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The activity of polyclonal IgY derived from Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in inhibiting colonization of Fusobacterium nucleatum and Streptococcus sanguinis Oktaviani Suci Lestari; Rini Devijanti Ridwan; Tuti Kusumaningsih; S. Sidarningsih
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 2 (2019): June 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Fusobacterium nucleatum (F. nucleatum) and Streptococcus sanguinis (S. sanguinis) play a role in dental plaque formation which leads to periodontitis. Immunoglobulin Y (IgY) is present in both serum and egg yolk and can bind to the surface components of bacteria. F. nucleatum and S. sanguinis feature the same type of IV pili as Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans). Saliva binding protein (SsaB) in S. sanguinis is a FimA homolog. FimA constitutes a surface element of Porphyromonas gingivalis (P. gingivalis). F. nucleatum and P. gingivalis possess the same outer membrane protein (OMP) molecular mass. Purpose: The study aimed to determine the activity of A. actinomycetemcomitans and P. gingivalis polyclonal IgY present in serum and egg yolk that can inhibit colonization of F. nucleatum and S. sanguinis. Methods: IgY samples were diluted with phosphate buffer saline (PBS). Several holes were made in the nutrient medium with 10 μl antigen (F. nucleatum/S. sanguinis) being inserted into the center hole. 10 μl PBS, 1:1, 1:2, 1:4, 1:8, 1:16 A. actinomycetemcomitans or P. gingivalis polyclonal IgY were subsequently introduced into the surrounding holes. The results of incubation at 37°C were observed after 24-48 hours. Kruskal Wallis and MannWhitney tests were administered to analyse the data. Results: A. actinomycetemcomitans and P. gingivalis polyclonal IgY groups in serum showed a precipitation line at dilution ratios of 1:1 and 1:2, whereas in egg yolk this occurred only at a 1:1 dilution ratio with F. nucleatum and S. sanguinis bacteria in this study. No significant differences were evident between each dilution (p>0.05) and none existed between serum and egg yolk (p>0.05). Conclusion: IgY polyclonal of A. actinomycetemcomitans and P. gingivalis in both serum and egg yolk initiate activities that can inhibit colonization of F. nucleatum and S. sanguinis.

Exercise as a method to reduce the risk of oral cancer: A narrative review Anis Irmawati; Lia Aulia Rachma; S. Sidarningsih; Muhammad Naufal Hatta; Ira Arundina; Mohammed Aljunaid
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 1 (2022): March 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i1.p56-61

Background: Cancer is a major cause of death worldwide. One of the most common forms of cancer is oral cancer, which can occur due to exposure to carcinogenic factors, such as tobacco cigarettes, alcohol, betel-nut chewing, ultraviolet rays or human papillomavirus infection. Physical exercise is known to have many benefits and can contribute to reducing the risk of cancer, minimising the side-effects of treatment and increasing the curative effect of cancer treatment. Purpose: This study aimed to explain the role of exercise as a method to reduce oral cancer risk. Reviews: Studies examining the impact of exercise on reducing oral cancer risk are currently limited due to a lack of research on this subject. However, according to several laboratory experimental research studies on Mus musculus test subjects, moderate-intensity exercise contributes to suppressing the proliferation and development of oral squamous epithelial cells, which can subsequently become cancer cells. Exercise can also increase intracellular proteins that can induce apoptosis in cells (e.g. wild protein p53, the ratio of Bax/Bcl-2, and caspase-3), and can also decrease p53 mutant expression and transformed cells that can trigger cancer. Exercise must be optimally performed to prevent or control cancer symptoms, although the exact duration and intensity of exercise required to reduce cancer risk in humans have not been established. Conclusion: Exercise plays a role in reducing oral cancer risk by inducing apoptosis and preventing the development of transformed cells that can lead to developing cancer.

