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All Journal Jurnal Ilmu Kimia Universitas Brawijaya Pharmacon PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Kesehatan Rustida Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Jurnal Ilmiah Farmasi Akademi Farmasi Jember Ensiklopedia Research and Community Service Review Dedication : Jurnal Pengabdian Masyarakat
Diyan Ajeng Rossetyowati
Akademi Farmasi Jember
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AKTIVITAS PROTEASE DAN PROFIL PROTEIN PADA HEPAR TIKUS PUTIH (RATTUS NORVEGICUS) PASCA INDUKSI CYLOSPORINE-A Diyan, Ajeng; Aulanni'am, aulanni'am; Sutrisno, sutrisno
Jurnal Ilmu Kimia Universitas Brawijaya Vol 1, No 1 (2013)
Publisher : Jurusan Kimia, FMIPA Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (83.314 KB)

Abstract

Cyclosporine-A (CsA) adalah imunosupresan yang disintesis dari jamur Tolypocladium inflatum GamsIII. CsA secara luas digunakan dalam pengobatan penyakit autoimun. Namun, secara klinis dan eksperimental penggunaan CsA dibatasi oleh beberapa efek, salah satunya hepatotoksisitas.Pada penelitian ini digunakan hewan coba tikus putih jantan dengan pemberian dosis CsA  yaitu 3 mg/kg berat badan tikus. Hasil penelitian menunjukkan peningkatan aktivitas protease sebesar 40,3%  dengan aktivitas protease berturut-turut 0.163 ± 0.0015 dan 0.273 ± 0.0018 µmol/mL.menit untuk tikus kontrol dan pasca  induksi CsA. Sedangkan untuk hasil profil pita protein didapatkan perbedaan pita protein sebanyak 3 buah dengan adanya 2 pita protein baru pada BM secara berurut-turut sekitar 54.4 dan 99.8 kDa, serta adanya 1 pita protein yang hilang pada 79 kDa.Kata kunci: Cylosporine-A, aktivitas protease, profil protein
Kajian Penggunaan Antibiotik pada Pasien Meningitis dan Ensefalitis Bakteri di Bangsal Rawat Inap Rumah Sakit Rujukan Utama Diyan Ajeng Rossetyowati; Ika Puspitasari; Tri Murti Andayani; Titik Nuryastuti
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.16861

Abstract

Inadequate antibiotic therapy for meningitis and bacterial encephalitis is one of the factors that can jeopardize patient safety and turn into a public health issue in a number of nations, including Indonesia. This phenomena has the potential to raise health-care expenses, which should be avoided in the era of the JKN program's implementation. The goal of this research was to describe the profile of antibiotic use and cost in hospitalized meningitis and bacterial encephalitis patients. This cross-sectional observational study took place from January to December 2019. As study materials, patient medical records and billing data were employed. To enhance the data obtained, confirmation with medical and pharmaceutical personnel is required. Antibiotic use and expenditures were described using descriptive analysis. A total of 71 patients, both children and adults, met the study's inclusion criteria. Antibiotics were given to all of the patients, and the results revealed that third generation cephalosporins (49.375%) were the most commonly recommended antibiotic class, either alone or in combination. Antibiotic use receives 46.94% of total medication funding. According to the length of stay category, the majority of patients (45.99 %) were hospitalized for 8-14 days consecutively with antibiotic medication. Antibiotics, which are typically administered to patients with meningitis and bacterial encephalitis, had no effect on the length of stay in the hospital. Antibiotic prescriptions must be carefully reviewed at top referrel hospital, taking into account the local germ map.
Profil Tingkat Pengetahuan Penderita Kusta tentang Penyakit Kusta di Puskesmas Kemuningsari Kidul Kabupaten Jember Rosida Rosida; Siti Anawafi; Fanny Rizki; Diyan Ajeng Retnowati
Jurnal Ilmiah Kesehatan Rustida Vol 2 No 1 (2015): Juli
Publisher : Akademi Kesehatan Rustida

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89.364 KB)

