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Nurhadi Ibrahim
Departemen Fisiologi Kedokteran FK Universitas Indonesia
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Increase in Gamma Band qEEG Activity during Executive Coaching: Some Preliminary Observations and Possible Implications Lyra Puspa; Nurhadi Ibrahim; Paul T. Brown
International Conference of Mental Health, Neuroscience, and Cyber-psychology
Publisher : Fakultas Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32698/25263

Abstract

Executive coaching has become a well-established method of leadership development in many organizations. However, nothing is known about what effects coaching processes have on brain activity in understanding the neurobiological basis of behavioral changes. Using quantified electroencephalogram (qEEG) activity in the gamma-band range, this pilot study is the first attempt to elucidate the electro-cortical patterns that are induced during an executive coaching process whilst using a specific intervention called the CARE Model. Gamma-band oscillation has been related to gestalt perception, the state of consciousness, and cognitive functions. Synchronization of gamma-band has also been proposed as being involved in the mechanisms of functional integration underlying changes in neural circuitry. Despite the decades of gamma-band studies, the possibility that executive coaching might induce gamma-band oscillations has not yet been explored. The subjects were six top talent volunteers (male, mean age = 30). The EEG was recorded from 19 electrodes of the International 10/20 System in both the resting state as the baseline and the continuous 45-minute coaching session. Logarithmically transformed absolute spectral power values of gamma-band were calculated for 3s epochs; and a 182 epochs comparison of each CARE Model stage with the baseline was analyzed using Wilcoxon signed-rank test. Our preliminary qEEG observations show that gamma-band activity became significantly increased in the frontal and posterior regions of the subjects during the coaching process. These preliminary results suggest that the neural impact of executive coaching within the CARE Model may be to evoke a self-reflecting process, gestalt perception, and associative learning.
NILAI NORMAL LATENSI DAN AMPLITUDO GELOMBANG VISUAL EVOKED POTENTIAL PADA USIA DEWASA Ade Wijaya,* Manfaluthy Hakim,* Nurhadi Ibrahim,** Joedo Prihartono***
NEURONA Vol. 35 No. 2 Maret 2018
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION VISUAL EVOKED POTENTIALS VEP IS USED TO ASSESS THE VISUAL PATHWAY THROUGH THE OPTIC NERVES AND BRAIN VEP WAVE CAN BE AFFECTED BY PHYSIOLOGICAL AND NONPHYSIOLOGICAL FACTORS SOME OF WHICH CAN BE CONTROLLED WHILE OTHERS CANNOT THUS EACH VEP LABORATORY NEEDS ITS OWN SET OF NORMATIVE VALUES A NORMAL VEP RESPONSE TO A STIMULUS IS A POSITIVE OCCIPITAL PEAK THAT OCCURS AT A MEAN LATENCY OF 100MS MOST OF THE PUBLISHED NORMAL VALUE ORIGINATED FROM ABROAD WHERE DEMOGRAPHICAL AND ENVIRONMENT CONDITION ARE CONSIDERED LESS APPROPRIATE WITH INDONESIAN POPULATION
Combination of Aerobic Exercise and Continuous Environmental Enrichment Improves Adult Male Rats’ Spatial Memory: Study on Hippocampal Insulin Like Growth Factor 1 (IGF-1) and Fibroblast Growth Factor 2 (FGF-2) Expression Sophie Yolanda; Sri Redjeki; Trinovita Andraini; Dewi Irawati Soeria Santoso; Nurhadi Ibrahim; Rena Mailani
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.731

