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All Journal Neurologico Spinale Medico Chirurgico Asian Australasian Neuro and Health Science Journal (AANHS-J) Indonesian Journal of Cancer Neurona
Syaiful Ichwan
Department Of Neurosurgery Faculty Of Medicine Universitas Indonesia - RSUP Nasional Cipto Mangunkusumo Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Cervical Myelopathy as the Most Common Symptoms in Patients Undergoing C-Spine Surgery in the Spine Division, Department of Neurosurgery, Cipto Mangunkusumo General Hospital, from January 2012 to December 2016 Mohamad Saekhu; Jeremia Prasetya Pardede; Renindra Ananda Aman; Syaiful Ichwan; Wismaji Sadewo; Samsul Ashari; Setyowidi Nugroho
Neurologico Spinale Medico Chirurgico Vol 1 No 1 (2018)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.507 KB)

Abstract

Background: Cervical spine disease has the potential to reduce productivity in affected patients because of myelopathy and mood disorder (e.g. depression) which lead to decreasing of the patient’s quality of life.Objective: This study aims to elaborate on the most frequent symptoms and pathology of C-spine disease in patients who underwent a surgical procedure over the period time from January 2012 to December 2016.Method: This study is a retrospective. All patients who underwent surgery for the C-spine disease are included. The data was obtained from the records in our spine database.Result: The total number of surgical procedures for spine disease over the 5 years was 345 procedures, with 127 procedures in the C-spine which are the second most common procedures of spine surgery in Department of Neurosurgery FMUI. The C-spine diseases were more common in males, aged more than 50 years old. The most frequent disease or pathology is a degenerative disease, and yet, tumour cases show an increasing number and became the most common pathology in the year of 2016. The most common procedure is anterior cervicaldiscectomy and fusion (ACDF).Conclusion: Our study showed that the most common symptoms and pathology are myelopathies and degenerative disease respectively, which has similarity with another study in the term of the mostfrequent pathology and surgical procedure. The finding of the more advanced neurological condition by the time of surgery as the most common symptom is found to be contradictory with other studies in western countries.
PERCUTANEOUS EPIDURAL NEUROPLASTY (PEN) USING COMBINATION OF HYALURONIDASE AND HYPERTONIC SALINE (NaCl 3%) IN TREATING FAILED BACK SURGERY SYNDROME Wawan Mulyawan; Yudi Yuwono Wiwoho; Syaiful Ichwan
Neurologico Spinale Medico Chirurgico Vol 1 No 1 (2018)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1051.323 KB)

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Background: Following surgical treatments for low back pain, lower extremity pain or neurologic symptoms would last or recur, this is defined as failed sack surgery syndrome (FBSS). FBSS usually occurs in 5-40% of these surgical patients. The most common cause is an epidural scar adhesion. Percutaneous epidural neuroplasty is the non-mechanical treatment for this condition. Previously, the use of hyaluronidase and hypertonic saline separately is commonly used for epidurolysis but the combination of hyaluronidase and hypertonic saline 3% has not been explored.Objective: To investigate the two-year outcomes of percutaneous epidural neuroplasty using a combination of hyaluronidase and hypertonic saline 3% in patients with FBSS.Methods: Twelve patients who experience low back pain, with or without radiculopathy, who have underwent lumbar spine surgery previously were assigned to the study. Parameters, such as the visual analogue scale scores for the back (VAS-B) and legs (VAS-L), and the Oswestry disability index (ODI), were recorded and compared between pretreatment, 1 week, 1 month, 3 months, 1 year and 2 years follow-up.Results: For all 12 patients, the postoperative VAS-B, VAS-L, and ODI were significantly different from the preoperative values in all follow-up periods: 1 month, 3 months, 1 year, and 2 years.Conclusion: Based off this study group, percutaneous epidural neuroplasty using a combination of hyaluronidase and hypertonic saline 3% has a favourable outcome in the 2 years follow-up
The Difference of Hypoxia Inducible Factor 2α mRNA Expression in High-Grade and Low-Grade Glioma Tissue Bagus Ramasha Amangku; Syaiful Ichwan; Septelia Inawati Wanandi; Novi Silvia Hardiany
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (967.349 KB) | DOI: 10.33371/ijoc.v13i2.633

