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All Journal Sari Pediatri Paediatrica Indonesiana Indonesian Journal of Biomedicine and Clinical Sciences TECHNOLOGIC
Agung Triono
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Kesehatan Masyarakat Dan Keperawatan Universitas Gadjah Mada/RSUP Dr. Sardjito, Yogyakarta
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Sleep disturbance associations with blood pressure and body mass index in school-aged children Restu Maharany Arumningtyas; Agung Triono; Retno Sutomo
Paediatrica Indonesiana Vol 60 No 6 (2020): November 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.6.2020.303-9

Abstract

Background Sleep disturbances can lead to many health problems in school-aged children, including hypertension and obesity. However, a lack of consensus about the etiology of these conditions is due to conflicting reports on the possible effects of sleep disturbances. Objective To assess for possible associations between sleep disturbances and blood pressure as well as body mass index in school-aged children. Methods This cross-sectional study involved primary school children in the 4th-5th grades. Subjects’ blood pressure, body weight, and body height were measured and their parents completed the Sleep Disturbances Scale for Children (SDSC) questionnaire. Results Of the 816 children enrolled, 503 (61.6%) children had sleep disturbances. The most common type of sleep disturbance was initiating and maintaining sleep. Bivariate analysis revealed a significantly increased risk of hypertension among subjects with sleep disturbances (PR 15.06; 95%CI 8.13 to 27.90) and increased risk of obesity (PR 22.65; 95%CI 12.28 to 41.78). Conclusion The most common type of sleep disturbance is initiating and maintaining sleep. Sleep disturbances are significantly associated with hypertension and obesity in children.
Duration of active epilepsy as a predictor of seizure control after relapse in child epilepsy Charles Subakti; Madarina Julia; Agung Triono
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.202-7

Abstract

Background Epilepsy is a chronic illness that may affect childhood growth and development. Some epilepsy cases are easy to control, either with monotherapy or politherapy antiepilepticdrugs, but many cases are difficult to control. Several factors influence the risk of relapse, but information is limited on factors predictive of seizure control after relapse. Our study investigate patient with epilepsy relaps and see whether the duration of active epilepsy prior to initial remission can be use as a predictor of seizure control after relaps. Objective To assess whether duration of active epilepsy was predictive of seizure control after relapse. Methods This retrospective cohort study was performed in Dr Sardjito Hospital, Yogyakarta, on epileptic relapse patients aged 2 to 18 years , who had achieved remission for at least a 2-year seizure-free interval, and relapsed after antiepileptic drud (AED) discontinuation. We excluded patients with progressive neurological diseases, inborn errors of metabolism, febrile seizures, and those who could not be followed up for at least 2 years, or those with incomplete medical records. Subjects were divided into those who had a duration of active epilepsy prior to initial remission within 6 months and ≥6 months. Time to seizure control after relapse was analysed by Kaplan-Meier survival analysis. Results A total of 80 patients were included in the study. Overall median for seizure control after relapse was 3.6 (95%CI 1.1 to 6.0) months. Median for seizure control after relapse for those who had a duration of active epilepsy prior to initial remission within 6 months and >= 6 months were 3 (95%CI 0.1 to 5.8) months and 12 (95%CI 4.4 to 19.5) months, respectively. Log-rank test revealed no significant difference between groups (P=0.12). Conclusion Duration of active epilepsy prior to initial remission was not a predictor for seizure control after relapse.
Potentially predictive factors for hearing function improvement in pediatric cytomegalovirus infection therapy Agung Triono; Elisabeth Siti Herini; Braghmandita Widya; Dian Kesumapramudya Nurputra
Paediatrica Indonesiana Vol 61 No 5 (2021): September 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.5.2021.235-9