Abstract

BACKGROUND: Memory declines with the progression of age through the neurodegeneration process. Aerobic exercise and environmental enrichment can delay neurodegeneration by improving neuroplasticity via expression of insulin like growth factor 1 (IGF-1), fibroblast growth factor 2 (FGF-2) and other proteins. Combination treatment of aerobic exercise and continuous environmental enrichment and their effect on the expression of IGF-1 and FGF-2 which were expected to improve memory function has not been studied previously. Thus, this study aimed to observe it.METHODS: This is an experimental research using 24 male Wistar rats (Rattus norvegicus, 300-400 g, age 7-8 months) divided randomly into 4 groups: control (C), aerobic exercise (A), continuous (EE), and combination of aerobic exercise and continuous environmental enrichment (A-EE). At the end of an 8-week treatment, rats were sacrificed, and an enzyme-linked immunosorbent assay (ELISA) examination was performed to assess hippocampal IGF-1 and FGF-2 levels.RESULTS: In the 8th week, A-EE group showed the best improvement in rats’ spatial memory (47.84±10.6 %) followed by EE group (45.03±4.1 %), A group (38.61±3.8 %), and C group (22.76±7.12 %). However, A-EE group’s hippocampal IGF-1 (16.21±7.56 ng/mg protein) and FGF-2 (1.29±0.57 ng/mg protein) expression were not higher than other groups.CONCLUSION: Improvement in memory function in the combination group is a result of induction of various growth factors’ expression in the hippocampus, including IGF-1 and FGF-2, but the primary pathway of memory function improvement may be from other growth factors.KEYWORDS: spatial memory, aerobic exercise, environmental enrichment, hippocampus, IGF-1, FGF-2
Efek Proteksi Ekstrak Air Tanaman Akar Kucing (Acalypha Indica Linn) Terhadap Perubahan Struktur Neuron Hipokampus Paska Hipoksia Serebri Nurhadi Ibrahim; Ahmad Aulia Jusuf; Lina Marlina
JURNAL KESEHATAN BHAKTI HUSADA Vol 1 No 01 (2015): Jurnal Kesehatan Bhakti Husada
Publisher : UP3M AKPER-AKBID BHAKTI HUSADA CIKARANG

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Abstract

Latar Belakang : Beberapa penelitian telah membuktikan bahwa ekstrak air akar kucing memiliki kemampuan neuroterapi dan neuroprotektor baik secara in vivo maupun in vitro. Telah terbukti juga ekstrak akar kucing dapat mengatasi berbagai masalah kesehatan sebagai antidiuretik, anti emetik dan anti toksin. Akar kucing juga mengandung antioksidan sehingga pemberian ekstrak tanaman ini mampu mencegah kerusakan sel akibat hipoksia. Atas dasar penelitian – penelitian tersebut, akan dibuktikan bahwa pemberian ekstrak akar kucing prahipoksia akan mencegah kerusakan struktur neuron hipokampus . Tujuan : Menganalisis perubahan struktur neuron hipokampus yang mendapat ekstrak air tanaman akar kucing sebelum perlakuan hipoksia yang dilaksanakan selama 7 hari Metode : Lima kelompok tikus sprage dawley yang terdiri dari masing – masing 5 tikus dikelompokan menjadi kelompok kontrol negatif hanya diberi aqua, kontrol positif dengan diberikan vitamin B1 dan 3 kelompok yang diberikan ekstrak air akar kucing dengan dosis 300 mg/kgBB, 400 mg/kgBB dan 500 mg/kgBB selama 7 hari sebelum paparan hipoksia.Setelah perlakuan hipoksia diambil jaringan hipokampusnya dan dilihat struktur neuronnya dengan pewarnaan hematoksilin eosin dan sel yang masih normal dihitung dengan menggunakan optilab viewer dan image raster. Hasil : Ekstrak akar kucing dengan dosis 300 mg/kgBB, 400 mg/kgBB dan 500 mg/kgBB menunjukan struktur neuron dan jumlah sel neuron dengan kelompok kontrol negatif ( tanpa ekstrak akar kucing) secara signifikan di area CA3 dan lapisan dalam girus dentatus hipokampus (p= 0,000) Kesimpulan : Ekstrak akar kucing dengan dosis 300, 400 dan 500 mg/kgBB mempunyai efek protektif terhadap kerusakan neuron di hipokampus
QEEG as a Novel Parameter of Neuroplasticity in Elderly with Mild Cognitive Impairment Martina Wiwie Setiawan Nasrun; La Febry Andira Rose Cynthia; Nurhadi Ibrahim; Zenik Kusrini; Khamelia Malik; Wanarani Alwin
Indonesian Journal of Electrical Engineering and Informatics (IJEEI) Vol 10, No 3: September 2022
Publisher : IAES Indonesian Section