Abstract

Penyakit kusta merupakan penyakit menular yang dapat menimbulkan masalah yang sangat kompleks, terutama dalam anggota keluarga yang sering terpapar secara kontak langsung dan terus menerus. Di Puskesmas Kemuningsari Kidul hasil pendataan penderita kusta 3 tahun terakhir yaitu tahun 2010 tercatat 15 orang, tahun 2011 tercatat 16 orang, dan pada tahun 2012 sebanyak 18 orang.Tujuan penelitian ini untuk mengetahui Tingkat Pengetahuan Penderita Kusta tentang Penyakit Kusta di Puskesmas Kemuningsari Kidul Kabupaten Jember. Jenis penelitian menggunakan deskriptif. Populasi pada penelitian ini Penderita Kusta yang aktif di Puskesmas Kemuningsari Kidul Kabupaten Jember sebanyak 30 orang dengan menggunakan teknik sampling total sampling. Alat ukur penelitian menggunakan kuesioner.Data yang diperoleh selanjutnya dianalisis didapatkan hasil penelitian pengetahuan penderita kusta tentang penyakit kusta menunjukkan prosentase terbesar berpengetahuan kurang atau 93% sedangkan prosentase terkecil berpengetahuan cukup atau 7%.
Effective Empiric Antimicrobial Therapy of Bacterial Meningitis and Encephalitis Diyan Ajeng Rossetyowati; Ika Puspita Sari; Tri Murti Andayani; Titik Nuryastuti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.13257

Abstract

Bacterial meningitis-encephalitis (ME) management therapy is critical to appropriately manage clinical outcomes. This study aims to provide recommendations on appropriate empiric antimicrobial to support the healing period and reduce the risk of disease severity. A cross-sectional study, including inpatients without comorbid diagnosed with bacterial ME, was conducted, and records of antimicrobial prescriptions were obtained. Sociodemographic, clinical (diagnostic), and pharmacological (antimicrobial) variables were assessed. Through multivariate analysis, variables associated with the use of antimicrobials for bacterial infections were identified. A total of 45 patients with ME. The patients, who were from surrounding Center Java and Yogyakarta, had a mean age of 11.27 ± 16.93 years and a male predominance of 56.9% (n = 23). The most frequent bacterial infections were caused by: S. haemolyticus and S. epidermidis (25.93%). A total of 100% the patients (n = 45) received a prescription for empiric antibiotics, predominantly 3rd generation cephalosporin e.c ceftriaxone (35.56%) and cefotaxime (13.33%). Empiric antimicrobials are frequently prescribed for the first management of bacterial ME, are considered an inappropriate practice due to a lack of clinical benefits, increased generation of antimicrobial resistance, and risk of adverse reactions due to the use of medications that patients do not require. Drug utilization studies are a great tool for monitoring how antimicrobial is being used and planning interventions to improve their use.
HUBUNGAN DUKUNGAN KELUARGA DENGAN TINGKAT KEPATUHAN PASIEN HEMODIALISA TERHADAP TERAPI GAGAL GINJAL DI RSUD BLAMBANGAN BANYUWANGI Diyan Ajeng, Dessy
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2016: April - Vol.1 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.798 KB) | DOI: 10.53864/jifakfar.v1i1.7

Abstract

Chronic Renal Failure (CRF) is a chronic disorder of renal function is progressive and irreversible. In which the body fails to maintain metabolic and fluid and electrolyte balance, causing uremia and could eventually cause a disruption in the body's immune system. According Raharjo (1996) and Lopez (2006), the estimated number of patients with chronic renal failure continues to increase and the estimated growth of about 10% every year.This research design was a descriptive cross sectional study. Have done a study of 55 patients with chronic renal failure who had been treated at the Hospital Medicine at Blambangan, Banyuwangi in 2014 patient data information obtained from the patient visit checklist. This study was to determine the relationship of family support with chronic renal failure patient adherence to therapy in poly Haemodialysis Haemodialysis in hospital Blambangan, Banyuwangi in 2014.Research was obtained as many as 15 people (27.28%) patients with chronic renal failure aged 25-30 years, and 17 (30.9%) aged 41-50 years with a self-employed job and most of the heavy labor. Researchers hope that the hospitals can provide direction Blambangan Banyuwangi, in-depth knowledge about chronic kidney disease to patients and families of patients so that the family can fully support patient compliance in taking medication and undergoing therapy in a timely and appropriate.From the research, it was concluded that 9.1% of patients not adherent and 90.9% patient compliance with the treatment given by the hospitals Blambangan Banyuwangi.Keywords: Chronic Renal Failure, Hemodialysis, Family Support
POTENSI EKSTRAK ETANOL KULIT BUAH PISANG (Musa acuminata Colla) SEBAGAI OBAT LUKA BAKAR TERHADAP TIKUS GALUR WISTAR PENDERITA DIABETES Rosida, Sri Winarsih, Diyan Ajeng R.
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2016: Desember - Vol.1 No.2
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.746 KB) | DOI: 10.53864/jifakfar.v1i2.13

