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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan EduChemia: Jurnal Kimia dan Pendidikan Jurnal Pendidikan Kimia Universitas Riau JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Farmasi Higea Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi Jurnal Sains dan Kesehatan Journal of Pharmascience
Havizur Rahman
Jurusan Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Jambi, Jambi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Invitro: Evaluasi Aktifitas Peluruhan Batu Ginjal Ekstrak Daun Kemangi (Ocimum Basilicum) Menggunakan Spektrofotometer Serapan Atom: Invitro: Evaluation of Anticalculi Activity with Kemangi Leaf Extract (Ocimum Basilicum) Using Atomic Absorption Spectrophotometer Meliza Harianja; Havizur Rahman; Sri Wigati
Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i3.359

Abstract

A kidney stone is a disease that is quite often found in the community. Kidney stone disease is characterized by the formation of small stones due to precipitation in the urine. This stone can clog urethra and cause pain. The most common kidney stone content is calcium oxalate. Kemangi (Ocimum basilicum) contains several secondary metabolites such as flavonoids, saponins, phenols, and tannins. The content of secondary metabolites is thought to shed kidney stone. This study aims to reveal other properties of kemangi plant as anticalculi. Method: The stages in this study consisted of making kemangi leaf ethanol extract, extract characterization, phytochemical extract screening, kidney stone calcium making, and kidney stone calcium decay test stage. Testing the effect of the destruction of kidney stone is carried out in vitro by testing the rate of decay of kidney stone calcium components in various concentrations of ethanol extracts of kemangi leaf in physiological NaCl. Kidney stone calcium decay was analyzed by atomic absorption spectrophotometer (ASS). Data were analyzed with one-way ANOVA and continued with the LSD test. Results: ethanol extract of kemangi leaf at a concentration of 600 ? x ?1600 ppm could shed kidney stone calcium significantly greater than negative controls. Conclusion: the kemangi leaf ethanol extract has potential as the destruction of kidney stone.
Uji Preklinik: Aktivitas Penyembuhan Luka Bakar Ekstrak Air Daun Singkong (Manihot esculenta) Havizur Rahman; Raudhatul Jannah; Elisma Elisma; Fathnur Sani
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13707

Abstract

Daun singkong (Manihot esculenta) merupakan tanaman yang sering digunakan masyarakat untuk mengobati luka bakar, luka bernanah, atau luka baru. Daun singkong mengandung metabolit sekunder yang beraktivitas sebagai antiinflamasi, antioksidan dan antibakteri. Kuersetin merupakan salah satu senyawa golongan flavonoid yang banyak terkandung pada daun singkong yang memiliki kemampuan menghambat radikal bebas. Antioksidan dari senyawa kuersetin mampu memicu kolagen dan peningkatan vaskular endothelia growth factor (VEGF), sebagai parameter kesembuhan luka bakar. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas penyembuhan luka bakar dari ekstrak daun singkong. Penelitian ini merupakan penelitian eksperimental menggunakan metode rancangan acak lengkap (RAL) yang terdiri dari 5 kelompok perlakuan: kontrol positif (Bioplacenton®), kontrol negatif (vaselin flavum), dan ekstrak air daun singkong dengan konsentrasi 2,5%, 5% serta 7,5%. Hasil pengukuran diameter kesembuhan luka bakar menunjukkan adanya aktivitas penyembuhan luka dengan perbedaan yang nyata (p < 0,05) pada tiap perlakuan terhadap kontrol negatif. Konsentrasi terbaik terdapat pada konsentrasi 7,5% dengan presentase kesembuhan 82,18% dan diikuti dengan konsentrasi 5% serta 2,5%. Berdasarkan hal tersebut dapat disimpulkan bahwa ekstrak daun singkong telah menunjukan aktivitas penyembuhan luka bakar pada konsentrasi terendah yaitu 2,5%. Kata Kunci: Ekstrak Air, Daun Singkong, AUC, Penyembuhan Luka Bakar Cassava leaf (Manihot esculenta) is a plant that is often used by the community to treat burns, festering wounds or new wounds. Cassava leaves contain compounds of alkaloids, flavonoids, tannins, phenolics and saponins which act as anti-inflammatory, antioxidant and antibacterial. Quercetin is one of the flavonoid groups contained in cassava leaves which has the ability to inhibit free radicals. Antioxidants from quercetin compounds are able to trigger collagen and increase vascularity endothelia growth factor as a burn wound healing parameter. The purpose of this study was to determine the burn healing activity of cassava leaf extract. This study was an experimental study using a completely randomized design (CRD) method consisting of 5 treatment groups: positive control (Bioplacenton), negative control (vaseline flavum) and water extract of cassava leaves with a concentration of 2.5%, 5%, 7.5 %. Based on the results of measuring the diameter of the burn wound healing  showed a significant difference in each treatment given to the negative control, which indicated the presence of wound healing activity in each treatment. The best concentration is 7.5% with a cure percentage of 82.18%. Followed by a concentration of 5% and 2.5%. It can be concluded that cassava leaf extract has shown burn healing activity at the lowest concentration of 2.5%. 
Co-Authors Arina Widya Murni Dika Zamri Yanni Dika Zamri Yanni Dyah Ayu Mulya Patmasari Elisma Elisma Elisma Elisma Faizar Farid Fitrianingsih Fitrianingsih Helmi Arifin Ilmavia Wilantika Intan Lestari Madyawati Latief Meliza Harianja Mia Prajuwita Mia Prajuwita Putri Maya Sari Putri Maya Sari Putri Maya Sari Raudhatul Jannah Sani K, Fathnur Shindi Amanda Rizki Sholeha Annisa Martines Sri Wigati syamsurizal syamsurizal Teresia Anggi Octavia Uce Lestari