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52549/ijeei.v10i3.3555

Abstract

Neuroplasticity is the ability of the brain to change structurally and functionally in compensation for changes related to age or disease. In elderly people, the most common neuroplasticity problem is mild cognitive impairment (MCI). MCI is a syndrome defined as a decrease in cognitive function that is not appropriate for a person's age and educational level. One way to minimize the progress of deterioration in MCI is by doing physical exercise, such as walking. In this study, participants did physical activity by walking at least 4000 steps/day for 3 months. Cognitive function was measured by brain wave parameters with Quantitative Electroencephalography (QEEG). Electroencephalography (EEG) signals were recorded before and after the intervention. The EEG results showed that the QEEG wave parameters after the intervention increased in the alpha frequency band and decreased in the delta frequency band. 
Peran Ketamin pada Nyeri di Tingkat Sel Rizal Zainal; Irfannuddin Irfannuddin; Legiran Legiran; Nurhadi Ibrahim; Muhammad Ramli Ahmad
JAI (Jurnal Anestesiologi Indonesia) Vol 15, No 1 (2023): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.51613

Abstract

Ketamin adalah salah satu analgesia yang dapat digunakan baik di dalam atau di luar kamar operasi. Selain efek analgesik, ketamin bersifat bronkodilator, simpatomimetik, dan sedasi yang dapat memberikan kemudahan dalam periode perioperatif. Ketamin berfungsi dalam modulasi sensitisasi sentral, menurunkan toleransi hiperalgesia yang diinduksi opioid, memberikan potensi analgesia opioid dalam dosis hiperalgesia, dan mengurangi eksitasi presinaptik substansi P di sum-sum tulang belakang. Ketamin juga dapat memodulasi reseptor muscarinic acetylcholine yang berpotensi mengurangi tahanan sensitivitas nyeri, up-regulasi reseptor a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) yang dapat memperbaiki mood dan respons emosional terhadap nyeri. Aktivasi reseptor NMDA menyebabkan influks kalsium, mengaktivasi formasi intraseluler oleh secondary messenger, prostaglandin, dan nitric oxide. Ketamin adalah analog phencyclidine dan bersifat antagonis N-methyl-D-aspartate (NMDA), sehingga efek ketamin dapat mengurangi frekuensi dan waktu pembukaan kanal Ca2+ dan mencegah influks Ca2+. Ketamin juga berperan dalam regulasi respons imun yang berhubungan terhadap sinyal nyeri seperti toll-like receptor. Komponen molekuler yang terlibat pada kerja ketamin di tingkat seluler seperti inhibisi pada reseptor substansi P, inhibisi mAChR, inhibisi reseptor serotonin 1 dan 2, modulasi farmakologi sel glial pada inhibitor glial, L-α-aminoadipate, dan menghambat enzim glial termasuk transporter glutamat (GLT1).
Neuroprotective effect of South Sulawesi propolis on neurogenesis in primary cultures of rat cerebral cortical neurons Nurhadi Ibrahim; Trinovita Andraini; Amirah Yusnidar; Putu Indah Paramita Adi Putri; Imelda Rosalyn Sianipar
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.137-149

