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PENGARUH OLAHRAGA ANGKAT BEBAN TERHADAP TEKANAN INTRAOKULER Aldwin Arwidyardi Sukahar; Maharani Maharani; Riski Prihatningtias
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 6, No 3 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang: Tekanan intraokuler (TIO) akan meningkat dengan signifikan pada saat melakukan angkat beban. Pada saat mengangkat beban terjadi efek menahan nafas seperti pada valsava manuver sehingga terjadi peningkatan TIO. Maka peneliti ingin mengetahui pengaruh olahraga angkat beban terhadap TIO. Tujuan : Mengetahui pengaruh olahraga angkat beban terhadap TIO. Metode : Observasional analitk dengan pemilihan sampel consecutive sampling. Sampel dalam penelitian ini sejumlah 34 orang. Setiap sampel sebelum melakukan olahraga angkat beban ditetesi obat tetes mata anestesi lokal Panthocain hydrochloride 0,5 %. Sampel penelitian melakukan angkat beban sebanyak 4 set dan setiap setnya nya pengukuran TIO masing masing sampel diukur menggunakan tonopen – xl setelah selesai set ke 4 ditetesi obat tetes mata gentamisin 0,3 %. Penelitian ini dianalisis uji t beda berpasangan , setelah menentukan uji normalitas data dan mendapatkan hasil distribusi yang tidak normal,maka menggunakan ujiWilcoxon. Hasil : Perbandingan antara pre set dengan set ke 1, set ke 2, dan set ke 3 didapatkan tidak bermakna ( P > 0,05) sedangkan perbandingan antara pre set dengan set ke 4 didpatkan bermakna (p < 0,05).Simpulan : TIO dapat menurun setelah melakukan olahraga angkat beban

Clinical Spectrum of Neuritis Optic Patients Receiving Intravenous Corticosteroid Treatments in Doctor Kariadi Hospital Semarang Gadis Sativa; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 47 No 2 (2021): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v47i2.100303

Introduction and Objective: Optic neuritis is inflammation of the optic nerve leading to sudden loss of vision that takes place over several hours or days. Corticosteroids have been widely used in the treatment of optic neuritis due to their anti-inflammatory effects. This study aimed to retrospectively review cases of optic neuritis that have been the administration of intravenous corticosteroid treatment on visual acuity. Methods: The authors conducted a retrospective study of patients who underwent 3 days of intravenous corticosteroid therapy for neuritis optic from January 2018 to December 2018 in Kariadi Hospital. The data collected included patient demographics, onset, clinical examinations, and visual acuity. Result: The authors included 22 eyes from 16 patients who received intravenous corticosteroid treatment for 3 consecutive days during the study period. The study found a mean age of 32,91±9,32 years (18-49 years). The mean onset was 2,36±3,07 months (0,1-12 months). Ten eyes (45,5%) had positive RAPD and five eyes (22,7%) had ocular movement pain. Thirteen patients (59,1%) had papil edema in funduscopy examination. Fourteen eyes (63,6%) had visual acuity at or below 6/60 at the time of presentation. The mean visual acuity at the time of presentation was 2,45±1,79 LogMar units (Range 0,2-5,0 LogMar units). After three days of intravenous corticosteroid treatment, the mean visual acuity was 1,81±1,42 LogMar units (Range 0,1-5,0 LogMar units). The visual acuity before and after treatment were analyzed using the Wilcoxon test and gave p=0,004 as result. Conclusion: Treatment of intravenous corticosteroid commonly gave a better visual acuity on neuritis optic patients. There are no significant differences of onset and clinical examinations in intravenous corticosteroid treatment visual outcome.

MILLER FISHER SYNDROME: A RARE BENIGN VARIANT OF GUILLAIN- BARRE SYNDROME: Poster Presentation - Case Report - General practitioner Ayu Anggraini Kusumaningrum; Zahira Rikiandraswida; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/14dt6n54

