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All Journal Natural Science: Journal of Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Jurnal Ilmiah Medicamento

Alwiyah Mukaddas

Tadulako University

Author-ID : 323932

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profil Penggunaan Obat Antidotum Di Rumah Sakit Umum Daerah Undata Provinsi Sulawesi Tengah Periode 2016-2018: Profile of Using Antidotum at Undata General Hospital Central Sulawesi Province Periode of 2016-2018 Mukaddas, Alwiyah; Faustine, Ingrid; Ulti, Putri Hijjah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Antidotes drug is indicated in intoxication or poisoning patients, in addition to the antidote drugs, it can also be used as an appropriate therapeutic indication of his own medicine. The high increasing number of the antidote drug used every year in inpatient instalation Undata hospital, for exmple atropine, N-acetylcysteine and pyridoxine (vitamin B6). Therefore, this study aims to determine the percentage of drug use of antidote category indicated as an antidote therapy in Undata hospitals Central Sulawesi Province period 2016-2018. This is a descriptive study with retrospective approach and using purposive sampling techniques.The results showed that the sample size was 75 patients, with the percentage of drug use as antidotes category in Undata Hospital Central Sulawesi province period 2016-2018, namely pyridoxine (vitamin B6) of 49.33%, N-acetylcysteine drug of 42.66% and the atropine drug of 8%. The use of antidotes drug category are indicated as an antidote to the poisoning therapy drugs obtained 0%. It can be concluded that there is no antidote drug category that used as an antidote therapy on patients with drug poisoning in inpatient instalation Undata hospital Central Sulawesi Province Period 2016-2018.

Penambatan Molekuler dan Simulasi Dinamika Molekuler Senyawa Dari Genus Nigella Terhadap Penghambatan Aktivitas Enzim Protease HIV-1: Molecular Docking and Molecular Dynamics Simulation of Compounds from Nigella Genus on Protease HIV-1 Enzyme Inhibitors Zubair, Muhammad Sulaiman; Maulana, Saipul; Mukaddas, Alwiyah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Nigella plant genus has potential as anti-HIV. One species of Nigella, Nigella sativa has been reported to have HIV-1 protease enzyme inhibitory activity. This research aims to determine the compounds of the Nigella genus that have activity as HIV-1 protease enzyme inhibitory activity through molecular docking method by Autodock Vina and to compare interaction stability through molecular dynamics simulations by AMBER. The metabolite of the Nigella genus was obtained from the KnapSack website, and enzyme model was obtained from the Protein Data Bank (3NU3). The results of molecular docking found the lowest affinity energy of Nigella compound is Nigellidine 4-O-sulfite (-13.4 kcal/mol). Meanwhile, the affinity energy of the ligand native (Amprenavir) was -12.1 kcal/mol. The lowest affinity energy of Nigellidine 4-O-sulfite might be predicted to have potency as an HIV-1 Protease inhibitor. Molecular dynamics simulation showed Root Mean Square Fluctuation (RMSF) value of Nigellidine 4-O-sulfite with the amino acid active site is 0.4064 Ã… for ASP:25 and 0.5667 Ã… for ASP: 125. Whereas RMSF ligand native with the amino acid active site, ASP: 25 is 0.3647 Ã… and ASP: 125 is 0.3639 Ã…. The higher RMSF value of Nigellidine 4-O-sulfite describes the lower interaction stability than the ligand native.

Effect of Metformin Therapy on Low Density Lipoprotein (LDL) Levels in Type 2 Diabetes Mellitus Patients at Undata Hospital in Palu City Central Sulawesi: Efek Terapi Metformin terhadap Level Low Density Lipoprotein (LDL) pada Pasien Diabetes Mellitus Tipe 2 pada RS Undata di Kota Palu Sulawesi Tengah Mukaddas, Alwiyah; Rumi, Amelia; Yulianti, Tri
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15596

Background: Metformin, which can control blood glucose levels, can reduce LDL levels in type 2 DM patients. Objectives: To determine the mean value of pre and post LDL in type 2 DM patients after receiving metformin therapy for three months. Methods: This study used a cross-sectional study with a prospective approach, It was done by conducting pre and post examination of LDL levels using metformin. This study was analyzed using the SPSS Wilcoxon statistical test. The total sample that met the inclusion and exclusion criteria was 18 respondents. Results: This study used a single metformin value (sig = 0.000 <0.05) with a baseline mean value of 148.22 mg / dL and an evaluation of 133.56 mg / dL where the difference in reduction was 14.66 mg / dL. Conclusion: There was a decrease in LDL levels in type 2 DM patients after using metformin for three months.

Co-Authors Aldu Wijaya Febrianto amelia rumi, amelia Fahrul Fahrul Fandi, Indra Dwi Faradillah, Nurul Inggrid Faustine Ingrid Faustine Khusnul Diana LESTARI, WIDYA Mardiyani Lolopayung Moh Zainal Rizky Muhammad Sulaiman Zubair Nofriyanti Nofriyanti Ririen Hardani Saipul Maulana Sri Rahayu Yulianti Sunaryani, Rachelia Tandah, M. Rinaldhi Tri Yulianti, Tri Ulti, Putri Hijjah

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