INOVASI PEMBUATAN HAND SANITIZER UNTUK MENINGKATKAN PERILAKU HIDUP BERSIH DAN SEHAT BAGI KOMUNITAS DI BONDOWOSO Rini Devijanti Ridwan; Tuti Kusumaningsih; Indeswati Diyatri; Sidarningsih Sidarningsih
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 5 No. 2 (2021): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v5i2.2021.287-291

AbstractClean and Healthy Living Behaviors as known as PHBS are all health behaviors that are carried out with awareness, so that family members or families can help themselves in the health sector and play an active role in health activities in the community. One of the activities that can be carried out to achieve PHBS is washing hands using soap (hand rub / hand wash) or cleaning fluid (hand sanitizer). About 98% of the spread of microorganisms in the body comes from our own hands. Maintaining hand hygiene is an effort to avoid various diseases. The benefits of washing hands are very large, washing hands using soap / hand rub or using a hand sanitizer only takes 20 seconds but is very useful for killing microorganisms, namely bacteria, fungi, and viruses. One way to combat the new corona virus or COVID-19, which has become a pandemic at this time, is to always maintain hand hygiene. With the pandemic, the price of hand sanitizers has skyrocketed because the need has increased sharply. When used too often, alcohol as the main ingredient of hand sanitizers, besides being able to irritate the skin, it can also lift natural oils on the hands and tend to be drier, so herbal ingredients are needed as natural ingredients to reduce the side effects of these hand sanitizers. This community service activity was carried out in collaboration with communities in the Bondowoso district, namely the KAPAS Community in Sumbergading Village, Sumberwringin District and the TSS Community in Sukosari Lor Village, Sukosari District. In the Bondowoso area, there are many youth communities with various activities aimed at advancing people's lives and improving the socio-economy in the region. Various plants can be found in the area, including aloe vera and betel leaf.Keywords : Health, hand wash, hand sanitizer, aloe vera, betel leafAbstrakPerilaku Hidup Bersih dan Sehat (PHBS) merupakan semua perilaku kesehatan yang dilakukan atas kesadaran, sehingga anggota keluarga atau keluarga dapat menolong dirinya sendiri di bidang kesehatan dan berperan aktif dalam kegiatan kesehatan di masyarakat. Salah satu kegiatan yang dapat dilakukan guna tercapainya PHBS adalah mencuci tangan menggunakan sabun (hand rub/hand wash) atau cairan pembersih (hand sanitaizer). Sekitar 98% penyebaran mikroorganisme di tubuh bersumber dari tangan kita sendiri. Menjaga kebersihan tangan salah satu upaya terhindar dari berbagai penyakit. Manfaat mencuci tangan sangat besar, mencuci tangan memakai sabun/hand rub atau menggunakan hand sanitizer hanya membutuhkan waktu 20 detik namun sangat berguna untuk membunuh mikroorganisme, yaitu bakteri, jamur dan virus. Salah satu cara untuk memerangi virus korona baru atau COVID-19 yang telah menjadi pandemi saat ini adalah dengan selalu menjaga kebersihan tangan. Masa pandemi ini mengakibatkan harga hand sanitizer melambung tinggi karena kebutuhan meningkat tajam. Alkohol sebagai bahan utama dari hand sanitizer bila terlalu sering digunakan, selain dapat membuat kulit iritasi juga dapat mengangkat minyak alami pada tangan dan cenderung jadi lebih kering, sehingga diperlukan bahan herbal sebagai bahan alami untuk mengurangi efek samping dari hand sanitizer tersebut. Pada kegiatan pengmas ini dilakukan kerjasama dengan komunitas di wilayah kabupaten Bondowoso yaitu Komunitas KAPAS di Desa Sumbergading Kecamatan Sumberwringin dan komunitas TSS Desa Sukosari Lor Kecamatan Sukosari. Di wilayah Bondowoso banyak didapatkan komunitas anak muda dengan beragam kegiatan yang bertujuan memajukan kehidupan masyarakat dan meningkatkan sosial ekonomi di wilayah tersebut. Beragam tanaman dapat dijumpai di wilayah tersebut, diantaranya aloe vera dan sirih.Kata kunci: Kesehatan, cuci tangan, hand sanitizer, aloe vera, daun sirih

PELATIHAN DAN PENYULUHAN MANFAAT CIPLUKAN BAGI KESEHATAN DAN BUDIDAYANYA DI KECAMATAN SUMBERWRINGIN DAN KECAMATAN MAESAN KABUPATEN BONDOWOSO Tuti Kusumaningsih; Rini Devijanti Ridwan; Sidarningsih Sidarningsih
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 5 No. 2 (2021): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v5i2.2021.292-301