Abstract

Background: HIF-2α is a transcription factor in hypoxic condition, and high expression levels of it correlate with the concepts of metastasis, therapy opposition and reduced quality of prognosis in various forms of cancerous growth. Due to the exceedingly infiltrative ability of brain glioma cells, gliomas cannot be completely deteriorated with surgery and the relapse rate is high. This study goal to identify the relative expression of HIF-2α gene in the direction of glioma malignancy and its classification. Methods: Specimens used in this research comprise of 20 glioma samples obtained from glioma patients in Cipto Mangunkusumo Hospital. Relative expression of HIF-2α was measured by utilizing quantitative Real Time-Polymerase Chain Reaction (RT-PCR). Cycle threshold (CT) values were achieved correlated with the amplified DNA, and then the relative expression was attained by using Livak method of calculation. Results: The results produced a greater average of relative expression of HIF-2α in the grade III and IV types (18.64; n=7) rather than in the lower grades (5.68; n=13). However, the data is statistically inconsequential. Conclusions: High-grade glioma tends to express HIF-2α mRNA higher compared to the lower grade. Therefore, it is possible to use HIF-2α as a prognostic marker for glioma- diagnosed patients, although additional experiments need to be performed to strengthen these facts.
Surgery of Left Temporal Region Arachnoid Cyst with Neuroendoscopy: A Case Report Wiwoho, Yudi Yuwono; Rolian, Danu; Ichwan, Syaiful; Mulyawan, Wawan
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 3 No. 1 (2021): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhsj.v3i1.5935

Abstract

Introduction: Today, the development of minimally invasive neurosurgery technique, has become a choice of treatment for many neurosurgical disease.  Dr.Suyoto Hospital, Rehabilitation Center, Ministry of Defence of the Republic of Indonesia and Indonesian Airforce Hospital Dr. Esnawan Antariksa, Halim Perdanakusuma, Jakarta, Indonesia, has responsibility in public health services for military and civilian community. This paper has an objective to share experience in giving treatment with intracranial neuroendoscopy technique for patient with left temporal region arachnoid cyst. Case Report: Case Report 1 : Girl, 17 years old, with headache. There was no neurological deficit, and from brain CT Scan, there was a cystic lesion at the left temporal region. The diagnosis was arachnoid cyst. She performed neuroendoscopic cystotomy and insertion of Omaya reservoir. After surgery, she had no headache, and there were no post-operative complications. Histopatology finding was arachnoid cyst. From follow up of brain CT Scan, there was improvement. We used intracranial neuroendoscopy device from B-Braun Aesculap, Germany, 2015. Case Report 2 : Boy, 8 years old, with seizure and headache. There was no neurological deficit, and from brain CT Scan, there was a cystic lesion at the left temporal region. The diagnosis was arachnoid cyst. He performed neuroendoscopic cystotomy and insertion of Omaya reservoir. Dicussion: After surgery, he had no headache and also had no seizure, and there were no post-operative complications. Histopatology finding was arachnoid cyst. From follow up of brain CT Scan, there was improvement. We used intracranial neuroendoscopy device from B-Braun Aesculap, Germany, 2015. Conclusion: Intracranial neuroendoscopy technique can be applied for the treatment of many special and selective neurosurgical diseases, including arachnoid cyst. In this patient, intracranial neuroendoscopy had good result. We still need more many of cases for determine the success rate of this intracranial neuroendoscopy technique statistically
LUARAN PERDARAHAN INTRAVENTRIKEL YANG DILAKUKAN OPERASI DI DEPARTEMEN BEDAH SARAF RSUPN DR. CIPTO MANGUNKUSUMO Sadewo, Wismaji; Amelia, Liza; Tobing, Hanif Gordang; Nugroho, Setyo Widi; Ichwan, Syaiful; Ashari, Samsul
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.45

