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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Ophthalmologica Indonesiana
Nurjati Chairani Siregar
Faculty Of Medicine, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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ANALISIS EKSPRESI TRANSPORTER ZINK (ZNT-1) SEBAGAI FAKTOR PROGNOSIS ADENOKARSINOMA PROSTAT Feriandri Utomo; Nurjati Chairani Siregar; Ria Kodariah
Majalah Kedokteran Andalas Vol 39, No 1 (2016): Published in April 2016
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.629 KB) | DOI: 10.22338/mka.v39.i1.p11-20.2016

Abstract

Penurunan kadar Zink (Zn) berkorelasi dengan peningkatan skor Gleason adenokarsinoma prostat, dan rendahnya Caspase-3 (eksekutor apoptosis). Ekspresi ZIP-1 (importer Zn) turun pada adenokarsinoma prostat. Korelasi ZnT-1 (eksporter Zn), ZIP-1 dan Caspase-3 diduga berpotensi menjadi faktor prognosis adenokarsinoma prostat. Penelitian ini bertujuan menganalisis korelasi ekspresi ZnT-1, ZIP-1, Caspase-3 dan skor Gleason adenokarsinoma prostat. Studi retrospektif analitik potong lintang dilakukan pada 14 kasus adenokarsinoma prostat skor Gleason ≤7 dan 16 kasus dengan skor Gleason >7. Ekspresi ZnT-1 dinilai dengan metode imunohistokimia. Analisis tambahan dilakukan untuk melihat korelasi ZnT-1, ZIP-1 dan Caspase-3. Hasil penelitian didapatkan ZnT-1 pada skor Gleason >7 lebih rendah daripada skor Gleason ≤7. ZnT-1 berkorelasi dengan skor Gleason. ZnT-1 berkorelasi dengan ZIP-1 pada skor Gleason >7. ZIP-1 berkorelasi dengan Caspase-3 pada skor Gleason ≤7. ZIP-1 berkorelasi kuat dengan Caspase-3 pada skor Gleason 8. Penelitian ini menyimpulkan rendahnya ekspresi ZnT-1 dan ZIP-1 berpotensi menjadi faktor prognosis adenokarsinoma prostat.
Malignant Triton Tumor without Von Recklinghausen’s Neurofibromatosis in a 16 year-old Indonesian Girl: A Case Report Neni Anggraini; Nurjati Chairani Siregar
Majalah Oftalmologi Indonesia Vol 43 No 1 (2017): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v43i1.129

Abstract

Background: To diagnose malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation in malignant triton tumor which has a rare incidence. Case Illustration: We reported a case in a 16 year-old girl who presented with progressively painless proptosis of the left eye and decreased visual acuity. There was no evidence of Recklinghausen’s disease. She underwent surgery and radiotherapy. The histopatologic findings showed malignant peripheral nerve sheath tumor (MPNST). Four years later, she suffered recurrence proptosis and decreased visual acuity. Histomorphology supported by immunostaining with S-100 protein confirmed the diagnosis of malignant triton tumor. She underwent chemotherapy and enucleation. Conclusion: This case highlights the prudent use of immunohistochemistry that is essential in making an early detection and a correct diagnosis.
Ekstrak Teh Hijau Mengurangi Luas Area Fibrosis Paru Tikus Desdiani; Iris Rengganis; Samsuridjal Djauzi; Agus Setiyono; Mohammad Sadikin; Sri Widia A. Jusman; Nurjati Chairani Siregar; Suradi; Putri C. Eyanoer
Majalah Patologi Indonesia Vol. 29 No. 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.403

Abstract

BackgroundPulmonary fibrosis is often found in infectious diseases and chemical exposure in the work environment. Antifibrotic effects can befibropreventive and fibrolysis. Bleomycin can cause inflammation and pulmonary fibrosis. Catechin is proven can repair liverdamages due to alcohol induction. The aim of this study is to examine the effect of antifibrotic green tea catechin on reducing thearea of rat lung fibrotic.MethodsThis research was carried out in vivo experimentally in the Laboratory Animal Management Unit at Faculty of Veterinary MedicineIPB in 4 groups of rat experiments, consisting of 3 rats in the negative control group, 3 rats in the positive control group, 3 rats in thegroup of rats given bleomycin on the 8th day and 28thwith green tea extract every day from day 0 to 49 days (fibropreventive), 3groups of rats given bleomycin days 0 and 21 with green tea extract every day from day 15 to 49 (fibrolysis). Histopathologicalexamination was performe for all groups of rats.ResultsThis study showed that administration of green tea extract in fibropreventive groups and fibrolysis groups could reduce the fibrosisarea in rat lungs based on Aschroft's modified scale.ConclusionBased on the results of this study it was found that the anti-fibrotic activity of green tea extract was proven to be able to suppressthe development of pulmonary fibrosis both by fibropreventive and fibrolysis
Co-Authors Agus Setiyono Alida Harahap Andrijono Andrijono Anggraini, Neni Tri Desdiani Dewi Jantika Dian Sari Oethia Vathonati Dwi Retna Lestari Evelina Kodrat Evelina Kodrat Feriandri Utomo Fita Ferdiana Helmi Helmi Iris Rengganis Jenny Bashiruddin Jusman, Sri Widia Azraki Lilis Lilis Mohammad Sadikin Murdani Abdullah Niniek Hardini Noza Hilbertina Puspita Eka Wuyung Puspita Eka Wuyung Putri C. Eyanoer Ria Kodariah Rina Effendi Ros Nirmawati, Samsuridjal Djauzi Septelia Inawati Wanandi Sri Widia Jusman Suradi Widodo, Dini Widiarni