AbstractCiplukan is a wild plant with the Latin name Physalis angulata L which grows a lot in rice fields and community gardens. Ciplukan plants that grow wild everywhere, at first glance it seems that there is no price, even though besides being rich in benefits, the price of ciplukan fruit is quite fantastic Rp. 100.000,-/kg. Bondowoso has 23 sub-districts, including Maesan and Sumberwringin sub-districts. Currently, there are many youth communities emerging in the two sub-districts, including the MPK 8320 and FPS communities. The activities of the two communities include hydroponic training, plant nurseries, economic development, etc. For this reason, the Community Service Team of the Faculty of Dentistry, Universitas Airlangga designed an activity to combine the existing problems in community groups, namely the lack of knowledge or information about the benefits to health, economic value, and cultivation of ciplukan plants. The existence of this problem causes community members not to have the courage to cultivate ciplukan plants, the low level of income from community members makes it difficult to find sources of funds to cultivate ciplukan plants. The purpose of this activity is to increase knowledge and skills about the health benefits and cultivation of ciplukan which will have an impact on improving the economy. The solutions offered are 1. Providing counseling and promoting ciplukan as a toga plant and its health benefits. 2. As an initial stage, distributing ciplukan plants to the community around the community 3. Providing counseling about ciplukan cultivation. This activity received a very good response from the community around the community in particular and the Bondowoso community in general, even community members have hopes and aspirations for ciplukan fruit to become the "Icon" of Bondowoso city.Keywords : tanaman ciplukan, komunitas FPS, komunitas MPK 8320AbstrakCiplukan merupakan tanaman liar yang bernama latin Physalis angulata L yang banyak tumbuh diarea persawahan dan kebun warga. Tanaman ciplukan yang tumbuh liar, sepintas terlihat tidak ada harganya, padahal selain kaya manfaat kini harga buah ciplukan cukup fantastis Rp.100.000,-/kg. Bondowoso mempunyai 23 kecamatan, diantaranya adalah kecamatan Maesan dan Sumberwringin. Saat ini banyak sekali bermunculan komunitas anak muda yang berada di dua kecamatan tersebut, diantaranya adalah komunitas MPK 8320 dan FPS. Kegiatan dari kedua komunitas tersebut antara lain pelatihan hidroponik, pembibitan tanaman, pengembangan perekonomian dll. Untuk itu Tim Pengabdian Masyarakat Fakultas Kedokteran Gigi Universitas Airlangga merancang kegiatan menggabungkan adanya permasalahan yang ada pada kelompok komunitas yaitu kurangnya pengetahuan atau informasi tentang manfaat terhadap kesehatan, nilai ekonomis dan budidaya tanaman ciplukan. Adanya permasalahan ini yang menyebabkan anggota komunitas tidak punya keberanian untuk membudidayakan tanaman ciplukan, rendahnya tingkat penghasilan dari anggota komunitas sehingga kesulitan mencari sumber dana untuk membudidayakan tanaman ciplukan. Tujuan kegiatan ini meningkatkan pengetahuan dan ketrampilan tentang manfaat kesehatan dan budidaya ciplukan yang akan berdampak pada peningkatan ekonomi. Solusi yang ditawarkan yaitu 1.Memberikan penyuluhan dan mempromosikan ciplukan sebagai tanaman toga dan manfaatnya terhadap kesehatan.2.Sebagai tahap awal membagikan tanaman ciplukan kepada masyarakat di sekitar komunitas 3.Memberikan penyuluhan tentang budidaya ciplukan. Kegiatan ini mendapat respons yang sangat baik dari masyarakat di sekitar komunitas khususnya dan masyarakat Bondowoso pada umumnya, bahkan anggota komunitas mempunyai harapan dan cita-cita agar buah ciplukan menjadi ICON kota Bondowoso.Kata kunci : ciplukan, komunitas FPS, komunitas MPK 8320

INNOVATION FOR MANUFACTURING FERTILIZER FROM COFFEE LEATHER WASTE FOR THE COMMUNITY AND FARMER GROUP IN BONDOWOSO Rini Devijanti Ridwan; Indeswati Diyatri; Sidarningsih; Yuliati
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 6 No. 1 (2022): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v6i1.2022.212-218