Abstract Introduction : Guillain-Barré Syndrome (GBS) is a broad category of syndromes that includes several types of acute immune-mediated polyneuropathy. Miller Fisher Syndrome (MFS) is a scarce variant of GBS (1-2:1,000,000) that presents at least 2 of ataxia, areflexia, and ophthalmoplegia. Case Illustration : A 32 years-old-man came to JEC-Candi with ophthalmic discomfort and exhibited a week onset of total ophthalmoplegia, ptosis, diplopia, and lagophthalmos. Two weeks backward, the patient had a respiratory infection then emerged symmetrical sensory abnormalities (glove-and-stocking-type pinprick sensations in distal extremities). Neurological examinations were performed, and the patient got multiple cranial nerve weaknesses (oculomotor, trochlear, abducens, trigeminal, and facial) both in motoric and sensory, ataxia (positive Romberg sign, stepping test, gait, shallow-knee- bend), and negative pathologic reflexes. Hematology showed leukocytosis, MRI and CT-Scan were normal. Pulse therapy was given (Methylprednisolone 1g/day) for three days, neuroprotector and artificial tears added. Ataxia and diplopia improved, then the patient was referred to Kariadi Hospital for five-times plasmapheresis that involved neurologist and internist. Ophthalmoplegia improved slowly, and lagophthalmos disappeared one month after hospital admission. Discussion : GBS subvariant could overlap; this case presents bifacial weakness with paresthesia and MFS. Viral infection precedes neurological symptoms in most cases, with an average of 10 days of the incubation period. Ataxia, diplopia, and ophthalmoplegia may confuse the physician and presume an upper motor neuron sign or central cause. Steroid and plasmapheresis evince meaningful upturn. Conclusion : This rare disease requires a multidisciplinary approach to cure and diagnose. Nonetheless, MFS has a good prognosis. Appropriate treatment selection will enhance patients' quality of life.

OPTICAL COHERENCE TOMOGRAPHY PREDICTS VISUAL RECOVERY OF PATIENTS WITH PITUITARY ADENOMA FOLLOWING SURGERY IN DR KARIADI HOSPITAL SEMARANG: Oral Presentation - Observational Study - Resident GALUH YULIETA NITIHAPSARI; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/knksb410

Abstract Introduction & Objectives : The characteristics, symptoms, and clinical manifestations of pituitary adenoma in Indonesia have not been widely studied. In 26 patients undergoing pituitary surgery at Dr. Kariadi Hospital, we compared visual acuity pre-surgery and post-surgery from normal and thin optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell layer-internal plexiform layer (GCL-IPL). Methods : A retrospective study from medical record from Januari 2020 to December 2022 was done. 21 of the 26 patients had surgery by the transsphenoidal route and the rest by craniotomy. All patients had macroadenoma (tumor size >1cm) and histologically confirmed. Visual acuity before and after surgery was evaluated along with patient’s OCT value. Results : The thinner pre-surgery RNFL thickness was associated with worse visual acuity (VA). Patients with normal RNFL had a median VA of 20/200 while those with thin RNFL had to count their fingers (CF). The patients with normal pre-surgery RNFL had a significant improvement in median VA after surgery, from 20/200 to 20/32 (p=0.022), whereas the patients with thin RNFL did not improve (CF to CF, p=0.026). The patients with normal pre-surgery GCL-IPL had non-significant improvement in median VA after surgery from CF to 20/20 (p=0.505), also the patients with thin GCL-IPL from CF to 20/200 (p=0.151). Conclusion : Based on this study, the visual recovery after pituitary adenoma surgery is likely to be predicted by pre-surgery OCT RNFL. Patients with normal RNFL thickness show an increase propensity in visual recovery after surgery.

COENZYME Q10 EFFECT ON NMDA RECEPTOR EXPRESSION AND RETINAL GANGLION CELL DENSITY (Experimental Study in Traumatic Optic Neuropathy Model of Wistar Rat) FRANSISKA BANJARNAHOR; RISKI PRIHATNINGTIAS; TRILAKSANA NUGROHO; HERMAWAN ISTIADI
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1s6kza05

Abstract Introduction & Objectives : Traumatic optic neuropathy is a visual disturbance condition after acute injury to optic nerve. This injury results in retinal ganglion cells ischemic leading to excitotoxicity and apoptosis. Coenzyme Q10 (CoQ10) is an antioxidant and cofactor in electron transport within mitochondria that inhibits glutamate excitotoxicity and thereby preventing retinal ganglion cell apoptosis. This research aims to prove the effect of coenzyme Q10 on NMDA receptor expression and retinal ganglion cell density in rat model of traumatic optic neuropathy. Methods : This study use post-test only randomized controlled groups design. Traumatic optic neuropathy wistar rats model was made by optic nerve crushed method, then given oral CoQ10 100mg/kgBW after 1 hour for 14 days in treatment group. Retinal histopathological specimen was made with immunohistochemistry and Haematoxyllin-eosin staining and examined under microscope with 400x magnification. Data was verified and statistically analyzed. Results : The NMDA receptor expression in the treatment group was significantly lower than control (p=0.009). The retinal ganglion cell density in the treatment group was significantly higher than control (p=0.009). There was a significant correlation between NMDA receptor expression and retinal ganglion cell density in the treatment group (p = 0.012) with a strong negative correlation direction (r = - 0.652). Conclusion : Administration of CoQ10 in traumatic optic neuropathy model rats affects NMDA receptor expression and retinal ganglion cell density. NMDA receptor expression was lower with higher retinal ganglion cell density in the treatment group. NMDA receptor expression was inversely proportional to retinal ganglion cell density in the treatment group.