Abstract

      INTRAVENTRICULAR HEMORRHAGE OUTCOME OPERATED ON NEUROSURGERY DEPARTMENT OF CIPTO MANGUNKUSUMO HOSPITALABSTRACTIntroduction: Intraventricular hemorrhage (IVH) is a spontaneous hemorrhage occurring within the ventricular system, 30-45% often associated with intracerebral hemorrhage (ICH). Evaluating accurate and precise daily activity in post-stroke patients is critical for the quality of care and measurement of post-stroke outcomes. Modified Rankin Scale (mRS) is a global disability measurement scale used for the evaluation of stroke recovery.Aims: Configuring outcome data of patient with intraventricular hemorrhage operated at neurosurgery department of Cipto Mangunkusumo Hospital based on mRS.Methods: A retrospective study with cross sectional design towards patient with intraventricular hemorrhage at neurosurgery department Cipto Mangunkusmo Hospital, Jakarta, between Januari 2019 and August 2016. Subject or family member was interviewed to assess the subject’s functional status 6 month after operation using mRS.Results: There were 23 subjects mostly under 60 years old (60.8%) with 6 months IVH overall outcomes independent (47.8%) based on mRS. Majority of the subjects were admitted in severe condition with IVH score mostly >15 (65.25), mean Glasgow Coma Scale (GCS) 7.6±2.14, and mean arterial pressure >100 (87%) with factor risk for hypertension (82.6%).Discussion: Operation procedure on patient with intraventricular hemorrhage gives a relatively good outcome although with poor baseline at the time of admission.Keywords: Intracerebral  hemorrhage, intraventricular hemorrhage, Modified Rankin ScaleABSTRAKPendahuluan: Perdarahan intraventrikel (intraventricular hemorrhage/IVH) merupakan perdarahan spontan yang terjadi di dalam sistem ventrikel, 30-45% sering berhubungan dengan perdarahan intraserebral (PIS). Evaluasi aktifitas sehari-hari yang akurat dan tepat pada pasien pascastroke sangat penting untuk kualitas perawatan dan pengukuran luaran pascaperawatan stroke. Modified Rankin Scale (mRS) merupakan skala pengukuran disabilitas yang dipakai secara global untuk evaluasi pemulihan dari stroke.Tujuan: Menelaah data luaran penderita perdarahan intraventrikel yang dilakukan operasi di Departemen Bedah Saraf RSUPN Dr. Cipto Mangunkusumo berdasarkan mRS.Metode: Penelitian retrospektif secara potong lintang terhadap pasien dengan perdarahan intraventrikel yang dikelola oleh Departemen Bedah Saraf RSUPN Dr. Cipto Mangunkusumo, Jakarta, pada bulan Januari 2010 hingga Agustus 2016. Subjek atau keluarga diwawancara untuk menilai status fungsional 6 bulan pascaoperasi menggunakan mRS.Hasil: Didapatkan 23 subjek yang sebagian besar berusia di bawah 60 tahun (60,8%) dengan luaran 6 bulan yang dalam keadaan independen (47,8%) berdasarkan mRS. Mayoritas subjek masuk dalam keadaan yang buruk dengan skor IVH terbanyak adalah >15 (65,2%), rerata Skala Koma Glasgow (SKG) 7,6±2,14, dan mean arterial pressure >100 (87%), serta memiliki faktor risiko hipertensi (82,6%).Diskusi: Tata laksana operasi pada pasien dengan perdarahan intraventrikel memberikan luaran yang cukup baik, walaupun pasien masuk dalam keadaan yang buruk.Kata kunci: Modified Rankin Scale, perdarahan intraserebral, perdarahan intraventrikel
Co-Authors A.A. Ketut Agung Cahyawan W Affan Priyambodo Alida Harahap Aman, Renindra Ananda Amelia, Ria Bagus Ramasha Amangku David Tandian David Tandian David Tandian,* Muhammad Harisyah,* Hanif Gordang Tobing,* Samsul Ashari,* Renindra Ananda Aman,* Sy Febrial Hikmah Fidinny Hamid HANS-JOACHIM FREISLEBEN Hilman Mahyuddin Ina S. Timan Jeremia Prasetya Pardede Kurniawan, Azhar Farisyabdi Liza Amelia Martin Susanto Mohamad Saekhu Mohammad A. Aulia Nia Yuliatri Novi S. Hardiany Novi Silvia Hardiany Nugroho, Setyo Widi Padmo Santjojo Renindra A. Aman Renindra A. Aman Renindra A. Aman Renindra Ananda Aman Rolian, Danu Sadewo, Wismaji Samsul Ashari SAMSUL ASHARI, SAMSUL Septelia Inawati Wanandi Setyo W. Nugroho Setyo Widi Nugroho Wawan Mulyawan Wawan Mulyawan Wismaji Sadewo Wiwoho, Yudi Yuwono Yudi Yuwono Wiwoho