Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.789

P-Index

This Author published in this journals

All Journal Jurnal Anestesiologi Indonesia Medical Journal of Indonesia Indonesian Journal of Electrical Engineering and Informatics (IJEEI) The Indonesian Biomedical Journal Biomedical Journal of Indonesia Universa Medicina Global Conference Index Eksakta : Berkala Ilmiah Bidang MIPA Majalah Kedokteran Neurosains Biomolecular and Health Science Journal JURNAL KESEHATAN BHAKTI HUSADA Indonesian Journal of Multidisciplinary Science Neurona Jurnal Kedokteran Meditek

Nurhadi Ibrahim

Departemen Fisiologi Kedokteran FK Universitas Indonesia

Author-ID : 284879

Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 20 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Increased cell viability and proliferation in post-hypoxic hippocampal tissue culture treated with Acalypha indica root extract Yolanda, Sophie; Bachtiar, Endang W.; Ibrahim, Nurhadi
Medical Journal of Indonesia Vol 20, No 2 (2011): May
Publisher : Faculty of Medicine Universitas Indonesia

Background: This research was done to study the influence of Acalypha indica Linn root extract towards relative cellÂ viability and proliferation as parameters of neurogenesis in post-hypoxic hippocampal tissue culture.Methods: Experimental in vitro study using 24 primary neuronal cell cultures obtained from adult Sprague DawleyÂ rat exposed to hypoxia with 5% O2/5% CO2/N2 balance gas for 24 hours. Post-hypoxia, Acalypha indica Linn rootÂ extract was added at doses of 10, 15, and 20 mg/mL to 3 treatment groups. No treatment was given to the control group.Â Each group consists of 6 samples. After 90 hours of incubation, relative cell viability was measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) examination, and cell proliferation was measured byÂ using 5-bromo2â-deoxy-uridine (BrdU) for cell proliferation. Data was analyzed using one way ANOVA parametricÂ tests, then further analyzed with post-hoc analysis.Results: The relative cell viability of rat hippocampal tissue culture treated with Acalypha indica Linn root extractÂ with dose of 10, 15, and 20 mg/mL was significantly higher than control (176.95%, 220.62%, and 386.02% vs. 100%).Â Cell proliferation of rat hippocampal tissue culture treated with Acalypha indica Linn root extract with dose of 10, 15,Â and 20 mg/mL was significantly higher than control (0.132, 0.117, 0.114 vs 0.096).Conclusion: Acalypha indica Linn root extract with doses of 10, 15, and 20 mg/mL can increase relative cell viabilityÂ and proliferation in post-hypoxic hippocampal tissue culture. (Med J Indones 2011; 20:94-9)Keywords: Acalypha indica Linn (akar kucing), cell proliferation, hypoxia, neurogenesis, relative cell viability

Acalypha indica Linn root extract improved hippocampal cell viability and increased brain-derived neurotrophic factor (BDNF) in hypoxic condition Ibrahim, Nurhadi; Rahadian, Julia; Suniarti, Dewi F.
Medical Journal of Indonesia Vol 21, No 3 (2012): August
Publisher : Faculty of Medicine Universitas Indonesia

Background: This study was done to determine the effect of root extract of Acalypha indica Linn (akar kucing) in protecting neuron viability of the rat hippocampus on tissue culture in hypoxic condition.Methods: This is an experimental study of in vitro primary cell culture of hippocampus of Sprague Dowley adult rat. The cultures were group into control (C) and exposure to root extract of Acalypha indica Linn with dose of 10 mg/mL, 15 mg/mL, and 20 mg/mL for 72 hours. The cultures were then exposed to hypoxic gas (5% oxygen, 5% carbondioxide, nitrogen balance) for 24 hours. After that, relative cell viability was measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), cell proliferation by 5-bromo2â-deoxy-uridine (BrdU), and Brain-derived Neurotrophic Factor (BDNF) levels by BDNF ELISA kit.Results: The result showed MTT viability (C: 99.7%, A indica L 10: 326.3%, A indica L 15: 411.7%, A indica L 20: 445.9%), BrdU absorbance (C: 0.07, A indica L 10: 0.10, A indica L 15: 0.12, A indica L 20: 0.13) of the exposured hippocampal cell were significantly higher than the control group (p < 0.01) accompany by increased level of BDNF (C: 11.3 pg/mL, A indica L 10: 12.5 pg/mL, A indica L 15: 23.1 pg/mL, A indica L 20: 18.1 pg/mL).Conclusion: The root extract of Acalypha indica Linn is able to improve rat hippocampal cell viability and endogenous BDNF levels in hypoxic condition. (Med J Indones. 2012;21:141-6)Keywords: BDNF, hippocampal cell viability, hypoxia, root of Acalypha indica Linn

