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All Journal Biology, Medicine, & Natural Product Chemistry IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)
Elfita Elfita
Sriwijaya University
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Medicine & Pharmacology Public Health

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Triacylglycerols produced by biomass of endophytic fungus Neopestalotiopsis surinamensis from the Scurrula atropurpurea Elfita Elfita; Muharni Muharni; Mardiyanto Mardiyanto; Fitrya Fitrya; Elisa Nurmawati; Hary Widjajanti
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 5, No 3 (2020): October 2020
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v5.i3.95

Abstract

In Indonesia, Scurrula atropurpurea is a medicinal plant known as benalu. Triacylglycerols can be produced by plants, animals, algae, and microorganisms such as endophytic fungi. Triacylglycerols can be used in cosmetics, food, and medicine because they have biological activities such as antitumor, antibacterial, and cytotoxic. Besides, the compound can be used as a biodiesel substitute for triacylglycerols sourced from oil palm. This study aims to isolate and characterize triacylglycerol from biomass of endophytic fungal N. surinamensis from the S. atropurpurea  leaves. The compound was isolated and purified by the column chromatography method. The structure of the compound was determined by spectroscopic data ( FTIR, 1H-NMR, and 13C-NMR). Analysis of the spectrum and compared with the literature, the isolated compound is a triacylglycerol.
Phytochemical Profiling and Cytotoxic Evaluation of Marasi (Curculigo latifolia) Leaf Extract and Fractions Against MCF-7 Breast Cancer Cells Nanda Lia Putri Sari; Salni Salni; Elfita Elfita; Laila Hanum; Elisa Nurnawati
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.1725-1735

Abstract

Breast cancer has the highest incidence among women in Indonesia. The exploration of natural products as sources of selective anticancer agents with minimal side effects continues to attract considerable attention. Marasi (Curculigo latifolia) is reported to contain secondary metabolites with potential antiproliferative properties. This study aimed to perform phytochemical profiling using thin-layer chromatography (TLC) and liquid chromatography–mass spectrometry (LC–MS), as well as to evaluate the cytotoxic activity of C. latifolia leaf extracts and fractions against MCF-7 breast cancer cells. TLC analysis indicated that the leaf extract of C. latifolia and its fractions comprise diverse secondary metabolites, such as phenolics, terpenoids, flavonoids, and tannins. Meanwhile, LC–MS profiling demonstrated that nitrogen-bearing heterocyclic compounds predominate, particularly triazine derivatives, tetrazoles, and benzothiazoles. Cytotoxicity assessment demonstrated that the extracts and fractions displayed low inhibitory activity against MCF-7 cells, with the strongest effect observed at an IC50 value of 234.8782 ppm, which remains above the accepted threshold for significant cytotoxic activity. Although the activity against MCF-7 cells was limited, further investigation involving other cancer models and isolation of active constituents is necessary to better understand and potentially enhance the biological activity of C. latifolia leaf.
Co-Authors Elisa Nurnawati Elisa Nurnawati Fitrya Fitrya Hary Widjajanti Laila Hanum Mardiyanto Mardiyanto Muharni Muharni Nanda Lia Putri Sari Salni Salni