Comparative Validity of LEA Contrast Sensitivity Chart to Pelli-Robson Contrast Sensitivity Chart in Neuroophthalmology Patients: Oral Presentation - Observational Study - Resident Lovenia Valencia; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/m0amyh19

Abstract Introduction & Objectives : The Pelli-Robson and LEA contrast sensitivity chart are widely used to measure clinical contrast sensitivity. The Pelli-Robson is a gold standard with the limitation of its bulky size. The LEA contrast sensitivity chart offers a reliable test in a way more practical and portable chart. This condition led to a question of whether we can predict Pelli-Robson score based on the LEA score. This study developed a conversion method to facilitate the transition from the LEA to the Pelli-Robson and validating the conversion score. Methods : This study retrospectively examined the relationship between LEA and Pelli-Robson Contrast Sensitivity Test. There were 120 eyes included in this study. We produced a conversion table using the equipercentile equating method. Then, we evaluated the reliability and accuracy of this algorithm to convert the LEA to the Pelli-Robson contrast sensitivity score. Results : LEA scores were converted to Pelli-Robson scores according to a conversion table that achieved a reliability of 0.91 based on intraclass correlation. The accuracy of this algorithm was 81.6% within 1 point difference from the raw score. Conclusion : This study reported a reliable and comparable conversion algorithm for transforming LEA scores into converted estimated Pelli-Robson scores. This method will enhance the utility of existing data in clinical and research settings.

EFFECT OF ORAL CURCUMIN ADMINISTRATION ON NMDA RECEPTOR EXPRESSION AND RETINAL GANGLION CELL DENSITY: Oral Presentation - Experimental Study - Ophthalmologist SALMAH ALAYDRUS; RISKI PRIHATNINGTIAS; ARNILA NOVITASARI; HERMAWAN ISTIADI
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/ck9gj262

Abstract Introduction & Objectives : To prove the effect of oral curcumin on NMDA receptor expression and retinal ganglion cell density. Methods : Wistar rats model of traumatic optic neuropathy were divided into 2 groups. The treatment group was given oral curcumin 150mg/kgBW/24 hours for 14 days 1 hour after trauma. NMDA receptor expression was examined by IHC staining and retinal ganglion cell density was examined by HE staining. Data were collected and analyzed. Results : NMDA expression was found to be significantly lower in the treatment group compared to the control group (p = 0.046). The mean of ganglion density in the control and treatment group was 12.88 ± 2.44 and 17.92 ± 6.95, respectively. The treatment group had a significantly higher ganglion density (p = 0.043). There was a significant relationship between NMDA receptor expression and retinal ganglion density (p = 0.043, r = -0.591). Conclusion : Curcumin can suppress the expression of NMDA receptors to maintain retinal ganglion density in rat models of optic neuropathy

EFFECT OF TOPICAL BRIMONIDINE ON NMDA RECEPTOR EXPRESSION AND RETINA GANGLION CELL DENSITY IN TRAUMATIC OPTIC NEUROPATHY RATS MODEL: Oral Presentation - Experimental Study - Resident RR. WIDYASTUTI PASPARINI; Riski Prihatningtias; Arief Wildan; Hermawan Istiadi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/bz09ta84

