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Anti-hepatitis B surface (anti-HBs) seroprotection in children with acute lymphoblastic leukemia post hepatitis B vaccination in Indonesia Roni Naning, Yustinah Nenny Sri Mulyani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 01 (2014)
Publisher : Universitas Gadjah Mada

Children with acute lymphoblastic leukemia (ALL) receiving chemotherapy are at high risk fordeveloping hepatitis B infection. Protective effect of hepatitis B vaccination in children withALL in Indonesia has not been investigated yet. The aim of study was to determine the proportiondifference of anti-HBs seroprotection between children with ALL and without malignancy posthepatitis B vaccination. We had conducted a case-control study from January to February 2012at Dr. Sardjito General Hospital, Yogyakarta. We ascertained 1-15 years old children with ALLreceiving chemotherapy and without malignancy who had hepatitis B vaccination. Sixty sevenchildren were included in this study. Anti-HBs seroprotection level was measured using anenzyme-linked immunosorbent assay (ELISA). The results were analyzed using Chi-square test.Twenty one children (65.6%) with ALL and 13 children (37.1%) without malignancy showedanti-HBs seroprotection. The difference was statistically significant with p-value of 0.020(prevalence ratio [PR]=0.3; 95% CI=0.11-0.84). Both groups showed no significantly differenceof anti-HBs seroprotection according to either female gender, risk classification, or phase ofchemotherapy with p-value of 0.38 (PR =4; 95% CI=1.05-15.2), 0.248 (PR =3.37; 95%CI=0.58-19.6) or 0.214, respectively. In conclusion, the proportion of anti-HBs seroprotectionin children with ALL is higher than those without malignancy.

The effect of fructooligosaccharide (FOS) in Children With Diarrhea Yati Soenarto, Mohammad Juffrie Yunri Istari, Nenny Sri Mulyani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Universitas Gadjah Mada

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Latar belakang: Penyakit diare masih merupakan penyebab penting kesakitan dan kematian bayi dan anak di negara berkembang. Penyakit diare ini disebabkan oleh ketidakseimbangan flora usus yang dipengaruhi oleh jumlah bakteria yang menguntungkan . FOS dapat menstimulasi pertumbuhan bakteri yang menguntungkna dan menghambat bakteri pastogen yang menyebabkan infeksi saluran cernaÂ Tujuan: Mengetahui efekFructooligosaccharide pada diareBahan dan cara: penelitina kendali acak dilakukan di 8 puskesmas di Yogyakarta. Seratus delapan belas sampel ikut dalam penelitian ini, 93 masuk dalam kelompok FOS yang mendapat FOS 2,5 gram atau 5 gram per hari sesuai umur, dan 25 masuk dalam kelompok plasebo. Lamanya diare dan keasaman tinja diukur selama penelitianHasil: Lama diare lebih pendek secara bermakna pada kelompok FOS dibanding plasebo p

The effect of fructooligosaccharide (FOS) in Children With Diarrhea Mohammad Juffrie Yunri Istari, Nenny Sri Mulyani Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.182 KB)

Latar belakang: Penyakit diare masih merupakan penyebab penting kesakitan dan kematian bayi dan anak di negara berkembang. Penyakit diare ini disebabkan oleh ketidakseimbangan flora usus yang dipengaruhi oleh jumlah bakteria yang menguntungkan . FOS dapat menstimulasi pertumbuhan bakteri yang menguntungkna dan menghambat bakteri pastogen yang menyebabkan infeksi saluran cerna Tujuan: Mengetahui efekFructooligosaccharide pada diareBahan dan cara: penelitina kendali acak dilakukan di 8 puskesmas di Yogyakarta. Seratus delapan belas sampel ikut dalam penelitian ini, 93 masuk dalam kelompok FOS yang mendapat FOS 2,5 gram atau 5 gram per hari sesuai umur, dan 25 masuk dalam kelompok plasebo. Lamanya diare dan keasaman tinja diukur selama penelitianHasil: Lama diare lebih pendek secara bermakna pada kelompok FOS dibanding plasebo p

