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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Jurnal Aplikasi Teknologi Pangan Jurnal Aplikasi Teknologi Pangan JIMR - Journal of Islamic Medicine Research Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Klinik dan Riset Kesehatan Jurnal Kedokteran Komunitas (Journal of Community Medicine)
Merlita Herbani
Fakultas Kedokteran, Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Genistein Increase Intracellular Distribution of the High Motility Group Box-1 through p38 Pathway in HeLa culture cells induced by Tumor Necrosis Factor-α Merlita Herbani; Aris Widodo; Hidayat Suyuti
Journal of Tropical Life Science Vol. 4 No. 2 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

Cervical cancer is one kind of many cancer that cause death to women around the world. Many studies had support the statement that inflammation has a strong linkage with cancer development. Several factors like proinflammatory factor can influence tumor cell microenvironment, and induce a faster proliferation. TNF-α is suspected can induce proliferation. While cancer itself can induce inflammation, which is marked by several marker. One of them is HMGB1, released from the cell as active secretory lysosomes or passive diffusion. Genistein has demonstrated growth inhibitory effects of various types of cancer cells. It inhibits tyrosine kinase pathway, which can be activated by TNF-α. One of those pathways that have the link with proliferation is p38. This study tries to reveal about inhibitory effect of genistein toward p38 pathway that had been activated by TNF-α. This research was conducted by exposing cultured HeLa cells with various doses of genistein for 90 minutes, and then exposed to TNF - α 10 ng / mL for 20 minutes. Observations were made with a confocal microscope, by staining the cells with pp38-TRITC and HMGB1 antibody. The intensity was measured and analyzed by Fluoview software. The results suggest that there be significant differences between pp38 intranuclear intensity and HMGB1 extranuclear intensity of each dose of genistein (p = 0.000, ANOVA). pp38 and HMGB1 intensity were increased along with increasing genistein dose, but at high dose there were noted decreasing of pp38 and HMGB1 intensity. At apoptotic dose, pp38 and HMGB1 intensity were increased markedly, showing the effect of apoptosis. In general, increasing doses of genistein increase intranuclear p38 activation and HMGB1 extranuclear translocation. So there were a strong linkage between p38 activation and HMGB1 translocation in this study.
Studi Docking Molekuler Penghambatan Reseptor Neprilysin Bunga Lawang (Illicium verum) sebagai Anti Hipertensi dan Prediksi Profil Farmakokinetikanya Andri Tilaqza; Merlita Herbani; Zaenab Aqilah
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 9 No 1 (2023): Agustus 2023
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/e-jbst.v9i1.529

Abstract

Prosedur TEVAR pada Diseksi Aorta Klasik tipe B Kronis Herbani, Merlita; Kurnianingsih , Novi
Jurnal Klinik dan Riset Kesehatan Vol 3 No 2 (2024): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.2.8

Abstract

Introduction : Type B aortic dissection still become health burden that can cost quality of life. In this case, TEVAR procedure still become treatment of choice if indicated. However, TEVAR in chronic type B aortic dissection still often questioned between advantage and complication. Case Illustration : A 42 year old man with complaints of chest pain, was diagnosed with Chronic Type B Aortic Dissection. The TEVAR procedure is performed on the patient, with clinical and radiological indications. A CT scan evaluation was performed 3 months later and found closure of the false lumen, and the left kidney received collateral vascularization with a reduction in size. Currently the patient does not complain of any symptoms. Discussion : The TEVAR procedure for chronic type B aortic dissection according to indications can increase the patient's life expectancy. Regular evaluation is still needed for early detection of complications and evaluation of the blood vessels around the stent-graft. Conclusion : The TEVAR procedure in patients with chronic type B aortic dissection can be considered to increase patient survival.
Co-Authors Adam Bregas Regowo Andri Tilaqza Aris Widodo Damayanti, Dini Sri Desy Amalia Wulandari Diah Andriana Doti Wahyuningsih Heni Pujiastuti Hidayat Suyuti Hidayat Suyuti Kurnianingsih , Novi Moch. Saifudin Oktavia Rahayu Puspitarini Yoni Rina Bintari Zaenab Aqilah