Abstract

BackgroundNeurodegenerative diseases have a significant risk factor, namely aging, which is associated with increased neuronal dysfunction and death. Propolis has been widely used as medicine due to its various benefits. This research study investigated the effect of propolis from the stingless bee (Tetragonula sapiens) from South Sulawesi, Indonesia, on neurogenesis in primary cultures of embryonic cerebral cortex of Wistar rats at 17-18 days of gestation. Methods This research was an experimental study involving 4 female pregnant Wistar rats, which were terminated and the cerebral cortex of the embryos collected and grown as primary cultures. The cultures were divided into 3 groups, i.e. control, vehicle, and propolis extract group. The research began with 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) to obtain the optimal dose among propolis doses of 0.5 μg/mL, 1 μg/mL, 5 μg/mL, 10 μg/mL, 25 μg/mL, and 100 μg/mL. The study was continued by using the best dose in immunostaining examination using microtubule-associated protein 2 (MAP2) primary antibody and qRT-PCR examination of brain-derived neurotrophic factor (BDNF) mRNA expression. One Way ANOVA and Kruskal-Wallis test were used to analyse the data. ResultsThe results showed that the propolis doses of 0.5 μg/mL and 1 μg/mL significantly increase cell viability compared to the other doses (p=0.011) and stimulate dendritic growth. The propolis dose group of 1 μg/mL induces a significantly higher expression of BDNF mRNA than the control group (p=0.031). ConclusionOur findings indicate that stingless bee propolis has neuroprotective effects against BDNF mRNA in rats. It is shown that propolis can be a candidate inhibitor in neurodegenerative diseases.
Potensi Hibiscus sabdariffa Linn. Memodulasi GLP-1 dan Neuropeptide Y (NPY) di Nucleus Arcuatus pada Tikus Obes Rickie; Neng Tine Kartinah; Minarma Siagian; Nurhadi Ibrahim; Suci Anggraini
Jurnal Kedokteran Meditek Vol 28 No 2 (2022): MEI-AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i2.2346

Abstract

Gangguan pada pusat pengaturan nafsu makan dapat menyebabkan obesitas. Glucagon like Peptide -1 (GLP-1) dan Neuropeptide Y (NPY) merupakan dua peptida penting yang terlibat dalam pengendalian nafsu makan. Beberapa penelitian menunjukkan Hibiscus sabdariffa Linn. memiliki potensi dalam pengendalian obesitas dengan memodulasi kadar GLP-1 dan NPY di perifer. Penelitian ini bertujuan untuk mengetahui bagaimana potensi Hibiscus sabdariffa Linn.(HSL) dalam memodulasi kadar GLP-1 dan NPY di sentral khususnya di Nucleus Arcuatus. Penelitian ini merupakan penelitian lanjutan yang menggunakan jaringan otak tikus tersimpan yang berasal dari 24 ekor tikus Spraque Dawley jantan umur 6 -10 minggu, berat badan antara 90 -160 gram, yang dibagi dalam 4 kelompok yaitu: Normal(C); Obes(Ob); Obes-Hib200(Ob-Hib200); Obes-Hib400(Ob-Hib400). Ekstrak HSL diberikan secara oral satu kali per hari selama 5 minggu. Sampel diperoleh dari hasil isolasi ARC, kemudian dilakukan pengukuran kadar GLP-1 dan NPY menggunakan metode ELISA. Hasil penelitian menunjukkan ekstrak HSL dosis 400mg/KgBB/hari dapat meningkatkan kadar GLP-1 paling tinggi, dibandingkan dengan kelompok tikus lainnya, sekaligus dapat menurunkan kadar NPY dibandingkan dengan kelompok tikus Obes(Ob) dan Obes-Hib(200), meskipun secara analisis tidak terdapat perbedaan bermakna. Dosis ekstrak HSL berperan penting dalam efektifitasnya memodulasi kadar GLP-1 dan NPY di ARC untuk membantu mengendalikan nafsu makan sehingga dapat mengurangi resiko terjadinya obesitas.
‘Wanting' and ‘Liking' Brain Mechanisms in Coaching: A qEEG Study using the CARE Coaching Model Puspa, Lyra; Ibrahim, Nurhadi; Brown, Paul T.
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.429 KB) | DOI: 10.20473/bhsj.v2i2.14900