The coffee husk waste has not been utilized optimally by farmers. Coffee skin waste, which has been considered as a leftover material from the production of ground coffee, turns out to have many benefits and uses in life. Based on the results of research by experts, coffee husk waste is useful in agriculture, animal husbandry and fisheries, namely as compost, protein nutrition and additional fiber in animal feed. This solid waste of coffee rind has high levels of organic matter and nutrients that can improve soil structure. One of the efforts that can be done to handle the increasing amount of coffee husk waste is by processing coffee skin waste into compost. The by-products in the form of coffee skins range from 50-60 percent of the harvest. If the yield is 1000 kg of fresh coffee, then about 400-500 kg of coffee beans will be produced and the rest is a by-product in the form of coffee husks. The advantage of this coffee skin compost is that its nitrogen content is quite high, around 6% so that it can substitute for fertilizers containing nitrogen. The problem is that the C/N ratio is high enough that it takes a long time to decompose or the solution is to add nitrogen sources and a decomposer to speed up decomposition. This community service activity was carried out in collaboration with the community in the Bondowoso district, namely the KAPAS Community in Sumbergading Village, Sumberwringin District and the TSS community in Sukosari Lor Village, Sukosari District. In the Bondowoso area, there are many youth communities with various activities aimed at advancing people's lives and improving the socio-economic status of the area. Coffee husk waste is very common in the area, so far, coffee skin waste has not been used optimally, so its benefits cannot be obtained. The solutions offered in this community service activity include: Provide an understanding of the importance of utilizing existing coffee husk waste for communities and communities in the Bondowoso area, Provide training on making fertilizer from coffee husk waste as an innovation in making fertilizer to increase agricultural yields in the Bondowoso area, Exploring and empowering the natural potential that exists in the community environment so that it can be put to good use, Initiate the business of making fertilizer from coffee husk waste as an innovation in making fertilizer for cost efficiency in agriculture Keywords : waste, coffee husk, innovation, fertilizer, health DAFTAR PUSTAKA Dzung NA., Dzung TT.,Khanh VTP.,2013. Evaluation of Coffe Husk Compost for Improving Soil Fertility and Sustainable Coffee Production in Rural Central Highland of Vietnam. Resources and Environment, 3(4), 77-82 Abdoellah, S dan A.Wardani. 1993. Impact of Cocoa Development on Marginal Land to Farmers Income: A Case in Gunung Kidul Regency, Indonesia. Pelita Perkebunan, 9(3), 97 – 104 Bressani, R.1979. The by-products of coffee berries.dalam coffee pulp: composition, technology, and utilization. Editor J. E. Braham and R. Bressani. Ottawa: Institute of Nutrition of Central America and Panama. Berlian, Z., Syarifah, dan Sari DS., 2015. Pengaruh Pemberian Limbah Kulit Kopi (Coffea robusta L.) terhadap Pertumbuhan Cabai Keriting (Capsicum annum L.). Jurnal Biota, 1(1), 22-32. Sahputra, A., Barus A., dan Sipayung R., 2013. Pertumbuhan dan produksi bawang merah (Allium ascalonicum L.) terhadap pemberian kompos kulit kopi dan pupuk organik cair. Jurnal Online Agroekoteknologi, 2(1), 26-35. Maruli, A. 2010. Limbah kopi antar mahasiswa ke jerman. http://www.antaranews.com/berita/2 27334/limbah-kopi-antarmahasiswake jerman/2017.07.18. Afrizon, 2015. Potensi Kopi Sebagai bahan Baku Pupuk Kompos Di Propinsi Bengkulu. AGRITEPA, 2(1). 1, 21-32 Novita E., Fathurrohman A., Pradana HA.,2018. Pemanfaatan Kompos Blok Limbah Kulit Kopi sebagai Media Tanam. Jurnal Agrotek, 2(2), 61- 72 Muryanto, 2004 Muryanto. (2004). Potensi Limbah Kulit Kopi Sebagai Pakan Ternak. Jurnal Lokakarya, 1, 112-114. Triawan DA., Banon C., Adfa M., 2020. Biokonversi Kulit Kopi Menjadi Pupuk Kompos Pada Kelompok Tani Pangestu Rakyat Kabupaten Rejang Lebong. Jurnal Pengabdian Al-Ikhlas, 5(2), 159-165