The nerve protection and in vivo therapeutic effect of Acalypha indica extract in frogs Purwaningsih, Ernie H.; Ibrahim, Nurhadi; Zain, Hamdani
Medical Journal of Indonesia Vol 19, No 2 (2010): May
Publisher : Faculty of Medicine Universitas Indonesia

Aim To demonstrate nerve protection and/or treatment effect of Acalypha indica Linn. extract on nerve paralysisÂ induced by subcutaneus injection of pancuronium bromide on frogâs back.Methods The study was performed on sixty frogs (Bufo melanostictus Schneider) that divided into two groups, i.e.Â the neuro-protection and neuro-therapy group. Each group was divided further into 6 sub-treatment groups: negativeÂ control group treated by water and positive control group treated by piracetam, treatment groups received the extractsÂ 200, 300, 400, 500 mg/kgBW. Pancuronium bromide 0.2% (1 : 20 dilutions) were injected subcutaneously as muscleÂ relaxant. The protective effect was studied by giving the extract orally, 1 hour prior to injection; while the therapeuticÂ effect of the extract was studied by 10 minute treatment after injecting pancuronium bromide solution. The parametersÂ measured were the onset and duration of paralysis (in minutes) and the recovery time (time needed to recover intoÂ normal condition).Results The study showed significantly different protective effect of Acalypha indica Linn. root water extract at 400Â and 500 mg/KgBW compared to negative control group and positive control group (piracetam (p < 0.05); while theÂ therapeutic effect was obvious at the dose 200-500 mg/KgBW compared to negative control group (p = 0.000). ThereÂ was no significant difference compared to positive control group (piracetam), except at 300 mg/KgBW (p = 0.012).Conclusion These results have proven that the water extract of Acalypha indica Linn. root has comparable protectiveÂ and treatment effect on nerves system, as piracetam, but further studies should be performed to provide more evidencesÂ particularly pharmacokinetic and pharmacodynamic studies on two animal models that commonly used. (Med JÂ Indones 2010; 19:96-102)Keywords: Acalypha indica Linn, Bufo melanostictus Schneider, nerve-protection

MMP-9, brain edema, and length of hospital stay of patients with spontaneous supratentorial intracerebral hemorrhage after hematoma evacuation along with the administration of tigecycline Saekhu, Mohamad; Ibrahim, Nurhadi; Timan, Ina S.; Madjid, Amir S.; Muttaqin, Zainal; Ronokusumo, Teguh A.S.; Sastroasmoro, Sudigdo; Mahyuddin, Hilman
Medical Journal of Indonesia Vol 25, No 4 (2016): December
Publisher : Faculty of Medicine Universitas Indonesia

Background: The high plasma level of matrix metalloproteinses–9 (MMP-9) is believed to disrupt the blood-brain barrier (BBB) and cause brain edema, as well as increase patient’s length of hospital stay (LOS). Tigecycline showed ability to reduce the MMP-9 level on study in animals. This study aimed to evaluate whether tigecycline can reduce the plasma levels of MMP-9; brain edema; and LOS of patients with supratentorial spontaneous intracerebral hemorrhage (SSICH).Methods: A randomized clinical trial (RCT) was conducted on 72 SSICH patients who underwent hematoma evacuation in eleven hospitals in Jakarta; 100 mg tigecycline (n=35) or 2 g fosfomycine (n=37) administered intravenously before skin incision as an prophylactic antibiotics to avoid post-operative infections. Plasma levels of MMP-9 were measured in all subjects before and on the first and seventh day after the surgery. Reduction of brain edema was assessed by comparing the extent of brain edema on computed tomography scan (CT scan) before and CT scan after surgery. The length of stay (LOS) was recorded at the time of hospital discharge either survive or death. Data were analyzed using Mann-Whitney and Chi-Square test.Results: There were non-significant statistical differences between two groups in the proportion of subjects with reduced MMP-9 levels on the first day (48% vs 50%; p=0.902; OR=1.1) and seventh day after the surgery (33% vs 48%; p=0.296; OR=1.9); proportion of the subjects with brain edema reduction (86% vs 80%, p=0.58); LOS (median 12 days vs 13 days, p=0.256; LOS ≥15 days 40% vs 27%; p=0.243; OR=1.81; NNT=8).Conclusion: On SSICH patients who underwent hematoma evacuation, tigecycline did not either reduce MMP-9 levels and brain edema or shorthen LOS.

