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All Journal HAYATI Journal of Biosciences The Indonesian Biomedical Journal Asian Australasian Neuro and Health Science Journal (AANHS-J) JSIP: Jurnal Studi Ilmu Pemerintahan Salam (Islamic Economics Journal) Saraq Opat : Jurnal Administrasi Publik
Wawan Mulyawan
Institure for Aerospace Medicine (Lakespra) Saryanto Air Force, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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How can local Governments become Pioneers in Tourism Development? Analysis of Organizational Performance and Influencing Factors Mulyawan, Wawan
Jurnal Studi Ilmu Pemerintahan Vol. 5 No. 1 (2024): JSIP: Jurnal Studi Ilmu Pemerintahan
Publisher : Department of Government Studies, Universitas Muhammadiyah Buton.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35326/jsip.v5i1.5073

Abstract

This study examines the pivotal role of accountability and responsibility, together with the influence of organizational structure, human resource capabilities, and financial management, in enhancing the performance of tourist sector growth in Bima Regency. This study employs qualitative primary and secondary data-gathering techniques, including interviews, documentation analysis, and direct observation. The research informants included officials from the Bima Regency Culture and Tourism Service, Village Heads, and community leaders in the local government. The research findings indicate that the regional government's dedication to performance accountability, achieved through the transparent allocation of budget and monitoring of tourism destination performance, along with its responsibility to preserve the environment, develop sustainable products, and promote community participation, establishes a harmonious equilibrium between economic growth and environmental sustainability. A well-designed organizational structure promotes efficient coordination and decision-making, while improved human resource skills and prudent financial management bolster the success of tourist development programs, establishing a strong basis for sustained growth in Bima Regency. This study offers valuable insights into how local governments may lead tourist development by prioritizing accountability, responsibility, organizational structure, and efficient administration of human and financial resources.
Surgery of Left Temporal Region Arachnoid Cyst with Neuroendoscopy: A Case Report Wiwoho, Yudi Yuwono; Rolian, Danu; Ichwan, Syaiful; Mulyawan, Wawan
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 3 No. 1 (2021): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhsj.v3i1.5935

Abstract

Introduction: Today, the development of minimally invasive neurosurgery technique, has become a choice of treatment for many neurosurgical disease.  Dr.Suyoto Hospital, Rehabilitation Center, Ministry of Defence of the Republic of Indonesia and Indonesian Airforce Hospital Dr. Esnawan Antariksa, Halim Perdanakusuma, Jakarta, Indonesia, has responsibility in public health services for military and civilian community. This paper has an objective to share experience in giving treatment with intracranial neuroendoscopy technique for patient with left temporal region arachnoid cyst. Case Report: Case Report 1 : Girl, 17 years old, with headache. There was no neurological deficit, and from brain CT Scan, there was a cystic lesion at the left temporal region. The diagnosis was arachnoid cyst. She performed neuroendoscopic cystotomy and insertion of Omaya reservoir. After surgery, she had no headache, and there were no post-operative complications. Histopatology finding was arachnoid cyst. From follow up of brain CT Scan, there was improvement. We used intracranial neuroendoscopy device from B-Braun Aesculap, Germany, 2015. Case Report 2 : Boy, 8 years old, with seizure and headache. There was no neurological deficit, and from brain CT Scan, there was a cystic lesion at the left temporal region. The diagnosis was arachnoid cyst. He performed neuroendoscopic cystotomy and insertion of Omaya reservoir. Dicussion: After surgery, he had no headache and also had no seizure, and there were no post-operative complications. Histopatology finding was arachnoid cyst. From follow up of brain CT Scan, there was improvement. We used intracranial neuroendoscopy device from B-Braun Aesculap, Germany, 2015. Conclusion: Intracranial neuroendoscopy technique can be applied for the treatment of many special and selective neurosurgical diseases, including arachnoid cyst. In this patient, intracranial neuroendoscopy had good result. We still need more many of cases for determine the success rate of this intracranial neuroendoscopy technique statistically
Intermittent Exposure to Hypobaric Hypoxia Increases VEGF, HIF-1α, and Nrf-2 Expressions in Brain Tissue Wardaya, Wardaya; Sukmawati, Dewi; Ibrahim, Nurhadi; Ferdinal, Frans; Mudjihartini, Ninik; Sadikin, Mohamad; Jusman, Sri Widia A.; Satriotomo, Irawan; Mulyawan, Wawan
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3519

Abstract

BACKGROUND: Hypoxia inducible factor-1α (HIF-1α), nuclear factor erythroid 2-related factor 2 (Nrf-2), and vascular endothelial growth factor (VEGF), play a crucial role as neuroprotective factors. Currently, there is a lack of studies examining the biomolecular responses of the brain to intermittent hypoxia resulting from various pressures. This study was conducted to investigate the physiological responses, histopathological features, and cellular adaptive responses in the brains of rats that were intermittently exposed to hypobaric hypoxic conditions.METHODS: Thirty male Sprague Dawley rats were divided into six groups: a control group and five treatment groups exposed to hypobaric hypoxia. The treatment groups were placed in a hypobaric chamber simulating an altitude of 3,048 meters for 1 hour/day for 1, 7, 14, 21, and 28 days. After exposure, brain tissue was collected for histopathological analysis and protein quantification of HIF-1α, Nrf-2, cytoglobin (Cygb), neuroglobin (Ngb), VEGF, malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT).RESULTS: In the brain, intermittent hypobaric hypoxia significantly increased HIF-1α expression (p=0.000) and its downstream proteins Cygb (p=0.000), and VEGF (p=0.001), with a peak at 14x IHH exposure compared to control. This was followed by a significant increase in Nrf-2 expression (p=0.000), SOD (p=0.000), Gpx (p=0.000), and CAT activity (p=0.000), indicating an adaptive antioxidant response. Conversely, MDA levels was decreased with prolonged exposure, suggesting reduced oxidative damage.CONCLUSION: IHH elevates HIF-1α, Nrf-2, and oxidative stress markers, triggering an adaptive antioxidant response in the rat’s brains.KEYWORDS: HIF-1α, intermittent hypobaric hypoxia, Nrf-2, oxidative stress
APBN DAN PENDAPATAN NASIONAL Mulyawan, Wawan
Salam (Islamic Economics Journal) Vol. 1 No. 2 (2020): December 2020
Publisher : Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/slm.v1i2.7929

