Article Per Year (5 Year)
p-Index From 2021 - 2026
0.983
P-Index
This Author published in this journals
All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Biomedika Magna Neurologica
Mochamad Bahrudin
Universitas Muhammadiyah Malang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 16 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 16 Documents
Search

 1   2 
Sensitivity, Specificity, and Diagnosting Value of Bahrudin’s Score in Diagnosing Stroke Compared to CT-Scan Mochamad Bahrudin; Salsabilla Rihadatul Aisy
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.15044

Abstract

Stroke is an emergency situation leading to disability and death. Fast, precise, and easy diagnostic tools is needed as an substitute for CT-Scan, especially when CT-Scan is not available. This study is conducted to determined sensitivity, specificity, and diagnostic value of Bahrudin’s Score compared to CT-Scan in diagnosing bleeding or infarct stroke. This research was conducted at Gambiran Kediri Hospital and Lamongan Muhammadiyah Hospital using 89 patients as samples. It was analyzed to define sensitivity, specificity, positive predictive value, negative predictive value,  positive likelihood ratio, negative likelihood ratio, accuracy, reciever operating characteristic curve, and area under curve in order to define diagnostic value of Bahrudin’s Score. Infarct stroke was found in 54%, 58% happened in male and 96,6% found in age over 40.   Sensitivity of Bahrudin’s Score is 0.868, specificity 0.860, positive predictive value os 0.825, negative predictive value is 0.896, positive likelihood ratio is 6.600, negative likelihood ratio is 0.153, accuracy 0.864, and AUC 86.4%. It is determined that Bahrudin’s score with AUC 86.4% is feasible to replace CT-Scan when it is not available.
PENGARUH BUBUK CANGKANG TELUR BEBEK TERHADAP PERTUMBUHAN OSTEOBLAS FEMUR MENCIT OSTEOPOROSIS Risky Amalia; Dian Yuliartha Lestari; Mochamad Bahrudin
Biomedika Vol 14, No 1 (2022): Biomedika Februari 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i1.15322

Abstract

ABSTRAKGlucocorticoid induce-osteoporosis merupakan osteoporosis akibat terapi glukokortikoid jangka panjang.  Osteoporosis terjadi akibat adanya hambatan pada faktor pertumbuhan tulang sehingga diferensiasi osteoblas menurun. Peningkatan kalsium ekstraseluler dengan cara suplementasi kalsium mampu mendorong proliferasi sel dan mineralisasi matriks sel mesenkimal, yang merupakan sel induk osteoblas. Kalsium terkandung tinggi dalam bubuk cangkang telur bebek. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian bubuk cangkang telur bebek terhadap pertumbuhan osteoblas tulang femur mencit jantan (Mus musculus) model osteoporosis dengan induksi deksametason. Metode yang digunakan true experimental dengan posttest-only control group design, 24 ekor mencit jantan dibagi menjadi 4 kelompok, yaitu kontrol positif (K+), kelompok perlakuan bubuk cangkang telur bebek dosis 1,04mg/hari (P1), 2,08mg/hari (P2), dan 3,12mg/hari (P3).  Semua tikus diinduksi deksametason 0,0029mg/20gBB/hari selama 28 hari, kemudian kelompok perlakuan diberi bubuk cangkang telur bebek selama 14 hari.. Analisis data menggunakan One-Way Anova, Post Hoc Bonferroni, dan regresi linier. Pada penelitian ini,jumlah osteoblas secara signifikan berbeda (p 0,05) antar kelompok. perlakuan dibandingkan kelompok control positif. Sehingga dapat disimpulkan bahwa bubuk cangkang telur bebek meningkatkan pertumbuhan osteoblas tulang femur mencit jantan (Mus musculus) model osteoporosis.Kata Kunci: Bubuk Cangkang Telur Bebek, Osteoblas, Osteoporosis ABSTRACTGlucocorticoid induce-osteoporosis is osteoporosis due to long-term glucocorticoid therapy. Osteoporosis occurs due to inhibition of bone growth factors so that osteoblast differentiation decreases. The increase of extracellular calcium with calcium supplementation is able to promote cell proliferation and mineralization of mesenchymal cell matrix, which is the stem cell of osteoblasts. Calcium is high in duck egg shell powder. This study aimed to determine the effect of duck egg shell powder suplementation on the growth of male mice (Mus musculus) femoral bone osteoblasts with dexamethasone-induced osteoporosis model. The method used was true experimental with posttest-only control group design, 24 male mice were divided into 4 groups, there were positive control (K+), duck egg shell powder treatment group at a dose of 1.04 mg/day (P1), 2.08 mg/day (P2), and 3.12 mg/day (P3). All rats were induced with dexamethasone 0.0029mg/20gBW/day for 28 days, then the treatment group was given duck eggshell powder for 14 days. Data analysis used One-Way Anova, Post Hoc Bonferroni, and linear regression. In this study, the number of osteoblasts was significantly different (p0.05) between treatment groups compared to the positive control group. So it can be concluded that duck egg shell powder increased the growth of femoral bone osteoblasts of male mice (Mus musculus) osteoporosis model. Keywords: Duck Eggshell Powder, Osteoblast Cell, Osteoporosis
The Effect of Brain Training Game activities on Improvement of Cognitive Function measured by Montreal Cognitive Assesment Indonesia version (MoCA-Ina) Mochamad Bahrudin; Adni Pratiwi; Anang Bayu Seta; Risma Karlina Prabawati
Saintika Medika Vol. 18 No. 1 (2022): June 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM1.21569

