with bone pain, anemia, slight hypercalcemia, good renal function, negative results of protein and immunoelectrophoresis detecting monoclonal gammopathy, and positive clonal proliferation of plasma cells and atypical plasma cells in bone marrow biopsy. Immunophenotypic study resulted negative pan-B cell antigens and positive CD 79a. Patient condition was improved after institution of combination chemotherapy and 1 year afterward. (Med J Indones 2007; 16:257-60)Keywords: multiple myeloma, non-secretory multiple myeloma, diagnosis, management

Co-Authors A. Harijadi Agus Siswanto Astuti, Herni David Dwi Putera Diah Ari Safitri Dwi Rohmawati Dwi Wulansih Eiji Tatsumi Ganda Hidayat Herni Astuti Hiroyuki Sakoda I Dewa Putu Pramantara I Dewa Putu Pramantara I Ketut Suada I Wayan Dwija Karyasa Ibnu Purwanto Jamhari Jamhari Jarir At Thobari Kaho Furuta Kartika W. Taroeno-Hariadi Kartika Widayati Taroeno Hariadi Karyasa, I Wayan Dwija Katsuyasu Saigo Kayoko Masuda Ken-Ichi Nagai Mardiah Suci Hardianti Meilani Syampurnawati Muhammad Ihsan Qomaruzzaman Nina Mulyani Noor Asyiqah Sofia Nugroho Wiyadi Prafita Cahya Dewanti Puntodewo Puntodewo Qomaruzzaman, Muhammad Ihsan Sagiri Mangunsudirjo Seiji Kawano Selvyana, Dita Ria Setsuki Isono Shin-Ichi Kondo Shunichi Kumagai Sofia M. Haryana Sukendro Sendjaja Susetyowati Syahru Agung Setiawan Takayuki Takahashi Teguh Triyono Wahyu Wulaningsih Yenita . Yenita Yenita Yoshitaka Hayashi

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