Anti-hepatitis B surface (anti-HBs) seroprotection in children with acute lymphoblastic leukemia post hepatitis B vaccination in Indonesia . Yustinah; Nenny Sri Mulyani; Roni Naning
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 01 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Children with acute lymphoblastic leukemia (ALL) receiving chemotherapy are at high risk fordeveloping hepatitis B infection. Protective effect of hepatitis B vaccination in children withALL in Indonesia has not been investigated yet. The aim of study was to determine the proportiondifference of anti-HBs seroprotection between children with ALL and without malignancy posthepatitis B vaccination. We had conducted a case-control study from January to February 2012at Dr. Sardjito General Hospital, Yogyakarta. We ascertained 1-15 years old children with ALLreceiving chemotherapy and without malignancy who had hepatitis B vaccination. Sixty sevenchildren were included in this study. Anti-HBs seroprotection level was measured using anenzyme-linked immunosorbent assay (ELISA). The results were analyzed using Chi-square test.Twenty one children (65.6%) with ALL and 13 children (37.1%) without malignancy showedanti-HBs seroprotection. The difference was statistically significant with p-value of 0.020(prevalence ratio [PR]=0.3; 95% CI=0.11-0.84). Both groups showed no significantly differenceof anti-HBs seroprotection according to either female gender, risk classification, or phase ofchemotherapy with p-value of 0.38 (PR =4; 95% CI=1.05-15.2), 0.248 (PR =3.37; 95%CI=0.58-19.6) or 0.214, respectively. In conclusion, the proportion of anti-HBs seroprotectionin children with ALL is higher than those without malignancy.

Virus transfusion transmitted pada anak dengan transfusi berulang Nenny Sri Mulyani; . Sumadiono; Hijikata M; Mishiro S; . Mulyanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 38, No 04 (2006)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5432.86 KB)

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Trends of Rotavirus Diarrhea in Hospitalized Children in Yogyakarta Year 2013 –2015 Nenny Sri Mulyani; Dian Anggraini; Retno Palupi Baroto; Asal Wahyuni Erlin Mulyadi; Rizki Anindita; Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Diarrhea, together with pneumonia, is accountable for 25% death of children under five globally (IVAC, 2017). In Indonesia, diarrhea is also among the top ten diseases of cause of death in children under five (WHO, 2015). Rotavirus diarrhea is responsible for 60% in 2006 (Soenarto et al, 2009) of children diarrhea in Indonesia. Rotavirus vaccine in Indonesia was introduced commercially in 2011, nonetheless its use was reportedly low. Despite the declining rate of rotavirus incidence, surveillance is important to show the burden of rotavirus diarrhea in children. Thus, this study aims to describe the incidence of rotavirus diarrhea in hospitalized children under five in Yogyakarta province. This was a prospective study, conducted in two participating hospitals in Yogyakarta: RSUP Sardjito Yogyakarta and RSUD Wates from January 2013 – December 2015. This study is a part of the Indonesia surveilance entitled “Hospital-based surveillance of rotavirus diarrhea in children in Indonesia”, enrolling children under five hospitalized due to acute watery diarrhea. The questionare was modified from the WHO generic protocol of rotavirus surveillance (WHO, 2002). Data collection was perfomed after informed consent was signed by parent or guardian. The stool samples were tested for rotavirus with the EIA test and tested for genotyping with RT-PCR. The data were analysed and presented using descriptive analytic method. Of 684 eligible patients hospitalized with acute watery diarrhea, 557 subjects were enrolled with 518 feces were tested for rotavirus. The percentage of rotavirus incidence in year 2013, 2014, and 2015 were 37%, 41% and 61 % respectively. The predominant rotavirus genotyping was G3P [8]. Rotavirus mostly found in children age 6 – 23 months (55 %), and was identified more in male than female (62 % vs 38%). During the 3 years study period, rotavirus occurred all year round, and showed to reach its peak on January 2015. Rotavirus positive diarrhea commonly presented with dehydration (79%) compare to negative rotavirus diarrhea (55%). It indicated that the incidence rate of rotavirus diarrhea in Yogyakarta is quite high and rotavirus diarrhea remains as significant contributor to hospitalized children with diarrhea. The trend of rotavirus diarrhea in children under 5 years increased over the years’ period. The rotavirus diarrhea mostly presented with dehydration, thus rotavirus diarrhea remains as significant contributor to hospitalized children with diarrhea. This shows an evidence that the burden of rotavirus diarrhea in children under 5 years remains prominent.

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