Abstract

The function of cognition in young adults (around the age of 20 years) mostly does not develop to its peak, even though at that age a person needs better cognitive abilities to deal with the lectures. Brain training game activities by playing games through the NeuronationTM application can improve cognitive function. To determine the effect of Brain training activities on improvement of cognitive function. Experimental study with two group pre and post design. 74 Sample were medical students of Faculty of Medicine, University of Muhammadiyah Malang class of 2017-2018, divided into control and treatment groups of 37 samples each. The treatment group was given by game brain game training 30 minutes a day, 20 times in 4 weeks.. Cognitive function was measured by the MoCA-Ina test in the control group and pre and post test. The hypothesis test used the pairet samples test. Cognitive function of pre and post test of the control group good cognitive function increased 2.69% and cognitive function of pre and post test of treatment group increased 58.8% with the result of pairet sample analysis of significant p = 0,000 which means that in the control group there was a tendency for increased function cognition after treatment (post test) but the improvement was not significant. In the treatment group with brain training activities cognitive function increased sharply and statistically significant, Brain training activities affect the improvement of cognitive function.
The Relationship between Sleep Disturbance and Tension Type Headache Mochamad Bahrudin; Indra Setiawan; Noor Alvira Jihad
Saintika Medika Vol. 19 No. 1 (2023): June 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM1.27851

Abstract

Background: Type of Tension The most typical kind of primary headache is a headache. Sleep disturbances are one of the causes of TTH. Further study is necessary to fully comprehend the connection between sleep disruptions and TTH, however, as their interaction is quite complex. Understanding the connection between sleep issues and tension headaches is one of our main objectives. Methods: Use Google Scholar and PubMed to look up papers and books. Criteria for Scopus-indexed international journals in quartiles 1-4 and national journals 1-6 with SINTA accreditation (S1-6) The last 10 years' worth of periodicals and textbooks were used to compile the literature review. The time period utilized, however, is the most recent ten years due to challenges in locating articles. Results: It was determined from various investigations that TTH and sleep problems are related. There is a reciprocal relationship between the two; headaches can lead to sleep problems, and vice versa.Inference: The prevalence of TTH is correlated with sleep problems.
The Relationship between Level of D-Dimer Serum with Mortality in Acute Stroke Patiens with COVID-19 Tarmidi, Moch Syahrial Pramudia; Bahrudin, Mochamad
Magna Neurologica Vol. 2 No. 2 (2024): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v2i2.955