Abstract

Background Symptomatic congenital cytomegalovirus (CMV) infection has an impact mainly on neurological sequelae, including sensorineural deafness. Because of the long-term impact, early treatment of CMV infection is mandatory. However, predictive factors for hearing function improvement in CMV infection therapy remain unexamined. Objective To evaluate potential predictive factors for hearing improvement in pediatric CMV infection therapy. Methods All medical record data of patients aged 0-6 years with CMV infection who completed a 6-week course of ganciclovir therapy or a combination of a 4-week course of ganciclovir and a 2-week course valganciclovir from January 2013 to December 2017 were collected. Age at onset of therapy, gender, gestational age, nutritional status, multi-organ involvement, and neurological symptoms were studied as potential predictive factors of hearing improvement in CMV therapy. The effectiveness of CMV infection therapy on improving hearing function was measured with the brainstem evoked response audiometry (BERA) test. Results BERA tests proportion in the right, left, and best ear showed significant improvement after therapy. All variables analyzed were not statistically significant as predictive factors for hearing improvement in CMV infection therapy. Conclusion Ganciclovir/valganciclovir therapy in CMV infection patients accounted for the improvement of hearing impairment. However, none of the assessed factors were considered predictive for improving hearing function in CMV infection therapy.
Erasmus Guillain-Barre Syndrome Outcome Score (EGOS) to predict functional outcomes Maria Ulfa; Titis Widowati; Agung Triono
Paediatrica Indonesiana Vol 62 No 2 (2022): March 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.2.2022.130-7

Abstract

Background Guillain-Barre syndrome (GBS) has a highly diverse clinical course and prognosis. Predicting functional outcomes is needed in order to give appropriate treatment and counseling. Erasmus Guillaine-Barre Syndrome Outcome Score (EGOS) is simple scoring based on age onset, pre existing diarhea and GDS score obtained from medical record and physical findings that can be used by clinician to predict the functional outcomes of the child with GBS.. Objective To assess the usefulness of EGOS to predict functional outcomes of GBS patients. Methods A retrospective cohort study to see the functional outcomes which is walking or not walking of children with GBS aged 6 months to 18 years hospitalized in RSUP Dr. Sardjito, Yogyakarta from 2014 to 2019 were enrolled by a purposive sampling method. Bivariate and logistic regression multivariate backward method analyses were used to assess for possible correlations between predictive factors and functional outcomes in GBS patients. Results A total of 33 patients were enrolled and analyzed. After six months of weakness, 57.1% of patients with high EGOS (> 4) had poor functional outcomes according to the Hughes scale, scoring to asses functional outcomes . Patient with high EGOS (> 4) had greater risk of poor functional outcomes compared to patients with lower EGOS (≤ 4) (P=0.006; OR 33.3; 95%CI 2.74 to 404.94). Poor functional outcomes of GBS patients was not influenced by preceding upper respiratory tract infection, cranial nerve involvement, use of ventilator, autonomic dysfunction, immunotherapy, complicating disease, rehabilitation, or nutritional status. Conclusion High EGOS of >4 is a predictor for poor functional outcomes in children with GBS.
Status epilepticus in pediatric patients severity score (STEPPS) as an outcome predictor in children Niken Iswarajati; Intan Fatah Kumara; Agung Triono
Paediatrica Indonesiana Vol 62 No 6 (2022): November 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.6.2022.396-403

Abstract

Background Status epilepticus (SE) is a neurological emergency, with short-term mortality ranging from 0.9 to 3.6% in children. The disease burden of SE includes morbidity, treatment costs, and mortality. Various scoring tools for predicting outcomes in adult SE cases have been widely studied, but there are few tools for predicting outcomes in children with SE. Objective To evaluate the usefulness of status epilepticus in pediatric patients severity score (STEPSS), a clinical score for predicting functional outcome and mortality in pediatric patients with status epilepticus, as well as to identify characteristics of SE patients. Methods This retrospective cohort study included 88 pediatric patients with status epilepticus aged >1 month to ?18 years by consecutive sampling, who were treated at Dr. Sardjito Hospital, Yogyakarta. All subjects underwent assessment by STEPPS score, which were compared to functional outcome assessed by Pediatric Overall Performance Capacity (POPC) score and mortality. Results STEPPS > 3 was significantly correlated with poor functional outcome (OR 2.85; 95%CI 1.04 to 7.87; P=0.043), but was not significantly correlated with mortality outcome in children with SE (P=0.411). Conclusion STEPPS score with cut-off >3 can be used as a predictor of poor functional outcome in pediatric patients with SE aged >1 month to ?18 years, but cannot be used as a predictor of mortality.
Health comorbidities in children with down syndrome (DS) at Dr. Sardjito General Hospital, Yogyakarta Suryono Yudha Patria; Agung Triono
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.16062