Abstract

Perencanaan anggaran dalam sebuah Negara mutlak diperlukan sebagai instrument untuk mencapai stabilitasi suatu pemerintahan dalam jangka waktu tertentu, termasuk didalamnya Anggaran Pendapatan dan Belanja Negara (APBN). Sedangkan pendapatan nasional sendiri memiliki cakupan yang lebih spesifik dari APBN itu sendiri dimana pendapatan nasional itu dihitung berdasarkan jumlah pendapatan yang diterima oleh seluruh Rumah Tangga Keluarga (RTK) di suatu Negara dari penyerahan faktor-faktor produksi dalam satu periode waktu tertentu (biasanya dihitung dalam jangka waktu satu tahun).
Intermittent Hypobaric Hypoxia Preconditioning Ameliorates Kidney Damage Compared to Acute Hypoxia Sadikin, Abdul Halim; Jusman, Sri Widia Azraki; Mulyawan, Wawan; Prijanti, Ani Retno
HAYATI Journal of Biosciences Vol. 32 No. 6 (2025): November 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.6.1437-1446

Abstract

Many studies have reported that intermittent hypobaric hypoxia (IHH) can cause oxidative stress and tissue damage in the kidneys, which can lead to impaired kidney function. However, a study using simulated intermittent hypobaric hypoxia was considered to have a protective role for the kidneys. This study aims to determine the effect of IHH on kidney adaptation to oxidative stress and kidney damage. Twenty-five rats were divided into five groups: control, one-time hypoxia (AHH), two-time hypoxia (IHH 1), three-time hypoxia (IHH 2), and four-time hypoxia (IHH 3). The intermittent interval was one week, and at the time of treatment, the rats were placed in a hypoxic chamber. At the end of treatment, the rats were sacrificed, and the kidneys, urine, and blood were collected. The kidney tissues were used for protein assay, ELISA (HIF-1α and VEGF), qPCR (cytoglobin (Cygb) and renin), SOD and GPx activity assay. Blood was used for creatinine and urea assay, and urine was used for KIM-1 ELISA. Formalin-submerged tissues were used for histopathological analysis. The level of HIF-1α and VEGF increased significantly from AHH to IHH 1. Cygb and renin expressions peaked at AHH and decreased at subsequent IHH groups. The Nrf2 level and GPx activity didn’t show any difference, but SOD activity peaked at IHH 1. The creatinine level only peaked at IHH 2; other groups remained the same as the control. Urea levels decreased with more IHH sessions, and KIM-1 didn’t show any difference. Our findings exhibit that hypoxia preconditioning by IHH treatment leads to the kidney’s adaptability to hypoxia and does not cause kidney damage.
Analisis Penanggulangan Kemiskinan melalui metode Sharing Profit pada Pengelolaan wisata “Pulau Ular” di Desa Pai Kecamata Wera Kabupaten Bima Firdaus, Firdaus; Tasrif, Tasrif; Mulyawan, Wawan
Saraq Opat: Jurnal Administrasi Publik Vol 4 No 2 (2022): Juli : Saraq Opat: Jurnal Administrasi Publik
Publisher : Universitas Gajah Putih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55542/saraqopat.v4i2.359

Abstract

Tourism has an influence on economic growth through several channels (Brida et al, 2010). First, the tourism sector as a foreign exchange earner to obtain capital goods used in the production process (McKinnon, 1964). Second, tourism development stimulates investment in infrastructure (Sakai, 2006). Third, the development of the tourism sector encourages the development of other economic sectors through direct, indirect, and induced effects (Spurr, 2006). Fourth, tourism contributes to increasing job opportunities and increasing income (Lee & Chang, 2008). Fifth, tourism causes positive economies of scale (Weng & Wang, 2004). Tourism is also an important factor in the dissemination of technical knowledge, encouraging research and development, and the accumulation of human capital (Blake et al, 2006). The purpose of this study is to describe the process of Poverty Reduction through the Profit Sharing method in the management of "Snake Island" tourism in Pai Village, Wera District, Bima Regency towards improving the welfare of the community. Qualitative data analysis used an interaction analysis model consisting of data collection, data reduction, data presentation, conclusion drawing, and verification.
Co-Authors Ani Retno Prijanti Dewi Sukmawati Firdaus Firdaus Frans Ferdinal Jusman, Sri Widia Azraki Jusman, Sri Widia Azraki Mohamad Sadikin Ninik Mudjihartini Novi S. Hardiany Nurhadi Ibrahim Rolian, Danu Sadikin, Abdul Halim Satriotomo, Irawan Septelia I. Wanandi Syaiful Ichwan Tasrif Tasrif Wardaya Wardaya Wiwoho, Yudi Yuwono