Abstract

Kulit buah pisang merupakan salah satu bahan alami yang dapat digunakan dalam proses penyembuhan luka bakar. Hal ini disebabkan adanya kandungan flavonoid yang memiliki aktivitas antioksidan sehingga dapat mempercepat fase inflamasi dan meningkatkan sintesis kolagen. Tujuan dari penelitian ini membuktikan ekstrak etanol kulit buah pisang (Musa acuminata Colla) dalam proses penyembuhan luka bakar pada tikus galur wistar penderita diabetes. Metode penelitian menggunakan desain pre and post control group. Sebanyak enam belas ekor tikus dibagi menjadi 4 kelompok perlakuan. Kelompok I (kontrol negatif) diberi basis, kelompok II, III dan IV (kelompok perlakuan) diberi ekstrak etanol kulit buah pisang dengan dosis 25%, 50% dan 75%. Sebelum dibuat model luka bakar, tikus diinduksi aloksan dengan dosis 150 mg/kg BB selama tiga hari. Tikus yang digunakan sebagai model luka bakar adalah tikus dengan kadar gula darah diatas 200 mg/dL. Model luas luka bakar sebesar 225 mm2. Pemberian ekstrak kulit buah pisang secara topikal dilakukan tiap hari selama 16 hari. Pengukuran luas luka diamati pada hari ke 4, 8, 12 dan 16. Hasil penelitian menunjukkan bahwa ekstrak kulit buah pisang (Musa acuminata Colla) berpotensi sebagai obat luka bakar pada tikus putih penderita diabetes (p 0,05).Kata Kunci : Musa acuminata, Luka bakar, Diabetes
THE LEVEL OF MOTHER'S KNOWLEDGE IN HANDLING FEVER IN CHILDREN IN SUCI VILLAGE, PANTI JEMBER SUB-DISTRICT Amaliyah Nurul Hidayah; Alfira Septia Wahyuni; Diyan Ajeng Rossetyowati
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 1 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.106 KB) | DOI: 10.53864/jifakfar.v4i1.43

Abstract

Fever is a condition often found in toddlers. Fever is a condition when the body temperature is above normal temperature (36-37ºC). The general objective of the study was to describe the level of knowledge of mothers in handling fever in children under five years old in Suci village, Panti Jember district. The research used a descriptive design. Samples were taken by random samplingand obtained 81 mothers who have toddlers. This research instrument uses a questionnaire. The results showed that the level of mother's knowledge in handling fever in toddlers in the realm of know was 86%, in the realm of understand was 76%, and in the realm of application was 75%. It can be concluded that the level of mother's knowledge in handling fever in toddlers in Suci village, Panti Jember sub-district in the realm of know and in the realm of understand was a good criterion, and in the realm of application was a fairly good criterion.\Keywords: toddlers, fever, mother's knowledge level
PENENTUAN AKTIVITAS ANTIOKSIDAN DAN KADAR FENOL TOTAL PADA EKSTRAK KULIT BUAH PISANG (Musa acuminata Colla) Rosida, Diyan Ajeng RA
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Juli - Vol.2 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.329 KB) | DOI: 10.53864/jifakfar.v2i1.20