Low estradiol levels escalate menopausal symptoms leading to mild cognitive impairment in postmenopausal women Hestiantoro, Andon; Jasirwan, Shanty Olivia; Wiwie, Martina; Shadrina, Amalia; Ibrahim, Nurhadi; Astuti, Brilliant Putri Kusuma
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

BACKGROUND Women in menopause experience dramatic alterations in gonadal hormone concentrations, including diminished estradiol levels. It has been hypothesized that these hormonal changes may be responsible for the occurrences of menopausal symptoms, such as hot flushes, sleep disruption, night sweats, and irritability, as well as mild cognitive impairment (MCI) in postmenopausal women. Therefore, this study was aimed to determine if there is any association between hormonal changes and menopausal symptoms, including MCI in postmenopausal women.METHODS A total of 245 postmenopausal women were recruited for this cross-sectional study and classified into 2 groups; MCI and non-MCI groups. Diagnosis of MCI was made using the modified Petersen criteria. Variables such as subjects’ age, duration of menopause, menopausal symptoms, anthropometric status, hormone levels, and cognitive status were assessed and statistically analyzed.RESULTS Of the 245 subjects enrolled in this study, 53.9% had MCI. Multivariate analysis found that sleep disruption and estradiol levels were independent risk factors of MCI in postmenopausal women. No significant correlation was found between menopausal symptoms and estradiol concentration.CONCLUSIONS Low estradiol levels were associated with higher risks of experiencing menopausal symptoms and MCI. Sleep disruption and estradiol levels were the most influential factors in the development of MCI in postmenopausal women.

Increase in Gamma Band qEEG Activity during Executive Coaching: Some Preliminary Observations and Possible Implications Lyra Puspa; Nurhadi Ibrahim; Paul T. Brown
International Conference of Mental Health, Neuroscience, and Cyber-psychology
Publisher : Fakultas Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32698/25263

Executive coaching has become a well-established method of leadership development in many organizations. However, nothing is known about what effects coaching processes have on brain activity in understanding the neurobiological basis of behavioral changes. Using quantified electroencephalogram (qEEG) activity in the gamma-band range, this pilot study is the first attempt to elucidate the electro-cortical patterns that are induced during an executive coaching process whilst using a specific intervention called the CARE Model. Gamma-band oscillation has been related to gestalt perception, the state of consciousness, and cognitive functions. Synchronization of gamma-band has also been proposed as being involved in the mechanisms of functional integration underlying changes in neural circuitry. Despite the decades of gamma-band studies, the possibility that executive coaching might induce gamma-band oscillations has not yet been explored. The subjects were six top talent volunteers (male, mean age = 30). The EEG was recorded from 19 electrodes of the International 10/20 System in both the resting state as the baseline and the continuous 45-minute coaching session. Logarithmically transformed absolute spectral power values of gamma-band were calculated for 3s epochs; and a 182 epochs comparison of each CARE Model stage with the baseline was analyzed using Wilcoxon signed-rank test. Our preliminary qEEG observations show that gamma-band activity became significantly increased in the frontal and posterior regions of the subjects during the coaching process. These preliminary results suggest that the neural impact of executive coaching within the CARE Model may be to evoke a self-reflecting process, gestalt perception, and associative learning.

NILAI NORMAL LATENSI DAN AMPLITUDO GELOMBANG VISUAL EVOKED POTENTIAL PADA USIA DEWASA Ade Wijaya,* Manfaluthy Hakim,* Nurhadi Ibrahim,** Joedo Prihartono***
NEURONA Vol. 35 No. 2 Maret 2018
Publisher : Neurona Majalah Kedokteran Neuro Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar

INTRODUCTION VISUAL EVOKED POTENTIALS VEP IS USED TO ASSESS THE VISUAL PATHWAY THROUGH THE OPTIC NERVES AND BRAIN VEP WAVE CAN BE AFFECTED BY PHYSIOLOGICAL AND NONPHYSIOLOGICAL FACTORS SOME OF WHICH CAN BE CONTROLLED WHILE OTHERS CANNOT THUS EACH VEP LABORATORY NEEDS ITS OWN SET OF NORMATIVE VALUES A NORMAL VEP RESPONSE TO A STIMULUS IS A POSITIVE OCCIPITAL PEAK THAT OCCURS AT A MEAN LATENCY OF 100MS MOST OF THE PUBLISHED NORMAL VALUE ORIGINATED FROM ABROAD WHERE DEMOGRAPHICAL AND ENVIRONMENT CONDITION ARE CONSIDERED LESS APPROPRIATE WITH INDONESIAN POPULATION

Combination of Aerobic Exercise and Continuous Environmental Enrichment Improves Adult Male Rats’ Spatial Memory: Study on Hippocampal Insulin Like Growth Factor 1 (IGF-1) and Fibroblast Growth Factor 2 (FGF-2) Expression Sophie Yolanda; Sri Redjeki; Trinovita Andraini; Dewi Irawati Soeria Santoso; Nurhadi Ibrahim; Rena Mailani
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.731

BACKGROUND: Memory declines with the progression of age through the neurodegeneration process. Aerobic exercise and environmental enrichment can delay neurodegeneration by improving neuroplasticity via expression of insulin like growth factor 1 (IGF-1), fibroblast growth factor 2 (FGF-2) and other proteins. Combination treatment of aerobic exercise and continuous environmental enrichment and their effect on the expression of IGF-1 and FGF-2 which were expected to improve memory function has not been studied previously. Thus, this study aimed to observe it.METHODS: This is an experimental research using 24 male Wistar rats (Rattus norvegicus, 300-400 g, age 7-8 months) divided randomly into 4 groups: control (C), aerobic exercise (A), continuous (EE), and combination of aerobic exercise and continuous environmental enrichment (A-EE). At the end of an 8-week treatment, rats were sacrificed, and an enzyme-linked immunosorbent assay (ELISA) examination was performed to assess hippocampal IGF-1 and FGF-2 levels.RESULTS: In the 8th week, A-EE group showed the best improvement in rats’ spatial memory (47.84±10.6 %) followed by EE group (45.03±4.1 %), A group (38.61±3.8 %), and C group (22.76±7.12 %). However, A-EE group’s hippocampal IGF-1 (16.21±7.56 ng/mg protein) and FGF-2 (1.29±0.57 ng/mg protein) expression were not higher than other groups.CONCLUSION: Improvement in memory function in the combination group is a result of induction of various growth factors’ expression in the hippocampus, including IGF-1 and FGF-2, but the primary pathway of memory function improvement may be from other growth factors.KEYWORDS: spatial memory, aerobic exercise, environmental enrichment, hippocampus, IGF-1, FGF-2

Efek Proteksi Ekstrak Air Tanaman Akar Kucing (Acalypha Indica Linn) Terhadap Perubahan Struktur Neuron Hipokampus Paska Hipoksia Serebri Nurhadi Ibrahim; Ahmad Aulia Jusuf; Lina Marlina
JURNAL KESEHATAN BHAKTI HUSADA Vol 1 No 01 (2015): Jurnal Kesehatan Bhakti Husada
Publisher : UP3M AKPER-AKBID BHAKTI HUSADA CIKARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.783 KB)

