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Journal : MEDICINUS

Pendekatan Multiperspektif dalam Manajemen Penyakit Asma Dito Anurogo
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.108

Abstract

Asthma is a chronic inflammatory disorder of the respiratory tract. This scientific review aims to provide comprehensive explanation about asthma, including epidemiology, etiology, diet and nutrition, genetic and epigenetic factor, pathophysiology, asthma control evaluation, imaging, management, and trend toward novel therapy in the future, such as nanotechnology.
Terapi Sel Punca dan Tata Laksana Covid-19 Dito Anurogo; Zahradiva Putu Fitria Hermawan; Nur Rahmah Awaliah; Taruna Ikrar
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.113

Abstract

Covid-19 was first identified in Wuhan, China, and known as a disease that can damage the lungs, as well as other organs and system organs such as the heart and the immune system. To date, there is no specific treatment for this disease, however, scientists in China have conducted many clinical studies of cell-based therapies for patients with Covid-19 and other respiratory diseases, especially mesenchymal stem (stromal) cells (MSC), by utilizing MSC-derived conditioned media (CM) or extracellular vesicles and several other cell types. Recent preclinical data from respiratory viral infection models and clinical studies related to the use of MSCs by altering the expression of proinflammatory cytokines, and facilitate the repair of damaged tissue in Covid-19 patients. This research method uses descriptive case study method. The purpose of this study was to determine the effectiveness of therapy using stem cells or mesenchymal stem cells (MSCs) in the management of Covid-19. The results suggest that administration of allogeneic MSCs could accelerate the process of tissue repair in the lungs, thus reducing the need for further mesenchymal cell activation. Positive responses in subjects receiving UC-MSC treatment indicated a decrease in inflammatory cytokines, rather than a change in viral load. The high cost of cell therapy makes researchers only able to conduct limited clinical studies on cell therapy for Covid-19 patients.
Potensi farmakologi Kasumba Turatea (Carthamus tinctorius L.) sebagai antibakteri Lismayana Hansur; Ami Febriza; Dito Anurogo; Dara Ugi Aras; Endah Dwijayanti
MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6zstjd88

Abstract

Kasumba turatea (Carthamus tinctorius L.) is a plant that has been used as traditional medicine in South Sulawesi. Themain component of C. tinctorius L. flowers is hydroxysafflor yellow A, which functions as an anti-inflammatory, antioxidant,and platelet aggregation inhibitor. This review highlights pharmacological potential of C. tinctorius L. as an antibacterialagent. The method involves a literature review from various databases such as PubMed, Google Scholar, and Scopus. Theresults show that C. tinctorius L. extracts are effective against various pathogenic bacteria such as Listeria monocytogenes,Streptococcus iniae, Staphylococcus aureus, and Escherichia coli. Bioactive compounds like carthamin, phenolics, and flavonoids exhibit significant antibacterial activity. Additionally, C. tinctorius L. extracts also show potential as anthelminticand antioxidant agents. Further research is required to isolate and characterize specific bioactive compounds, followed by in vivo validation and clinical study to confirm their efficacy as well as safety.