Abstract

Background: COVID-19 has significantly increased morbidity and mortality in Indonesia, particularly at Gambiran General Hospital in Kediri, East Java, following the WHO's pandemic declaration. The global incidence of acute stroke with COVID-19 is 1.4%, presenting varying clinical features from mild to severe outcomes, and even death. The identification of specific biomarkers, such as elevated D-dimer serum levels, is crucial for predicting severe complications in acute stroke patients with COVID-19. Objective: This study aimed to explore the correlation between elevated levels of mild, moderate, and severe D-dimer serum and mortality in acute stroke patients with COVID-19. Methods: Conducted as an observational analytical study using a cross-sectional approach, this research utilized secondary data from medical records at Kediri Gambiran General Hospital (March 2020 to June 2023). Inclusion and exclusion criteria were applied to hospitalized patients, categorized based on D-dimer levels: normal, mild, moderate, and severe. Statistical analyses, including the Spearman correlation test and Chi-square correlation test, were employed to assess the relationship between D-dimer levels and total mortality. Results: Among the 101 enrolled patients, 53 were male (52.48%), with 90 exhibiting elevated D-dimer levels. Out of these, 44 patients died. The Spearman correlation test showed a non-significant value of 0.069 (p>0.005). The Chi-square correlation test for mild, moderate, and severe D-dimer levels on total mortality also yielded a non-significant value of 0.878. Conclusion: This study found no significant relationship between elevated levels of mild, moderate, and severe D-dimer serum and mortality in acute stroke patients with COVID-19 at Gambiran General Hospital.
Effectiveness Of Watermelon (Citrullus lanatus) Red Flesh Extract On Reducing Coronary Artery Foam Cells and Thinning Of The Aortical Intima In Wistar Rats (Rattus norvegicus strain Wistar) Atherosclerosis Model Bahrudin, Mochamad; Dian Yuliartha Lestari; Nabila Risma Anjana; Tiara Lastari
Saintika Medika Vol. 19 No. 2 (2023): December 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM2.32403

Abstract

Introduction: Atherosclerosis (AS) is a process of narrowing of the lumen of arteries due to progressive plaque buildup. Foam Cell and plaque appear as a result of lipoprotein metabolism disorders which result in inflammatory reactions. The incidence of AS in the world is increasing, resulting in various complications that can lead to death. Lycopene is contained in the red flesh of watermelon, which is an antioxidant that can control free radicals and can reduce the risk of AS. Objective: To determine the effectiveness of watermelon (Cittrulus lanatus) red flesh extract on reducing coronary artery foam cells and thinning of the aortic intima in Wistar rats (Rattus norvegicus strain Wistar) atherosclerosis model. Method: This research was an experimental study (true experimental) using the Post Test Only Control Group Design method, which measures the number of coronary artery foam cells and the thickness of the aortic intima in Wistar rats (five groups) after administration of a hypercholesterolemic diet and watermelon red flesh extract at a dose of 250,500,750 mg /kgBW. Data analysis was carried out using One-Way ANOVA and Post Hoc Bonferroni tests. Results: The One-Way ANOVA statistical test showed results of 0.020 for foam cells and 0.008 for thickness of the intimal tunica, which means that there was a real influence of watermelon red flesh extract on decreasing foam cells and significant thinning of the intimal tunica in the treatment group. Furthermore, the Post Hoc Bonferroni test showed that the dose of 750 mg/kgBW had the most effect on reducing foam cells (p=0.046) and thinning the intima (p=0.015). Conclusion: Watermelon (Citrullus lanatus) red flesh extract at a dose of 750 mg/kgBW has a significant effect on reducing the number of foam cells and thinning of the aorta of the Wistar rat model of atherosclerosis.
Co-Authors Adni Pratiwi Alief, Hafif Fitra Anang Bayu Seta Annisa Bunga Nafara Dian Yuliartha Lestari Hafif Fitra Alief Indra Setiawan Nabila Risma Anjana Nafara, Annisa Bunga Noor Alvira Jihad Putra, Resi Lystianto Resi Lystianto Putra Risky Amalia Risma Karlina Prabawati Salsabilla Rihadatul Aisy Tarmidi, Moch Syahrial Pramudia Tiara Lastari