Latar Belakang : Beberapa penelitian telah membuktikan bahwa ekstrak air akar kucing memiliki kemampuan neuroterapi dan neuroprotektor baik secara in vivo maupun in vitro. Telah terbukti juga ekstrak akar kucing dapat mengatasi berbagai masalah kesehatan sebagai antidiuretik, anti emetik dan anti toksin. Akar kucing juga mengandung antioksidan sehingga pemberian ekstrak tanaman ini mampu mencegah kerusakan sel akibat hipoksia. Atas dasar penelitian – penelitian tersebut, akan dibuktikan bahwa pemberian ekstrak akar kucing prahipoksia akan mencegah kerusakan struktur neuron hipokampus . Tujuan : Menganalisis perubahan struktur neuron hipokampus yang mendapat ekstrak air tanaman akar kucing sebelum perlakuan hipoksia yang dilaksanakan selama 7 hari Metode : Lima kelompok tikus sprage dawley yang terdiri dari masing – masing 5 tikus dikelompokan menjadi kelompok kontrol negatif hanya diberi aqua, kontrol positif dengan diberikan vitamin B1 dan 3 kelompok yang diberikan ekstrak air akar kucing dengan dosis 300 mg/kgBB, 400 mg/kgBB dan 500 mg/kgBB selama 7 hari sebelum paparan hipoksia.Setelah perlakuan hipoksia diambil jaringan hipokampusnya dan dilihat struktur neuronnya dengan pewarnaan hematoksilin eosin dan sel yang masih normal dihitung dengan menggunakan optilab viewer dan image raster. Hasil : Ekstrak akar kucing dengan dosis 300 mg/kgBB, 400 mg/kgBB dan 500 mg/kgBB menunjukan struktur neuron dan jumlah sel neuron dengan kelompok kontrol negatif ( tanpa ekstrak akar kucing) secara signifikan di area CA3 dan lapisan dalam girus dentatus hipokampus (p= 0,000) Kesimpulan : Ekstrak akar kucing dengan dosis 300, 400 dan 500 mg/kgBB mempunyai efek protektif terhadap kerusakan neuron di hipokampus

QEEG as a Novel Parameter of Neuroplasticity in Elderly with Mild Cognitive Impairment Martina Wiwie Setiawan Nasrun; La Febry Andira Rose Cynthia; Nurhadi Ibrahim; Zenik Kusrini; Khamelia Malik; Wanarani Alwin
Indonesian Journal of Electrical Engineering and Informatics (IJEEI) Vol 10, No 3: September 2022
Publisher : IAES Indonesian Section

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52549/ijeei.v10i3.3555

Neuroplasticity is the ability of the brain to change structurally and functionally in compensation for changes related to age or disease. In elderly people, the most common neuroplasticity problem is mild cognitive impairment (MCI). MCI is a syndrome defined as a decrease in cognitive function that is not appropriate for a person's age and educational level. One way to minimize the progress of deterioration in MCI is by doing physical exercise, such as walking. In this study, participants did physical activity by walking at least 4000 steps/day for 3 months. Cognitive function was measured by brain wave parameters with Quantitative Electroencephalography (QEEG). Electroencephalography (EEG) signals were recorded before and after the intervention. The EEG results showed that the QEEG wave parameters after the intervention increased in the alpha frequency band and decreased in the delta frequency band.

Co-Authors A.A. Ketut Agung Cahyawan W Ahmad Aulia Ahmad Aulia Jusuf Amir S. Madjid, Amir S. Amirah Yusnidar Andon Hestiantoro Arjo Tedjo Astuti, Brilliant Putri Kusuma Brown, Paul T. Citra Ariani, Citra Dewi F. Suniarti Dewi Sukmawati Endang W. Bachtiar Erni Hernawati Purwaningsih, Erni Hernawati Ernie H. Purwaningsih Frans Ferdinal Hakim, Manfaluthy Hamdani Zain Hamdani Zain Imelda Rosalyn Sianipar Ina S. Timan, Ina S. Irfannuddin Irfannuddin Jasirwan, Shanty Olivia Jaslindo, Lieka Nugrahi Joedo Prihartono Julia Rahadian Jusman, Sri Widia Azraki Khamelia Malik La Febry Andira Rose Cynthia Legiran Legiran Lina Marlina Lyra Puspa Mahyuddin, Hilman Mailani, Rena Makkiyah, Feda Anisah Martina Wiwie Setiawan Nasrun Martina Wiwie Setiawan Nasrun Minarma Siagian Minarma Siagian Mohamad Sadikin Mohamad Saekhu Muhammad Ramli Ahmad Neng Tine Kartinah Almuktabar Ninik Mudjihartini Paul T. Brown Puspa, Lyra Putu Indah Paramita Adi Putri Rickie Rifqi Sabita Rifqi Sabita Rizal Zainal Roman Goenarjo Ronokusumo, Teguh A.S. Salim Harris Santoso, Dewi Irawati Soeria Satriotomo, Irawan Shadrina, Amalia Sophie Yolanda Sophie Yolanda Sri Redjeki Sri Yani Suci Anggraini Sudigdo Sastroasmoro Trinovita Andraini Trinovita Andraini Wanarani Alwin Wardaya Wardaya Wawan Mulyawan Wijaya, Ade Zenik Kusrini

Title

Found 20 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 20 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 20 Documents
Search