Abstract Introduction & Objectives : Traumatic optic neuropathy is a visual disturbance caused by acute injury to the optic nerve which results in retinal ganglion cell apoptosis through the glutamate excitotoxicity pathway. Brimonidine is an alpha 2-receptor agonist that acts as a neuroprotector in the glutamate excitotoxicity pathway and causes modulation of NMDA receptors associated with glutamate. Objective of this study is to prove the effect of topical brimonidine on NMDA receptor expression and retinal ganglion cell density in a rat model of traumatic optic neuropathy Methods : Rat models of traumatic optic neuropathy was carried out using the optic nerve crush method. The treatment group was given topical brimonidine 0.15% 1 drop/12 hours for 14 days. NMDA receptor expression was assessed by immunohistochemical staining and retinal ganglion cell density was assessed by Hematoxylin-eosin staining. Statistical analysis was performed to assess the correlation between NMDA receptor expression and retinal ganglion cell density Results : The Allred score of NMDA receptors expression in the treatment group was lower than control group, with significant difference (p=0.002). The mean density of retinal ganglion cells in the treatment and control group was 20,99  7,76 and 12,51  3,10, respectively with a significant difference (p=0.032). There was a significant correlation between NMDA receptor expression and retinal ganglion cell density in the treatment group (p=0.035) with strong negative correlation (r= -0.611) Conclusion : Topical administration of brimonidine to the Wistar rat model of traumatic optic neuropathy can suppress NMDA receptor expression and maintain retinal cell ganglion density

ANALYSIS OF OCT-A PERFORMED AMONG NAION PATIENTS VERSUS OTHER CAUSES Usamah Haidar; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 51 No 1 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i1.101499

Introduction: Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) is the type of optic neuropathy with crowding structural of microcirculation on optic nerve head. The vascular factor has the role on its pathophysiology. The aim of this study to analyse OCT-A among NAION patients compared to patients of papil atrophy with other causes. Methods: A retrospective case control study held from medical record of patients. Two group diagnosis of NAION and papil atrophy due to other causes who performed OCT-A in Dr. Kariadi Hospital Semarang. The analysis of the study including vessel perfusion density (VPD) and flux index (FI) among two groups. The bivariate analysis is using Independent-T test. Results: Totally 40 patients consisted of 20 NAION (12 bilateral eyes) and 20 papil atrophy with other causes (15 bilateral eyes). Age over 50 years old were 19 NAION (95%) and 17 other causes (85%). The results found there is statistically significant difference between VPD among NAION and other causes in average, superior, and nasal (p value <0.05, respectively 0.008, 0.008, 0.030), but there is no significant difference between FI among NAION and other causes both average, inferior, superior, nasal, and temporal (p value > 0.05). Mean VPD both average, inferior, superior, nasal and temporal in NAION were lower than other causes (respectively 39,98±3,69, 38,57±6,01, 36,77±5,25, 40,78±4,06, 43,91±3,42). Conclusion: This study found there is statistically significant difference between VPD among NAION and other causes in average, superior, and nasal. VPD in NAION were lower compared to other causes.

VISUAL OUTCOME OF TRAUMATIC OPTIC NEUROPATHYAFTER STEROID TREATMENT IN KARIADI HOSPITAL Roosdhantia, Isnia Rahmi; Riski Prihatningtias
Majalah Oftalmologi Indonesia Vol 50 No 1 (2024): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1hn23p60

Introduction: The occurrence of Traumatic Optic Neuropathy (TON) often occurs in the form of head injuries resulting from traffic accidents. TON is an important cause of impaired visual function which may be improved with steroid therapy. Objective: To determine the visual outcome in patients with TON treated with steroids in Kariadi Hospital, Semarang Methods: This research was a retrospective study. Thirty patients (20 males and 10 females) with TON in ophthalmology clinic, Kariadi Hospital Semarang between Januari 2019 and December 2020. Visual acuity, contrast sensitivity and color blindness test were included data from medical record. Steroid therapy were divided into 3 groups. Intraveous steroid injection alone, intravenous steroid followed with oral steroid, and oral steroid alone. The Wilcoxon and paired-t test as comparison test of pre-post therapy in one group and friedman test as comparison test in 3 groups. Results: There were 5 cases that received intravenous steroid, 18 cases received intravenous steroid with oral steroid, and 7 cases received oral steroid. There were difference visual acuity in intravenous steroid with oral steroid (p = 0.001), visual acuity in oral steroid (p = 0.017), and color blindness test in intravenous steroid with oral steroid in pre-post therapy groups (p = 0.036). There were no difference in visual acuity, color blindness test, and contrast sensitivity between pre-post therapy groups when compared between 3 groups (p= 0.692, p =0.368, p=0.273). Conclusion: Patients with TON had better visual outcome after treated with intravenous steroid followed with oral steroid.

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