Study of adhesin from Aggregatibacter actinomycetemcomitans local isolate on alveolar bone destruction in aggressive periodontitis disease Rini Devijanti Ridwan; Tuti Kusumaningsih; Sidarningsih Sidarningsih; Soetjipto Soetjipto
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 21 No 2 (2016): June 2016
Publisher : The East Java Biological Society

Adhesion is a powerful survival mechanism as well as a virulence mechanism for bacterial pathogens. Bacterial adhesin is a media for bacteria to invade the host. Bacterial adhesin,is a medium for bacteria to invade the host. Baterial adhe-sion, moreover, is depend on the ligand interaction as a signaling mediator that will influence the invasion process and increase pro and anti-inflammatory due tob the influence of the receptors of innate immune response. Aggregatibacter actimycetemcomitans (A.actinomycetemcomitan) have many virulence factors that may result in tissue and alveolar bone damage. One of the virulence factors is adhesin that can be isolated from the fimbriae. This research purposed to analyze the ability of adhesin protein from A.actinomycetemcomitan that cause the destruction of alveolar bone. Thus, the number of osteoblasts and osteoclasts as well as osteocalcin expression can be used as a marker of damage on the alveolar bone of Wistar rats. The research was conducted through several processes. First, the adhesin of A.actinomycetemcomitan with a molecular weight (MW) of 24 kDa is induced into Wistar rats. Next, to determine the number of osteoblasts and osteoclasts performed, hematoxylin eosin staining is conducted. Meanwhile, to determine osteocalcin expression performed, immunohistochemical techniques is used. This research shows the decreasing of the number of osteoblasts and increasing of the number of osteoclasts in the treatment groups induced by adhesin proteins, A. actinomycetemcomitans + adhesin protein, and A.actinomycetemcomitan compared those in the control group. It also shows the increasing of osteocalcin expressions on the alveolar bone of Wistar rats in the groups induced by adhesin proteins, A. actinomycetemcomitans + adhesin protein, and A. actinomycetemcomitans than those in the control group. It can be concluded that the adhesin protein of A. actinomycetemcomitans plays an important role in the destruction of alveolar bone through the reduction of the number of osteoblasts, the increasing of the number of osteoclasts and oste-ocalcin expression in aggressive periodontitis.

The expression of TLR-2 and NOD-2 in gingival epithelium of rat after probiotic Lactobacillus reuteri supplementation to inhibit Streptococcus mutans growth Tuti Kusumaningsih; Subijanto Marto Sudarmo; Retno Indrawati; Rini Devijanti Ridwan; Sidarningsih Sidarningsih
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 21 No 1 (2015): December 2015
Publisher : The East Java Biological Society

Lactobacillus reuteri is probiotic from Gram positive bacteria which has specific molecular structure, consisted of peptidoglycan (PG) and lipotheihoic acid (LTA). These structure have potential in pattern recognition receptors (PRRs) activation, such as TLR-2 and NOD-2 that are the up stream of beta defensin-2 (BD-2) signaling cascade. BD-2 is antimocrobial peptides naturally produced in mouth cavity that can against Streptococcus mutans effectively. This study was aimed to prove that probiotic L. reuteri supplementation can increase the expression of TLR-2 and NOD-2 in gingival epithelium. Experimental design in this study was randomized control group post test only design. Study was carried on 24 white rat (Rattus norvegicus) Wistar strain which divided into 4 groups. Positive control was rats that induced with S. mutans, while rats in negative control group were not induced. Group I was rats that suppelemented with L. reuteri for 14 days (day 1-14) and induced with S. mutans for 7 days (day 8-14). Group II was rats that supplemented with L. reuteri and induced with S. mutans simustaneously for 14 days (day 1-14). Concentration of bacterial suspension was 108 cfu ∕ml for L. reuteri and 1010 cfu/ml for S. mutans. Both of these two bacteria was given orally to rats. TLR-2 and NOD-2 expressions were evaluated with immunohistochemistry technique. Significant differences of protein expression between each treatment groud was analyzed with ANOVA (p=0.001). TLR-2 and NOD-2 expressions were higher than negative control. It can be conclude that L. reuteri supplementation as probiotic could increase the expression of TLR-2 and NOD-2 in gingival epithelium of rat.