Abstract

Introduction: Coaching has become increasingly popular for leadership development and behavioral change in organizations. Recent studies suggest that motivation is essential in enhancing the effectiveness of workplace coaching. A number of studies revealed that delta and beta-gamma oscillations are associated with the human motivational process through ‘wanting' and ‘liking' mechanisms. However, the brain mechanisms of motivation in coaching have not been studied. This preliminary study is the first attempt to explore the ‘wanting' and ‘liking' mechanism of coaching, by investigating the activity of the delta and beta oscillations during a face-to-face coaching session through quantitative electroencephalogram (qEEG).Methods: Six male, right-handed, middle managers of an organization (mean age = 31.6) were recruited voluntarily as participants. A multichannel EEG (19 electrodes, 10/20 System) was used to record brain activity in both the resting state and the continuous 45-minute coaching session whilst using the CARE Model. The artifact-free EEG data were then quantified using wavelet analysis to obtain induced band power. Results: Significant increase was shown in delta and beta-gamma activities throughout the coaching session. Increased delta absolute power was found in the frontal, parietal, and occipital regions, whilst increased beta-gamma activity was significantly detected in the frontal, posterior temporal, and occipital regions. Conclusion: This preliminary result suggests that coaching, with regard to the CARE Model, induces both ‘wanting' and ‘liking' mechanisms simultaneously. Thus, the present findings provide the first preliminary neuroscientific underpinnings of the role of motivation in enhancing the effectiveness of workplace coaching through induced ‘wanting' and ‘liking' mental processes.
Learning and Memory Impairment in High Fat Diet Induced Obesity Ariani, Citra; Ibrahim, Nurhadi; Yolanda, Sophie
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 01 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss01/483

Abstract

Obesity is a manifestation of abnormal fat accumulation which can lead to impairment in several organs, including the brain. Neuroinflammation is considered the cause of cell death as well as reactive oxygen species in hippocampal neuron cells. It results in disturbance of memory forming process. Impaired learning and memory function affects a person's ability to carry out daily tasks and lower quality of life over time, so they should be circumvented with preventive, curative, and rehabilitative measures. The understanding of the pathological mechanisms of obesity-induced memory impairment based on the changes at molecular levels is imperative for an effective management. We collected and reviewed research articles to summarize the pathological mechanisms. Twenty studies were included in this review in terms of signaling pathway, molecular markers in brain and changes in memory and behavior pattern. It is showed that memory changes in obesity could be resulted from inflammation, impaired neurogenesis and cell senescence via various mechanisms and pathways. In conclusion, the understanding of the pathomechanisms in obesity-induced memory impairment aids to its the prevention and treatment.
Co-Authors A.A. Ketut Agung Cahyawan W Ahmad Aulia Amir S. Madjid, Amir S. Amirah Yusnidar Andon Hestiantoro Arjo Tedjo Astuti, Brilliant Putri Kusuma Brown, Paul T. Budi Iman Santoso Citra Ariani, Citra Dewi F. Suniarti Dewi Sukmawati Endang W. Bachtiar Erni Hernawati Purwaningsih, Erni Hernawati Ernie H. Purwaningsih Erwinanto Frans Ferdinal Goenarjo, Roman Hakim, Manfaluthy Hamdani Zain Hamdani Zain Harrina Erlianti Rahardjo, Harrina Erlianti Imelda Rosalyn Sianipar Ina S. Timan, Ina S. Irfannuddin Irfannuddin Jasirwan, Shanty Olivia Jaslindo, Lieka Nugrahi Joedo Prihartono Julia Rahadian Jusman, Sri Widia Azraki Khamelia Malik La Febry Andira Rose Cynthia Legiran Legiran Lina Marlina Lyra Puspa Mahyuddin, Hilman Mailani, Rena Makkiyah, Feda Anisah Martina Wiwie Setiawan Nasrun Martina Wiwie Setiawan Nasrun Minarma Siagian Minarma Siagian Mohamad Sadikin Mohamad Saekhu Muhammad Ramli Ahmad Neng Tine Kartinah Almuktabar Ninik Mudjihartini Paul T. Brown Puspa, Lyra Putu Indah Paramita Adi Putri Rickie Rizal Zainal Ronokusumo, Teguh A.S. Sabita, Rifqi Salim Harris, Salim Santoso, Dewi Irawati Soeria Satriotomo, Irawan Shadrina, Amalia Siti Setiati Sophie Yolanda Sophie Yolanda Sri Redjeki Suci Anggraini Sudigdo Sastroasmoro Surahman Hakim Trinovita Andraini Trinovita Andraini Wanarani Alwin Wardaya Wardaya Wawan Mulyawan Widjajalaksmi Kusumaningsih, Widjajalaksmi Wijaya, Ade Wresti Indriatmi B. Makes Yani, Sri Zenik Kusrini