Abstract

Down syndrome (DS) is a disease caused by trisomy of chromosome 21. The phenotype in DS leads to manifestations in several organ systems. This study aimed to identify the pattern of comorbidities in DS patients. It was a single-center, cross-sectional study at Dr. Sardjito General Hospital, Yogyakarta. Medical records of pediatric patients with DS from a period of January 2022 to May 2023 were included. Descriptive analysis was performed to demonstrate demographic and clinical characteristics. A total of 355 pediatric patients with DS were found at Dr. Sardjito General Hospital and the majority were male (196 children or 55.2%). As much as 339 children (95.49%) had comorbidities. The highest comorbidity was congenital heart disease (230 patients or 67.84%) in specifics were atrial septal defect (41 patients or 12.39%), atrioventricular septal defect (29 patients or 8.17%), and patent ductus arteriosus (28 patients or 7.88%). The second highest comorbidity was endocrine system disorders (102 patients or 30.09%), with 100 patients (28.16%) children suffering hypothyroidism. The number of children who had one comorbidity was 248 patients (69.86%), 74 patients (20.48%) had two comorbidities, and 17 patients (4.79%) had three or more comorbidities. The highest co-prevalence of the two comorbidities was congenital heart disease and endocrine system disorders (36 patients or 10.14%). The highest co-prevalence of 3 or more comorbidities was a combination of congenital heart disease, visual impairment, and hearing impairment (6 patients or 1.69%). In conclusion, 95.49% of children with DS have comorbidities. The most common comorbidity was heart defects. About 25.63% of patients had more than one comorbidity. Children with DS who have comorbidities require more attention to prevent complications and to reduce morbidity.
METODE CEK ANTARA RULER CALIBRATOR UNTUK JAMINAN MUTU INTERNAL KALIBRASI Amalia Rakhmawat; Agung Triono
Technologic Vol 11 No 1 (2020): Eleventh Volume of Technologic Series
Publisher : LPPM Politeknik Astra

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Abstract

Salah satu standar panjang yang ada di laboratorium kalibrasi adalah ruler calibrator yang digunakan untuk mengkalibrasi alat ukur besaran panjang konvensional yaitu berupa batangan maupun pita panjang berskala umumnya terbuat dari bahan plastik, logam baja atau kuningan. Sesuai dengan standar ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories klausul 6.4 bahwa “pengecekan antara (intermediate check)” harus dilakukan sesuai prosedur tertentu bila diperlukan untuk menjamin kepercayaan terhadap unjuk kerjanya sehingga laboratorium kalibrasi perlu melakukan pengecekan antara peralatan standar untuk menjamin status peralatan yang digunakan. Penelitian ini akan membahas cek antara ruler calibrator untuk jaminan mutu internal kalibrasi. Ruler calibrator memiliki ketelitian 0,005 mm dengan kapasitas 2000 mm akan dilakukan cek antara menggunakan artefak steel ruler pada panjang 100 mm. Pengulangan pengambilan data sebanyak 5 kali selama 20 hari dengan data 10 hari di awal dan 10 hari di akhir. Hal tersebut dilakukan untuk mendapatkan Fhitung perbandingan awal dan akhir dan Ftabel metode uji F. Dari data pengukuran didapatkan nilai µawal = 100,0059 mm dan nilai σawal = 0,006488, serta nilai µakhir = 100,0060 mm dan nilai σakhir = 0,006182. Dari data σawal dan σakhir didapatkan nilai Fhitung = 1,10, sedangkan nilai Ftabel dari tabel F yaitu 3,18. Karena data Fhitung ≤ Ftabel maka alat ukur ruler calibrator dinyatakan masih baik pada titik ukur 100 mm. Dari data tersebut didapatkan Control Chart yang dapat diambil kesimpulan bahwa bahwa nilai rata-rata masih berada di bawah batas UWL dan LWL sehingga alat ukur ruler calibrator dinyatakan masih baik pada titik ukur tersebut.
CEK ANTARA ALAT UKUR BURETTE UNTUK JAMINAN MUTU INTERNAL HASIL KALIBRASI Amalia Rakhmawati; Agung Triono
Technologic Vol 11 No 1 (2020): Eleventh Volume of Technologic Series
Publisher : LPPM Politeknik Astra