Inovasi Pembuatan Pasta Gigi Bahan Herbal untuk Pemberdayaan dan Peningkatan Kesehatan Gigi dan Mulut pada Komunitas di Bondowoso Rini Devijanti Ridwan; Indeswati Diyatri; Sidarningsih Sidarningsih; Yuliati Yuliati; Salsabilla Syifa; Dyah Kusumaningrum; Mohammed Ahmed Al Junaid
Jurnal Abdi Masyarakat Indonesia Vol 4 No 1 (2024): JAMSI - Januari 2024
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.1043

Salah satu permasalahan dalam rongga mulut yang sering dihadapi masyarakat Indonesia adalah karies gigi. Data dari WHO, 90% penduduk Indonesia menderita karies gigi. Data RISKESDAS, 2018 menunjukkan prevalensi masalah kesehatan gigi dan mulut 57,6%, proporsi terbesar adalah gigi berlubang (45,3%). Kegiatan dilakukan pada komunitas Peduli Alam dan Sosial (KAPAS) di Sumbergading, Sumberwringin dan komunitas Tretan Sukosari Sumberwringin (TSS) di Sukosari Lor, Sukosari Bondowoso bertujuan memberikan pemahaman pentingnya kesehatan gigi dan mulut serta pelatihan dan pendampingan pembuatan pasta gigi berbahan herbal. Bahan herbal yang digunakan : daun jambu biji, daun sirih, daun kemangi, daun jeruk nipis dan jeruk nipis. Kegiatan ini diikuti 60 orang peserta, anggota komunitas dan masyarakat setempat. Metode kegiatan : penyuluhan kesehatan gigi dan mulut serta pengaruhnya pada kesehatan, cara pembuatan dan pendampingan pembuatan pasta gigi bahan herbal dan evaluasi. Hasil evaluasi kegiatan menunjukkan peningkatan pengetahuan masyarakat tentang pasta gigi herbal, persentase rerata jawaban tepat kuisoner sebelum penyuluhan 19,9%, sesudah pelatihan meningkat 91,76 %. Data menunjukkan sebagian besar anggota komunitas dan masyarakat sudah memahami tentang pentingnya menjaga kesehatan gigi dan mulut dan perlunya penggunaan pasta gigi untuk menunjang kebersihan rongga mulut (55,5%). Anggota komunitas dan masyarakat mempunyai minat yang tinggi untuk membuat pasta gigi herbal setelah kegiatan pelatihan.

Epigallocatechin gallate Mucoadhesive Gingival Patch as Potential Biomaterial to Regulate Macrophage and Lymphocyte Cells in Periodontitis: A Review Sidarningsih, Sidarningsih; Diyatri, Indeswati; Pratiwi, Reinaya Tifa; Nabilla, Jihan Hijriya; Yuliati, Yuliati; Ridwan, Rini Devijanti
Indonesian Journal of Dental Medicine Vol. 5 No. 1 (2022): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v5i1.2022.32-36

Background: Periodontitis is a periodontal disease that affects more than 743 million peopleworldwide and causes damage to the periodontal ligament and alveolar bone. One of the bacteriathat can cause periodontitis is Porphyromonas gingivalis (P.gingivalis). P. gingivalis has virulence factors that can damage the periodontal tissue. Treatment of periodontitis is in the form of non- surgical therapy such as scaling and root planning and some cases, doxycycline can be given as adjunctive therapy after scaling and root planing. Epigallocatechin gallate (EGCG) is one of the catechins found in green tea and has anti-bacterial properties. Purpose: The study aimed to describe the potency of the mucoadhesive gingival patch with EGCG green tea against the number of macrophage cells and lymphocyte cells during periodontitis through narrative review. Review: Mucoadhesive gingiva patch loaded with EGCG has the advantages such as maintaining drug bioavailability, non-invasive, and optimizing drug distribution. Using a mucoadhesive gingiva patch with EGCG can reduce macrophage and lymphocyte cells by inhibiting lipopolysaccharide, a virulence factor of P. gingivalis. Inhibited lipopolysaccharide will inhibit pro-inflammatory cytokines such as TNF-α and IL-6. Macrophage and lymphocyte cells will reduce due to the inhibition of pro inflammatory cytokines. Conclusion: Mucoadhesive gingiva patch with EGCG green tea potentially to decreased macrophage and lymphocyte cells in periodontitis.

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