Abstract

Antioksidan merupakan senyawa yang mampu menghambat oksidasi molekul lain. Tubuh tidak mempunyai sistem pertahanan antioksidatif yang berlebihan, sehingga tubuh membutuhkan antioksidan eksogen. Kekhawatiran terhadap efek samping antioksidan sintetik menjadikan antioksidan alami menjadi alternatif yang dipilih. Flavonoid merupakan senyawa fenolat (hidroksil fenolik) yang mampu bertindak sebagai antioksidan dan umumnya terdapat pada tanaman. Salah satu limbah tanaman yang mempunyai kandungan flavonoid adalah kulit buah pisang (Musa acuminata). Tujuan dari penelitian ini adalah untuk menetapkan kadar flavonoid total dan melakukan pengujian aktivitas antioksidan kulit buah pisang menggunakan diphenyl picryl hydrazil hydrate (DPPH) sebagai radikal bebas. Metode ekstraksi yang digunakan adalah remaserasi dengan pelarut etanol 96%. Penetapan kadar flavonoid total menggunakan katekin sebagai standar dan pengujian DPPH menggunakan metode spetrofotometri. Hasil penelitian menunjukkan kandungan flavonoid total ekstrak etanol kulit buah pisang sebesar 0,79 ± 0,03 %b/b, aktivitas antioksidan tertinggi dalam IC50 terhadap DPPH sebesar 70,41 mg/L.Kata Kunci : kulit buah pisang, flavonoid total, aktivitas antioksidan, IC50
Edukasi Bahan Pangan Lokal Murah Dan Sehat Untuk Balita Dan Ibu Hamil Beresiko Tinggi Di Desa Slateng Ledokombo Jember Dyan Maulani; Diyan Ajeng Rossetyowati; Siti Nur Azizah; Amaliyah Nurul Hidayah
Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Vol 6, No 2 (2023): Jurnal Abdimas Berdaya
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jab.v6i2.484

Abstract

Kasus stunting di Kabupaten Jember mencapai 23%, kematian ibu hamil dan ibu nifas juga mengalami peningkatan dari tahun 2017-2021 terutama pada kelompok umur 20-34 tahun. Kegiatan pengabdian kepada masyarakat (PkM) adalah penyuluhan mengenai peningkatan status gizi balita dan ibu hamil. Metode pelaksanaan PkM untuk mendapatkan hasil yang direncanakan ada 4 (empat) yaitu (1) penyuluhan kepada ibu hamil dan ibu yang memiliki balita (2) pengukuran pengetahuan ibu hamil dan ibu yang memiliki balita tentang stunting sebelum dan sesudah dilaksanakan penyuluhan, (3) pembagian bahan pangan pokok untuk ibu hamil terindikasi kurang energi kronis (KEK) dan balita terindikasi stunting, (4) pelatihan memasak olahan bahan pangan lokal yang praktis dan sehat. Pengetahuan peserta menjadi meningkat setelah peserta memperoleh materi dari hasil penilaian pretes dan postes yaitu 77,53% menjadi 86,48%.
PENGETAHUAN MASYARAKAT TENTANG BEYOND USE DATE (BUD) PADA PENGGUNAAN OBAT TETES MATA Rossetyowati, Diyan Ajeng; Nurmalasari, Dewi Riskha; Rohma, Tamara Aisa
Ensiklopedia Research and Community Service Review Vol 4, No 1 (2024): Vol. 4 No. 1 Oktober 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/err.v4i1.3019

Abstract

Eye drops are sterile preparations in the form of solutions or suspensions used by dripping on the mucous membranes and eyelids. Eye drops should not used more than one month after the lid is opened.  Beyond Use Date (BUD) is the time limit for the use of a medicinal product after it has been compounded or prepared or after its primary packaging has been opened or tampered with. This study aimed to determine the description of public knowledge about Beyond Use Date (BUD) in eye drops. This is a descriptive quantitative study. Sample collected by non probability with consecutive sampling method. There are 66 respondents from Gebang Poreng, Jember, who had met the inclusion criteria. Data was obtained by distributing questionnaires filled out by the respondents. Based on the results of the study it can be concluded the respondent's knowledge is included in fewer categories with a percentage is 54,88%.Keywords: Eye drops, Beyond Use Date
Co-Authors A.A. Ketut Agung Cahyawan W Alfira Septia Wahyuni Aulanni'am, Aulanni'am Azizah , Siti Nur Dewi Riskha Nurmalasari Dyan Maulani Fanny Rizki Hadi Barru Hakam Fajar Siddiq IKA PUSPITA SARI Ika Puspitasari Rohma, Tamara Aisa rosida hari Siti Anawafi Siti Nur Azizah Titik Nuryastuti Tri Murti Andayani