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Abstract

Pengukuran volume berperan penting dalam menjaga mutu dari produk yang dihasilkan. Salah satu alat ukur volume yang banyak digunakan adalah burette. Sesuai dengan standar ISO/IEC 17025:2017 laboratorium pengujian dan kalibrasi perlu melakukan pengecekan antara peralatan standar untuk menjamin status peralatan yang digunakan. Cek antara dilakukan dengan membandingkan berat isi yaitu berat cairan dalam gelas penampung yang dikeluarkan oleh valve burette dengan pembacaan standar electronic analytical balance ketelitian 0,0001 g. Data yang diambil sebanyak 5 kali selama 20 hari di awal dan di akhir untuk mendapatkan data perbandingan awal dan akhir yang akan digunakan untuk mendapatkan nilai Fhitung yang kemudian dibandingkan dengan nilai Ftabel pada metode uji F. Dari data awal didapatkan nilai µawal = 46,69108 g dan nilai σawal = 0,000109. Dan dari data akhir didapatkan nilai µakhir = 46,69110 g dan nilai σakhir = 0,000065. Dari data σawal dan σakhir didapatkan nilai Fhitung = 2,80, sedangkan nilai Ftabel dari tabel F yaitu 3,18. Karena data Fhitung ≤ Ftabel maka alat ukur burette dinyatakan masih baik pada titik ukur 10 mL. Dari control chart didapatkan nilai rata-rata masih berada pada wilayah UWL dan LWL sehingga alat ukur burette dinyatakan masih baik pada titik ukur tersebut.
METODE CEK ANTARA PRESSURE GAUGE UNTUK JAMINAN MUTU INTERNAL LABORATORIUM KALIBRASI Amalia Rakhmawati; Agung Triono
Technologic Vol 11 No 1 (2020): Eleventh Volume of Technologic Series
Publisher : LPPM Politeknik Astra

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Berdasarkan standar ISO/IEC 17025:2017 laboratorium pengujian dan kalibrasi perlumelakukan pengecekan antara peralatan standar untuk menjamin status peralatan yang digunakan.Penelitian ini membahas jaminan mutu internal hasil kalibrasi pressure gauge melalui cek antara yangwajib dilakukan oleh labroratorium. Pengambilan data dilakukan dengan pengulangan sebanyak 5 kaliselama 10 hari di antara selang waktu interval kalibrasi. Penelitian ini mengambil data sebanyak 20 haridi awal dan di akhir untuk mendapatkan nilai Fhitung yang akan dibandingkan dengan nilai Ftabel metode ujiF. Dari data awal didapatkan nilai µawal = 10,005 kgf/cm2 dan nilai σawal = 0,004137. Dari data akhirdidapatkan nilai µakhir = 10,010 kgf/cm2 dan nilai σakhir = 0,004789. Dari data σawal dan σakhir didapatkan nilaiFhitung = 0,75, sedangkan nilai Ftabel dari tabel F yaitu 3,18 untuk total 100 data pada k = 2. Karena nilaiFhitung ≤ Ftabel maka alat ukur pressure gauge digital dinyatakan masih baik pada titik ukur 10 kgf/cm2. Dari evaluasi ketidakpastian didapatkan nilai U95 yaitu ± 0,0093 kgf/cm2 sehingga nilai rata-rata data akhir dandata awal 10,008 ± 0,0093 kgf/cm2 masih masuk dalam area keberterimaan pada titik ukur tersebut.
Co-Authors Afiarina Dhevianty Amalia Rakhmawat Amalia Rakhmawati Aninditya Dwi Messaurina Arydina Arydina Braghmandita Widya Braghmandita Widya Indraswari Cahya Dewi Satria Charles Subakti Eggi Arguni Elisabeth S Herini Elisabeth Siti Herini Indah Kartika Murni Intan Fatah Kumara Irawan Mangunatmadja Madarina Julia Maria Ulfa Medina Permatawati Mei Neni Sitaresmi Nadia Qoriah Firdausy Niken Iswarajati Noormanto Noormanto Nurputra, Dian Kesumapramudya Restu Maharany Arumningtyas Retno Palupi Baroto Retno Sutomo Riona Sari Ruth Kania Permatasari Sari Wardhani Sasmito Nugroho Sumadiono Sumadiono Suryono Yudha Patria Titis Widowati